Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.
Holiday Schedule: Addgene will be closed December 24 - January 1, 2020. For more information, see our holiday shipping schedule. If you have any questions, please contact us at [email protected].

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected] Learn more

human beta-catenin pcDNA3 Citations (32)

Plasmid Article: Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression.
Kolligs FT, Hu G, Dang CV, Fearon ER Mol Cell Biol. 1999 Aug . 19(8):5696-706.
PubMed

Articles Citing human beta-catenin pcDNA3

Articles
A re-evaluation of two key reagents for in vivo studies of Wnt signaling. Ahrens MJ, Romereim S, Dudley AT. Dev Dyn. 2011 Sep;240(9):2060-8. doi: 10.1002/dvdy.22704. Epub 2011 Jul 25. PubMed
Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and beta-catenin activity in colon cancer cells. Hinkel I, Duluc I, Martin E, Guenot D, Freund JN, Gross I. Gastroenterology. 2012 Apr;142(4):875-885.e3. doi: 10.1053/j.gastro.2011.12.037. Epub 2011 Dec 24. PubMed
Regulation of the DLG tumor suppressor by beta-catenin. Subbaiah VK, Narayan N, Massimi P, Banks L. Int J Cancer. 2012 Nov 15;131(10):2223-33. doi: 10.1002/ijc.27519. Epub 2012 Mar 28. PubMed
The Cdc42/Rac nucleotide exchange factor protein beta1Pix (Pak-interacting exchange factor) modulates beta-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of beta1PIX with beta-catenin. Chahdi A, Raufman JP. J Biol Chem. 2013 Nov 22;288(47):34019-29. doi: 10.1074/jbc.M113.480103. Epub 2013 Oct 15. PubMed
DKK1 promotes hepatocellular carcinoma cell migration and invasion through beta-catenin/MMP7 signaling pathway. Chen L, Li M, Li Q, Wang CJ, Xie SQ. Mol Cancer. 2013 Dec 10;12:157. doi: 10.1186/1476-4598-12-157. PubMed
Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia. Ng OH, Erbilgin Y, Firtina S, Celkan T, Karakas Z, Aydogan G, Turkkan E, Yildirmak Y, Timur C, Zengin E, van Dongen JJ, Staal FJ, Ozbek U, Sayitoglu M. Blood Cancer J. 2014 Mar 14;4:e192. doi: 10.1038/bcj.2014.12. PubMed
Ras regulates SCF(beta-TrCP) protein activity and specificity via its effector protein NORE1A. Schmidt ML, Donninger H, Clark GJ. J Biol Chem. 2014 Nov 7;289(45):31102-10. doi: 10.1074/jbc.M114.594283. Epub 2014 Sep 12. PubMed
Protein kinase A activation enhances beta-catenin transcriptional activity through nuclear localization to PML bodies. Zhang M, Mahoney E, Zuo T, Manchanda PK, Davuluri RV, Kirschner LS. PLoS One. 2014 Oct 9;9(10):e109523. doi: 10.1371/journal.pone.0109523. eCollection 2014. PubMed
beta-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma. Dere R, Perkins AL, Bawa-Khalfe T, Jonasch D, Walker CL. J Am Soc Nephrol. 2015 Mar;26(3):553-64. doi: 10.1681/ASN.2013090984. Epub 2014 Oct 13. PubMed
SOX9 inhibits beta-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties. Deng W, Vanderbilt DB, Lin CC, Martin KH, Brundage KM, Ruppert JM. J Cell Sci. 2015 Jan 27. pii: jcs.162164. PubMed

