hCRISPRi-v2, genome-wide, top 5 sgRNAs/gene Citations (20)
Originally described in: Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS Elife. 2016 Sep 23;5. pii: e19760. doi: 10.7554/eLife.19760. PubMed Journal
Articles Citing hCRISPRi-v2, genome-wide, top 5 sgRNAs/gene
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| New cell lines from mouse epiblast share defining features with human embryonic stem cells. Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD. Nature. 2007 Jul 12. 448(7150):196-9. PubMed |
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.
Adamson B, Norman TM, Jost M, Cho MY, Nunez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS.
Cell. 2016 Dec 15;167(7):1867-1882.e21. doi: 10.1016/j.cell.2016.11.048.
PubMed
Associated Plasmids |
| New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J. J Cell Biol. 2019 Nov 4;218(11):3861-3879. doi: 10.1083/jcb.201902028. Epub 2019 Sep 5. PubMed |
| A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity. Palmer AC, Chidley C, Sorger PK. Elife. 2019 Nov 19;8. pii: 50036. doi: 10.7554/eLife.50036. PubMed |
| Lysosome-targeting chimaeras for degradation of extracellular proteins. Banik SM, Pedram K, Wisnovsky S, Ahn G, Riley NM, Bertozzi CR. Nature. 2020 Aug;584(7820):291-297. doi: 10.1038/s41586-020-2545-9. Epub 2020 Jul 29. PubMed |
Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore.
Pinzaru AM, Kareh M, Lamm N, Lazzerini-Denchi E, Cesare AJ, Sfeir A.
Genes Dev. 2020 Dec 1;34(23-24):1619-1636. doi: 10.1101/gad.337287.120. Epub 2020 Oct 29.
PubMed
Associated Plasmids |
| Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. Wisnovsky S, Mockl L, Malaker SA, Pedram K, Hess GT, Riley NM, Gray MA, Smith BAH, Bassik MC, Moerner WE, Bertozzi CR. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5). pii: 2015024118. doi: 10.1073/pnas.2015024118. PubMed |
| CRISPRi/a Screening with Human iPSCs. Nishiga M, Qi LS, Wu JC. Methods Mol Biol. 2021;2320:261-281. doi: 10.1007/978-1-0716-1484-6_23. PubMed |
| Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC. Cell. 2022 May 12;185(10):1676-1693.e23. doi: 10.1016/j.cell.2022.04.005. Epub 2022 Apr 29. PubMed |
| Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen. Pedersen SF, Collora JA, Kim RN, Yang K, Razmi A, Catalano AA, Yeh YJ, Mounzer K, Tebas P, Montaner LJ, Ho YC. J Virol. 2022 Jul 13;96(13):e0057722. doi: 10.1128/jvi.00577-22. Epub 2022 Jun 22. PubMed |
A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.
Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM.
BMC Genomics. 2023 Oct 30;24(1):651. doi: 10.1186/s12864-023-09754-y.
PubMed
Associated Plasmids |
| Genome-Scale Analysis of Cellular Restriction Factors That Inhibit Transgene Expression from Adeno-Associated Virus Vectors. Ngo AM, Puschnik AS. J Virol. 2023 Apr 27;97(4):e0194822. doi: 10.1128/jvi.01948-22. Epub 2023 Mar 27. PubMed |
Compact CRISPR genetic screens enabled by improved guide RNA library cloning.
Heo SJ, Enriquez LD, Federman S, Chang AY, Mace R, Shevade K, Nguyen P, Litterman AJ, Shafer S, Przybyla L, Chow ED.
Genome Biol. 2024 Jan 19;25(1):25. doi: 10.1186/s13059-023-03132-3.
PubMed
Associated Plasmids |
| The HRI branch of the integrated stress response selectively triggers mitophagy. Chakrabarty Y, Yang Z, Chen H, Chan DC. Mol Cell. 2024 Mar 21;84(6):1090-1100.e6. doi: 10.1016/j.molcel.2024.01.016. Epub 2024 Feb 9. PubMed |
| A genome-wide screen links peroxisome regulation with Wnt signaling through RNF146 and tankyrase. Vu JT, Tavasoli KU, Mandjikian L, Sheedy CJ, Bacal J, Morrissey MA, Richardson CD, Gardner BM. bioRxiv [Preprint]. 2024 Feb 4:2024.02.02.578667. doi: 10.1101/2024.02.02.578667. PubMed |
Triaging of alpha-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS.
Mol Cell. 2024 Mar 21;84(6):1101-1119.e9. doi: 10.1016/j.molcel.2024.01.028. Epub 2024 Feb 29.
PubMed
Associated Plasmids |
| In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis. Arriaga JM, Ronaldson-Bouchard K, Picech F, Nunes de Almeida F, Afari S, Chhouri H, Vunjak-Novakovic G, Abate-Shen C. Oncogene. 2024 Apr;43(17):1303-1315. doi: 10.1038/s41388-024-02995-5. Epub 2024 Mar 7. PubMed |
| Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB. Carnie CJ, Acampora AC, Bader AS, Erdenebat C, Zhao S, Bitensky E, van den Heuvel D, Parnas A, Gupta V, D'Alessandro G, Sczaniecka-Clift M, Weickert P, Aygenli F, Gotz MJ, Cordes J, Esain-Garcia I, Melidis L, Wondergem AP, Lam S, Robles MS, Balasubramanian S, Adar S, Luijsterburg MS, Jackson SP, Stingele J. Nat Cell Biol. 2024 May;26(5):797-810. doi: 10.1038/s41556-024-01391-1. Epub 2024 Apr 10. PubMed |
| A systematic search for RNA structural switches across the human transcriptome. Khoroshkin M, Asarnow D, Zhou S, Navickas A, Winters A, Goudreau J, Zhou SK, Yu J, Palka C, Fish L, Borah A, Yousefi K, Carpenter C, Ansel KM, Cheng Y, Gilbert LA, Goodarzi H. Nat Methods. 2024 Sep;21(9):1634-1645. doi: 10.1038/s41592-024-02335-1. Epub 2024 Jul 16. PubMed |
| The Role of IRF9 Upregulation in Modulating Sensitivity to Olaparib and Platinum-Based Chemotherapies in Breast Cancer. Choi S, Bae HG, Jo DG, Kim WY. Genes (Basel). 2024 Jul 22;15(7):959. doi: 10.3390/genes15070959. PubMed |
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