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pRK5-HA-Ubiquitin-WT Citations (147)

Plasmid Article: Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.
Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM J Neurosci. 2005 Feb 23. 25(8):2002-9.
PubMed Journal

Articles Citing pRK5-HA-Ubiquitin-WT

Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane. Knodler LA, Winfree S, Drecktrah D, Ireland R, Steele-Mortimer O. Cell Microbiol. 2009 Nov;11(11):1652-70. doi: 10.1111/j.1462-5822.2009.01356.x. Epub 2009 Jul 13. PubMed

Associated Plasmids

Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection. Livingston CM, Ifrim MF, Cowan AE, Weller SK. PLoS Pathog. 2009 Oct . 5(10):e1000619. PubMed

Associated Plasmids

Degradation of an intramitochondrial protein by the cytosolic proteasome. Azzu V, Brand MD. J Cell Sci. 2010 Feb 15;123(Pt 4):578-85. doi: 10.1242/jcs.060004. Epub 2010 Jan 26. PubMed
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. Cui M, Tang X, Christian WV, Yoon Y, Tieu K. J Biol Chem. 2010 Apr 9. 285(15):11740-52. PubMed
Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries. Wang L, Gulappa T, Menon KM. Biochim Biophys Acta. 2010 May;1803(5):591-7. doi: 10.1016/j.bbamcr.2010.02.003. Epub 2010 Feb 16. PubMed
ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination. Marx C, Held JM, Gibson BW, Benz CC. Cancer Res. 2010 May 1;70(9):3709-17. doi: 10.1158/0008-5472.CAN-09-3768. Epub 2010 Apr 20. PubMed
Comparative analysis of nonaspanin protein sequences and expression studies in zebrafish. Pruvot B, Laurens V, Salvadori F, Solary E, Pichon L, Chluba J. Immunogenetics. 2010 Oct;62(10):681-99. doi: 10.1007/s00251-010-0472-x. Epub 2010 Sep 4. PubMed
Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding. Wang YE, Park A, Lake M, Pentecost M, Torres B, Yun TE, Wolf MC, Holbrook MR, Freiberg AN, Lee B. PLoS Pathog. 2010 Nov 11;6(11):e1001186. doi: 10.1371/journal.ppat.1001186. PubMed
Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Bottero V, Kerur N, Sadagopan S, Patel K, Sharma-Walia N, Chandran B. J Virol. 2011 Mar;85(5):1980-93. doi: 10.1128/JVI.01911-10. Epub 2010 Dec 15. PubMed
The role of monoubiquitination in endocytic degradation of human ether-a-go-go-related gene (hERG) channels under low K+ conditions. Sun T, Guo J, Shallow H, Yang T, Xu J, Li W, Hanson C, Wu JG, Li X, Massaeli H, Zhang S. J Biol Chem. 2011 Feb 25;286(8):6751-9. doi: 10.1074/jbc.M110.198408. Epub 2010 Dec 21. PubMed
Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis. Tseng LA, Bixby JL. Mol Cell Neurosci. 2011 Aug;47(4):254-64. doi: 10.1016/j.mcn.2011.04.005. Epub 2011 Apr 28. PubMed
c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway. Oshikawa G, Nagao T, Wu N, Kurosu T, Miura O. J Biol Chem. 2011 Sep 2;286(35):30263-73. doi: 10.1074/jbc.M111.232348. Epub 2011 Jul 18. PubMed
Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1. Balut CM, Loch CM, Devor DC. FASEB J. 2011 Nov;25(11):3938-48. doi: 10.1096/fj.11-187005. Epub 2011 Aug 9. PubMed
Assessing ubiquitination of viral proteins: Lessons from flavivirus NS5. Taylor RT, Best SM. Methods. 2011 Oct;55(2):166-71. doi: 10.1016/j.ymeth.2011.08.003. Epub 2011 Aug 10. PubMed
TRIM79alpha, an interferon-stimulated gene product, restricts tick-borne encephalitis virus replication by degrading the viral RNA polymerase. Taylor RT, Lubick KJ, Robertson SJ, Broughton JP, Bloom ME, Bresnahan WA, Best SM. Cell Host Microbe. 2011 Sep 15;10(3):185-96. doi: 10.1016/j.chom.2011.08.004. PubMed
DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3beta. Nagao T, Oshikawa G, Wu N, Kurosu T, Miura O. PLoS One. 2011;6(11):e27397. doi: 10.1371/journal.pone.0027397. Epub 2011 Nov 8. PubMed
De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Mahul-Mellier AL, Pazarentzos E, Datler C, Iwasawa R, AbuAli G, Lin B, Grimm S. Cell Death Differ. 2012 May;19(5):891-9. doi: 10.1038/cdd.2011.185. Epub 2011 Dec 16. PubMed
Role of ubiquitin in parainfluenza virus 5 particle formation. Harrison MS, Schmitt PT, Pei Z, Schmitt AP. J Virol. 2012 Apr;86(7):3474-85. doi: 10.1128/JVI.06021-11. Epub 2012 Jan 18. PubMed
Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate. Grou CP, Francisco T, Rodrigues TA, Freitas MO, Pinto MP, Carvalho AF, Domingues P, Wood SA, Rodriguez-Borges JE, Sa-Miranda C, Fransen M, Azevedo JE. J Biol Chem. 2012 Apr 13;287(16):12815-27. doi: 10.1074/jbc.M112.340158. Epub 2012 Feb 27. PubMed
De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Mahul-Mellier AL, Datler C, Pazarentzos E, Lin B, Chaisaklert W, Abuali G, Grimm S. Biochim Biophys Acta. 2012 Aug;1823(8):1353-65. doi: 10.1016/j.bbamcr.2012.05.022. Epub 2012 May 30. PubMed
TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation. Zurek B, Schoultz I, Neerincx A, Napolitano LM, Birkner K, Bennek E, Sellge G, Lerm M, Meroni G, Soderholm JD, Kufer TA. PLoS One. 2012;7(7):e41255. doi: 10.1371/journal.pone.0041255. Epub 2012 Jul 19. PubMed
Non-covalent interaction between polyubiquitin and GTP cyclohydrolase 1 dictates its degradation. Zhao Y, Zhu H, Zou MH. PLoS One. 2012;7(9):e43306. doi: 10.1371/journal.pone.0043306. Epub 2012 Sep 12. PubMed
Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2. Wiech M, Olszewski MB, Tracz-Gaszewska Z, Wawrzynow B, Zylicz M, Zylicz A. PLoS One. 2012;7(12):e51426. doi: 10.1371/journal.pone.0051426. Epub 2012 Dec 12. PubMed
Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. Radovanac K, Morgner J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fassler R, Wickstrom SA. EMBO J. 2013 May 15;32(10):1409-24. doi: 10.1038/emboj.2013.90. Epub 2013 Apr 23. PubMed
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Kurokawa M, Kim J, Geradts J, Matsuura K, Liu L, Ran X, Xia W, Ribar TJ, Henao R, Dewhirst MW, Kim WJ, Lucas JE, Wang S, Spector NL, Kornbluth S. Sci Signal. 2013 May 7;6(274):ra32. doi: 10.1126/scisignal.2003741. PubMed
The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. Lockwood WW, Chandel SK, Stewart GL, Erdjument-Bromage H, Beverly LJ. PLoS One. 2013 May 2;8(5):e63610. doi: 10.1371/journal.pone.0063610. Print 2013. PubMed
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW. Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113. PubMed
Pyrrolidine dithiocarbamate inhibits herpes simplex virus 1 and 2 replication, and its activity may be mediated through dysregulation of the ubiquitin-proteasome system. Qiu M, Chen Y, Cheng L, Chu Y, Song HY, Wu ZW. J Virol. 2013 Aug;87(15):8675-86. doi: 10.1128/JVI.00869-13. Epub 2013 Jun 5. PubMed
CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production. Nishanth G, Deckert M, Wex K, Massoumi R, Schweitzer K, Naumann M, Schluter D. PLoS Pathog. 2013;9(6):e1003455. doi: 10.1371/journal.ppat.1003455. Epub 2013 Jun 27. PubMed
Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice. Bi L, Chiang JY, Ding WX, Dunn W, Roberts B, Li T. J Lipid Res. 2013 Oct;54(10):2754-62. doi: 10.1194/jlr.M039347. Epub 2013 Jul 31. PubMed
BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by betaTrCP1. Moustafa-Kamal M, Gamache I, Lu Y, Li S, Teodoro JG. Cell Death Differ. 2013 Oct;20(10):1393-403. doi: 10.1038/cdd.2013.93. Epub 2013 Aug 2. PubMed
Peroxynitrite-dependent zinc release and inactivation of guanosine 5'-triphosphate cyclohydrolase 1 instigate its ubiquitination in diabetes. Zhao Y, Wu J, Zhu H, Song P, Zou MH. Diabetes. 2013 Dec;62(12):4247-56. doi: 10.2337/db13-0751. Epub 2013 Aug 23. PubMed
Endoplasmic reticulum-associated degradation controls cell surface expression of gamma-aminobutyric acid, type B receptors. Zemoura K, Schenkel M, Acuna MA, Yevenes GE, Zeilhofer HU, Benke D. J Biol Chem. 2013 Nov 29;288(48):34897-905. doi: 10.1074/jbc.M113.514745. Epub 2013 Oct 10. PubMed
RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9. PubMed
Ginkgo biloba extract individually inhibits JNK activation and induces c-Jun degradation in human chondrocytes: potential therapeutics for osteoarthritis. Ho LJ, Hung LF, Liu FC, Hou TY, Lin LC, Huang CY, Lai JH. PLoS One. 2013 Dec 11;8(12):e82033. doi: 10.1371/journal.pone.0082033. eCollection 2013. PubMed
Activation of duck RIG-I by TRIM25 is independent of anchored ubiquitin. Miranzo-Navarro D, Magor KE. PLoS One. 2014 Jan 23;9(1):e86968. doi: 10.1371/journal.pone.0086968. eCollection 2014. PubMed
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. Birsa N, Norkett R, Wauer T, Mevissen TE, Wu HC, Foltynie T, Bhatia K, Hirst WD, Komander D, Plun-Favreau H, Kittler JT. J Biol Chem. 2014 May 23;289(21):14569-82. doi: 10.1074/jbc.M114.563031. Epub 2014 Mar 26. PubMed

Associated Plasmids

USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy. Hall JA, Tabata M, Rodgers JT, Puigserver P. Mol Endocrinol. 2014 Jun;28(6):912-24. doi: 10.1210/me.2013-1420. Epub 2014 Apr 2. PubMed
N-Glycan-dependent and -independent quality control of human delta opioid receptor N-terminal variants. Lackman JJ, Markkanen PM, Hogue M, Bouvier M, Petaja-Repo UE. J Biol Chem. 2014 Jun 20;289(25):17830-42. doi: 10.1074/jbc.M114.566273. Epub 2014 May 5. PubMed
HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator. Bhattacharya S, Ghosh MK. FEBS J. 2014 Jul;281(13):3061-78. doi: 10.1111/febs.12843. Epub 2014 Jun 10. PubMed
Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Jang J, Wang Y, Kim HS, Lalli MA, Kosik KS. Stem Cells. 2014 Oct;32(10):2616-25. doi: 10.1002/stem.1764. PubMed
AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions. Ribeiro-Rodrigues TM, Catarino S, Marques C, Ferreira JV, Martins-Marques T, Pereira P, Girao H. FASEB J. 2014 Nov;28(11):4629-41. doi: 10.1096/fj.13-248963. Epub 2014 Jul 28. PubMed
SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN. De Melo J, Lin X, He L, Wei F, Major P, Tang D. Cell Signal. 2014 Dec;26(12):2749-56. doi: 10.1016/j.cellsig.2014.08.013. Epub 2014 Aug 22. PubMed
RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR. Brand K, Kentsch H, Glashoff C, Rosenberger G. Hum Mutat. 2014 Nov;35(11):1372-81. doi: 10.1002/humu.22682. PubMed
A RING finger protein 114 (RNF114) homolog from Chinese sturgeon (Acipenser sinensis) possesses immune-regulation properties via modulating RIG-I signaling pathway-mediated interferon expression. Liao Z, Chen X, Nie D, Wang J, Wu M. Fish Shellfish Immunol. 2014 Dec;41(2):507-16. doi: 10.1016/j.fsi.2014.09.030. Epub 2014 Oct 5. PubMed