Associated Plasmids

Kruppel-like factor 5 incorporates into the beta-catenin/TCF complex in response to LPA in colon cancer cells. Guo L, He P, No YR, Yun CC. Cell Signal. 2015 May;27(5):961-8. doi: 10.1016/j.cellsig.2015.02.005. Epub 2015 Feb 12. PubMed
Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells. Yoshino Y, Ishioka C. Sci Rep. 2015 Aug 21;5:13249. doi: 10.1038/srep13249. PubMed
DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes beta-catenin-mediated invasion. Im JY, Yoon SH, Kim BK, Ban HS, Won KJ, Chung KS, Jung KE, Won M. Biochim Biophys Acta. 2016 Nov;1859(11):1449-1458. doi: 10.1016/j.bbagrm.2016.07.003. Epub 2016 Jul 10. PubMed
Axitinib blocks Wnt/beta-catenin signaling and directs asymmetric cell division in cancer. Qu Y, Gharbi N, Yuan X, Olsen JR, Blicher P, Dalhus B, Brokstad KA, Lin B, Oyan AM, Zhang W, Kalland KH, Ke X. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9339-44. doi: 10.1073/pnas.1604520113. Epub 2016 Aug 1. PubMed
Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of beta-catenin signaling. Berwick DC, Javaheri B, Wetzel A, Hopkinson M, Nixon-Abell J, Granno S, Pitsillides AA, Harvey K. Mol Neurodegener. 2017 Jan 19;12(1):9. doi: 10.1186/s13024-017-0153-4. PubMed
Genetic basis of calcifying cystic odontogenic tumors. Yukimori A, Oikawa Y, Morita KI, Nguyen CTK, Harada H, Yamaguchi S, Kayamori K, Yamaguchi A, Ikeda T, Sakamoto K. PLoS One. 2017 Jun 28;12(6):e0180224. doi: 10.1371/journal.pone.0180224. eCollection 2017. PubMed
beta-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Long MJ, Lin HY, Parvez S, Zhao Y, Poganik JR, Huang P, Aye Y. Cell Chem Biol. 2017 Aug 17;24(8):944-957.e7. doi: 10.1016/j.chembiol.2017.06.009. Epub 2017 Jul 20. PubMed
Ergosterol peroxide inhibits ovarian cancer cell growth through multiple pathways. Tan W, Pan M, Liu H, Tian H, Ye Q, Liu H. Onco Targets Ther. 2017 Jul 13;10:3467-3474. doi: 10.2147/OTT.S139009. eCollection 2017. PubMed
APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Cho SG. Oncol Lett. 2017 Oct;14(4):4845-4852. doi: 10.3892/ol.2017.6801. Epub 2017 Aug 23. PubMed
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Blakely CM, Watkins TBK, Wu W, Gini B, Chabon JJ, McCoach CE, McGranahan N, Wilson GA, Birkbak NJ, Olivas VR, Rotow J, Maynard A, Wang V, Gubens MA, Banks KC, Lanman RB, Caulin AF, St John J, Cordero AR, Giannikopoulos P, Simmons AD, Mack PC, Gandara DR, Husain H, Doebele RC, Riess JW, Diehn M, Swanton C, Bivona TG. Nat Genet. 2017 Dec;49(12):1693-1704. doi: 10.1038/ng.3990. Epub 2017 Nov 6. PubMed
Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M. Dev Cell. 2017 Nov 20;43(4):507-521.e4. doi: 10.1016/j.devcel.2017.10.028. PubMed
High expression of beta-catenin contributes to the crizotinib resistant phenotype in the stem-like cell population in neuroblastoma. Alshareef A, Gupta N, Zhang HF, Wu C, Haque M, Lai R. Sci Rep. 2017 Dec 4;7(1):16863. doi: 10.1038/s41598-017-17319-9. PubMed
Beta-catenin cleavage enhances transcriptional activation. Goretsky T, Bradford EM, Ye Q, Lamping OF, Vanagunas T, Moyer MP, Keller PC, Sinh P, Llovet JM, Gao T, She QB, Li L, Barrett TA. Sci Rep. 2018 Jan 12;8(1):671. doi: 10.1038/s41598-017-18421-8. PubMed
USP20 positively regulates tumorigenesis and chemoresistance through beta-catenin stabilization. Wu C, Luo K, Zhao F, Yin P, Song Y, Deng M, Huang J, Chen Y, Li L, Lee S, Kim J, Zhou Q, Tu X, Nowsheen S, Luo Q, Gao X, Lou Z, Liu Z, Yuan J. Cell Death Differ. 2018 Nov;25(10):1855-1869. doi: 10.1038/s41418-018-0138-z. Epub 2018 Jun 4. PubMed
GSK-3beta Inhibitor Alsterpaullone Attenuates MPP(+)-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells. Wang J, Li Y, Gao L, Yan F, Gao G, Li L. Front Cell Neurosci. 2018 Aug 30;12:283. doi: 10.3389/fncel.2018.00283. eCollection 2018. PubMed
beta-Catenin expression is associated with cell invasiveness in pancreatic cancer. Nan JN, Kim OR, Lee MA. Korean J Intern Med. 2018 Oct 26. pii: kjim.2017.155. doi: 10.3904/kjim.2017.155. PubMed
Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE. PLoS Biol. 2019 Mar 21;17(3):e2006540. doi: 10.1371/journal.pbio.2006540. eCollection 2019 Mar. PubMed
Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation. Wang CH, Hung PW, Chiang CW, Lombes M, Chen CH, Lee KH, Lo YC, Wu MH, Chang WC, Lin DY. Biochim Biophys Acta Mol Cell Res. 2019 Aug;1866(8):1282-1297. doi: 10.1016/j.bbamcr.2019.03.014. Epub 2019 Mar 29. PubMed
Promotion of growth factor signaling as a critical function of beta-catenin during HCC progression. Kim E, Lisby A, Ma C, Lo N, Ehmer U, Hayer KE, Furth EE, Viatour P. Nat Commun. 2019 Apr 23;10(1):1909. doi: 10.1038/s41467-019-09780-z. PubMed
Translation of the circular RNA circbeta-catenin promotes liver cancer cell growth through activation of the Wnt pathway. Liang WC, Wong CW, Liang PP, Shi M, Cao Y, Rao ST, Tsui SK, Waye MM, Zhang Q, Fu WM, Zhang JF. Genome Biol. 2019 Apr 26;20(1):84. doi: 10.1186/s13059-019-1685-4. PubMed
Deoxynivalenol induces inhibition of cell proliferation via the Wnt/beta-catenin signaling pathway. Tang S, Chen S, Huang B, Jiang J, Wen J, Deng Y. Biochem Pharmacol. 2019 Aug;166:12-22. doi: 10.1016/j.bcp.2019.05.009. Epub 2019 May 7. PubMed
Downregulated Wnt/beta-catenin signalling in the Down syndrome hippocampus. Granno S, Nixon-Abell J, Berwick DC, Tosh J, Heaton G, Almudimeegh S, Nagda Z, Rain JC, Zanda M, Plagnol V, Tybulewicz VLJ, Cleverley K, Wiseman FK, Fisher EMC, Harvey K. Sci Rep. 2019 May 13;9(1):7322. doi: 10.1038/s41598-019-43820-4. PubMed

If you have published an article using this plasmid, please email us at [email protected] to have your article added to this page.