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FUW-M2rtTA Citations (113)

Plasmid Article: A drug-inducible system for direct reprogramming of human somatic cells to pluripotency.
Hockemeyer D, Soldner F, Cook EG, Gao Q, Mitalipova M, Jaenisch R Cell Stem Cell. 2008 Sep 11. 3(3):346-53.
PubMed Journal

Articles Citing FUW-M2rtTA

Leukemia inhibitory factor (LIF)-dependent, pluripotent stem cells established from inner cell mass of porcine embryos. Telugu BP, Ezashi T, Sinha S, Alexenko AP, Spate L, Prather RS, Roberts RM. J Biol Chem. 2011 Aug 19;286(33):28948-53. doi: 10.1074/jbc.M111.229468. Epub 2011 Jun 24. PubMed
Genetic background affects induced pluripotent stem cell generation. Schnabel LV, Abratte CM, Schimenti JC, Southard TL, Fortier LA. Stem Cell Res Ther. 2012 Aug 3;3(4):30. doi: 10.1186/scrt121. PubMed
Elevating SOX2 levels deleteriously affects the growth of medulloblastoma and glioblastoma cells. Cox JL, Wilder PJ, Desler M, Rizzino A. PLoS One. 2012;7(8):e44087. doi: 10.1371/journal.pone.0044087. Epub 2012 Aug 28. PubMed
Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways. Lee YL, Peng Q, Fong SW, Chen AC, Lee KF, Ng EH, Nagy A, Yeung WS. PLoS One. 2012;7(9):e45633. doi: 10.1371/journal.pone.0045633. Epub 2012 Sep 21. PubMed
Predicting stem cell fate changes by differential cell cycle progression patterns. Roccio M, Schmitter D, Knobloch M, Okawa Y, Sage D, Lutolf MP. Development. 2013 Jan 15;140(2):459-70. doi: 10.1242/dev.086215. Epub 2012 Nov 28. PubMed
Barcoding cells using cell-surface programmable DNA-binding domains. Mali P, Aach J, Lee JH, Levner D, Nip L, Church GM. Nat Methods. 2013 Mar 17. doi: 10.1038/nmeth.2407. PubMed

Associated Plasmids

Neural progenitor cell survival in mouse brain can be improved by co-transplantation of helper cells expressing bFGF under doxycycline control. Liang Y, Agren L, Lyczek A, Walczak P, Bulte JW. Exp Neurol. 2013 Sep;247:73-9. doi: 10.1016/j.expneurol.2013.04.001. Epub 2013 Apr 6. PubMed
Regulation of anoikis by deleted in breast cancer-1 (DBC1) through NF-kappaB. Park SH, Riley P 4th, Frisch SM. Apoptosis. 2013 Aug;18(8):949-62. doi: 10.1007/s10495-013-0847-1. PubMed
Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. Christoforou N, Chellappan M, Adler AF, Kirkton RD, Wu T, Addis RC, Bursac N, Leong KW. PLoS One. 2013 May 21;8(5):e63577. doi: 10.1371/journal.pone.0063577. Print 2013. PubMed
NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. Stefos GC, Soppa U, Dierssen M, Becker W. PLoS One. 2013 Jun 25;8(6):e67470. doi: 10.1371/journal.pone.0067470. Print 2013. PubMed
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cheng AW, Wang H, Yang H, Shi L, Katz Y, Theunissen TW, Rangarajan S, Shivalila CS, Dadon DB, Jaenisch R. Cell Res. 2013 Aug 27. doi: 10.1038/cr.2013.122. PubMed

Associated Plasmids

Identification of epithelial stromal interaction 1 as a novel effector downstream of Kruppel-like factor 8 in breast cancer invasion and metastasis. Li T, Lu H, Shen C, Lahiri SK, Wason MS, Mukherjee D, Yu L, Zhao J. Oncogene. 2014 Sep 25;33(39):4746-55. doi: 10.1038/onc.2013.415. Epub 2013 Oct 7. PubMed
Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma. Li Z, Tang M, Ling B, Liu S, Zheng Y, Nie C, Yuan Z, Zhou L, Guo G, Tong A, Wei Y. J Mol Med (Berl). 2014 Mar;92(3):291-303. doi: 10.1007/s00109-013-1104-3. Epub 2013 Nov 27. PubMed
Overlap of Doxycycline Fluorescence with that of the Redox-Sensitive Intracellular Reporter roGFP. Khader H, Solodushko V, Al-Mehdi AB, Audia J, Fouty B. J Fluoresc. 2013 Nov 28. PubMed
Matrix identity and tractional forces influence indirect cardiac reprogramming. Kong YP, Carrion B, Singh RK, Putnam AJ. Sci Rep. 2013 Dec 11;3:3474. doi: 10.1038/srep03474. PubMed

