We narrowed to 18,715 results for: IRE

1. pARD (pKD-G4)

   Plasmid

   #62683

   Purpose

   Mammalian expression of amiR-eGFP from the broadly active CAG promoter/enhancer

   Depositor

   Masato Ohtsuka

   Article

   Miura et al PLoS One. 2015 Aug 18;10(8):e0135919. do

   Insert

   amiR-eGFP419
   

   Use

   RNAi

   Tags

   Expression

   Mammalian

   Mutation

   Promoter

   Available since

   Aug. 24, 2015

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

2. pCVD518

   Plasmid

   #66158

   Purpose

   Six copies of the 415 bp PstI fragment of pCVD512, carrying the tdh1 gene probe from Vibrio parahaemolyticus WP1, for generation of probe

   Depositor

   James Kaper

   Article

   Nishibuchi et al Infect Immun. 1985 Sep;49(3):481-6.

   Insert

   tdh1
   

   Use

   Cloning vector

   Tags

   Expression

   Mutation

   Promoter

   Unknown

   Available since

   July 8, 2015

   Availability

   Academic Institutions and Nonprofits only

3. pNB762

   Plasmid

   #60150

   Purpose

   Firefly luciferase (Promega) driven by LEU1 promoter.

   Depositor

   Nicolas Buchler

   Article

   Mazo-Vargas et al Mol Biol Cell. 2014 Sep 17. pii: mbc.E14

   Insert

   FLuc
   

   Use

   Tags

   Expression

   Yeast

   Mutation

   FLuc has A4V & S504G (no functional effect)

   Promoter

   LEU1pr

   Available since

   March 25, 2015

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

4. pNB767

   Plasmid

   #60159

   Purpose

   Firefly luciferase (Promega) driven by SIC1 promoter.

   Depositor

   Nicolas Buchler

   Article

   Mazo-Vargas et al Mol Biol Cell. 2014 Sep 17. pii: mbc.E14

   Insert

   FLuc
   

   Use

   Tags

   Expression

   Yeast

   Mutation

   A4V & S504G (no functional effect)

   Promoter

   SIC1pr

   Available since

   March 25, 2015

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

5. RASL12

   Plasmid

   #55679

   Purpose

   expression of mouse RASL12

   Depositor

   Julian Downward

   Article

   Fritsch et al Cell. 2013 May 23;153(5):1050-63. doi: 1

   Insert

   RASL12 (Rasl12 Mouse)
   

   Use

   Tags

   Expression

   Bacterial

   Mutation

   Promoter

   lac

   Available since

   Sept. 30, 2014

   Availability

   Academic Institutions and Nonprofits only

6. pHL 342

   Plasmid

   #53012

   Purpose

   PLtetO-1:mCherry, PLlacO-1:araC, Plar:ompC::gfp

   Depositor

   Han Lim

   Article

   Hussein et al Nucleic Acids Res. 2012 May 22.

   Inserts

   mCherry
   araC
   ompC
   

   Use

   Synthetic Biology

   Tags

   gfp

   Expression

   Bacterial

   Mutation

   contains -81 to +36 relative to start codon

   Promoter

   Plar, pLlacO-1, and pLtetO-1

   Available since

   May 16, 2014

   Availability

   Academic Institutions and Nonprofits only

7. Phamret-H2B/pcDNA3

   Plasmid

   #51955

   Purpose

   mammalian expression of Phamret, a monomeric photoconvertible fluorescent protein, fused to H2B

   Depositor

   Takeharu Nagai

   Article

   Matsuda et al Nat Methods. 2008 Apr;5(4):339-45. doi:

   Insert

   Phamret
   

   Use

   Tags

   human H2B

   Expression

   Mammalian

   Mutation

   Promoter

   Available since

   April 15, 2014

   Availability

   Academic Institutions and Nonprofits only

8. Phamret-Fibrillarin/pcDNA3

   Plasmid

   #51954

   Purpose

   mammalian expression of Phamret, a monomeric photoconvertible fluorescent protein, fused to Fibrillarin for nucleolar localization

   Depositor

   Takeharu Nagai

   Article

   Matsuda et al Nat Methods. 2008 Apr;5(4):339-45. doi:

