pCMV delta R8.2 Citations (166)
Originally described in: Trono Lab Packaging and Envelope PlasmidsUnpublished
Articles Citing pCMV delta R8.2
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| Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Thiyagarajan S, Bhatia N, Reagan-Shaw S, Cozma D, Thomas-Tikhonenko A, Ahmad N, Spiegelman VS. Cancer Res. 2007 Nov 15;67(22):10642-6. PubMed |
| Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. Lu L, Wang S, Zheng L, Li X, Suswam EA, Zhang X, Wheeler CG, Nabors LB, Filippova N, King PH. J Biol Chem. 2009 Dec 4. 284(49):33989-98. PubMed |
| Pseudotyping incompatibility between HIV-1 and gibbon ape leukemia virus Env is modulated by Vpu. Lucas TM, Lyddon TD, Cannon PM, Johnson MC. J Virol. 2010 Mar;84(6):2666-74. doi: 10.1128/JVI.01562-09. Epub 2009 Dec 30. PubMed |
| Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Gordon JA, Hassan MQ, Saini S, Montecino M, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Mol Cell Biol. 2010 Jul;30(14):3531-41. doi: 10.1128/MCB.00889-09. Epub 2010 May 3. PubMed |
| Two distinct mechanisms regulate recruitment of murine leukemia virus envelope protein to retroviral assembly sites. Lucas TM, Lyddon TD, Grosse SA, Johnson MC. Virology. 2010 Sep 30;405(2):548-55. doi: 10.1016/j.virol.2010.06.017. Epub 2010 Jul 23. PubMed |
| Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Cells Tissues Organs. 2011;194(2-4):146-50. doi: 10.1159/000324790. Epub 2011 May 19. PubMed |
| Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM 3rd, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA. J Exp Med. 2012 Apr 9;209(4):855-69. doi: 10.1084/jem.20111721. Epub 2012 Apr 2. PubMed |
| Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes. Griffin LM, Cicchini L, Pyeon D. Virology. 2013 Mar 1;437(1):12-9. doi: 10.1016/j.virol.2012.12.004. Epub 2013 Jan 4. PubMed |
| DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Soda T, Frank C, Ishizuka K, Baccarella A, Park YU, Flood Z, Park SK, Sawa A, Tsai LH. Mol Psychiatry. 2013 Aug;18(8):898-908. doi: 10.1038/mp.2013.38. Epub 2013 Apr 16. PubMed |
| Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages. Bai X, Feldman NE, Chmura K, Ovrutsky AR, Su WL, Griffin L, Pyeon D, McGibney MT, Strand MJ, Numata M, Murakami S, Gaido L, Honda JR, Kinney WH, Oberley-Deegan RE, Voelker DR, Ordway DJ, Chan ED. PLoS One. 2013 Apr 25;8(4):e61925. doi: 10.1371/journal.pone.0061925. Print 2013. PubMed |
| Lentiviral overexpression of miRNAs. Zollner H, Hahn SA, Maghnouj A. Methods Mol Biol. 2014;1095:177-90. doi: 10.1007/978-1-62703-703-7_15. PubMed |
| Human keratinocyte cultures in the investigation of early steps of human papillomavirus infection. Griffin LM, Cicchini L, Xu T, Pyeon D. Methods Mol Biol. 2014;1195:219-38. doi: 10.1007/7651_2013_49. PubMed |
| Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling. Spindler V, Dehner C, Hubner S, Waschke J. J Invest Dermatol. 2014 Jun;134(6):1655-64. doi: 10.1038/jid.2014.21. Epub 2014 Jan 17. PubMed |
| Design and analysis of site-specific single-strand nicking endonucleases for gene correction. Metzger MJ, Certo MT. Methods Mol Biol. 2014;1114:237-44. doi: 10.1007/978-1-62703-761-7_15. PubMed |
| Chikungunya virus glycoproteins pseudotype with lentiviral vectors and reveal a broad spectrum of cellular tropism. Hu D, Zhang J, Wang H, Liu S, Yu L, Sun L, Qu Y. PLoS One. 2014 Oct 21;9(10):e110893. doi: 10.1371/journal.pone.0110893. eCollection 2014. PubMed |
| APOBEC3A functions as a restriction factor of human papillomavirus. Warren CJ, Xu T, Guo K, Griffin LM, Westrich JA, Lee D, Lambert PF, Santiago ML, Pyeon D. J Virol. 2015 Jan;89(1):688-702. doi: 10.1128/JVI.02383-14. Epub 2014 Oct 29. PubMed |
| Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Mol Psychiatry. 2015 Feb;20(2):162-9. doi: 10.1038/mp.2014.143. Epub 2014 Nov 18. PubMed |
| Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Mathias RA, Greco TM, Oberstein A, Budayeva HG, Chakrabarti R, Rowland EA, Kang Y, Shenk T, Cristea IM. Cell. 2014 Dec 18;159(7):1615-25. doi: 10.1016/j.cell.2014.11.046. PubMed |
| The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. Nat Neurosci. 2015 Jul;18(7):1008-16. doi: 10.1038/nn.4023. Epub 2015 May 25. PubMed |
| CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells. Flynn R, Grundmann A, Renz P, Hanseler W, James WS, Cowley SA, Moore MD. Exp Hematol. 2015 Oct;43(10):838-848.e3. doi: 10.1016/j.exphem.2015.06.002. Epub 2015 Jun 19. PubMed |
| MicroRNA-665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic Mechanisms. Heair HM, Kemper AG, Roy B, Lopes HB, Rashid H, Clarke JC, Afreen LK, Ferraz E, Kim E, Javed A, Beloti M, MacDougall M, Hassan M. Mol Cell Biol. 2015 Jun 29. pii: MCB.00093-15. PubMed |
Improvement of HIV-1 and Human T Cell Lymphotropic Virus Type 1 Replication-Dependent Vectors via Optimization of Reporter Gene Reconstitution and Modification with Intronic Short Hairpin RNA.
Shunaeva A, Potashnikova D, Pichugin A, Mishina A, Filatov A, Nikolaitchik O, Hu WS, Mazurov D.
J Virol. 2015 Oct 15;89(20):10591-601. doi: 10.1128/JVI.01940-15. Epub 2015 Aug 12.
