Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected] Learn more

lentiMPH v2 Citations (25)

Plasmid Article: Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.
Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23.
PubMed Journal

Articles Citing lentiMPH v2

Articles
A transcribed enhancer dictates mesendoderm specification in pluripotency. Alexanian M, Maric D, Jenkinson SP, Mina M, Friedman CE, Ting CC, Micheletti R, Plaisance I, Nemir M, Maison D, Kernen J, Pezzuto I, Villeneuve D, Burdet F, Ibberson M, Leib SL, Palpant NJ, Hernandez N, Ounzain S, Pedrazzini T. Nat Commun. 2017 Nov 27;8(1):1806. doi: 10.1038/s41467-017-01804-w. PubMed
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. Cell. 2018 Apr 19;173(3):649-664.e20. doi: 10.1016/j.cell.2018.03.052. PubMed
Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, Larson NB, McDonnell SK, Patel PS, Liang Y, Yao CQ, van der Kwast T, Lupien M, Feng FY, Zoubeidi A, Tsao MS, Thibodeau SN, Boutros PC, He HH. Cell. 2018 Jul 26;174(3):564-575.e18. doi: 10.1016/j.cell.2018.06.014. Epub 2018 Jul 19. PubMed
A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection. Dukhovny A, Lamkiewicz K, Chen Q, Fricke M, Jabrane-Ferrat N, Marz M, Jung JU, Sklan EH. J Virol. 2019 Jul 30;93(16). pii: JVI.00211-19. doi: 10.1128/JVI.00211-19. Print 2019 Aug 15. PubMed
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27. PubMed
Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma. Zhao WS, Yan WP, Chen DB, Dai L, Yang YB, Kang XZ, Fu H, Chen P, Deng KJ, Wang XY, Xie XW, Chen HS, Chen KN. Am J Cancer Res. 2019 Jun 1;9(6):1183-1200. eCollection 2019. PubMed
Genome-scale CRISPR activation screening identifies a role of LRP8 in Sorafenib resistance in Hepatocellular carcinoma. Cai J, Chen J, Wu T, Cheng Z, Tian Y, Pu C, Shi W, Suo X, Wu X, Zhang K. Biochem Biophys Res Commun. 2020 Jun 11;526(4):1170-1176. doi: 10.1016/j.bbrc.2020.04.040. Epub 2020 Apr 18. PubMed
CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system. Yamamoto A, Kurata M, Onishi I, Sugita K, Matsumura M, Ishibashi S, Ikeda M, Yamamoto K, Kitagawa M. PeerJ. 2020 May 6;8:e9046. doi: 10.7717/peerj.9046. eCollection 2020. PubMed
ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Jing Y, Wang S, Zhang W, Liu GH, Qu J. Nucleic Acids Res. 2020 Jun 19;48(11):6001-6018. doi: 10.1093/nar/gkaa425. PubMed
Direct-seq: programmed gRNA scaffold for streamlined scRNA-seq in CRISPR screen. Song Q, Ni K, Liu M, Li Y, Wang L, Wang Y, Liu Y, Yu Z, Qi Y, Lu Z, Ma L. Genome Biol. 2020 Jun 8;21(1):136. doi: 10.1186/s13059-020-02044-w. PubMed

