pCMV-PEmax-P2A-hMLH1dn Citations (15)
Originally described in: Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. PubMed Journal
Articles Citing pCMV-PEmax-P2A-hMLH1dn
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Mutation-specific reporter for optimization and enrichment of prime editing.
Schene IF, Joore IP, Baijens JHL, Stevelink R, Kok G, Shehata S, Ilcken EF, Nieuwenhuis ECM, Bolhuis DP, van Rees RCM, Spelier SA, van der Doef HPJ, Beekman JM, Houwen RHJ, Nieuwenhuis EES, Fuchs SA.
Nat Commun. 2022 Mar 1;13(1):1028. doi: 10.1038/s41467-022-28656-3.
PubMed
Associated Plasmids |
A time-resolved, multi-symbol molecular recorder via sequential genome editing.
Choi J, Chen W, Minkina A, Chardon FM, Suiter CC, Regalado SG, Domcke S, Hamazaki N, Lee C, Martin B, Daza RM, Shendure J.
Nature. 2022 Jul 6. pii: 10.1038/s41586-022-04922-8. doi: 10.1038/s41586-022-04922-8.
PubMed
Associated Plasmids |
CRISPR prime editing for unconstrained correction of oncogenic KRAS variants.
Jang G, Kweon J, Kim Y.
Commun Biol. 2023 Jun 30;6(1):681. doi: 10.1038/s42003-023-05052-1.
PubMed
Associated Plasmids |
| A molecular proximity sensor based on an engineered, dual-component guide RNA. Choi J, Chen W, Liao H, Li X, Shendure J. bioRxiv [Preprint]. 2023 Aug 14:2023.08.14.553235. doi: 10.1101/2023.08.14.553235. PubMed |
| Development of a highly efficient prime editor system in mice and rabbits. Qian Y, Wang D, Niu W, Shi Z, Wu M, Zhao D, Li J, Gao X, Zhang Z, Lai L, Li Z. Cell Mol Life Sci. 2023 Nov 4;80(11):346. doi: 10.1007/s00018-023-05003-3. PubMed |
| Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo. Liu M, Zhang C, Gong X, Zhang T, Lian MM, Chew EGY, Cardilla A, Suzuki K, Wang H, Yuan Y, Li Y, Naik MY, Wang Y, Zhou B, Soon WZ, Aizawa E, Li P, Low JH, Tandiono M, Montagud E, Moya-Rull D, Rodriguez Esteban C, Luque Y, Fang M, Khor CC, Montserrat N, Campistol JM, Izpisua Belmonte JC, Foo JN, Xia Y. Cell Stem Cell. 2024 Jan 4;31(1):52-70.e8. doi: 10.1016/j.stem.2023.12.003. PubMed |
| Chromatin context-dependent regulation and epigenetic manipulation of prime editing. Li X, Chen W, Martin BK, Calderon D, Lee C, Choi J, Chardon FM, McDiarmid TA, Daza RM, Kim H, Lalanne JB, Nathans JF, Lee DS, Shendure J. Cell. 2024 May 9;187(10):2411-2427.e25. doi: 10.1016/j.cell.2024.03.020. Epub 2024 Apr 11. PubMed |
| Massively parallel screen uncovers many rare 3' UTR variants regulating mRNA abundance of cancer driver genes. Fu T, Amoah K, Chan TW, Bahn JH, Lee JH, Terrazas S, Chong R, Kosuri S, Xiao X. Nat Commun. 2024 Apr 18;15(1):3335. doi: 10.1038/s41467-024-46795-7. PubMed |
Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells.
Bulcaen M, Kortleven P, Liu RB, Maule G, Dreano E, Kelly M, Ensinck MM, Thierie S, Smits M, Ciciani M, Hatton A, Chevalier B, Ramalho AS, Casadevall I Solvas X, Debyser Z, Vermeulen F, Gijsbers R, Sermet-Gaudelus I, Cereseto A, Carlon MS.
Cell Rep Med. 2024 May 21;5(5):101544. doi: 10.1016/j.xcrm.2024.101544. Epub 2024 May 1.
PubMed
Associated Plasmids |
| Directed evolution of hyperactive integrases for site specific insertion of transgenes. Hew BE, Gupta S, Sato R, Waller DF, Stoytchev I, Short JE, Sharek L, Tran CT, Badran AH, Owens JB. Nucleic Acids Res. 2024 Jul 2:gkae534. doi: 10.1093/nar/gkae534. PubMed |
Engineering oncogenic hotspot mutations on SF3B1 via CRISPR-directed PRECIS mutagenesis.
Fernandez M, Yu L, Jia Q, Wang X, Hart KL, Jia Z, Lin RJ, Wang L.
Cancer Res Commun. 2024 Aug 28. doi: 10.1158/2767-9764.CRC-24-0145.
PubMed
Associated Plasmids |
| A protocol for the detection of precision genome editing in human cells using One-pot DTECT. Langley J, Baudrier L, Billon P. STAR Protoc. 2024 Sep 20;5(3):103307. doi: 10.1016/j.xpro.2024.103307. Epub 2024 Sep 16. PubMed |
A molecular proximity sensor based on an engineered, dual-component guide RNA.
Choi J, Chen W, Liao H, Li X, Shendure J.
Elife. 2025 Feb 12;13:RP98110. doi: 10.7554/eLife.98110.
PubMed
Associated Plasmids |
| EXPERT expands prime editing efficiency and range of large fragment edits. Xiong Y, Su Y, He R, Han X, Li S, Liu M, Xi X, Liu Z, Wang H, Xie S, Xu X, Li K, Zhang J, Xu J, Li X, Zhao S, Ruan J. Nat Commun. 2025 Feb 13;16(1):1592. doi: 10.1038/s41467-025-56734-9. PubMed |
| Precise Generation of Human Induced Pluripotent Stem Cell-derived Cell Lines Harboring Disease-relevant Single Nucleotide Variants Using a Prime Editing System. Kanno S, Sato K, Nakazawa T. Bio Protoc. 2025 Feb 20;15(4):e5191. doi: 10.21769/BioProtoc.5191. eCollection 2025 Feb 20. PubMed |
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