Hot Plasmids April 2018 - Protein Degradation, Nanoscopy, FIRE-Cas9, and Yeast Expression Tools
Type
Blog Post
...difficult-to-manipulate primary cells, achieving knockdown within 1-2 hr of reagent delivery. TRIM-Away is suitable for ...factor 1 controls expression of transcription factor 2, which directly controls expression of a reporter ...modulating the induction of transcription factors 1 and 2. See Aranda-Díaz et al. for more information. The ...Podcast!
TRIM-Away: Targeted endogenous protein degradation
Article contributed by Mary Gearing
Listen to...tool existed for rapid, customizable protein degradation. Enter TRIM-Away - an antibody-based system developed...the protein of interest led to rapid, targeted degradation that is dependent on proteasome function. TRIM-away...