Chemogenetics Guide
Type
Guide
.... DREADDs for Neuroscientists. Neuron, 89 (4), 683–694. https://doi.org/10.1016/j.neuron.2016.01.040 PMID...control of neuronal activity. Table 1: Descriptions of DREADDs and their activity in neurons DREADD Receptor... and outcome in neurons. Table 2: Descriptions of PSAMs and their activity in neurons PSAM Ion Pore Domain...influx Neuronal activation Magnus et al., 2019 PSAM Q79G,Q139G Gly PSEM 22S Cl - influx Neuronal inhibition...influx Neuronal activation Magnus et al., 2011 PSAM L141F,Y115F Gly PSEM 89S Cl - influx Neuronal inhibition...expressed. However, neuronal control through PSAMs and LMOs is direct, while neuronal control of DREADDs...Specificity hSyn1, CaMKIIa Neurons GFAP Glia CD68 Microglia Dlx Interneurons EF1a, CAG General expression...