We narrowed to 949 results for: APP

...random and difficult to predict. In therapeutic applications, like chimeric antigen receptor T cell (CAR-...Pseudotyped lentiviral vectors are common in clinical applications, like gene therapy, as you can more specifically...accurate and multiplexable method for genome-wide mapping of lentiviral integration sites. Molecular Therapy... in chromatin architecture through large-scale mapping of lentiviral integration sites. Nature Protocols...2020). An analytical pipeline for identifying and mapping the integration sites of HIV and other retroviruses...begins, by definition, at the beginning of R, is capped, and proceeds through U5 and the rest of the provirus...

...neurons) that can be turned on or off by the application of a small molecule ligand. The ideal chemogenetic...translational studies because it is FDA and EMA approved. One pitfall of a suite of muscarinic-based DREADDs... develop a PSAM that responded to a clinically approved drug, the PSAM domain was engineered to respond..., B. L., & Wess, J. (2009). A chemical-genetic approach to study G protein regulation of β cell function...chemogenetics for research and potential clinical applications. Science, 364 (6436), eaav5282. https://doi....

...the light source. Optogenetics has been broadly applied to study the physiology of the brain and nervous... peak expression of the opsin is reached. This approach is especially powerful when combined with site...conformation/dimerization. In addition to the applications described above, both LOV and Dronpa can control...Deisseroth, K. (2010). Molecular and cellular approaches for diversifying and extending optogenetics. ...Yizhar, O., & Deisseroth, K. (2011). Principles for applying optogenetic tools derived from direct comparative...

...mice, and cultured human cells. Have diverse applications — Although plasmids were originally used to ...a primer. A primer is a small piece of DNA, approximately 18–22 nucleotides, that binds to complementary...form of a chromatogram. Sanger can sequence approximately 500–1,000 bases downstream of the known primer...pieces in only a few reactions. There are multiple approaches to acquire NGS, but one of the most common is...

...contains an introduction to each vector and its applications, tips for using vectors in your experiments,...your transferable skills, and tips on the job application process. Close About Overlay Select CRISPR 101...introductions and helpful tips for antibody-based applications, from flow to IHC! Close About Overlay 0 of ...

..., which has limited their use in therapeutic applications. However, this has also made them the most widely...Adenovirus-mediated gene delivery: potential applications for gene and cell-based therapies in the new...

...written and video protocols for a wide range of applications in molecular biology, plasmid cloning, and virus...

...specific binding to other proteins. Antibody-based applications, which often use antibodies conjugated to a ...

...regulatory elements. The proximal promoter is found approximately 250 base pairs upstream from the TSS and is ...