We narrowed to 36,146 results for: Mut

1. pCDH-EF1-FHC-POLQ-DY2230AA

   Plasmid

   #64878

   Purpose

   lentiviral expression of human POLQ -DY2230AA mutant (a polymerase domain mutant)

   Depositor

   Richard Wood

   Article

   Yousefzadeh et al PLoS Genet. 2014 Oct 2;10(10):e1004654.

   Insert

   POLQ (POLQ Human)
   

   Use

   Lentiviral

   Tags

   FLAG and HA

   Expression

   Mammalian

   Mutation

   D2330A,Y2331A, in the DNA polymerase domain (POL)…

   Promoter

   EF1alpha

   Available Since

   July 11, 2016

   Availability

   Academic Institutions and Nonprofits only

   

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2. pAAV-FLEX-SaCas9-U6-sgGria1

   Plasmid

   #124853

   Purpose

   Mutagenesis of Gria1

   Depositor

   Larry Zweifel

   Article

   Hunker et al Cell Rep. 2020 Mar 24;30(12):4303-4316.e

   Insert

   Gria1 (Gria1 Mouse)
   

   Use

   AAV, CRISPR, and Mouse Targeting

   Tags

   Expression

   Mutation

   Promoter

   Available Since

   May 6, 2019

   Availability

   Academic Institutions and Nonprofits only

   

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3. pAAV-FLEX-SaCas9-U6-sgSlc17a6

   Plasmid

   #124847

   Purpose

   Mutagenesis of Slc17a6 with SauCas9

   Depositor

   Larry Zweifel

   Article

   Hunker et al Cell Rep. 2020 Mar 24;30(12):4303-4316.e

   Insert

   Slc17a6 gRNA (Slc17a6 Mouse)
   

   Use

   AAV, CRISPR, and Mouse Targeting

   Tags

   Expression

   Mutation

   Promoter

   Available Since

   May 3, 2019

   Availability

   Academic Institutions and Nonprofits only

   

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4. pDEST53-LRRK2-R1441C

   Plasmid

   #25046

   Depositor

   Mark Cookson

   Article

   Greggio et al Neurobiol Dis. 2006 Aug . 23(2):329-41.

   Insert

   LRRK2 (LRRK2 Human)
   

   Use

   Tags

   GFP

   Expression

   Mammalian

   Mutation

   Arginine 1441 mutated to Cysteine

   Promoter

   Available Since

   June 17, 2010

   Availability

   Academic Institutions and Nonprofits only

5. pLPC-Progerin

   Plasmid

   #69061

   Purpose

   encodes the lamin A mutant with a 50 amino acids deletion responsible for the Hutchinson-Gilford Progeria Syndrome

   Depositor

   Gerardo Ferbeyre

   Article

   Moiseeva et al Cell Cycle. 2015 Aug 3;14(15):2408-21. d

   Insert

   Progerin (LMNA Human)
   

   Use

   Retroviral

   Tags

   Expression

   Mammalian

   Mutation

   Promoter

   CMV

   Available Since

   Dec. 15, 2015

   Availability

   Academic Institutions and Nonprofits only

6. pGL4.0-TERT G228A

   Plasmid

   #84926

   Purpose

   luciferase reporter for mutant TERT promoter

   Depositor

   Joseph Costello

   Article

   Bell et al Science. 2015 May 29;348(6238):1036-9. d

   Insert

   TERT promoter (TERT Human)
   

   Use

   Luciferase

   Tags

   luciferase

   Expression

   Mammalian

   Mutation

   G228A

   Promoter

   TERT

   Available Since

   March 8, 2017

   Availability

   Academic Institutions and Nonprofits only

   

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7. pGL4.0-TERT G250A

   Plasmid

   #84925

   Purpose

   luciferase reporter for mutant TERT promoter

   Depositor

   Joseph Costello

   Article

   Bell et al Science. 2015 May 29;348(6238):1036-9. d

   Insert

   TERT promoter (TERT Human)
   

   Use

   Luciferase

   Tags

   luciferase

   Expression

   Mammalian

   Mutation

   G250A

   Promoter

   TERT

   Available Since

   March 8, 2017

   Availability

   Academic Institutions and Nonprofits only

8. fluoPEER-GFP>BFP

   Plasmid

   #185477

   Purpose

   Fluorescent reporter for a Y66H mutation to convert a GFP to BFP.