Associated Plasmids

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12. Khan OM, Almagro J, Nelson JK, Horswell S, Encheva V, Keyan KS, Clurman BE, Snijders AP, Behrens A. Nat Commun. 2021 Apr 6;12(1):2043. doi: 10.1038/s41467-021-22319-5. PubMed
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, Wylie A, Newkirk SJ, Jones AE, Lee M Jr, Botten GA, Deng M, Dickerson KE, Zhang CC, An W, Abrams JM, Xu J. Nat Genet. 2021 May;53(5):672-682. doi: 10.1038/s41588-021-00829-8. Epub 2021 Apr 8. PubMed
In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. Dai M, Yan G, Wang N, Daliah G, Edick AM, Poulet S, Boudreault J, Ali S, Burgos SA, Lebrun JJ. Nat Commun. 2021 May 24;12(1):3055. doi: 10.1038/s41467-021-23316-4. PubMed
Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma. Zhu GD, Yu J, Sun ZY, Chen Y, Zheng HM, Lin ML, Ou-Yang S, Liu GL, Zhang JW, Shao FM. Cell Death Dis. 2021 Jul 21;12(8):724. doi: 10.1038/s41419-021-04000-3. PubMed
Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi. Jensen TI, Mikkelsen NS, Gao Z, Fosselteder J, Pabst G, Axelgaard E, Laustsen A, Konig S, Reinisch A, Bak RO. Genome Res. 2021 Nov;31(11):2120-2130. doi: 10.1101/gr.275607.121. Epub 2021 Aug 18. PubMed
A CRISPR knockout screen reveals new regulators of canonical Wnt signaling. Evron T, Caspi M, Kazelnik M, Shor-Nareznoy Y, Armoza-Eilat S, Kariv R, Manber Z, Elkon R, Sklan EH, Rosin-Arbesfeld R. Oncogenesis. 2021 Sep 22;10(9):63. doi: 10.1038/s41389-021-00354-7. PubMed
TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis. Hu J, Lai Y, Huang H, Ramakrishnan S, Pan Y, Ma VWS, Cheuk W, So GYK, He Q, Geoffrey Lau C, Zhang L, Cho WCS, Chan KM, Wang X, Rebecca Chin Y. Br J Cancer. 2022 Jan;126(1):57-71. doi: 10.1038/s41416-021-01596-3. Epub 2021 Oct 30. PubMed
SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II. King R, Lin Z, Balbin-Cuesta G, Myers G, Friedman A, Zhu G, McGee B, Saunders TL, Kurita R, Nakamura Y, Engel JD, Reddy P, Khoriaty R. Sci Adv. 2021 Nov 26;7(48):eabj5293. doi: 10.1126/sciadv.abj5293. Epub 2021 Nov 24. PubMed
A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells. Sofer S, Lamkiewicz K, Armoza Eilat S, Partouche S, Marz M, Moskovits N, Stemmer SM, Shlomai A, Sklan EH. FASEB J. 2022 Mar;36(3):e22191. doi: 10.1096/fj.202101507RR. PubMed
CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Joung J, Kirchgatterer PC, Singh A, Cho JH, Nety SP, Larson RC, Macrae RK, Deasy R, Tseng YY, Maus MV, Zhang F. Nat Commun. 2022 Mar 25;13(1):1606. doi: 10.1038/s41467-022-29205-8. PubMed
Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sanchez-Sanchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araujo BMP, Velho PENF, Haddad GG, Muotri AR. Nat Commun. 2022 May 2;13(1):2387. doi: 10.1038/s41467-022-29942-w. PubMed
The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression. Yang H, Ting X, Geng YH, Xie Y, Nierenberg JL, Huo YF, Zhou YT, Huang Y, Yu YQ, Yu XY, Li XF, Ziv E, Zhang H, Fang WG, Shen Y, Tian XX. Sci Adv. 2022 Jun 10;8(23):eabn3509. doi: 10.1126/sciadv.abn3509. Epub 2022 Jun 10. PubMed
CRISPR activation screen identifies TGFbeta-associated PEG10 as a crucial tumor suppressor in Ewing sarcoma. Saratov V, Ngo QA, Pedot G, Sidorov S, Wachtel M, Niggli FK, Schafer BW. Sci Rep. 2022 Jun 23;12(1):10671. doi: 10.1038/s41598-022-12659-7. PubMed
Comparative analysis of dCas9-VP64 variants and multiplexed guide RNAs mediating CRISPR activation. Omachi K, Miner JH. PLoS One. 2022 Jun 28;17(6):e0270008. doi: 10.1371/journal.pone.0270008. eCollection 2022. PubMed
3D Chromatin Organization Involving MEIS1 Factor in the cis-Regulatory Landscape of GJB2. Le Nabec A, Blotas C, Briset A, Collobert M, Ferec C, Moisan S. Int J Mol Sci. 2022 Jun 23;23(13). pii: ijms23136964. doi: 10.3390/ijms23136964. PubMed

If you have published an article using this plasmid, please email us at [email protected] to have your article added to this page.