Associated Plasmids

Counteracting activities of OCT4 and KLF4 during reprogramming to pluripotency. Tiemann U, Marthaler AG, Adachi K, Wu G, Fischedick GU, Arauzo-Bravo MJ, Scholer HR, Tapia N. Stem Cell Reports. 2014 Feb 20;2(3):351-65. doi: 10.1016/j.stemcr.2014.01.005. eCollection 2014 Mar 11. PubMed
The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons. Kulangara K, Adler AF, Wang H, Chellappan M, Hammett E, Yasuda R, Leong KW. Biomaterials. 2014 Jul;35(20):5327-36. doi: 10.1016/j.biomaterials.2014.03.034. Epub 2014 Apr 4. PubMed
Transdifferentiation of mouse fibroblasts and hepatocytes to functional neurons. Marro S, Yang N. Methods Mol Biol. 2014;1150:237-46. doi: 10.1007/978-1-4939-0512-6_16. PubMed
The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation. Soppa U, Schumacher J, Florencio Ortiz V, Pasqualon T, Tejedor FJ, Becker W. Cell Cycle. 2014;13(13):2084-100. doi: 10.4161/cc.29104. Epub 2014 May 7. PubMed
lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6. Eades G, Wolfson B, Zhang Y, Li Q, Yao Y, Zhou Q. Mol Cancer Res. 2015 Feb;13(2):330-8. doi: 10.1158/1541-7786.MCR-14-0251. Epub 2014 Sep 24. PubMed
Cell divisions are not essential for the direct conversion of fibroblasts into neuronal cells. Fishman VS, Shnayder TA, Orishchenko KE, Bader M, Alenina N, Serov OL. Cell Cycle. 2015;14(8):1188-96. doi: 10.1080/15384101.2015.1012875. PubMed
Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. Xiong J, Todorova D, Su NY, Kim J, Lee PJ, Shen Z, Briggs SP, Xu Y. J Cell Biol. 2015 Mar 2;208(5):513-20. doi: 10.1083/jcb.201408106. PubMed
Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. Shi Y, Chen J, Karner CM, Long F. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4678-83. doi: 10.1073/pnas.1502301112. Epub 2015 Mar 30. PubMed
Derivation of LIF-independent mouse iPS cells with modified Oct4. Hirai H, Firpo M, Kikyo N. Stem Cell Res. 2015 Sep;15(2):384-6. doi: 10.1016/j.scr.2015.08.005. Epub 2015 Aug 17. PubMed
Establishment of leukemia inhibitory factor (LIF)-independent iPS cells with potentiated Oct4. Hirai H, Firpo M, Kikyo N. Stem Cell Res. 2015 Nov;15(3):469-80. doi: 10.1016/j.scr.2015.09.002. Epub 2015 Sep 12. PubMed
Phosphatidic Acid Improves Reprogramming to Pluripotency by Reducing Apoptosis. Jiang Y, Du M, Wu M, Zhu Y, Zhao X, Cao X, Li X, Long P, Li W, Hu B. Stem Cells Dev. 2016 Jan 1;25(1):43-54. doi: 10.1089/scd.2015.0159. Epub 2015 Nov 10. PubMed
Derivation of Ethnically Diverse Human Induced Pluripotent Stem Cell Lines. Chang EA, Tomov ML, Suhr ST, Luo J, Olmsted ZT, Paluh JL, Cibelli J. Sci Rep. 2015 Oct 20;5:15234. doi: 10.1038/srep15234. PubMed
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation. McDonald JI, Celik H, Rois LE, Fishberger G, Fowler T, Rees R, Kramer A, Martens A, Edwards JR, Challen GA. Biol Open. 2016 May 11. pii: bio.019067. doi: 10.1242/bio.019067. PubMed