PubMed
Associated Plasmids |
| Optimization of a multiplex CRISPR/Cas system for use as an antiviral therapeutic. Kennedy EM, Kornepati AV, Mefferd AL, Marshall JB, Tsai K, Bogerd HP, Cullen BR. Methods. 2015 Dec;91:82-6. doi: 10.1016/j.ymeth.2015.08.012. Epub 2015 Aug 17. PubMed |
| TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. Pasini L, Re A, Tebaldi T, Ricci G, Boi S, Adami V, Barbareschi M, Quattrone A. BMC Cancer. 2015 Oct 24;15:777. doi: 10.1186/s12885-015-1791-y. PubMed |
| CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells. Jing W, Zhang X, Sun W, Hou X, Yao Z, Zhu Y. Biomed Res Int. 2015;2015:326042. doi: 10.1155/2015/326042. Epub 2015 Nov 30. PubMed |
| C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells. Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z. Exp Neurol. 2016 Mar;277:171-7. doi: 10.1016/j.expneurol.2015.12.022. Epub 2015 Dec 31. PubMed |
| beta-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkotter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beissbarth T, Klemm F, Binder C, Pukrop T. Clin Exp Metastasis. 2016 Apr;33(4):309-23. doi: 10.1007/s10585-016-9780-3. Epub 2016 Feb 9. PubMed |
| In Vitro Differentiation of Mouse Granulocytes. Reinhart R, Wicki S, Kaufmann T. Methods Mol Biol. 2016;1419:95-107. doi: 10.1007/978-1-4939-3581-9_8. PubMed |
| TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis. Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga N, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K, Matsuura Y. Nat Commun. 2016 May 4;7:11379. doi: 10.1038/ncomms11379. PubMed |
| Mouse RAGE Variant 4 Is a Dominant Membrane Receptor that Does Not Shed to Generate Soluble RAGE. Peng Y, Horwitz N, Lakatta EG, Lin L. PLoS One. 2016 Sep 21;11(9):e0153657. doi: 10.1371/journal.pone.0153657. eCollection 2016. PubMed |
| Interaction of microtubules with the actin cytoskeleton via cross-talk of EB1-containing +TIPs and gamma-actin in epithelial cells. Dugina V, Alieva I, Khromova N, Kireev I, Gunning PW, Kopnin P. Oncotarget. 2016 Nov 8;7(45):72699-72715. doi: 10.18632/oncotarget.12236. PubMed |
| A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression. Johnson AL, Dirk BS, Coutu M, Haeryfar SM, Arts EJ, Finzi A, Dikeakos JD. mSphere. 2016 Nov 9;1(6). pii: e00288-16. eCollection 2016 Nov-Dec. PubMed |
| Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2681-2686. doi: 10.1073/pnas.1621508114. Epub 2017 Feb 17. PubMed |
| CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses. Descours B, Petitjean G, Lopez-Zaragoza JL, Bruel T, Raffel R, Psomas C, Reynes J, Lacabaratz C, Levy Y, Schwartz O, Lelievre JD, Benkirane M. Nature. 2017 Mar 23;543(7646):564-567. doi: 10.1038/nature21710. Epub 2017 Mar 15. PubMed |
| Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. Shen JP, Zhao D, Sasik R, Luebeck J, Birmingham A, Bojorquez-Gomez A, Licon K, Klepper K, Pekin D, Beckett AN, Sanchez KS, Thomas A, Kuo CC, Du D, Roguev A, Lewis NE, Chang AN, Kreisberg JF, Krogan N, Qi L, Ideker T, Mali P. Nat Methods. 2017 Jun;14(6):573-576. doi: 10.1038/nmeth.4225. Epub 2017 Mar 20. PubMed |
| In Vivo Enrichment of Diabetogenic T Cells. Thelin MA, Kissler S, Vigneault F, Watters AL, White D, Koshy ST, Vermillion SA, Mooney DJ, Serwold T, Ali OA. Diabetes. 2017 Aug;66(8):2220-2229. doi: 10.2337/db16-0946. Epub 2017 Apr 10. PubMed |
| A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer. Carter EP, Gopsill JA, Gomm JJ, Jones JL, Grose RP. Breast Cancer Res. 2017 Apr 21;19(1):50. doi: 10.1186/s13058-017-0843-4. PubMed |
| Recurrent rhinovirus infections in a child with inherited MDA5 deficiency. Lamborn IT, Jing H, Zhang Y, Drutman SB, Abbott JK, Munir S, Bade S, Murdock HM, Santos CP, Brock LG, Masutani E, Fordjour EY, McElwee JJ, Hughes JD, Nichols DP, Belkadi A, Oler AJ, Happel CS, Matthews HF, Abel L, Collins PL, Subbarao K, Gelfand EW, Ciancanelli MJ, Casanova JL, Su HC. J Exp Med. 2017 Jul 3;214(7):1949-1972. doi: 10.1084/jem.20161759. Epub 2017 Jun 12. PubMed |
| Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice. Lee S, Kivimae S, Szoka FC. Mol Ther Methods Clin Dev. 2017 Sep 7;7:60-73. doi: 10.1016/j.omtm.2017.08.007. eCollection 2017 Dec 15. PubMed |
| An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells. Li G, Montgomery JE, Eckert MA, Chang JW, Tienda SM, Lengyel E, Moellering RE. Nat Commun. 2017 Nov 24;8(1):1775. doi: 10.1038/s41467-017-01854-0. PubMed |
| The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4(+) T cells. Pawlak EN, Dirk BS, Jacob RA, Johnson AL, Dikeakos JD. Retrovirology. 2018 Jan 12;15(1):6. doi: 10.1186/s12977-018-0388-3. PubMed |
| Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells. Debernardi J, Hollville E, Lipinski M, Wiels J, Robert A. Oncogene. 2018 May;37(18):2410-2421. doi: 10.1038/s41388-018-0123-5. Epub 2018 Feb 14. PubMed |