De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells. Chang YW, Chen HA, Tseng CF, Hong CC, Ma JT, Hung MC, Wu CH, Huang MT, Su JL. Oncotarget. 2014 Nov 15;5(21):10558-70. PubMed
HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation. Choi YB, Harhaj EW. PLoS Pathog. 2014 Oct 23;10(10):e1004458. doi: 10.1371/journal.ppat.1004458. eCollection 2014 Oct. PubMed
Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination. Xu C, Feng K, Zhao X, Huang S, Cheng Y, Qian L, Wang Y, Sun H, Jin M, Chuang TH, Zhang Y. Autophagy. 2014;10(12):2239-50. doi: 10.4161/15548627.2014.981792. PubMed
Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex. Gong W, Gohla RM, Bowlin KM, Koyano-Nakagawa N, Garry DJ, Shi X. J Biol Chem. 2015 Jun 12;290(24):15350-61. doi: 10.1074/jbc.M114.629956. Epub 2015 May 4. PubMed
Metformin increases degradation of phospholamban via autophagy in cardiomyocytes. Teng AC, Miyake T, Yokoe S, Zhang L, Rezende LM Jr, Sharma P, MacLennan DH, Liu PP, Gramolini AO. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7165-70. doi: 10.1073/pnas.1508815112. Epub 2015 May 26. PubMed
Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding. Cha-Molstad H, Sung KS, Hwang J, Kim KA, Yu JE, Yoo YD, Jang JM, Han DH, Molstad M, Kim JG, Lee YJ, Zakrzewska A, Kim SH, Kim ST, Kim SY, Lee HG, Soung NK, Ahn JS, Ciechanover A, Kim BY, Kwon YT. Nat Cell Biol. 2015 Jul;17(7):917-29. doi: 10.1038/ncb3177. Epub 2015 Jun 15. PubMed
Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer. Chang YW, Tseng CF, Wang MY, Chang WC, Lee CC, Chen LT, Hung MC, Su JL. Oncogene. 2015 Jun 29. doi: 10.1038/onc.2015.214. PubMed
Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins. Shin YJ, Park SK, Jung YJ, Kim YN, Kim KS, Park OK, Kwon SH, Jeon SH, Trinh le A, Fraser SE, Kee Y, Hwang BJ. Sci Rep. 2015 Sep 16;5:14269. doi: 10.1038/srep14269. PubMed
Unexpected requirement for a binding partner of the syntaxin family in phagocytosis by murine testicular Sertoli cells. Dong YS, Hou WG, Li Y, Liu DB, Hao GZ, Zhang HF, Li JC, Zhao J, Zhang S, Liang GB, Li W. Cell Death Differ. 2015 Oct 23. doi: 10.1038/cdd.2015.139. PubMed
POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y. Nat Commun. 2015 Oct 29;6:8704. doi: 10.1038/ncomms9704. PubMed
Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning. Park H, Yang J, Kim R, Li Y, Lee Y, Lee C, Park J, Lee D, Kim H, Kim E. Sci Rep. 2015 Nov 10;5:16410. doi: 10.1038/srep16410. PubMed
Ibuprofen Induces Mitochondrial-Mediated Apoptosis Through Proteasomal Dysfunction. Upadhyay A, Amanullah A, Chhangani D, Joshi V, Mishra R, Mishra A. Mol Neurobiol. 2015 Dec 15. PubMed
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Martinez IS, Schermer B, Hohne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Muller RU, Kruger M, Benzing T. Hum Mol Genet. 2016 Jan 19. pii: ddw016. PubMed
Enhanced ubiquitination and proteasomal degradation of catalytically deficient human choline acetyltransferase mutants. Morey TM, Albers S, Shilton BH, Rylett RJ. J Neurochem. 2016 May;137(4):630-46. doi: 10.1111/jnc.13574. Epub 2016 Mar 15. PubMed
E2F1 interactions with hHR23A inhibit its degradation and promote DNA repair. Singh RK, Dagnino L. Oncotarget. 2016 May 3;7(18):26275-92. doi: 10.18632/oncotarget.8362. PubMed
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. Cell Stem Cell. 2016 Aug 4;19(2):205-16. doi: 10.1016/j.stem.2016.04.002. Epub 2016 May 12. PubMed
