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pOTTC1270 - pAAV Rosa26 gRNA A+B EF1a EGFP

Plasmid

#113156

Purpose

An AAV vector that expresses guide RNAs targeting rat Rosa26 and expresses EGFP reporter

Depositor

Brandon Harvey

Article

Back et al Neuron. 2019 Feb 8. pii: S0896-6273(19)3

Insert

Two gRNAs for rat Rosa26

Use

AAV and CRISPR

Expression

Mammalian

Promoter

mU6 and hU6

Available Since

March 7, 2019

Availability

Academic Institutions and Nonprofits only

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40_pAAV-ProC9-CatCh-GFP-WPRE

Plasmid

#125944

Purpose

Targeting expression to neuronal and glial cell types in mice, non-human primates, and human retina

Depositor

Botond Roska

Article

Juttner et al Nat Neurosci. 2019 Jul 8. pii: 10.1038/s

Insert

CatCh-GFP

Use

AAV

Promoter

ProC9

Available Since

Sept. 20, 2019

Availability

Academic Institutions and Nonprofits only

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95_pAAV-ProA28-CatCh-GFP-WPRE

Plasmid

#125911

Purpose

Targeting expression to neuronal and glial cell types in mice, non-human primates, and human retina

Depositor

Botond Roska

Article

Juttner et al Nat Neurosci. 2019 Jul 8. pii: 10.1038/s

Insert

CatCh-GFP

Use

AAV

Promoter

ProA28

Available Since

Sept. 19, 2019

Availability

Academic Institutions and Nonprofits only

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61_pAAV-ProA18-CatCh-GFP-WPRE

Plasmid

#125901

Purpose

Targeting expression to neuronal and glial cell types in mice, non-human primates, and human retina

Depositor

Botond Roska

Article

Juttner et al Nat Neurosci. 2019 Jul 8. pii: 10.1038/s

Insert

CatCh-GFP

Use

AAV

Promoter

ProA18

Available Since

Sept. 18, 2019

Availability

Academic Institutions and Nonprofits only

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5_pAAV-ProA9-CatCh-GFP-WPRE

Plasmid

#125893

Purpose

Targeting expression to neuronal and glial cell types in mice, non-human primates, and human retina

Depositor

Botond Roska

Article

Juttner et al Nat Neurosci. 2019 Jul 8. pii: 10.1038/s

Insert

CatCh-GFP

Use

AAV

Promoter

ProA9

Available Since

Sept. 18, 2019

Availability

Academic Institutions and Nonprofits only

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214_pAAV-ProD22-CatCh-GFP-WPRE

Plasmid

#125998

Purpose

Targeting expression to neuronal and glial cell types in mice, non-human primates, and human retina

Depositor

Botond Roska

Article

Juttner et al Nat Neurosci. 2019 Jul 8. pii: 10.1038/s

Insert

CatCh-GFP

Use

AAV

Promoter

ProD22

Available Since

Sept. 17, 2019

Availability

Academic Institutions and Nonprofits only

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159_pAAV-ProD3-CatCh-GFP-WPRE

Plasmid

#125979

Purpose

Targeting expression to neuronal and glial cell types in mice, non-human primates, and human retina

Depositor

Botond Roska

Article

Juttner et al Nat Neurosci. 2019 Jul 8. pii: 10.1038/s

Insert

CatCh-GFP

Use

AAV

Promoter

ProD3

Available Since

Sept. 16, 2019

Availability

Academic Institutions and Nonprofits only

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AAV-KrasG13V/sgKras/Cre

Plasmid

#99860

Purpose

Expresses Cre-recombinase, a barcoded HDR template to introduce a G13V mutation into the endogenous Kras locus, and a Kras-targeting sgRNA to enhance HDR.

Depositor

Monte Winslow

Article

Winters et al Nat Commun. 2017 Dec 12;8(1):2053. doi:

Insert

Kras (Kras Mouse)

Use

AAV and Cre/Lox

Expression

Mammalian

Mutation

AvrII site (CAAAGG>CCTAGG), PAM/sgRNA mutation…

Available Since

Dec. 13, 2017

Availability

Academic Institutions and Nonprofits only

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AAV-Nppa-Cre-P2A-TagRFP

Plasmid

#247328

Purpose

Expresses Cre and TagRFP under the control of the Nppa promoter.

Depositor

William Pu, Mason Sweat

Article

Sweat et al Nat Cardiovasc Res. 2023 Oct;2(10):881-8

Insert

Cre-P2A-TagRFP

Use

AAV

Expression

Mammalian

Promoter

Nppa proximal promoter

Available Since

March 4, 2026

Availability

Academic Institutions and Nonprofits only

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pAAVLINK-EF1alpha-HA-5'-TNRC6C

Plasmid

#244340

Purpose

5' AAVLINK plasmid for TNRC6C expression

Depositor

Zhonghua Lu

Article

Lin et al Cell. 2026 Feb 5;189(3):969-986.e17. doi

Insert

TNRC6C (TNRC6C Human)

Use

AAV

Tags

HA

Promoter

EF1alpha

Available Since

Nov. 10, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV EfIa DIO CaBLAM

Plasmid

#244229

Purpose

Cre dependent bioluminescent reporter for calcium signaling

Depositor

Ute Hochgeschwender

Article

Lambert et al Nat Methods. 2025 Dec 2. doi: 10.1038/s4

Inserts

mNeonGreen
CaBLAM

Use

AAV

Available Since

Nov. 6, 2025

Availability

Academic Institutions and Nonprofits only

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AAV-Nppa-Cre

Plasmid

#247326

Purpose

Expresses Cre recombinase under the control of the Nppa Promoter.