| PB1 and UBA domains of p62 are essential for aggresome-like induced structure formation. Cabe M, Rademacher DJ, Karlsson AB, Cherukuri S, Bakowska JC. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2306-2311. doi: 10.1016/j.bbrc.2018.06.153. Epub 2018 Jul 2. PubMed |
| Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1.93.HH8793) and H (BE.93.VI997). Van Nynatten LR, Johnson AL, Dirk BS, Pawlak EN, Jacob RA, Haeryfar SMM, Dikeakos JD. Viruses. 2018 Sep 13;10(9). pii: v10090493. doi: 10.3390/v10090493. PubMed |
| The microRNA-23a cluster regulates the developmental HoxA cluster function during osteoblast differentiation. Godfrey TC, Wildman BJ, Beloti MM, Kemper AG, Ferraz EP, Roy B, Rehan M, Afreen LH, Kim E, Lengner CJ, Hassan Q. J Biol Chem. 2018 Nov 9;293(45):17646-17660. doi: 10.1074/jbc.RA118.003052. Epub 2018 Sep 21. PubMed |
| XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response. Fink EE, Moparthy S, Bagati A, Bianchi-Smiraglia A, Lipchick BC, Wolff DW, Roll MV, Wang J, Liu S, Bakin AV, Kandel ES, Lee AH, Nikiforov MA. Cell Rep. 2018 Oct 2;25(1):212-223.e4. doi: 10.1016/j.celrep.2018.09.013. PubMed |
| Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140. Ambrozkiewicz MC, Schwark M, Kishimoto-Suga M, Borisova E, Hori K, Salazar-Lazaro A, Rusanova A, Altas B, Piepkorn L, Bessa P, Schaub T, Zhang X, Rabe T, Ripamonti S, Rosario M, Akiyama H, Jahn O, Kobayashi T, Hoshino M, Tarabykin V, Kawabe H. Neuron. 2018 Dec 5;100(5):1097-1115.e15. doi: 10.1016/j.neuron.2018.10.008. Epub 2018 Nov 1. PubMed |
| Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes. Shakya S, Sharma P, Bhatt AM, Jani RA, Delevoye C, Setty SR. EMBO Rep. 2018 Dec;19(12). pii: embr.201845918. doi: 10.15252/embr.201845918. Epub 2018 Nov 7. PubMed |
Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout.
Parekh U, Wu Y, Zhao D, Worlikar A, Shah N, Zhang K, Mali P.
Cell Syst. 2018 Nov 12. pii: S2405-4712(18)30433-2. doi: 10.1016/j.cels.2018.10.008.
PubMed
Associated Plasmids |
| Generation of Stable Expression Mammalian Cell Lines Using Lentivirus. Tandon N, Thakkar KN, LaGory EL, Liu Y, Giaccia AJ. Bio Protoc. 2018 Nov 5;8(21). doi: 10.21769/BioProtoc.3073. PubMed |
| Divergent impact of actin isoforms on cell cycle regulation. Dugina V, Shagieva G, Khromova N, Kopnin P. Cell Cycle. 2018 Dec 5. doi: 10.1080/15384101.2018.1553337. PubMed |
| TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. Ma X, Yang T, Luo Y, Wu L, Jiang Y, Song Z, Pan T, Liu B, Liu G, Liu J, Yu F, He Z, Zhang W, Yang J, Liang L, Guan Y, Zhang X, Li L, Cai W, Tang X, Gao S, Deng K, Zhang H. Elife. 2019 Jan 17;8. pii: 42426. doi: 10.7554/eLife.42426. PubMed |
| Soluble CD93 is an apoptotic cell opsonin recognized by alphax beta2. Blackburn JWD, Lau DHC, Liu EY, Ellins J, Vrieze AM, Pawlak EN, Dikeakos JD, Heit B. Eur J Immunol. 2019 Apr;49(4):600-610. doi: 10.1002/eji.201847801. Epub 2019 Feb 7. PubMed |
| Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation. Yao CH, Wang R, Wang Y, Kung CP, Weber JD, Patti GJ. Elife. 2019 Jan 29;8. pii: 41351. doi: 10.7554/eLife.41351. PubMed |
| Quantification of human neuromuscular function through optogenetics. Vila OF, Uzel SGM, Ma SP, Williams D, Pak J, Kamm RD, Vunjak-Novakovic G. Theranostics. 2019 Jan 31;9(5):1232-1246. doi: 10.7150/thno.25735. eCollection 2019. PubMed |
| Analysis of herpes simplex type 1 gB, gD, and gH/gL on production of infectious HIV-1: HSV-1 gD restricts HIV-1 by exclusion of HIV-1 Env from maturing viral particles. Polpitiya Arachchige S, Henke W, Kalamvoki M, Stephens EB. Retrovirology. 2019 Apr 2;16(1):9. doi: 10.1186/s12977-019-0470-5. PubMed |
| Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. Dev Cell. 2019 May 6;49(3):393-408.e7. doi: 10.1016/j.devcel.2019.03.011. Epub 2019 Apr 11. PubMed |
| LLGL2 rescues nutrient stress by promoting leucine uptake in ER(+) breast cancer. Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK. Nature. 2019 May;569(7755):275-279. doi: 10.1038/s41586-019-1126-2. Epub 2019 Apr 17. PubMed |
| Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome. Thauland TJ, Pellerin L, Ohgami RS, Bacchetta R, Butte MJ. Front Immunol. 2019 Apr 12;10:753. doi: 10.3389/fimmu.2019.00753. eCollection 2019. PubMed |
| CCAAT/enhancer binding protein delta (C/EBPdelta) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma. Sowamber R, Chehade R, Bitar M, Dodds LV, Milea A, Slomovitz B, Shaw PA, George SHL. EBioMedicine. 2019 Jun;44:261-274. doi: 10.1016/j.ebiom.2019.05.002. Epub 2019 May 9. PubMed |
Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing.
Kumar A, Birnbaum MD, Moorthy BT, Singh J, Palovcak A, Patel DM, Zhang F.
BMC Genomics. 2019 Jul 24;20(1):609. doi: 10.1186/s12864-019-5963-z.
