Photosensitizer Induced Cell Ablation with FAP-TAP MG-2I-dL5**
Type
Blog Post
...expression of the FAP.
A new photosensitizer: FAP-TAP MG-2I-dL5**
MG-2I-dL5** is a new FAP-TAP complex where...protein partner thus forming the full FAP-TAP complex (MG-2I-dL5**). A FAP-TAP complex will light up if excited...composed of two parts: 1) an activatable protein (the FAP - fluorogen activating protein - dL5** in this case... where dL5** is the FAP. It’s job is to bind MG-2I, a photosensitizer fluorogenic dye. MG-2I is the TAP...increased ROS generation when bound by the dL5** FAP. The iodine-modifications also shift MG-2I’s excitation...Above is a brief schematic of how the MG-2I-dL5** FAP-TAP system works.
Find the Plasmids from the Publication...zebrafish’s heartbeat and blood circulation of following FAP-TAP light activation.
Video: https://www.youtube....