Associated Plasmids

MYC Is a Crucial Mediator of TGFbeta-Induced Invasion in Basal Breast Cancer. Cichon MA, Moruzzi ME, Shqau TA, Miller E, Mehner C, Ethier SP, Copland JA, Radisky ES, Radisky DC. Cancer Res. 2016 Jun 15;76(12):3520-30. doi: 10.1158/0008-5472.CAN-15-3465. Epub 2016 Apr 13. PubMed
Efficient generation of dopaminergic-like neurons by overexpression of Nurr1 and Pitx3 in mouse induced Pluripotent Stem Cells. Salemi S, Baktash P, Rajaei B, Noori M, Amini H, Shamsara M, Massumi M. Neurosci Lett. 2016 Jul 28;626:126-34. doi: 10.1016/j.neulet.2016.05.032. Epub 2016 May 18. PubMed
Forced expression of Hnf4a induces hepatic gene activation through directed differentiation. Yahoo N, Pournasr B, Rostamzadeh J, Fathi F. Biochem Biophys Res Commun. 2016 Aug 5;476(4):313-8. doi: 10.1016/j.bbrc.2016.05.119. Epub 2016 May 24. PubMed
Pancreatic Endoderm-Derived from Diabetic Patient-Specific Induced Pluripotent Stem Cell Generates Glucose-Responsive Insulin-Secreting Cells. Rajaei B, Shamsara M, Fakhr Taha M, Massumi M, Sanati MH. J Cell Physiol. 2016 Jun 16. doi: 10.1002/jcp.25459. PubMed
TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming. Miles DC, de Vries NA, Gisler S, Lieftink C, Akhtar W, Gogola E, Pawlitzky I, Hulsman D, Tanger E, Koppens M, Beijersbergen RL, van Lohuizen M. Stem Cells. 2017 Jan;35(1):147-157. doi: 10.1002/stem.2453. Epub 2016 Jul 6. PubMed
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lonnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L, Arenas E. EMBO J. 2016 Sep 15;35(18):1963-78. doi: 10.15252/embj.201593725. Epub 2016 Jun 28. PubMed
Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells. Sun AX, Yuan Q, Tan S, Xiao Y, Wang D, Khoo AT, Sani L, Tran HD, Kim P, Chiew YS, Lee KJ, Yen YC, Ng HH, Lim B, Je HS. Cell Rep. 2016 Aug 16;16(7):1942-53. doi: 10.1016/j.celrep.2016.07.035. Epub 2016 Aug 4. PubMed
Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane. Lee B, Lee TH, Shim J. Biochim Biophys Acta. 2017 Feb;1864(2):303-313. doi: 10.1016/j.bbamcr.2016.11.013. Epub 2016 Nov 16. PubMed
Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. van den Berg DL, Azzarelli R, Oishi K, Martynoga B, Urban N, Dekkers DH, Demmers JA, Guillemot F. Neuron. 2016 Dec 20. pii: S0896-6273(16)30915-1. doi: 10.1016/j.neuron.2016.11.047. PubMed
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program. Daniel MG, Pereira CF, Bernitz JM, Lemischka IR, Moore K. J Vis Exp. 2016 Dec 16;(118). doi: 10.3791/54372. PubMed
Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage. Christoforou N, Chakraborty S, Kirkton RD, Adler AF, Addis RC, Leong KW. Sci Rep. 2017 Jan 10;7:40285. doi: 10.1038/srep40285. PubMed
Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ. Curr Protoc Hum Genet. 2017 Jan 11;92:21.8.1-21.8.21. doi: 10.1002/cphg.33. PubMed
Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7. doi: 10.1016/j.stem.2016.11.018. Epub 2017 Jan 12. PubMed
Enhanced Cardiac Differentiation of Human Cardiovascular Disease Patient-Specific Induced Pluripotent Stem Cells by Applying Unidirectional Electrical Pulses Using Aligned Electroactive Nanofibrous Scaffolds. Mohammadi Amirabad L, Massumi M, Shamsara M, Shabani I, Amari A, Mossahebi Mohammadi M, Hosseinzadeh S, Vakilian S, Steinbach SK, Khorramizadeh MR, Soleimani M, Barzin J. ACS Appl Mater Interfaces. 2017 Mar 1;9(8):6849-6864. doi: 10.1021/acsami.6b15271. Epub 2017 Feb 15. PubMed
Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilarino M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sanchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nunez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC. Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036. PubMed
Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Scholer HR, Baron-Van Evercooren A, Kuhlmann T. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2243-E2252. doi: 10.1073/pnas.1614412114. Epub 2017 Feb 28. PubMed
Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R. Schizophr Res. 2017 Mar;181:75-82. doi: 10.1016/j.schres.2016.10.012. Epub 2016 Oct 27. PubMed
