We narrowed to 172 results for: TOX;

1. Antibody Validation for Flow Cytometry

   Type

   Blog Post

   ...target with very low expression, due to induced toxicity caused by the protein of interest. HLDA workshop...

2. CRISPR Methods for Bacteria: Genome Engineering, CRISPRa, CRISPRi, Base Editing, and More

   Type

   Blog Post

   ...system has generally low efficiencies or can be proteotoxic when used in Mycobacterial species, Sarah Fortune...

3. Troubleshooting and Optimizing a Western Blot

   Type

   Blog Post

   ...Western Blotting. Journal of Pharmacological and Toxicological Methods, 64, 233–237. https://doi.org/10.1016...

4. Fluorescent Protein Guide: Biosensors

   Type

   Collection

   ... reveals a role for pH regulation in hair cell toxicity and function. Dis Model Mech. 2014 Jul;7(7):847...

5. Viral Vectors 101: Systemic Capsids

   Type

   Blog Post

   ...susceptible to off-target transgene expression-induced toxicity in NHPs (Hordeaux et al, 2020; Hudry et al, 2023...

6. Optogenetics Guide

   Type

   Guide

   ...the target protein is to be sequestered Lumitoxin Peptide toxin for blocking K + (Kv) channels fused to...causes the photoswitch to unfold, lowering the toxin's local concentration near the cell surface, and ...

7. Lentiviral Vector Guide

   Type

   Guide

   ...stability of the viral particles. However, VSV-G is toxic under long-term, constitutive expression. In order...Lymphocytic Choriomeningitis Virus (LCMV) – less toxic and inflammatory; targets wide range of cell types...the target cell population and reduce cellular toxicity. Common Uses of Lentiviral Vectors Due to their...

8. CRISPR Guide

   Type

   Guide

   ...can increase the risk of off-target cutting or cytotoxicity, but naturally-occurring Acr (Anti-CRISPR) proteins...including resistances to chemotherapy drugs and toxins, cell viability, and tumor metastasis. One of the...

9. Guide to Using Pooled Libraries

   Type

   Guide

   ...vemurafenib , resistance to Clostridium septicum alpha-toxin , and resistance to to the nucleotide analog 6-thioguanine...

10. Plan Your Experiment

    Type

    Guide

    ...dividing and non-dividing cells AAV is the least toxic method for in vivo viral delivery RNA delivery of...

11. Gamma-Retroviral Vector Guide

    Type

    Guide

    ...stability of the viral particles. However, VSV-G is toxic under long-term, constitutive expression. In order...

12. Adeno-associated virus (AAV) Guide

    Type

    Guide

    ... (BBB) Layer of cells that prevent the entry of toxins and pathogens from the blood to the CNS. Concatemer...