PubMed
Associated Plasmids |
| SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering. Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M. EMBO J. 2019 Sep 2;38(17):e101289. doi: 10.15252/embj.2018101289. Epub 2019 Aug 1. PubMed |
| USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication. Pan T, Song Z, Wu L, Liu G, Ma X, Peng Z, Zhou M, Liang L, Liu B, Liu J, Zhang J, Zhang X, Huang R, Zhao J, Li Y, Ling X, Luo Y, Tang X, Cai W, Deng K, Li L, Zhang H. Elife. 2019 Aug 9;8. pii: 48318. doi: 10.7554/eLife.48318. PubMed |
| Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer. Lukey MJ, Cluntun AA, Katt WP, Lin MJ, Druso JE, Ramachandran S, Erickson JW, Le HH, Wang ZE, Blank B, Greene KS, Cerione RA. Cell Rep. 2019 Oct 1;29(1):76-88.e7. doi: 10.1016/j.celrep.2019.08.076. PubMed |
An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics.
Allen ME, Zhou W, Thangaraj J, Kyriakakis P, Wu Y, Huang Z, Ho P, Pan Y, Limsakul P, Xu X, Wang Y.
ACS Synth Biol. 2019 Oct 18;8(10):2359-2371. doi: 10.1021/acssynbio.9b00175. Epub 2019 Oct 8.
PubMed
Associated Plasmids |
| NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase. Knyazhanskaya E, Anisenko A, Shadrina O, Kalinina A, Zatsepin T, Zalevsky A, Mazurov D, Gottikh M. Retrovirology. 2019 Nov 6;16(1):30. doi: 10.1186/s12977-019-0492-z. PubMed |
| Embryonic Cells Redistribute SUMO1 upon Forced SUMO1 Overexpression. Lee A, Zhu Y, Sabo Y, Goff SP. mBio. 2019 Dec 3;10(6). pii: mBio.01856-19. doi: 10.1128/mBio.01856-19. PubMed |
| RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis. Cavanaugh KE, Staddon MF, Munro E, Banerjee S, Gardel ML. Dev Cell. 2020 Jan 27;52(2):152-166.e5. doi: 10.1016/j.devcel.2019.12.002. Epub 2019 Dec 26. PubMed |
| FGF13 promotes metastasis of triple-negative breast cancer. Johnstone CN, Pattison AD, Harrison PF, Powell DR, Lock P, Ernst M, Anderson RL, Beilharz TH. Int J Cancer. 2020 Jul 1;147(1):230-243. doi: 10.1002/ijc.32874. Epub 2020 Feb 24. PubMed |
| Optogenetic Control of RhoA to Probe Subcellular Mechanochemical Circuitry. Cavanaugh KE, Oakes PW, Gardel ML. Curr Protoc Cell Biol. 2020 Mar;86(1):e102. doi: 10.1002/cpcb.102. PubMed |
| Impaired differentiation of human induced neural stem cells by TOR1A overexpression. Stengel F, Vulinovic F, Meier B, Grutz K, Klein C, Capetian P. Mol Biol Rep. 2020 May;47(5):3993-4001. doi: 10.1007/s11033-020-05390-x. Epub 2020 Apr 1. PubMed |
| Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release. Opsomer R, Contino S, Perrin F, Gualdani R, Tasiaux B, Doyen P, Vergouts M, Vrancx C, Doshina A, Pierrot N, Octave JN, Gailly P, Stanga S, Kienlen-Campard P. eNeuro. 2020 May 28;7(3):ENEURO.0322-19.2020. doi: 10.1523/ENEURO.0322-19.2020. Print 2020 May/Jun. PubMed |
| CtBP determines ovarian cancer cell fate through repression of death receptors. Ding B, Yuan F, Damle PK, Litovchick L, Drapkin R, Grossman SR. Cell Death Dis. 2020 Apr 24;11(4):286. doi: 10.1038/s41419-020-2455-7. PubMed |
| Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth. Lopez-Leal R, Diaz-Viraque F, Catalan RJ, Saquel C, Enright A, Iraola G, Court FA. J Cell Sci. 2020 Jun 15;133(12). pii: jcs.239004. doi: 10.1242/jcs.239004. PubMed |
| Generation of Transgenic Rats using a Lentiviral Vector Approach. Koza P, Przybys J, Klejman A, Olech-Kochanczyk G, Konopka W. J Vis Exp. 2020 May 17;(159). doi: 10.3791/60570. PubMed |
| Generation of reporter cell lines for factors inducing muscle wasting in cancer cachexia. Cao Z, Jose I, Glab J, Puthalakath H, Osellame LD, Hoogenraad NJ. Anal Biochem. 2020 Oct 1;606:113877. doi: 10.1016/j.ab.2020.113877. Epub 2020 Jul 29. PubMed |
| Rapid generation of circulating and mucosal decoy ACE2 using mRNA nanotherapeutics for the potential treatment of SARS-CoV-2. Kim J, Mukherjee A, Nelson D, Jozic A, Sahay G. bioRxiv. 2020 Jul 25. doi: 10.1101/2020.07.24.205583. PubMed |
| Phosphorylation of Syntaxin-1a by casein kinase 2alpha regulates pre-synaptic vesicle exocytosis from the reserve pool. Shi VH, Craig TJ, Bishop P, Nakamura Y, Rocca D, Wilkinson KA, Henley JM. J Neurochem. 2021 Mar;156(5):614-623. doi: 10.1111/jnc.15161. Epub 2020 Sep 6. PubMed |
| Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing. Qiang L, Yang S, Cui YH, He YY. Autophagy. 2021 Sep;17(9):2128-2143. doi: 10.1080/15548627.2020.1816342. Epub 2020 Sep 18. PubMed |
| Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages. Yin C, Vrieze AM, Rosoga M, Akingbasote J, Pawlak EN, Jacob RA, Hu J, Sharma N, Dikeakos JD, Barra L, Nagpal AD, Heit B. Front Immunol. 2020 Oct 23;11:594136. doi: 10.3389/fimmu.2020.594136. eCollection 2020. PubMed |
| Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles. Lu M, Uchil PD, Li W, Zheng D, Terry DS, Gorman J, Shi W, Zhang B, Zhou T, Ding S, Gasser R, Prevost J, Beaudoin-Bussieres G, Anand SP, Laumaea A, Grover JR, Liu L, Ho DD, Mascola JR, Finzi A, Kwong PD, Blanchard SC, Mothes W. Cell Host Microbe. 2020 Dec 9;28(6):880-891.e8. doi: 10.1016/j.chom.2020.11.001. Epub 2020 Nov 13. PubMed |
| Generation of neighbor-labeling cells to study intercellular interactions in vivo. Ombrato L, Nolan E, Passaro D, Kurelac I, Bridgeman VL, Waclawiczek A, Duarte D, Lo Celso C, Bonnet D, Malanchi I. Nat Protoc. 2021 Feb;16(2):872-892. doi: 10.1038/s41596-020-00438-5. Epub 2020 Dec 11. PubMed |
| Epithelial cell transforming 2 is regulated by Yes-associated protein 1 and mediates pancreatic cancer progression and metastasis. Li C, Peng Z, Wang Y, Lam G, Nissen N, Tang J, Yuan X, Lewis M, Greene MI, Pandol SJ, Wang Q. Am J Physiol Gastrointest Liver Physiol. 2021 Mar 1;320(3):G380-G395. doi: 10.1152/ajpgi.00185.2020. Epub 2021 Jan 27. PubMed |
| Acute Kidney Injury Instigates Malignant Renal Cell Carcinoma via CXCR2 in Mice with Inactivated Trp53 and Pten in Proximal Tubular Kidney Epithelial Cells. Zhou X, Xiao F, Sugimoto H, Li B, McAndrews KM, Kalluri R. Cancer Res. 2021 May 15;81(10):2690-2702. doi: 10.1158/0008-5472.CAN-20-2930. Epub 2021 Feb 8. PubMed |
| Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption. Adams SD, Csere J, D'angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G, Mardakheh F, Godinho SA. Curr Biol. 2021 Apr 12;31(7):1403-1416.e7. doi: 10.1016/j.cub.2021.01.028. Epub 2021 Feb 15. PubMed |
| Quantitative analysis of dense-core vesicle fusion in rodent CNS neurons. Moro A, Hoogstraaten RI, Persoon CM, Verhage M, Toonen RF. STAR Protoc. 2021 Feb 3;2(1):100325. doi: 10.1016/j.xpro.2021.100325. eCollection 2021 Mar 19. PubMed |
| Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer. Johnstone CN, Tu Y, Langenbach S, Baloyan D, Pattison AD, Lock P, Britt KL, Lehmann BD, Beilharz TH, Ernst M, Anderson RL, Stewart AG. Cancers (Basel). 2021 Mar 8;13(5). pii: cancers13051154. doi: 10.3390/cancers13051154. PubMed |
| Influenza A virus infection-induced macroautophagy facilitates MHC class II-restricted endogenous presentation of an immunodominant viral epitope. Deng J, Lu C, Liu C, Oveissi S, Fairlie WD, Lee EF, Bilsel P, Puthalakath H, Chen W. FEBS J. 2021 May;288(10):3164-3185. doi: 10.1111/febs.15654. Epub 2020 Dec 18. PubMed |
| SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses. Mandolesi M, Sheward DJ, Hanke L, Ma J, Pushparaj P, Perez Vidakovics L, Kim C, Adori M, Lenart K, Lore K, Castro Dopico X, Coquet JM, McInerney GM, Karlsson Hedestam GB, Murrell B. Cell Rep Med. 2021 Apr 20;2(4):100252. doi: 10.1016/j.xcrm.2021.100252. Epub 2021 Apr 5. PubMed |
Psychedelic-inspired drug discovery using an engineered biosensor.
Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L.
Cell. 2021 Apr 8. pii: S0092-8674(21)00374-3. doi: 10.1016/j.cell.2021.03.043.
PubMed
Associated Plasmids |
| Impaired Expression of Cytoplasmic Actins Leads to Chromosomal Instability of MDA-MB-231 Basal-Like Mammary Gland Cancer Cell Line. Dugina V, Shagieva G, Novikova M, Lavrushkina S, Sokova O, Kireev I, Kopnin P. Molecules. 2021 Apr 8;26(8). pii: molecules26082151. doi: 10.3390/molecules26082151. PubMed |
| A Validated Functional Analysis of Partner and Localizer of BRCA2 Missense Variants for Use in Clinical Variant Interpretation. Brnich SE, Arteaga EC, Wang Y, Tan X, Berg JS. J Mol Diagn. 2021 Jul;23(7):847-864. doi: 10.1016/j.jmoldx.2021.04.010. Epub 2021 May 6. PubMed |
| An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation. Mumby MJ, Johnson AL, Trothen SM, Edgar CR, Gibson R, Stathopulos PB, Arts EJ, Dikeakos JD. J Virol. 2021 Jul 26;95(16):e0058821. doi: 10.1128/JVI.00588-21. Epub 2021 Jul 26. PubMed |
| Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. Mehibel M, Xu Y, Li CG, Moon EJ, Thakkar KN, Diep AN, Kim RK, Bloomstein JD, Xiao Y, Bacal J, Saldivar JC, Le QT, Cimprich KA, Rankin EB, Giaccia AJ. J Clin Invest. 2021 Jun 1;131(11). pii: e146256. doi: 10.1172/JCI146256. PubMed |
| Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia. Ecker V, Stumpf M, Brandmeier L, Neumayer T, Pfeuffer L, Engleitner T, Ringshausen I, Nelson N, Jucker M, Wanninger S, Zenz T, Wendtner C, Manske K, Steiger K, Rad R, Muschen M, Ruland J, Buchner M. Nat Commun. 2021 Jun 10;12(1):3526. doi: 10.1038/s41467-021-23752-2. PubMed |
Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch.
Dine E, Reed EH, Toettcher JE.
Cell Rep. 2021 Jun 22;35(12):109280. doi: 10.1016/j.celrep.2021.109280.
