Purpose
Contains human IgG1 CH1/mutated CH2/CH3 domains, for cloning of antibody VH domains using SapI restriction enzyme. Abolished Fc-mediated immune effector functions
Insert
Human IgG1 CH1/CH2/CH3 (mutated, no effector functions) (
IGHG1 Human)
Mutation
L234A/L235E/G237A and K322A/P331S
Available Since
Jan. 10, 2018
Availability
Academic Institutions and Nonprofits only