Bovine trophectoderm cells induced from bovine fibroblasts with induced pluripotent stem cell reprogramming factors. Talbot NC, Sparks WO, Phillips CE, Ealy AD, Powell AM, Caperna TJ, Garrett WM, Donovan DM, Blomberg LA. Mol Reprod Dev. 2017 Jun;84(6):468-485. doi: 10.1002/mrd.22797. Epub 2017 Apr 12. PubMed
Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions. Petkovich DA, Podolskiy DI, Lobanov AV, Lee SG, Miller RA, Gladyshev VN. Cell Metab. 2017 Apr 4;25(4):954-960.e6. doi: 10.1016/j.cmet.2017.03.016. PubMed
Promyelocytic Leukemia Protein Is an Essential Regulator of Stem Cell Pluripotency and Somatic Cell Reprogramming. Hadjimichael C, Chanoumidou K, Nikolaou C, Klonizakis A, Theodosi GI, Makatounakis T, Papamatheakis J, Kretsovali A. Stem Cell Reports. 2017 May 9;8(5):1366-1378. doi: 10.1016/j.stemcr.2017.03.006. Epub 2017 Apr 6. PubMed
Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin. Guan R, Zhang L, Su QP, Mickolajczyk KJ, Chen GY, Hancock WO, Sun Y, Zhao Y, Chen Z. Nat Commun. 2017 Apr 10;8:14951. doi: 10.1038/ncomms14951. PubMed
Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martin-Montanez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sanchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E. Nat Biotechnol. 2017 May;35(5):444-452. doi: 10.1038/nbt.3835. Epub 2017 Apr 10. PubMed
Deterministic versus stochastic model of reprogramming: new evidence from cellular barcoding technique. Yunusova AM, Fishman VS, Vasiliev GV, Battulin NR. Open Biol. 2017 Apr;7(4). pii: 160311. doi: 10.1098/rsob.160311. PubMed
Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells. Hossain MS, Oomura Y, Katafuchi T. Mol Neurobiol. 2017 May 13. doi: 10.1007/s12035-017-0578-3. PubMed
Generation of Induced Pluripotent Stem Cells in Defined Three-Dimensional Hydrogels. Caiazzo M, Tabata Y, Lutolf M. Methods Mol Biol. 2017;1612:65-78. doi: 10.1007/978-1-4939-7021-6_5. PubMed
SALL4 promotes glycolysis and chromatin remodeling via modulating HP1alpha-Glut1 pathway. Kim J, Xu S, Xiong L, Yu L, Fu X, Xu Y. Oncogene. 2017 Nov 16;36(46):6472-6479. doi: 10.1038/onc.2017.265. Epub 2017 Jul 31. PubMed
miR-524-5p of the primate-specific C19MC miRNA cluster targets TP53IPN1- and EMT-associated genes to regulate cellular reprogramming. Nguyen PNN, Choo KB, Huang CJ, Sugii S, Cheong SK, Kamarul T. Stem Cell Res Ther. 2017 Sep 29;8(1):214. doi: 10.1186/s13287-017-0666-3. PubMed
Reprogramming Factors Remodel Melanoma Cell Phenotype by Changing Stat3 Expression. Wang Y, Mou Y, Zhang H, Wang X, Li R, Cheng Z, Liu X. Int J Med Sci. 2017 Nov 2;14(13):1402-1409. doi: 10.7150/ijms.21952. eCollection 2017. PubMed
Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome. Rodriguez-Madoz JR, San Jose-Eneriz E, Rabal O, Zapata-Linares N, Miranda E, Rodriguez S, Porciuncula A, Vilas-Zornoza A, Garate L, Segura V, Guruceaga E, Agirre X, Oyarzabal J, Prosper F. PLoS One. 2017 Dec 27;12(12):e0190275. doi: 10.1371/journal.pone.0190275. eCollection 2017. PubMed
CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Liu P, Chen M, Liu Y, Qi LS, Ding S. Cell Stem Cell. 2018 Feb 1;22(2):252-261.e4. doi: 10.1016/j.stem.2017.12.001. Epub 2018 Jan 18. PubMed
Genome-wide tracking of dCas9-methyltransferase footprints. Galonska C, Charlton J, Mattei AL, Donaghey J, Clement K, Gu H, Mohammad AW, Stamenova EK, Cacchiarelli D, Klages S, Timmermann B, Cantz T, Scholer HR, Gnirke A, Ziller MJ, Meissner A. Nat Commun. 2018 Feb 9;9(1):597. doi: 10.1038/s41467-017-02708-5. PubMed
Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. Aneichyk T, Hendriks WT, Yadav R, Shin D, Gao D, Vaine CA, Collins RL, Domingo A, Currall B, Stortchevoi A, Multhaupt-Buell T, Penney EB, Cruz L, Dhakal J, Brand H, Hanscom C, Antolik C, Dy M, Ragavendran A, Underwood J, Cantsilieris S, Munson KM, Eichler EE, Acuna P, Go C, Jamora RDG, Rosales RL, Church DM, Williams SR, Garcia S, Klein C, Muller U, Wilhelmsen KC, Timmers HTM, Sapir Y, Wainger BJ, Henderson D, Ito N, Weisenfeld N, Jaffe D, Sharma N, Breakefield XO, Ozelius LJ, Bragg DC, Talkowski ME. Cell. 2018 Feb 22;172(5):897-909.e21. doi: 10.1016/j.cell.2018.02.011. PubMed
The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition. Pliatska M, Kapasa M, Kokkalis A, Polyzos A, Thanos D. Mol Cell Biol. 2018 Apr 30;38(10). pii: MCB.00669-17. doi: 10.1128/MCB.00669-17. Print 2018 May 15. PubMed