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| Different Neutralization Sensitivity of SARS-CoV-2 Cell-to-Cell and Cell-Free Modes of Infection to Convalescent Sera. Kruglova N, Siniavin A, Gushchin V, Mazurov D. Viruses. 2021 Jun 12;13(6). pii: v13061133. doi: 10.3390/v13061133. PubMed |
| TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. Maifrede S, Le BV, Nieborowska-Skorska M, Golovine K, Sullivan-Reed K, Dunuwille WMB, Nacson J, Hulse M, Keith K, Madzo J, Caruso LB, Gazze Z, Lian Z, Padella A, Chitrala KN, Bartholdy BA, Matlawska-Wasowska K, Di Marcantonio D, Simonetti G, Greiner G, Sykes SM, Valent P, Paietta EM, Tallman MS, Fernandez HF, Litzow MR, Minden MD, Huang J, Martinelli G, Vassiliou GS, Tempera I, Piwocka K, Johnson N, Challen GA, Skorski T. Cancer Res. 2021 Oct 1;81(19):5089-5101. doi: 10.1158/0008-5472.CAN-20-3761. Epub 2021 Jul 2. PubMed |
| Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models. Vangala D, Ladigan S, Liffers ST, Noseir S, Maghnouj A, Gotze TM, Verdoodt B, Klein-Scory S, Godfrey L, Zowada MK, Huerta M, Edelstein DL, de Villarreal JM, Marques M, Kumbrink J, Jung A, Schiergens T, Werner J, Heinemann V, Stintzing S, Lindoerfer D, Mansmann U, Pohl M, Teschendorf C, Bernhardt C, Wolters H, Stern J, Usta S, Viebahn R, Admard J, Casadei N, Frohling S, Ball CR, Siveke JT, Glimm H, Tannapfel A, Schmiegel W, Hahn SA. Genome Med. 2021 Jul 16;13(1):116. doi: 10.1186/s13073-021-00926-7. PubMed |
| Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jorgensen C. Cancer Cell. 2021 Sep 13;39(9):1227-1244.e20. doi: 10.1016/j.ccell.2021.06.017. Epub 2021 Jul 22. PubMed |
| Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion. Villodre ES, Hu X, Larson R, Finetti P, Gomez K, Balema W, Stecklein SR, Santiago-Sanchez G, Krishnamurthy S, Song J, Su X, Ueno NT, Tripathy D, Van Laere S, Bertucci F, Vivas-Mejia P, Woodward WA, Debeb BG. Mol Oncol. 2021 Aug 3. doi: 10.1002/1878-0261.13074. PubMed |
| A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation. Ernst O, Sun J, Lin B, Banoth B, Dorrington MG, Liang J, Schwarz B, Stromberg KA, Katz S, Vayttaden SJ, Bradfield CJ, Slepushkina N, Rice CM, Buehler E, Khillan JS, McVicar DW, Bosio CM, Bryant CE, Sutterwala FS, Martin SE, Lal-Nag M, Fraser IDC. Sci Signal. 2021 Aug 3;14(694). pii: 14/694/eabe0387. doi: 10.1126/scisignal.abe0387. PubMed |
| Bioengineered optogenetic model of human neuromuscular junction. Vila OF, Chavez M, Ma SP, Yeager K, Zholudeva LV, Colon-Mercado JM, Qu Y, Nash TR, Lai C, Feliciano CM, Carter M, Kamm RD, Judge LM, Conklin BR, Ward ME, McDevitt TC, Vunjak-Novakovic G. Biomaterials. 2021 Sep;276:121033. doi: 10.1016/j.biomaterials.2021.121033. Epub 2021 Jul 30. PubMed |
| Phosphatidylserine binding directly regulates TIM-3 function. Smith CM, Li A, Krishnamurthy N, Lemmon MA. Biochem J. 2021 Sep 17;478(17):3331-3349. doi: 10.1042/BCJ20210425. PubMed |
| Cytoplasmic Tail Truncation of SARS-CoV-2 Spike Protein Enhances Titer of Pseudotyped Vectors but Masks the Effect of the D614G Mutation. Chen HY, Huang C, Tian L, Huang X, Zhang C, Llewellyn GN, Rogers GL, Andresen K, O'Gorman MRG, Chen YW, Cannon PM. J Virol. 2021 Oct 27;95(22):e0096621. doi: 10.1128/JVI.00966-21. Epub 2021 Sep 8. PubMed |
| Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple-Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy. Lei JH, Lee MH, Miao K, Huang Z, Yao Z, Zhang A, Xu J, Zhao M, Huang Z, Zhang X, Chen S, Jiaying NG, Feng Y, Xing F, Chen P, Sun H, Chen Q, Xiang T, Chen L, Xu X, Deng CX. Adv Sci (Weinh). 2021 Nov;8(21):e2100974. doi: 10.1002/advs.202100974. Epub 2021 Sep 13. PubMed |
| Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication. Fukuda H, Chujo T, Wei FY, Shi SL, Hirayama M, Kaitsuka T, Yamamoto T, Oshiumi H, Tomizawa K. Nucleic Acids Res. 2021 Nov 18;49(20):11855-11867. doi: 10.1093/nar/gkab879. PubMed |
| DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis. Rahman F, Johnson JL, Zhang J, He J, Pestonjamasp K, Cherqui S, Catz SD. Autophagy. 2021 Oct 13:1-19. doi: 10.1080/15548627.2021.1971937. PubMed |
| Snake venom phospholipase A2s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2. Siniavin AE, Streltsova MA, Nikiforova MA, Kudryavtsev DS, Grinkina SD, Gushchin VA, Mozhaeva VA, Starkov VG, Osipov AV, Lummis SCR, Tsetlin VI, Utkin YN. Cell Mol Life Sci. 2021 Dec;78(23):7777-7794. doi: 10.1007/s00018-021-03985-6. Epub 2021 Oct 29. PubMed |
Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures.
Hu M, Lei XY, Larson JD, McAlonis M, Ford K, McDonald D, Mach K, Rusert JM, Wechsler-Reya RJ, Mali P.
Biomaterials. 2022 Jan;280:121276. doi: 10.1016/j.biomaterials.2021.121276. Epub 2021 Dec 2.
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| Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis. Lee BY, Hogg EKJ, Below CR, Kononov A, Blanco-Gomez A, Heider F, Xu J, Hutton C, Zhang X, Scheidt T, Beattie K, Lamarca A, McNamara M, Valle JW, Jorgensen C. Nat Commun. 2021 Dec 17;12(1):7336. doi: 10.1038/s41467-021-27607-8. PubMed |
| In Search of Small Molecules That Selectively Inhibit MBOAT4. Murzinski ES, Saha I, Ding H, Strugatsky D, Hollibaugh RA, Liu H, Tontonoz P, Harran PG. Molecules. 2021 Dec 15;26(24). pii: molecules26247599. doi: 10.3390/molecules26247599. PubMed |
Substratum stiffness regulates Erk signaling dynamics through receptor-level control.