Depositor

William Pu, Mason Sweat

Article

Sweat et al Nat Cardiovasc Res. 2023 Oct;2(10):881-8

Insert

Nppa-Cre

Use

AAV

Expression

Mammalian

Mutation

TagRFP is out of frame and therefore not translat…

Promoter

Nppa Proximal promoter

Available Since

Nov. 4, 2025

Availability

Academic Institutions and Nonprofits only

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pAAVLINK-EF1alpha-HA-5'-RALGAPB

Plasmid

#244258

Purpose

5' AAVLINK plasmid for RALGAPB expression

Depositor

Zhonghua Lu

Article

Lin et al Cell. 2026 Feb 5;189(3):969-986.e17. doi

Insert

RALGAPB (RALGAPB Human)

Use

AAV

Tags

HA

Promoter

EF1alpha

Available Since

Oct. 9, 2025

Availability

Academic Institutions and Nonprofits only

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pAAVLINK-EF1alpha-5'-NRXN2

Plasmid

#244274

Purpose

5' AAVLINK plasmid for NRXN2 expression

Depositor

Zhonghua Lu

Article

Lin et al Cell. 2026 Feb 5;189(3):969-986.e17. doi

Insert

NRXN2 (NRXN2 Human)

Use

AAV

Tags

HA

Promoter

EF1alpha

Available Since

Oct. 9, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-EF1a-FLEX(FLP)-OCaMP-WPRE

Plasmid

#224936

Purpose

pAAV vector for flippase(FLP)-dependent OCaMP (orange calcium indicator) expression under the control of EF1a promoter

Depositor

Alexander Lohman

Article

Aggarwal et al bioRxiv 2025.07.28.667269; doi: https://

Insert

OCaMP

Use

AAV

Tags

6xHis

Expression

Mammalian

Promoter

Ef1a

Available Since

July 28, 2025

Availability

Industry, Academic Institutions, and Nonprofits

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pAAVLINK-EF1alpha-5' PREX1

Plasmid

#236708

Purpose

5' AAVLINK plasmid for PREX1 expression

Depositor

Zhonghua Lu

Article

Lin et al Cell. 2026 Feb 5;189(3):969-986.e17. doi

Insert

PREX1 (PREX1 Human)

Use

AAV

Tags

HA

Promoter

EF1alpha

Available Since

July 24, 2025

Availability

Academic Institutions and Nonprofits only

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pAAVLINK-EF1alpha-5' PRR12

Plasmid

#236676

Purpose

5' AAVLINK plasmid for PRR12 expression

Depositor

Zhonghua Lu

Article

Lin et al Cell. 2026 Feb 5;189(3):969-986.e17. doi

Insert

PRR12 (PRR12 Human)

Use

AAV

Tags

HA

Promoter

EF1alpha

Available Since

July 24, 2025

Availability

Academic Institutions and Nonprofits only

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pAAVLINK-EF1alpha-5' NINL

Plasmid

#236690

Purpose

5' AAVLINK plasmid for NINL expression

Depositor

Zhonghua Lu

Article

Lin et al Cell. 2026 Feb 5;189(3):969-986.e17. doi

Insert

NINL (NINL Human)

Use

AAV

Tags

HA

Promoter

EF1alpha

Available Since

July 24, 2025

Availability

Academic Institutions and Nonprofits only

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pAAVLINK-EF1alpha-5' NEO1

Plasmid

#236700

Purpose

5' AAVLINK plasmid for NEO1 expression

Depositor

Zhonghua Lu

Article

Lin et al Cell. 2026 Feb 5;189(3):969-986.e17. doi

Insert

NEO1 (NEO1 Human)

Use

AAV

Tags

HA

Promoter

EF1alpha

Available Since

July 24, 2025

Availability

Academic Institutions and Nonprofits only

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AAV-U6-sgPlxnb2-KO-4-EF1a-LibVec

Plasmid

#239600

Purpose

expresses guide#4 to knock-out mouse Plxnb2, via CRISPR-Cas9

Depositor

Andreas Moor

Article

Borrelli et al Nature. 2024 Aug;632(8024):411-418. doi:

Insert

Plxnb2 (Plxnb2 Mouse)

Use

AAV

Expression

Mammalian

Promoter

hU6

Available Since

July 11, 2025

Availability

Academic Institutions and Nonprofits only

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AAV-U6-sgPlxnb2-KO-3-EF1a-LibVec