   Depositor

   Sabine Fuchs

   Article

   Schene et al Nat Commun. 2022 Mar 1;13(1):1028. doi:

   Insert

   GFP-Y66-editing-site
   

   Use

   Tags

   Expression

   Mammalian

   Mutation

   Promoter

   CMV

   Available Since

   July 28, 2022

   Availability

   Academic Institutions and Nonprofits only

   

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9. pcDNA6 asyn E46K

   Plasmid

   #105730

   Purpose

   Mammalian expression of mutant human alpha synuclein

   Depositor

   Hilal Lashuel

   Article

   Mbefo et al J Biol Chem. 2015 Apr 10;290(15):9412-27

   Insert

   alpha-synuclein E46K (SNCA Human)
   

   Use

   Tags

   Expression

   Mammalian

   Mutation

   E46K

   Promoter

   CMV

   Available Since

   March 29, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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10. ATG-2460

    Plasmid

    #108713

    Purpose

    EF1-CBR2opt-T2A-copGFP (construct used for lentiviral transduction)

    Depositor

    Keith Wood

    Article

    Hall et al Nat Commun. 2018 Jan 9;9(1):132. doi: 10

    Insert

    CBR2opt-copGFP fusion
    

    Use

    Lentiviral

    Tags

    CBR2opt fused to copGFP

    Expression

    Mutation

    Promega used directed evolution to create CBR (Cl…

    Promoter

    elongation factor-1

    Available Since

    Oct. 9, 2018

    Availability

    Academic Institutions and Nonprofits only

    

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11. pMYH9-D1424H-FLAG

    Plasmid

    #183513

    Purpose

    Gateway expression vector encoding D1424H mutant MYH9 cDNA, with N-terminal Flag tag. For mammalian expression.

    Depositor

    Emanuele Panza

    Article

    Panza et al Pathogenetics. 2008 Dec 1;1(1):5. doi: 1

    Insert

    MYH9 (MYH9 Human)
    

    Use

    Tags

    FLAG

    Expression

    Mammalian

    Mutation

    changed Aspartic acid 1424 to Histidine

    Promoter

    CMV

    Available Since

    May 17, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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12. pF150 pSOD1G93AAcGFP1

    Plasmid

    #26411

    Purpose

    contains G94A mutation in pSOD1

    Depositor

    Elizabeth Fisher

    Article

    Stevens et al PLoS One. 2010 . 5(3):e9541.

    Insert

    SOD1 (SOD1 Human)
    

    Use

    Tags

    GFP

    Expression

    Mammalian

    Mutation

    G94A

    Promoter

    Available Since

    Nov. 8, 2010

    Availability

    Academic Institutions and Nonprofits only

    

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13. pAAV-FLEX-SaCas9-U6-sgGrin1

    Plasmid

    #124852

    Purpose

    Mutagenesis of Grin1

    Depositor

    Larry Zweifel

    Article

    Hunker et al Cell Rep. 2020 Mar 24;30(12):4303-4316.e

    Insert

    Grin1 (Grin1 Mouse)
    

    Use

    AAV, CRISPR, and Mouse Targeting

    Tags

    Expression

    Mutation

    Promoter

    Available Since

    May 3, 2019

    Availability

    Academic Institutions and Nonprofits only

    