Chromatin analysis in human early development reveals epigenetic transition during ZGA. Wu J, Xu J, Liu B, Yao G, Wang P, Lin Z, Huang B, Wang X, Li T, Shi S, Zhang N, Duan F, Ming J, Zhang X, Niu W, Song W, Jin H, Guo Y, Dai S, Hu L, Fang L, Wang Q, Li Y, Li W, Na J, Xie W, Sun Y. Nature. 2018 May;557(7704):256-260. doi: 10.1038/s41586-018-0080-8. Epub 2018 May 2. PubMed
Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain. Murao N, Matsubara S, Matsuda T, Noguchi H, Mutoh T, Mutoh M, Koseki H, Namihira M, Nakashima K. Neurosci Res. 2018 May 31. pii: S0168-0102(18)30276-1. doi: 10.1016/j.neures.2018.05.007. PubMed
A systems mechanobiology model to predict cardiac reprogramming outcomes on different biomaterials. Kong YP, Rioja AY, Xue X, Sun Y, Fu J, Putnam AJ. Biomaterials. 2018 Oct;181:280-292. doi: 10.1016/j.biomaterials.2018.07.036. Epub 2018 Jul 28. PubMed
SIRT2 is required for efficient reprogramming of mouse embryonic fibroblasts toward pluripotency. Kim AY, Lee EM, Lee EJ, Kim JH, Suk K, Lee E, Hur K, Hong YJ, Do JT, Park S, Jeong KS. Cell Death Dis. 2018 Aug 30;9(9):893. doi: 10.1038/s41419-018-0920-3. PubMed
Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation. Lee SY, Long F. J Clin Invest. 2018 Dec 3;128(12):5573-5586. doi: 10.1172/JCI96221. Epub 2018 Nov 12. PubMed
Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical markers. Miskinyte G, Gronning Hansen M, Monni E, Lam M, Bengzon J, Lindvall O, Ahlenius H, Kokaia Z. PLoS One. 2018 Oct 11;13(10):e0204688. doi: 10.1371/journal.pone.0204688. eCollection 2018. PubMed
Immortalized murine fibroblast cell lines are refractory to reprogramming to pluripotent state. Skvortsova EV, Sinenko SA, Tomilin AN. Oncotarget. 2018 Oct 16;9(81):35241-35250. doi: 10.18632/oncotarget.26235. eCollection 2018 Oct 16. PubMed
Lipidomic Analysis of alpha-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. PubMed
Binding of HMGN proteins to cell specific enhancers stabilizes cell identity. He B, Deng T, Zhu I, Furusawa T, Zhang S, Tang W, Postnikov Y, Ambs S, Li CC, Livak F, Landsman D, Bustin M. Nat Commun. 2018 Dec 7;9(1):5240. doi: 10.1038/s41467-018-07687-9. PubMed
Paired Related Homeobox Protein 1 Regulates Quiescence in Human Oligodendrocyte Progenitors. Wang J, Saraswat D, Sinha AK, Polanco J, Dietz K, O'Bara MA, Pol SU, Shayya HJ, Sim FJ. Cell Rep. 2018 Dec 18;25(12):3435-3450.e6. doi: 10.1016/j.celrep.2018.11.068. PubMed
Reprogramming factors induce proliferation and inhibit apoptosis of melanoma cells by changing the expression of particular genes. Wang Y, Sun HJ, Li RG, Wang XM, Cheng ZQ, Lou N. Mol Med Rep. 2019 Feb;19(2):967-973. doi: 10.3892/mmr.2018.9753. Epub 2018 Dec 12. PubMed
Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells. Thier MC, Hommerding O, Panten J, Pinna R, Garcia-Gonzalez D, Berger T, Worsdorfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, Becker L, Milsom MD, Jauch A, Utikal J, Herrmann C, Monyer H, Edenhofer F, Trumpp A. Cell Stem Cell. 2019 Jan 3;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015. Epub 2018 Dec 20. PubMed
Type I interferon response impairs differentiation potential of pluripotent stem cells. Eggenberger J, Blanco-Melo D, Panis M, Brennand KJ, tenOever BR. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1384-1393. doi: 10.1073/pnas.1812449116. Epub 2019 Jan 3. PubMed
Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion. Matsuda T, Irie T, Katsurabayashi S, Hayashi Y, Nagai T, Hamazaki N, Adefuin AMD, Miura F, Ito T, Kimura H, Shirahige K, Takeda T, Iwasaki K, Imamura T, Nakashima K. Neuron. 2019 Feb 6;101(3):472-485.e7. doi: 10.1016/j.neuron.2018.12.010. Epub 2019 Jan 9. PubMed
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation. Kim J, Yu L, Chen W, Xu Y, Wu M, Todorova D, Tang Q, Feng B, Jiang L, He J, Chen G, Fu X, Xu Y. Cancer Cell. 2019 Feb 11;35(2):191-203.e8. doi: 10.1016/j.ccell.2018.12.012. Epub 2019 Jan 31. PubMed
NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells. Tchieu J, Calder EL, Guttikonda SR, Gutzwiller EM, Aromolaran KA, Steinbeck JA, Goldstein PA, Studer L. Nat Biotechnol. 2019 Mar;37(3):267-275. doi: 10.1038/s41587-019-0035-0. Epub 2019 Feb 25. PubMed

Associated Plasmids

WDR5, BRCA1, and BARD1 Co-regulate the DNA Damage Response and Modulate the Mesenchymal-to-Epithelial Transition during Early Reprogramming. Penalosa-Ruiz G, Bousgouni V, Gerlach JP, Waarlo S, van de Ven JV, Veenstra TE, Silva JCR, van Heeringen SJ, Bakal C, Mulder KW, Veenstra GJC. Stem Cell Reports. 2019 Apr 9;12(4):743-756. doi: 10.1016/j.stemcr.2019.02.006. Epub 2019 Mar 14. PubMed
Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector. Mayers S, Moco PD, Maqbool T, Silva PN, Kilkenny DM, Audet J. BMC Biotechnol. 2019 Apr 15;19(1):21. doi: 10.1186/s12896-019-0515-9. PubMed
Chemical screen for epigenetic barriers to single allele activation of Oct4. Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA. Stem Cell Res. 2019 Jul;38:101470. doi: 10.1016/j.scr.2019.101470. Epub 2019 May 24. PubMed
Embryonic Chimeras with Human Pluripotent Stem Cells. De Los Angeles A, Sakurai M, Wu J. Methods Mol Biol. 2019;2005:125-151. doi: 10.1007/978-1-4939-9524-0_9. PubMed
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons. Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP. Sci Rep. 2019 Jun 21;9(1):9000. doi: 10.1038/s41598-019-45265-1. PubMed
Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, Chen ZN, Jiang X. Nature. 2019 Aug;572(7769):402-406. doi: 10.1038/s41586-019-1426-6. Epub 2019 Jul 24. PubMed
Endogenous pluripotent factor expression after reprogramming cat fetal fibroblasts using inducible transcription factors. Zhou R, Comizzoli P, Keefer CL. Mol Reprod Dev. 2019 Nov;86(11):1671-1681. doi: 10.1002/mrd.23257. Epub 2019 Aug 19. PubMed
Tox4 modulates cell fate reprogramming. Vanheer L, Song J, De Geest N, Janiszewski A, Talon I, Provenzano C, Oh T, Chappell J, Pasque V. J Cell Sci. 2019 Oct 22;132(20). pii: jcs.232223. doi: 10.1242/jcs.232223. PubMed
Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Patzke C, Brockmann MM, Dai J, Gan KJ, Grauel MK, Fenske P, Liu Y, Acuna C, Rosenmund C, Sudhof TC. Cell. 2019 Oct 3;179(2):498-513.e22. doi: 10.1016/j.cell.2019.09.011. PubMed
L-type voltage-gated Ca(2+) channel CaV1.2 regulates chondrogenesis during limb development. Atsuta Y, Tomizawa RR, Levin M, Tabin CJ. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21592-21601. doi: 10.1073/pnas.1908981116. Epub 2019 Oct 7. PubMed
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, Srinivasan R, Li X, Devarajan K, Prelot L, Ang CE, Shibuya Y, Benayoun BA, Chang ALS, Wernig M, Wysocka J, Longaker MT, Snyder MP, Brunet A. Nature. 2019 Oct;574(7779):553-558. doi: 10.1038/s41586-019-1658-5. Epub 2019 Oct 23. PubMed
Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector. Ballester M, Bolonio M, Santamaria R, Castell JV, Ribes-Koninckx C, Bort R. Stem Cell Res Ther. 2019 Nov 4;10(1):317. doi: 10.1186/s13287-019-1416-5. PubMed
Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4. An Z, Liu P, Zheng J, Si C, Li T, Chen Y, Ma T, Zhang MQ, Zhou Q, Ding S. Cell Rep. 2019 Nov 12;29(7):1986-2000.e8. doi: 10.1016/j.celrep.2019.10.026. PubMed
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors. Silverio-Alves R, Gomes AM, Kurochkin I, Moore KA, Pereira CF. J Vis Exp. 2019 Nov 4;(153). doi: 10.3791/60112. PubMed
Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits. Linaro D, Vermaercke B, Iwata R, Ramaswamy A, Libe-Philippot B, Boubakar L, Davis BA, Wierda K, Davie K, Poovathingal S, Penttila PA, Bilheu A, De Bruyne L, Gall D, Conzelmann KK, Bonin V, Vanderhaeghen P. Neuron. 2019 Dec 4;104(5):972-986.e6. doi: 10.1016/j.neuron.2019.10.002. Epub 2019 Nov 21. PubMed
Reprogramming Fibroblasts to Neural Stem Cells by Overexpression of the Transcription Factor Ptf1a. Jin K, Zou M, Xiao D, Xiang M. Methods Mol Biol. 2020;2117:245-263. doi: 10.1007/978-1-0716-0301-7_15. PubMed
MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. Yu L, Kim J, Jiang L, Feng B, Ying Y, Ji KY, Tang Q, Chen W, Mai T, Dou W, Zhou J, Xiang LY, He YF, Yang D, Li Q, Fu X, Xu Y. Nat Commun. 2020 Feb 5;11(1):708. doi: 10.1038/s41467-020-14437-3. PubMed
Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. Aging (Albany NY). 2020 Apr 26;12(8):7431-7447. doi: 10.18632/aging.103090. Epub 2020 Apr 26. PubMed
The corepressor NCOR1 and OCT4 facilitate early reprogramming by suppressing fibroblast gene expression. Penalosa-Ruiz G, Mulder KW, Veenstra GJC. PeerJ. 2020 Apr 22;8:e8952. doi: 10.7717/peerj.8952. eCollection 2020. PubMed
Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells. Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M. Stem Cell Res. 2020 Oct;48:101945. doi: 10.1016/j.scr.2020.101945. Epub 2020 Aug 3. PubMed
Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection. Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Iskhakova M, Fernando MB, Deans PJM, Powell SK, Javidfar B, Murphy A, Peter C, Moeller R, Garcia MF, Kimura M, Iwasawa K, Crary J, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ. bioRxiv. 2020 Sep 21. doi: 10.1101/2020.09.20.300574. PubMed
Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens. Black JB, McCutcheon SR, Dube S, Barrera A, Klann TS, Rice GA, Adkar SS, Soderling SH, Reddy TE, Gersbach CA. Cell Rep. 2020 Dec 1;33(9):108460. doi: 10.1016/j.celrep.2020.108460. PubMed
Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons. Hulme AJ, McArthur JR, Maksour S, Miellet S, Ooi L, Adams DJ, Finol-Urdaneta RK, Dottori M. Front Cell Neurosci. 2020 Dec 4;14:600895. doi: 10.3389/fncel.2020.600895. eCollection 2020. PubMed
Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Habekost M, Qvist P, Denham M, Holm IE, Jorgensen AL. Mol Neurobiol. 2021 May;58(5):2075-2087. doi: 10.1007/s12035-020-02258-w. Epub 2021 Jan 7. PubMed
Methyl-CpG-binding domain 3 (Mbd3) is an important regulator for apoptosis in mouse embryonic stem cells. Dai Y, Li J, Li M, Liu Z, Liu J, An L, Du F. Am J Transl Res. 2020 Dec 15;12(12):8147-8161. eCollection 2020. PubMed
LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes. Xu A, Huang MF, Zhu D, Gingold JA, Bazer DA, Chang B, Wang D, Lai CC, Lemischka IR, Zhao R, Lee DF. Front Genet. 2021 Jan 15;11:611823. doi: 10.3389/fgene.2020.611823. eCollection 2020. PubMed
Dyshomeostatic modulation of Ca(2+)-activated K(+) channels in a human neuronal model of KCNQ2 encephalopathy. Simkin D, Marshall KA, Vanoye CG, Desai RR, Bustos BI, Piyevsky BN, Ortega JA, Forrest M, Robertson GL, Penzes P, Laux LC, Lubbe SJ, Millichap JJ, George AL Jr, Kiskinis E. Elife. 2021 Feb 5;10. pii: 64434. doi: 10.7554/eLife.64434. PubMed