Farahani PE, Lemke SB, Dine E, Uribe G, Toettcher JE, Nelson CM.
Cell Rep. 2021 Dec 28;37(13):110181. doi: 10.1016/j.celrep.2021.110181.
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Associated Plasmids |
| Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis. Katakam S, Anand S, Martin P, Riggi N, Stamenkovic I. Life Sci Alliance. 2022 Jan 4;5(3):e202101256. doi: 10.26508/lsa.202101256. Print 2022 Mar. PubMed |
Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity.
Katrekar D, Xiang Y, Palmer N, Saha A, Meluzzi D, Mali P.
Elife. 2022 Jan 19;11. pii: 75555. doi: 10.7554/eLife.75555.
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Associated Plasmids |
| Baf45a Mediated Chromatin Remodeling Promotes Transcriptional Activation for Osteogenesis and Odontogenesis. Busby T, Chen Y, Godfrey TC, Rehan M, Wildman BJ, Smith CM, Hassan Q. Front Endocrinol (Lausanne). 2022 Jan 3;12:763392. doi: 10.3389/fendo.2021.763392. eCollection 2021. PubMed |
Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41.
Maslennikova A, Kruglova N, Kalinichenko S, Komkov D, Shepelev M, Golubev D, Siniavin A, Vzorov A, Filatov A, Mazurov D.
mBio. 2022 Jan 25:e0358921. doi: 10.1128/mbio.03589-21.
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| Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification. Yoo S, Mittelstein DR, Hurt RC, Lacroix J, Shapiro MG. Nat Commun. 2022 Jan 25;13(1):493. doi: 10.1038/s41467-022-28040-1. PubMed |
| Pan-Cancer Analyses Reveal Oncogenic Role and Prognostic Value of F-Box Only Protein 22. Chen S, Ma S, Yan J, Wang H, Ding B, Guo Z, Ma Y, Chen X, Wang Y. Front Oncol. 2022 Jan 24;11:790912. doi: 10.3389/fonc.2021.790912. eCollection 2021. PubMed |
| Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4. Wolff DW, Deng Z, Bianchi-Smiraglia A, Foley CE, Han Z, Wang X, Shen S, Rosenberg MM, Moparthy S, Yun DH, Chen J, Baker BK, Roll MV, Magiera AJ, Li J, Hurley E, Feltri ML, Cox AO, Lee J, Furdui CM, Liu L, Bshara W, LaConte LEW, Kandel ES, Pasquale EB, Qu J, Hedstrom L, Nikiforov MA. Cell Chem Biol. 2022 Jun 16;29(6):970-984.e6. doi: 10.1016/j.chembiol.2022.01.007. Epub 2022 Feb 10. PubMed |
| SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy. Yang Z, Han Y, Ding S, Shi W, Zhou T, Finzi A, Kwong PD, Mothes W, Lu M. mBio. 2022 Feb 15:e0322721. doi: 10.1128/mbio.03227-21. PubMed |
| P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian beta-cell failure. Marcheva B, Weidemann BJ, Taguchi A, Perelis M, Ramsey KM, Newman MV, Kobayashi Y, Omura C, Manning Fox JE, Lin H, Macdonald PE, Bass J. Elife. 2022 Feb 21;11. pii: 75132. doi: 10.7554/eLife.75132. PubMed |
| Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration. Ilina EI, Cialini C, Gerloff DL, Duarte Garcia-Escudero M, Jeanty C, Thezenas ML, Lesur A, Puard V, Bernardin F, Moter A, Schuster A, Dieterle M, Golebiewska A, Gerardy JJ, Dittmar G, Niclou SP, Muller T, Mittelbronn M. iScience. 2022 Feb 2;25(2):103842. doi: 10.1016/j.isci.2022.103842. eCollection 2022 Feb 18. PubMed |
| Enhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model. Zhao P, Anami Y, Gao P, Fan X, Li L, Tsuchikama K, Zhang N, An Z. MAbs. 2022 Jan-Dec;14(1):2057269. doi: 10.1080/19420862.2022.2057269. PubMed |
| Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer. Saito Y, Matsuda S, Ohnishi N, Endo K, Ashitani S, Ohishi M, Ueno A, Tomita M, Ueda K, Soga T, Muthuswamy SK. Commun Biol. 2022 May 2;5(1):403. doi: 10.1038/s42003-022-03363-3. PubMed |
| FGFR2-BRD4 Axis Regulates Transcriptional Networks of Histone 3 Modification and Synergy Between Its Inhibitors and PD-1/PD-L1 in a TNBC Mouse Model. Lei JH, Zhang L, Wang Z, Peltier R, Xie Y, Chen G, Lin S, Miao K, Deng CX, Sun H. Front Immunol. 2022 Apr 25;13:861221. doi: 10.3389/fimmu.2022.861221. eCollection 2022. PubMed |
| hUC-MSC-mediated recovery of subacute spinal cord injury through enhancing the pivotal subunits beta3 and gamma2 of the GABAA receptor. Cao T, Chen H, Huang W, Xu S, Liu P, Zou W, Pang M, Xu Y, Bai X, Liu B, Rong L, Cui ZK, Li M. Theranostics. 2022 Mar 28;12(7):3057-3078. doi: 10.7150/thno.72015. eCollection 2022. PubMed |
| LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, Liu X, Deng M, Arase H, Zhu JJ, Huang TY, Zhao Y, Zhang C, Xu H, Tong Q, Zhang N, An Z. Mol Neurodegener. 2022 Jun 18;17(1):44. doi: 10.1186/s13024-022-00550-y. PubMed |
| Neuron-specific translational control shift ensures proteostatic resilience during ER stress. Wolzak K, Nolle A, Farina M, Abbink TE, van der Knaap MS, Verhage M, Scheper W. EMBO J. 2022 Aug 16;41(16):e110501. doi: 10.15252/embj.2021110501. Epub 2022 Jul 6. PubMed |
| Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice. Zhao P, Xu Y, Fan X, Li L, Li X, Arase H, Tong Q, Zhang N, An Z. MAbs. 2022 Jan-Dec;14(1):2107971. doi: 10.1080/19420862.2022.2107971. PubMed |
| Sall4 Guides p53-Mediated Enhancer Interference upon DNA Damage in Mouse Embryonic Stem Cells. Wang L, Tan X, Chen L, Xu S, Huang W, Chen N, Wu Y, Wang C, Zhou D, Li M. Stem Cells. 2022 Nov 29;40(11):1008-1019. doi: 10.1093/stmcls/sxac058. PubMed |
| Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2. Volkmar N, Gawden-Bone CM, Williamson JC, Nixon-Abell J, West JA, St George-Hyslop PH, Kaser A, Lehner PJ. EMBO J. 2022 Oct 4;41(19):e110777. doi: 10.15252/embj.2022110777. Epub 2022 Aug 22. PubMed |
| YAP and TAZ play a crucial role in human erythrocyte maturation and enucleation. Damkham N, Lorthongpanich C, Klaihmon P, Lueangamornnara U, Kheolamai P, Trakarnsanga K, Issaragrisil S. Stem Cell Res Ther. 2022 Sep 8;13(1):467. doi: 10.1186/s13287-022-03166-7. PubMed |
1-deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells.
