Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected]. Learn more


LAMP1-mRFP-FLAG Citations (21)

Originally described in: mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H-ATPase.
Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM Science. 2011 Nov 4;334(6056):678-83.
PubMed Journal

Articles Citing LAMP1-mRFP-FLAG

Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Feraille E, Brown D, Hasler U. Autophagy. 2013 Apr;9(4):550-67. doi: 10.4161/auto.23662. Epub 2013 Feb 4. PubMed
Single amino acid change in STING leads to constitutive active signaling. Tang ED, Wang CY. PLoS One. 2015 Mar 19;10(3):e0120090. doi: 10.1371/journal.pone.0120090. eCollection 2015. PubMed
Autophagy of metallothioneins prevents TNF-induced oxidative stress and toxicity in hepatoma cells. Ullio C, Brunk UT, Urani C, Melchioretto P, Bonelli G, Baccino FM, Autelli R. Autophagy. 2015;11(12):2184-98. doi: 10.1080/15548627.2015.1106662. PubMed
mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J, Monteleone E, Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi PP. Nature. 2017 Jan 12;541(7636):228-232. doi: 10.1038/nature21034. Epub 2016 Dec 26. PubMed
GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Serrano D, Ghobadi F, Boulay G, Ilangumaran S, Lavoie C, Ramanathan S. Front Immunol. 2017 Feb 7;8:94. doi: 10.3389/fimmu.2017.00094. eCollection 2017. PubMed
mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism. Lampada A, O'Prey J, Szabadkai G, Ryan KM, Hochhauser D, Salomoni P. Cell Death Differ. 2017 Jun;24(6):1045-1062. doi: 10.1038/cdd.2017.41. Epub 2017 May 5. PubMed
Modulating cancer cell survival by targeting intracellular cholesterol transport. Kuzu OF, Gowda R, Noory MA, Robertson GP. Br J Cancer. 2017 Aug 8;117(4):513-524. doi: 10.1038/bjc.2017.200. Epub 2017 Jul 11. PubMed
AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms. Nwadike C, Williamson LE, Gallagher LE, Guan JL, Chan EYW. Mol Cell Biol. 2018 Apr 30;38(10). pii: MCB.00023-18. doi: 10.1128/MCB.00023-18. Print 2018 May 15. PubMed
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV. Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31. PubMed

Associated Plasmids

Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes. Yap CC, Digilio L, McMahon LP, Garcia ADR, Winckler B. J Cell Biol. 2018 Sep 3;217(9):3141-3159. doi: 10.1083/jcb.201711039. Epub 2018 Jun 15. PubMed
Putative metal binding site in the transmembrane domain of the manganese transporter SLC30A10 is different from that of related zinc transporters. Zogzas CE, Mukhopadhyay S. Metallomics. 2018 Aug 15;10(8):1053-1064. doi: 10.1039/c8mt00115d. PubMed
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. Dev Cell. 2019 May 6;49(3):393-408.e7. doi: 10.1016/j.devcel.2019.03.011. Epub 2019 Apr 11. PubMed
The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, Seki A, Shen K, Iyer H, Han K, Hayer A, Wollman R, Ge X, Lin JR, Dey G, Talbot WS, Meyer T. Nat Cell Biol. 2019 May;21(5):614-626. doi: 10.1038/s41556-019-0321-6. Epub 2019 Apr 29. PubMed
Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis. Selyunin AS, Hutchens S, McHardy SF, Mukhopadhyay S. Life Sci Alliance. 2019 Jun 26;2(3). pii: 2/3/e201900439. doi: 10.26508/lsa.201900439. Print 2019 Jun. PubMed
mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux. Beaumatin F, O'Prey J, Barthet VJA, Zunino B, Parvy JP, Bachmann AM, O'Prey M, Kania E, Gonzalez PS, Macintosh R, Lao LY, Nixon C, Lopez J, Long JS, Tait SWG, Ryan KM. Mol Cell. 2019 Oct 3;76(1):163-176.e8. doi: 10.1016/j.molcel.2019.07.021. Epub 2019 Sep 3. PubMed
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis. Chen Q, Lei JH, Bao J, Wang H, Hao W, Li L, Peng C, Masuda T, Miao K, Xu J, Xu X, Deng CX. Adv Sci (Weinh). 2020 Feb 14;7(6):1903616. doi: 10.1002/advs.201903616. eCollection 2020 Mar. PubMed
The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7. Morel M, Shah KN, Long W. J Biol Chem. 2020 Jun 5;295(23):7970-7980. doi: 10.1074/jbc.RA120.012658. Epub 2020 Apr 28. PubMed
Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability. Almacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C. Autophagy. 2021 Mar;17(3):796-813. doi: 10.1080/15548627.2020.1764727. Epub 2020 Jun 23. PubMed
Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy. Pero ME, Meregalli C, Qu X, Shin GJ, Kumar A, Shorey M, Rolls MM, Tanji K, Brannagan TH, Alberti P, Fumagalli G, Monza L, Grueber WB, Cavaletti G, Bartolini F. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). pii: 2012685118. doi: 10.1073/pnas.2012685118. PubMed
SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance. Liu K, Kong L, Graham DB, Carey KL, Xavier RJ. Cell Rep. 2021 Jul 27;36(4):109434. doi: 10.1016/j.celrep.2021.109434. PubMed
LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy. Omrane M, Ben M'Barek K, Santinho A, Nguyen N, Nag S, Melia TJ, Thiam AR. Dev Cell. 2023 Jul 24;58(14):1266-1281.e7. doi: 10.1016/j.devcel.2023.05.009. Epub 2023 Jun 13. PubMed

If you have published an article using this material, please email us at [email protected] to have your article added to this page.