Plasmid

#239599

Purpose

expresses guide#3 to knock-out mouse Plxnb2, via CRISPR-Cas9

Depositor

Andreas Moor

Article

Borrelli et al Nature. 2024 Aug;632(8024):411-418. doi:

Insert

Plxnb2 (Plxnb2 Mouse)

Use

AAV

Expression

Mammalian

Promoter

hU6

Available Since

July 11, 2025

Availability

Academic Institutions and Nonprofits only

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AAV-U6-sgPlxnb2-KO-2-EF1a-LibVec

Plasmid

#239598

Purpose

expresses guide#2 to knock-out mouse Plxnb2, via CRISPR-Cas9

Depositor

Andreas Moor

Article

Borrelli et al Nature. 2024 Aug;632(8024):411-418. doi:

Insert

Plxnb2 (Plxnb2 Mouse)

Use

AAV

Expression

Mammalian

Promoter

hU6

Available Since

July 11, 2025

Availability

Academic Institutions and Nonprofits only

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AAV-U6-sgPlxnb2-KO-1-EF1a-LibVec

Plasmid

#239597

Purpose

expresses guide#1 to knock-out mouse Plxnb2, via CRISPR-Cas9

Depositor

Andreas Moor

Article

Borrelli et al Nature. 2024 Aug;632(8024):411-418. doi:

Insert

Plxnb2 (Plxnb2 Mouse)

Use

AAV

Expression

Mammalian

Promoter

hU6

Available Since

July 11, 2025

Availability

Academic Institutions and Nonprofits only

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AAV-U6-sgPlxnb2-CRISPRa-3-EF1a-LibVec

Plasmid

#239596

Purpose

expresses guide#3 to boost the expression of mouse Plxnb2, via CRISPRa

Depositor

Andreas Moor

Article

Borrelli et al Nature. 2024 Aug;632(8024):411-418. doi:

Insert

Plxnb2 (Plxnb2 Mouse)

Use

AAV

Expression

Mammalian

Promoter

hU6

Available Since

July 11, 2025

Availability

Academic Institutions and Nonprofits only

Enlarge
AAV-U6-sgPlxnb2-CRISPRa-1-EF1a-LibVec

Plasmid

#239594

Purpose

expresses guide#1 to boost the expression of mouse Plxnb2, via CRISPRa

Depositor

Andreas Moor

Article

Borrelli et al Nature. 2024 Aug;632(8024):411-418. doi:

Insert

Plxnb2 (Plxnb2 Mouse)

Use

AAV

Expression

Mammalian

Promoter

hU6

Available Since

July 11, 2025

Availability

Academic Institutions and Nonprofits only

Enlarge
AAV-U6-sgPlxnb2-CRISPRa-2-EF1a-LibVec

Plasmid

#239595

Purpose

expresses guide#2 to boost the expression of mouse Plxnb2, via CRISPRa

Depositor

Andreas Moor

Article

Borrelli et al Nature. 2024 Aug;632(8024):411-418. doi:

Insert

Plxnb2 (Plxnb2 Mouse)

Use

AAV

Expression

Mammalian

Promoter

hU6

Available Since

July 11, 2025

Availability

Academic Institutions and Nonprofits only

Enlarge
pAAVLINK-EF1alpha-5' UBN2

Plasmid

#236678

Purpose

5' AAVLINK plasmid for UBN2 expression

Depositor

Zhonghua Lu

Article

Lin et al Cell. 2026 Feb 5;189(3):969-986.e17. doi

Insert

UBN2 (UBN2 Human)

Use

AAV

Tags

HA

Promoter

EF1alpha

Available Since

June 23, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV hSyn INTRON HaloTag-STIM2 WPRE

Plasmid

#236235

Purpose

AAV expression of human STIM2 internally tagged with HaloTag

Depositor

Jennifer Lippincott-Schwartz

Article

Benedetti et al Cell. 2025 Jan 23;188(2):484-500.e22. do

Insert

HaloTag-STIM2 (STIM2 Human)

Use

AAV

Tags

HaloTag in position 29

Mutation

Signal peptide from STIM1 and residues 15-746 of …

Promoter

human Synapsin 1

Available Since

May 1, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-Loxp-CMV-Loxp-GFP-LA

Plasmid

#206199

Purpose

Expresses GFP-lamin-A only in non-myocyte when delivered into mice carrying a cardiomyocyte-specific Myh6-Cre transgene

Depositor

Yuxuan Guo

Article

Sun et al JACC Basic Transl Sci. 2024 Aug 21;9(11)

Insert

Lmna (LMNA Human)

Use

AAV

Tags

GFP

Promoter

CMV

Available Since

Aug. 23, 2024

Availability

Academic Institutions and Nonprofits only

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83_pAAV-ProC14-CatCh-GFP-WPRE

Plasmid

#125949

Purpose

Targeting expression to neuronal and glial cell types in mice, non-human primates, and human retina

Depositor

Botond Roska

Article

Juttner et al Nat Neurosci. 2019 Jul 8. pii: 10.1038/s

Insert

CatCh-GFP

Use

AAV

Promoter

ProC14

Available Since

Oct. 31, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge