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Damaged mitochondria recruit the effector NEMO to activate NF-kappaB signaling.

Harding O, Holzer E, Riley JF, Martens S, Holzbaur ELF
Mol Cell. 2023 Sep 7;83(17):3188-3204.e7. doi: 10.1016/j.molcel.2023.08.005. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
187897ParkinMammalian cell expression of untagged Parkin
187898HA-EGFP-NEMO-D304NMammalian cell expression of D304N mutation in NEMO
187899Halo-NEMOMammalian cell expression of Halo-tagged NEMO
187900Halo-OPTNMammalian cell expression of Halo-tagged OPTN
187901mCherry-p62-TIR-AAAMammalian cell expression of a triple mutant of p62: P228A, E230A, P232A
187909TFAM-SNAPfMammalian cell expression of SNAPf-labeled TFAM
187910EGFP-UbiquitinMammalian cell expression of EGFP-tagged Ubiquitin
187964Mito-SBFP2Mammalian cell expression of a fluorescent SBFP2-tagged mitochondrial marker
206480Mito-SNAPEncodes a mitochondrially-targeted SNAP tag for mammalian cell expression

Antibodies from Article