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pGL4.23 C3_21

Plasmid

#60296

Purpose

This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.

Depositor

Jorge Ferrer

Article

Pasquali et al Nat Genet. 2014 Feb;46(2):136-43. doi: 1

Insert

CDKN2BAS enhancer (CDKN2B-AS1 Human)

Use

Luciferase

Tags

Luciferase

Expression

Mammalian

Available Since

Dec. 2, 2014

Availability

Academic Institutions and Nonprofits only
pGL4.23 C3_19

Plasmid

#60302

Purpose

This plasmid contains a human pancreatic islet active enhancer, a minimal promoter and a luc2 gene.

Depositor

Jorge Ferrer

Article

Pasquali et al Nat Genet. 2014 Feb;46(2):136-43. doi: 1

Insert

THADA enhancer (THADA Human)

Use

Luciferase

Tags

Luciferase

Expression

Mammalian

Available Since

Dec. 2, 2014

Availability

Academic Institutions and Nonprofits only
TDP-43_CTD_12S→E_S305C/A326P

Plasmid

#248868

Purpose

Expresses MBP-tagged C-terminal domain of TDP-43 with 12S→E, S305C and A326P.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_12S→E_S305C/A326P (TARDBP Human)

Tags

6xHis tags-MBP

Expression

Bacterial

Mutation

changed S292E, S369E, S377E, S379E, S387E, S389E,…

Available Since

Dec. 3, 2025

Availability

Academic Institutions and Nonprofits only

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TDP-43_CTD_13S→E_S317C

Plasmid

#248845

Purpose

Expresses 6xHis-tagged C-terminal domain of TDP-43 with 13S→E and S317C.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_13S→E_S317C (TARDBP Human)

Tags

6xHis-tags

Expression

Bacterial

Mutation

changed S292E, S305E, S369E, S377E, S379E, S387E,…

Available Since

Dec. 3, 2025

Availability

Academic Institutions and Nonprofits only

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TDP-43_CTD_13S→E_S273C

Plasmid

#248859

Purpose

Expresses 6xHis-tagged C-terminal domain of TDP-43 with 13S→E and S273C.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_13S→E_S273C (TARDBP Human)

Tags

6xHis-tags

Expression

Bacterial

Mutation

changed S292E, S305E, S369E, S377E, S379E, S387E,…

Available Since

Dec. 3, 2025

Availability

Academic Institutions and Nonprofits only

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TDP-43_CTD_12S→E_S305C

Plasmid

#248867

Purpose

Expresses MBP-tagged C-terminal domain of TDP-43 with 12S→E and S305C.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_12S→E_S305C (TARDBP Human)

Tags

6xHis tags-MBP

Expression

Bacterial

Mutation

changed S292E, S369E, S377E, S379E, S387E, S389E,…

Available Since

Dec. 3, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-DIO-NES-SomaFRCaMPi

Plasmid

#232836

Purpose

AAV transfer plasmid for CAG-mediated Cre-dependent expression of soma-targeted FRCaMPi

Depositor

Kiryl Piatkevich

Article

Zhou et al PLoS Biol. 2025 Apr 29;23(4):e3003048. d

Insert

NES-FRCaMPi (NES Synthetic)

Use

AAV

Expression

Mammalian

Promoter

CAG

Available Since

Aug. 15, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-Syn-NES-SomaKGECO1

Plasmid

#232839

Purpose

AAV transfer plasmid for Syn-mediated expression of soma-targeted KGECO1

Depositor

Kiryl Piatkevich

Article

Zhou et al PLoS Biol. 2025 Apr 29;23(4):e3003048. d

Insert

NES-SomaKGECO1 (NES Synthetic)

Use

AAV

Expression

Mammalian

Promoter

Syn

Available Since

July 28, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-NES-FRCaMPi-P2A-mGreenLantern

Plasmid

#232841

Purpose

AAV transfer plasmid for CAG-mediated co-expression of FRCaMPi and mGreenLantern

Depositor

Kiryl Piatkevich

Article

Zhou et al PLoS Biol. 2025 Apr 29;23(4):e3003048. d

Insert

NES-FRCaMPi (NES Synthetic)

Use

AAV

Expression

Mammalian

Promoter

CAG

Available Since

July 28, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-NES-KGECO1-P2A-mGreenLantern

Plasmid

#232843

Purpose

AAV transfer plasmid for CAG-mediated co-expression of KGECO1 and mGreenLantern

Depositor

Kiryl Piatkevich

Article

Zhou et al PLoS Biol. 2025 Apr 29;23(4):e3003048. d

Inserts

NES-KGECO1 (NES Synthetic)
mGreenLantern

Use

AAV

Expression

Mammalian

Promoter

CAG

Available Since

July 28, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-NES-jRGECO1-P2A-mGreenLantern

Plasmid

#232844

Purpose

AAV transfer plasmid for CAG-mediated co-expression of jRGECO1 and mGreenLantern

Depositor

Kiryl Piatkevich

Article

Zhou et al PLoS Biol. 2025 Apr 29;23(4):e3003048. d

Inserts

NES-jRGECO1 (NES Synthetic)
mGreenLantern

Use

AAV

Expression

Mammalian

Promoter

CAG

Available Since

July 28, 2025

Availability

Academic Institutions and Nonprofits only

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pT3TS-RfxCas13d-2C-NLS

Plasmid

#239816

Purpose

Plasmid to carry out IVT of RfxCas13d with SV40 and nucleoplasmin long-NLP NLS (human codon-optimized)

Depositor

Miguel Angel Moreno-Mateos

Article

Moreno-Sanchez et al Nat Commun. 2025 Mar 16;16(1):2591. doi:

Insert

Rfx-Cas13d

Use

CRISPR

Tags

Nucleoplasmin long NLS and SV40 NLS

Available Since

July 21, 2025

Availability

Academic Institutions and Nonprofits only

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pCMV6-CNDP2-E166D

Plasmid

#226720

Purpose

Mammalian expression of cytosolic mouse CNDP2 mutant E166D

Depositor

Jonathan Long

Article

Moya-Garzon et al Cell. 2025 Jan 9;188(1):175-186.e20. doi

Insert

CNDP2 (Cndp2 Mouse)

Expression

Mammalian

Mutation

E166D

Available Since

July 10, 2025

Availability

Academic Institutions and Nonprofits only

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pCMV6-CNDP2-E166L

Plasmid

#226721

Purpose

Mammalian expression of cytosolic mouse CNDP2 mutant E166L

Depositor

Jonathan Long

Article

Moya-Garzon et al Cell. 2025 Jan 9;188(1):175-186.e20. doi

Insert

CNDP2 (Cndp2 Mouse)

Expression

Mammalian

Mutation

E166L

Available Since

July 10, 2025

Availability

Academic Institutions and Nonprofits only

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pCMV6-CNDP2-D195A

Plasmid

#226722

Purpose

Mammalian expression of cytosolic mouse CNDP2 mutant D195A

Depositor

Jonathan Long

Article

Moya-Garzon et al Cell. 2025 Jan 9;188(1):175-186.e20. doi

Insert

CNDP2 (Cndp2 Mouse)

Expression

Mammalian

Mutation

D195A

Available Since

July 10, 2025

Availability

Academic Institutions and Nonprofits only

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pCMV6-CNDP2-H445F

Plasmid

#226723

Purpose

Mammalian expression of cytosolic mouse CNDP2 mutant H445F

Depositor

Jonathan Long

Article

Moya-Garzon et al Cell. 2025 Jan 9;188(1):175-186.e20. doi

Insert

CNDP2 (Cndp2 Mouse)

Expression

Mammalian

Mutation

H445F

Available Since

July 10, 2025

Availability

Academic Institutions and Nonprofits only

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pcDNA3.1-GSDMD_H270A

Plasmid

#224701

Purpose

Expression of mutated Gasdermin D_H270A (GSDMD_H270A) in transfected mammalian cell lines

Depositor

Christopher Overall

Article

Grin et al Cell Rep. 2024 Dec 24;43(12):115080. doi

Insert

GSDMD_H270A (GSDMD Human)

Tags

FLAG

Expression

Mammalian

Mutation

H270A

Promoter

CMV

Available Since

July 2, 2025

Availability

Industry, Academic Institutions, and Nonprofits

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pcDNA3.1-GSDMD_Q29A

Plasmid

#224702

Purpose

Expression of mutated Gasdermin D_Q29A (GSDMD_Q29A) in transfected mammalian cell lines

Depositor

Christopher Overall

Article

Grin et al Cell Rep. 2024 Dec 24;43(12):115080. doi

Insert

GSDMD_Q29A (GSDMD Human)

Tags

FLAG

Expression

Mammalian

Mutation

Q29A

Promoter

CMV

Available Since

July 2, 2025

Availability

Industry, Academic Institutions, and Nonprofits

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pcDNA3.1-GSDMD_Q29A_H270A

Plasmid

#224703

Purpose

Expression of mutant Gasdermin D_Q29A_H270A (GSDMD_Q29A_H270A) in transfected mammalian cell lines

Depositor

Christopher Overall

Article

Grin et al Cell Rep. 2024 Dec 24;43(12):115080. doi

Insert

GSDMD_Q29A_H270A (GSDMD Human)

Tags

FLAG

Expression

Mammalian

Mutation

Q29A and H270A

Promoter

CMV

Available Since

July 2, 2025

Availability

Industry, Academic Institutions, and Nonprofits

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pcDNA3.1-GSDMD_D275A

Plasmid

#224704

Purpose

Expression of mutated Gasdermin D_D275A (GSDMD_D275A) in transfected mammalian cell lines

Depositor

Christopher Overall

Article

Grin et al Cell Rep. 2024 Dec 24;43(12):115080. doi

Insert

GSDMD_D275A (GSDMD Human)

Tags

FLAG

Expression

Mammalian

Mutation

D275A

Promoter

CVM

Available Since

July 2, 2025

Availability

Industry, Academic Institutions, and Nonprofits

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