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14. pT7-7 asyn E46K

    Plasmid

    #105728

    Purpose

    Bacterial expression of mutant human alpha synuclein

    Depositor

    Hilal Lashuel

    Article

    Mbefo et al J Biol Chem. 2015 Apr 10;290(15):9412-27

    Insert

    alpha-synuclein E46K (SNCA Human)
    

    Use

    Tags

    Expression

    Bacterial

    Mutation

    E46K

    Promoter

    T7

    Available Since

    April 2, 2018

    Availability

    Academic Institutions and Nonprofits only

    

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15. EGFR D770-N771 insNPG

    Plasmid

    #11016

    Purpose

    Retroviral construct for expressing human EGFR with D770-N771 insNPG mutation in human cells

    Depositor

    Matthew Meyerson

    Article

    Greulich et al PLoS Med. 2005 Oct 4. 2(11):e313.

    Insert

    EGFR D770-N771 insNPG (EGFR Human)
    

    Use

    Retroviral

    Tags

    Expression

    Mammalian

    Mutation

    D770-N771 insNPG

    Promoter

    Available Since

    Dec. 2, 2005

    Availability

    Academic Institutions and Nonprofits only

16. EGFR (del3) L747-E749del, A750P

    Plasmid

    #11015

    Purpose

    Retroviral construct for expressing human EGFR with L747-E749 deletion and A750P mutation in human cells

    Depositor

    Matthew Meyerson

    Article

    Greulich et al PLoS Med. 2005 Oct 4. 2(11):e313.

    Insert

    EGFR (del3) (EGFR Human)
    

    Use

    Retroviral

    Tags

    Expression

    Mammalian

    Mutation

    L747-E749 deleted, A750P

    Promoter

    Available Since

    Dec. 6, 2005

    Availability

    Academic Institutions and Nonprofits only

17. pcDNA6 asyn A30P

    Plasmid

    #105729

    Purpose

    Mammalian expression of mutant human alpha synuclein

    Depositor

    Hilal Lashuel

    Article

    Mbefo et al J Biol Chem. 2015 Apr 10;290(15):9412-27

    Insert

    alpha-synuclein A30P (SNCA Human)
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    A30P

    Promoter

    CMV

    Available Since

    March 29, 2018

    Availability

    Academic Institutions and Nonprofits only

    

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18. pCDH_CMV_dC_mKate2

    Plasmid

    #167336

    Purpose

    Expresses mKatet2 fused to TFAM dC-tail mutant in mammalian cells

    Depositor

    Tom Misteli

    Article

    Feric et al EMBO J. 2021 Mar 15;40(6):e107165. doi:

    Insert

    TFAM (TFAM Human)
    

    Use

    Lentiviral

    Tags

    mKate2

    Expression

    Mammalian

    Mutation

    Truncation mutant containing MTS (1-42) as well a…

    Promoter

    CMV

    Available Since

    April 15, 2021

    Availability

    Academic Institutions and Nonprofits only

    

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19. pDEST53-LRRK2-Y1699C

    Plasmid

    #25048

    Depositor

    Mark Cookson

    Article

    Greggio et al Neurobiol Dis. 2006 Aug . 23(2):329-41.

    Insert

    LRRK2 (LRRK2 Human)
    

    Use

    Tags

    GFP

    Expression

    Mammalian

    Mutation

    Tyrosine 1699 mutated to Cysteine

    Promoter

    Available Since

    June 17, 2010

    Availability

    Academic Institutions and Nonprofits only

20. pX62

    Plasmid

    #46854

    Purpose

    TOP Hupki-puro2A-G245S plasmid to introduce mutant p53 to PLF ESC or MEFs by IMCE

    Depositor

    Monica Hollstein

    Article

    Wei et al Cell Cycle. 2011 Apr 15;10(8):1261-70. E

    Insert

    attB-Puro-2A and Hupki p53 G245S (TP53 Human, Mouse)
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    G245S

    Promoter

    Available Since

    Aug. 22, 2013

    Availability

    Academic Institutions and Nonprofits only

    

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