Deubiquitinase Usp8 regulates alpha-synuclein clearance and modifies its toxicity in Lewy body disease. Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4688-97. doi: 10.1073/pnas.1523597113. Epub 2016 Jul 21. PubMed
Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway. Amanullah A, Upadhyay A, Chhangani D, Joshi V, Mishra R, Yamanaka K, Mishra A. J Cell Biochem. 2016 Aug 2. doi: 10.1002/jcb.25666. PubMed
RNF168 and USP10 regulate topoisomerase IIalpha function via opposing effects on its ubiquitylation. Guturi KK, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R. Nat Commun. 2016 Aug 25;7:12638. doi: 10.1038/ncomms12638. PubMed
The tumour suppressor CYLD regulates the p53 DNA damage response. Fernandez-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Buttner R, Thomas RK, Schumacher B, Pasparakis M. Nat Commun. 2016 Aug 26;7:12508. doi: 10.1038/ncomms12508. PubMed
Lys-63-linked Ubiquitination of gamma-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation. Zemoura K, Trumpler C, Benke D. J Biol Chem. 2016 Oct 7;291(41):21682-21693. Epub 2016 Aug 29. PubMed
Comparative Proteomics Reveals Strain-Specific beta-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. Ding S, Mooney N, Li B, Kelly MR, Feng N, Loktev AV, Sen A, Patton JT, Jackson PK, Greenberg HB. PLoS Pathog. 2016 Oct 5;12(10):e1005929. doi: 10.1371/journal.ppat.1005929. eCollection 2016 Oct. PubMed
CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes. Singh RK, Dagnino L. Oncotarget. 2017 Jan 17;8(3):4977-4993. doi: 10.18632/oncotarget.13636. PubMed
Ubiquitin Ligase NEDD4 Regulates PPARgamma Stability and Adipocyte Differentiation in 3T3-L1 Cells. Li JJ, Wang R, Lama R, Wang X, Floyd ZE, Park EA, Liao FF. Sci Rep. 2016 Dec 5;6:38550. doi: 10.1038/srep38550. PubMed
GSK-3beta controls NF-kappaB activity via IKKgamma/NEMO. Medunjanin S, Schleithoff L, Fiegehenn C, Weinert S, Zuschratter W, Braun-Dullaeus RC. Sci Rep. 2016 Dec 8;6:38553. doi: 10.1038/srep38553. PubMed
Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila. Urbanus ML, Quaile AT, Stogios PJ, Morar M, Rao C, Di Leo R, Evdokimova E, Lam M, Oatway C, Cuff ME, Osipiuk J, Michalska K, Nocek BP, Taipale M, Savchenko A, Ensminger AW. Mol Syst Biol. 2016 Dec 16;12(12):893. doi: 10.15252/msb.20167381. PubMed
ICAP-1 monoubiquitination coordinates matrix density and rigidity sensing for cell migration through ROCK2- MRCKalpha balance. Bouin AP, Kyurmurkov A, Regent-Kloeckner M, Ribba AS, Faurobert E, Fournier HN, Bourrin-Reynard I, Manet-Dupe S, Oddou C, Balland M, Planus E, Albiges-Rizo C. J Cell Sci. 2017 Jan 3. pii: jcs.200139. doi: 10.1242/jcs.200139. PubMed
TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). Li MM, Lau Z, Cheung P, Aguilar EG, Schneider WM, Bozzacco L, Molina H, Buehler E, Takaoka A, Rice CM, Felsenfeld DP, MacDonald MR. PLoS Pathog. 2017 Jan 6;13(1):e1006145. doi: 10.1371/journal.ppat.1006145. PubMed
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites. Kristensen LV, Oppermann FS, Rauen MJ, Hartmann-Petersen R, Thirstrup K. Neurochem Int. 2017 Jan 5. pii: S0197-0186(16)30196-6. doi: 10.1016/j.neuint.2016.12.019. PubMed
The STI and UBA Domains of UBQLN1 are Critical Determinants of Substrate Interaction and Proteostasis. Kurlawala Z, Shah PP, Shah C, Beverly LJ. J Cell Biochem. 2017 Jan 11. doi: 10.1002/jcb.25880. PubMed
Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. Hasanov E, Chen G, Chowdhury P, Weldon J, Ding Z, Jonasch E, Sen S, Walker CL, Dere R. Oncogene. 2017 Jun 15;36(24):3450-3463. doi: 10.1038/onc.2016.495. Epub 2017 Jan 23. PubMed
CyclinD-CDK4/6 complexes phosphorylate CDC25A and regulate its stability. Dozier C, Mazzolini L, Cenac C, Froment C, Burlet-Schiltz O, Besson A, Manenti S. Oncogene. 2017 Jun 29;36(26):3781-3788. doi: 10.1038/onc.2016.506. Epub 2017 Feb 13. PubMed
Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress. Kucharski TJ, Minshall PE, Moustafa-Kamal M, Turnell AS, Teodoro JG. Cell Rep. 2017 Feb 21;18(8):1982-1995. doi: 10.1016/j.celrep.2017.01.080. PubMed
Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity. Cetkovska K, Sustova H, Uldrijan S. Sci Rep. 2017 Feb 24;7:43180. doi: 10.1038/srep43180. PubMed
The papain-like protease of avian infectious bronchitis virus has deubiquitinating activity. Yu L, Zhang X, Wu T, Wang Y, Meng J, Liu Q, Niu X, Wu Y. Arch Virol. 2017 Jul;162(7):1943-1950. doi: 10.1007/s00705-017-3328-y. Epub 2017 Mar 18. PubMed
Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations. Zhang H, Reister Schultz A, Luty S, Rofelty A, Su Y, Means S, Bottomly D, Wilmot B, McWeeney SK, Tyner JW. Leukemia. 2017 Dec;31(12):2752-2760. doi: 10.1038/leu.2017.126. Epub 2017 Apr 25. PubMed
Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival. Benvegnu S, Mateo MI, Palomer E, Jurado-Arjona J, Dotti CG. Mol Cell. 2017 May 4;66(3):358-372.e7. doi: 10.1016/j.molcel.2017.04.005. PubMed
Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Wald JH, Hatakeyama J, Printsev I, Cuevas A, Fry WHD, Saldana MJ, VanderVorst K, Rowson-Hodel A, Angelastro JM, Sweeney C, Carraway KL Rd. Oncogene. 2017 Sep 7;36(36):5158-5167. doi: 10.1038/onc.2017.126. Epub 2017 May 8. PubMed
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Indomethacin Elicits Proteasomal Dysfunctions Develops Apoptosis Through Mitochondrial Abnormalities. Amanullah A, Mishra R, Upadhyay A, Reddy PP, Das R, Mishra A. J Cell Physiol. 2017 Jul 6. doi: 10.1002/jcp.26081. PubMed
Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway. Toloczko A, Guo F, Yuen HF, Wen Q, Wood SA, Ong YS, Chan PY, Shaik AA, Gunaratne J, Dunne MJ, Hong W, Chan SW. Cancer Res. 2017 Sep 15;77(18):4921-4933. doi: 10.1158/0008-5472.CAN-16-3413. Epub 2017 Jul 18. PubMed
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WW and C2 domain-containing proteins regulate hepatic cell differentiation and tumorigenesis through the hippo signaling pathway. Hermann A, Wennmann DO, Gromnitza S, Edeling M, Van Marck V, Sudol M, Schaefer L, Duning K, Weide T, Pavenstadt H, Kremerskothen J. Hepatology. 2018 Apr;67(4):1546-1559. doi: 10.1002/hep.29647. Epub 2018 Feb 18. PubMed
E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Benvegnu S, Wahle T, Dotti CG. Oncotarget. 2017 Aug 10;8(52):89439-89450. doi: 10.18632/oncotarget.20143. eCollection 2017 Oct 27. PubMed
Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates beta-Cell Mitophagy. Pearson G, Chai B, Vozheiko T, Liu X, Kandarpa M, Piper RC, Soleimanpour SA. Diabetes. 2018 Feb;67(2):265-277. doi: 10.2337/db17-0321. Epub 2017 Nov 27. PubMed
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RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases. Lin YH, Lucas M, Evans TR, Abascal-Palacios G, Doms AG, Beauchene NA, Rojas AL, Hierro A, Machner MP. PLoS Pathog. 2018 Feb 7;14(2):e1006897. doi: 10.1371/journal.ppat.1006897. eCollection 2018 Feb. PubMed