Associated Plasmids

NGN2 mmRNA-Based Transcriptional Programming in Microfluidic Guides hiPSCs Toward Neural Fate With Multiple Identities. Tolomeo AM, Laterza C, Grespan E, Michielin F, Canals I, Kokaia Z, Muraca M, Gagliano O, Elvassore N. Front Cell Neurosci. 2021 Feb 12;15:602888. doi: 10.3389/fncel.2021.602888. eCollection 2021. PubMed
MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation. Batlle C, Calvo I, Iglesias V, J Lynch C, Gil-Garcia M, Serrano M, Ventura S. Commun Biol. 2021 Mar 26;4(1):414. doi: 10.1038/s42003-021-01930-8. PubMed
SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System. Neyrinck K, Van Den Daele J, Vervliet T, De Smedt J, Wierda K, Nijs M, Vanbokhoven T, D'hondt A, Planque M, Fendt SM, Shih PY, Seibt F, Almenar JP, Kreir M, Kumar D, Broccoli V, Bultynck G, Ebneth A, Cabrera-Socorro A, Verfaillie C. Stem Cell Rev Rep. 2021 May 12. pii: 10.1007/s12015-021-10179-x. doi: 10.1007/s12015-021-10179-x. PubMed
Human cell transformation by combined lineage conversion and oncogene expression. Sahu B, Pihlajamaa P, Zhang K, Palin K, Ahonen S, Cervera A, Ristimaki A, Aaltonen LA, Hautaniemi S, Taipale J. Oncogene. 2021 Sep;40(36):5533-5547. doi: 10.1038/s41388-021-01940-0. Epub 2021 Jul 23. PubMed
Direct Cell Reprogramming of Mouse Fibroblasts into Functional Astrocytes Using Lentiviral Overexpression of the Transcription Factors NFIA, NFIB, and SOX9. Qiu B, de Vries RJ, Caiazzo M. Methods Mol Biol. 2021;2352:31-43. doi: 10.1007/978-1-0716-1601-7_3. PubMed
Direct Differentiation of Functional Neurons from Human Pluripotent Stem Cells (hPSCs). Hu R, Zhu X, Yang N. Methods Mol Biol. 2021;2352:117-126. doi: 10.1007/978-1-0716-1601-7_8. PubMed
Transcription Factor Programming of Human Pluripotent Stem Cells to Functionally Mature Astrocytes for Monocultures and Cocultures with Neurons. Quist E, Ahlenius H, Canals I. Methods Mol Biol. 2021;2352:133-148. doi: 10.1007/978-1-0716-1601-7_10. PubMed
Single Transcription Factor-Based Differentiation Allowing Fast and Efficient Oligodendrocyte Generation via SOX10 Overexpression. Neyrinck K, Garcia-Leon JA. Methods Mol Biol. 2021;2352:149-170. doi: 10.1007/978-1-0716-1601-7_11. PubMed
Restoration of the ATG5-dependent autophagy sensitizes DU145 prostate cancer cells to chemotherapeutic drugs. Peng K, Sun A, Zhu J, Gao J, Li Y, Shao G, Yang W, Lin Q. Oncol Lett. 2021 Sep;22(3):638. doi: 10.3892/ol.2021.12899. Epub 2021 Jul 6. PubMed

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