Cordes T, Kuna RS, McGregor GH, Khare SV, Gengatharan J, Muthusamy T, Metallo CM.
J Lipid Res. 2022 Sep 14:100281. doi: 10.1016/j.jlr.2022.100281.
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| Rapid Generation of Circulating and Mucosal Decoy Human ACE2 using mRNA Nanotherapeutics for the Potential Treatment of SARS-CoV-2. Kim J, Jozic A, Mukherjee A, Nelson D, Chiem K, Khan MSR, Torrelles JB, Martinez-Sobrido L, Sahay G. Adv Sci (Weinh). 2022 Dec;9(35):e2202556. doi: 10.1002/advs.202202556. Epub 2022 Oct 10. PubMed |
| Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina. Barbacena P, Dominguez-Cejudo M, Fonseca CG, Gomez-Gonzalez M, Faure LM, Zarkada G, Pena A, Pezzarossa A, Ramalho D, Giarratano Y, Ouarne M, Barata D, Fortunato IC, Misikova LH, Mauldin I, Carvalho Y, Trepat X, Roca-Cusachs P, Eichmann A, Bernabeu MO, Franco CA. Dev Cell. 2022 Oct 10;57(19):2321-2333.e9. doi: 10.1016/j.devcel.2022.09.002. PubMed |
| Cytomegalovirus US28 regulates cellular EphA2 to maintain viral latency. Wass AB, Krishna BA, Herring LE, Gilbert TSK, Nukui M, Groves IJ, Dooley AL, Kulp KH, Matthews SM, Rotroff DM, Graves LM, O'Connor CM. Sci Adv. 2022 Oct 28;8(43):eadd1168. doi: 10.1126/sciadv.add1168. Epub 2022 Oct 26. PubMed |
| Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells. Peng Q, Huang Z, Sun K, Liu Y, Yoon CW, Harrison RES, Schmitt DL, Zhu L, Wu Y, Tasan I, Zhao H, Zhang J, Zhong S, Chien S, Wang Y. Nat Commun. 2022 Dec 24;13(1):7933. doi: 10.1038/s41467-022-35504-x. PubMed |
| Low HER2 expression in normal breast epithelium enables dedifferentiation and malignant transformation via chromatin opening. Hayat A, Carter EP, King HW, Ors A, Doe A, Teijeiro SA, Charrot S, Godinho S, Cutillas P, Mohammed H, Grose RP, Ficz G. Dis Model Mech. 2023 Feb 1;16(2):dmm049894. doi: 10.1242/dmm.049894. Epub 2023 Feb 1. PubMed |
| Both ATM and DNA-PK Are the Main Regulators of HIV-1 Post-Integrational DNA Repair. Anisenko A, Nefedova A, Agapkina Y, Gottikh M. Int J Mol Sci. 2023 Feb 1;24(3):2797. doi: 10.3390/ijms24032797. PubMed |
| High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer. Wang H, Chen S, Kang W, Ding B, Cui S, Zhou L, Zhang N, Luo H, Wang M, Zhang F, Zhao Z, Guo Z, Wang C, Li L, Wang Z, Chen X, Wang Y. Discov Oncol. 2023 Feb 23;14(1):25. doi: 10.1007/s12672-023-00634-1. PubMed |
| Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation. Smith CJ, Williams JL, Hall C, Casas J, Caley MP, O'Toole EA, Prasad R, Metherell LA. J Lipid Res. 2023 Apr;64(4):100351. doi: 10.1016/j.jlr.2023.100351. Epub 2023 Mar 2. PubMed |
| Visualizing cell-cell communication using synthetic notch activated MRI. Wang T, Chen Y, Nystrom NN, Liu S, Fu Y, Martinez FM, Scholl TJ, Ronald JA. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2216901120. doi: 10.1073/pnas.2216901120. Epub 2023 Mar 9. PubMed |
| Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion. Tomas Bort E, Joseph MD, Wang Q, Carter EP, Roth NJ, Gibson J, Samadi A, Kocher HM, Simoncelli S, McCormick PJ, Grose RP. Elife. 2023 Mar 21;12:e86971. doi: 10.7554/eLife.86971. PubMed |
| Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo. Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Chen Z, Gaston N, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, Sontheimer EJ. bioRxiv. 2023 Mar 23:2023.03.20.533459. doi: 10.1101/2023.03.20.533459. Preprint. PubMed |
| Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma. Panizza E, Regalado BD, Wang F, Nakano I, Vacanti NM, Cerione RA, Antonyak MA. Life Sci Alliance. 2023 Apr 10;6(6):e202201680. doi: 10.26508/lsa.202201680. Print 2023 Jun. PubMed |
| Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology. Prahl LS, Porter CM, Liu J, Viola JM, Hughes AJ. iScience. 2023 Apr 11;26(5):106657. doi: 10.1016/j.isci.2023.106657. eCollection 2023 May 19. PubMed |
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