beta-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars. El Ayadi A, Prasai A, Wang Y, Herndon DN, Finnerty CC. J Invest Dermatol. 2018 Jul;138(7):1645-1655. doi: 10.1016/j.jid.2018.01.037. Epub 2018 Feb 22. PubMed
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Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R. J Clin Invest. 2018 Oct 1;128(10):4525-4542. doi: 10.1172/JCI120401. Epub 2018 Aug 2. PubMed
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Rapid degradation of progressive ankylosis protein (ANKH) in craniometaphyseal dysplasia. Kanaujiya J, Bastow E, Luxmi R, Hao Z, Zattas D, Hochstrasser M, Reichenberger EJ, Chen IP. Sci Rep. 2018 Oct 24;8(1):15710. doi: 10.1038/s41598-018-34157-5. PubMed
Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL). Roder K, Kabakov A, Moshal KS, Murphy KR, Xie A, Dudley S, Turan NN, Lu Y, MacRae CA, Koren G. J Biol Chem. 2019 Jan 4;294(1):351-360. doi: 10.1074/jbc.RA118.003852. Epub 2018 Nov 6. PubMed
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Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Ding S, Zhu S, Ren L, Feng N, Song Y, Ge X, Li B, Flavell RA, Greenberg HB. Elife. 2018 Nov 21;7. pii: 39494. doi: 10.7554/eLife.39494. PubMed
Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperone protein, has broad oncogenic properties. Zella D, Curreli S, Benedetti F, Krishnan S, Cocchi F, Latinovic OS, Denaro F, Romerio F, Djavani M, Charurat ME, Bryant JL, Tettelin H, Gallo RC. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12005-E12014. doi: 10.1073/pnas.1815660115. Epub 2018 Dec 3. PubMed
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POH1 contributes to hyperactivation of TGF-beta signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptors and caveolin-1. Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, Xu G, Tang M, Jing T, Wu L, Liu Y. EBioMedicine. 2019 Mar;41:320-332. doi: 10.1016/j.ebiom.2019.01.058. Epub 2019 Feb 7. PubMed
The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock. Arora H, Wilcox SM, Johnson LA, Munro L, Eyford BA, Pfeifer CG, Welch I, Jefferies WA. Immunity. 2019 Feb 19;50(2):418-431.e6. doi: 10.1016/j.immuni.2019.01.014. Epub 2019 Feb 12. PubMed
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Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling. Segala G, Bennesch MA, Ghahhari NM, Pandey DP, Echeverria PC, Karch F, Maeda RK, Picard D. Nat Commun. 2019 Apr 23;10(1):1833. doi: 10.1038/s41467-019-09800-y. PubMed
K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling. Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts ER, Izumi V, Zheng M, Jiang S, Yin X, Kim M, Cai J, Haura EB, Koomen JM, Smalley KSM, Wan L. Nat Commun. 2019 Apr 23;10(1):1870. doi: 10.1038/s41467-019-09844-0. PubMed
CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1. Douanne T, Andre-Gregoire G, Thys A, Trillet K, Gavard J, Bidere N. Cell Rep. 2019 May 7;27(6):1657-1665.e4. doi: 10.1016/j.celrep.2019.04.036. PubMed
Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis. Jalan-Sakrikar N, De Assuncao TM, Shi G, Aseem SO, Chi C, Shah VH, Huebert RC. Hepatology. 2019 May 9. doi: 10.1002/hep.30706. PubMed
Histone deacetylase 6 inhibitor tubastatin A attenuates angiotensin II-induced hypertension by preventing cystathionine gamma-lyase protein degradation. Chi Z, Byeon HE, Seo E, Nguyen QT, Lee W, Jeong Y, Choi J, Pandey D, Berkowitz DE, Kim JH, Lee SY. Pharmacol Res. 2019 Aug;146:104281. doi: 10.1016/j.phrs.2019.104281. Epub 2019 May 21. PubMed
