...transduces BALB/cJ, CBA/J, and FVB/NJ mice, with minimal liver transduction observed in both BALB/cJ and ...enhanced transgene expression, compared to AAV9, in BALB/cJ mice but is more effective than AAV9 in many ...brain endothelial cells in C57BL/6J mice, but not in BALB/cJ mice, meaning that systemic capsids that rely...rely on LY6A interactions cannot cross the BBB in BALB/cJ mice (Hordeaux et al., 2018). This results in ... called LY6C1. This protein is expressed in both BALB/cJ mice and C57BL/6J mice (Shay et al., 2023; Huang... effectively transduces cells in the CNS of both BALB/cJ and C57BL/6J mice (Shay et al., 2023).
AAV-PHP.AX... in transduction efficiency between C57BL/6J and BALB/cJ mice due to its LY6C1 dependence.
MDV1A and MDV1B...