The deubiquitinase Otub1 controls the activation of CD8(+) T cells and NK cells by regulating IL-15-mediated priming. Zhou X, Yu J, Cheng X, Zhao B, Manyam GC, Zhang L, Schluns K, Li P, Wang J, Sun SC. Nat Immunol. 2019 Jul;20(7):879-889. doi: 10.1038/s41590-019-0405-2. Epub 2019 Jun 10. PubMed
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Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52kDa) PINK1. Sun L, Bueler H. Biochem Biophys Res Commun. 2019 Sep 17;517(2):376-382. doi: 10.1016/j.bbrc.2019.07.051. Epub 2019 Jul 27. PubMed
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Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions. Kong W, Hayashi T, Fiches G, Xu Q, Li MZ, Que J, Liu S, Zhang W, Qi J, Santoso N, Elledge SJ, Zhu J. Genomics Proteomics Bioinformatics. 2019 Jun;17(3):319-331. doi: 10.1016/j.gpb.2018.12.010. Epub 2019 Sep 5. PubMed
RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21. Liu G, Zhang Q, Xia L, Shi M, Cai J, Zhang H, Li J, Lin G, Xie W, Zhang Y, Xu N. Cell Death Dis. 2019 Sep 18;10(10):688. doi: 10.1038/s41419-019-1927-0. PubMed
The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing. Lear TB, Lockwood KC, Ouyang Y, Evankovich JW, Larsen MB, Lin B, Liu Y, Chen BB. J Biol Chem. 2019 Nov 8;294(45):16527-16534. doi: 10.1074/jbc.AC119.010671. Epub 2019 Oct 4. PubMed
E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2. de la Rocha-Munoz A, Nunez E, Arribas-Gonzalez E, Lopez-Corcuera B, Aragon C, de Juan-Sanz J. Sci Rep. 2019 Oct 18;9(1):14944. doi: 10.1038/s41598-019-51301-x. PubMed
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Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration. Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S, Cutillas P, Nightingale TD. PLoS Biol. 2019 Dec 2;17(12):e3000554. doi: 10.1371/journal.pbio.3000554. eCollection 2019 Dec. PubMed
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SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mosbauer K, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, Muller-Myhsok B, Drosten C, Muller MA, Rein T. Nat Commun. 2019 Dec 18;10(1):5770. doi: 10.1038/s41467-019-13659-4. PubMed
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor. Novellasdemunt L, Kucharska A, Jamieson C, Prange-Barczynska M, Baulies A, Antas P, van der Vaart J, Gehart H, Maurice MM, Li VS. EMBO J. 2020 Feb 3;39(3):e102771. doi: 10.15252/embj.2019102771. Epub 2019 Dec 23. PubMed
The Lysosome Pathway Degrades CD81 on the Cell Surface by Poly-ubiquitination and Clathrin-Mediated Endocytosis. Hosokawa K, Ishimaru H, Watanabe T, Fujimuro M. Biol Pharm Bull. 2020 Mar 1;43(3):540-545. doi: 10.1248/bpb.b19-01097. Epub 2019 Dec 27. PubMed
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PBK attenuates paclitaxel-induced autophagic cell death by suppressing p53 in H460 non-small-cell lung cancer cells. Park JH, Park SA, Lee YJ, Park HW, Oh SM. FEBS Open Bio. 2020 May;10(5):937-950. doi: 10.1002/2211-5463.12855. Epub 2020 Apr 14. PubMed
A MAGEL2-deubiquitinase complex modulates the ubiquitination of circadian rhythm protein CRY1. Carias KV, Zoeteman M, Seewald A, Sanderson MR, Bischof JM, Wevrick R. PLoS One. 2020 Apr 21;15(4):e0230874. doi: 10.1371/journal.pone.0230874. eCollection 2020. PubMed
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