   Insert

   Phamret
   

   Use

   Tags

   Fibrillarin

   Expression

   Mammalian

   Mutation

   Promoter

   Available since

   April 15, 2014

   Availability

   Academic Institutions and Nonprofits only

9. CS2-GFP-nopo

   Plasmid

   #47964

   Purpose

   Expression of Fly nopo

   Depositor

   Laura Lee

   Article

   Merkle et al Development. 2009 Feb;136(3):449-59. doi

   Insert

   no poles (nopo Fly)
   

   Use

   Tags

   GFP

   Expression

   Mammalian

   Mutation

   Promoter

   Available since

   Dec. 20, 2013

   Availability

   Academic Institutions and Nonprofits only

10. pSS63

    Plasmid

    #47951

    Purpose

    rtTA positive feedback loop with single tet operator in the GAL1 promoter

    Depositor

    Attila Becskei

    Article

    Hsu et al Nat Commun. 2012 Feb 21;3:682. doi: 10.1

    Insert

    rtTA
    

    Use

    Tet inducible expression

    Tags

    Expression

    Yeast

    Mutation

    Promoter

    T3

    Available since

    Nov. 14, 2013

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

11. pCRII-Topo Tcrb-V13 in situ probe

    Plasmid

    #45622

    Depositor

    Jeffrey Macklis

    Article

    Molyneaux et al Neuron. 2005 Sep 15;47(6):817-31.

    Insert

    Tcrb-V13 in situ probe (Tcrb Mouse)
    

    Use

    In situ

    Tags

    Expression

    Mutation

    fragment contains bp# 533-1058 of X67128

    Promoter

    Available since

    July 9, 2013

    Availability

    Academic Institutions and Nonprofits only

12. Syntaxin-4 d44

    Plasmid

    #44191

    Depositor

    Thomas Weimbs

    Article

    Reales et al PLoS One. 2011;6(6):e21181. doi: 10.1371

    Insert

    Syntaxin-4
    

    Use

    Tags

    2xMyc and His

    Expression

    Mammalian

    Mutation

    deleted first 44 amino acids

    Promoter

    Available since

    July 1, 2013

    Availability

    Academic Institutions and Nonprofits only

13. Syntaxin-4 d24

    Plasmid

    #44189

    Depositor

    Thomas Weimbs

    Article

    Reales et al PLoS One. 2011;6(6):e21181. doi: 10.1371

    Insert

    Syntaxin-4
    

    Use

    Tags

    2xMyc and His

    Expression

    Mammalian

    Mutation

    deleted first 24 amino acids

    Promoter

    Available since

    July 1, 2013

    Availability

    Academic Institutions and Nonprofits only

14. Syntaxin-4 d10

    Plasmid

    #44188

    Depositor

    Thomas Weimbs

    Article

    Reales et al PLoS One. 2011;6(6):e21181. doi: 10.1371

    Insert

    Syntaxin-4
    

    Use

    Tags

    2xMyc and His

    Expression

    Mammalian

    Mutation

    deleted first 10 amino acids

    Promoter

    Available since

    July 1, 2013

    Availability

    Academic Institutions and Nonprofits only

15. Syntaxin-4 M1 (Y115A)

    Plasmid

    #44029

    Depositor

    Thomas Weimbs

    Article

    Reales et al PLoS One. 2011;6(6):e21181. doi: 10.1371

    Insert

    Syntaxin-4
    

    Use

    Tags

    2xMyc and His

    Expression

    Mammalian

    Mutation

    Y115A

    Promoter

    Available since

    July 1, 2013

    Availability

    Academic Institutions and Nonprofits only

16. MSCV-PM-BAF180-SH3

    Plasmid

    #41933

    Depositor

    Stephen Elledge

    Article

    Burrows et al Proc Natl Acad Sci U S A. 2010 Aug 10;10

    Insert

    BAF180
    

    Use

    Retroviral

    Tags

    Expression

    Mammalian

    Mutation

    Promoter

    Available since

    May 10, 2013

    Availability

    Academic Institutions and Nonprofits only

17. MSCV-PM-BAF180-SH1

    Plasmid

    #41931

    Depositor

    Stephen Elledge

    Article

    Burrows et al Proc Natl Acad Sci U S A. 2010 Aug 10;10

    Insert

    BAF180
    

    Use

    Retroviral

    Tags

    Expression

    Mammalian

    Mutation

    Promoter

    Available since

    May 10, 2013

    Availability

    Academic Institutions and Nonprofits only

18. pNH094

    Plasmid

    #42167

    Depositor

    Colin Dolphin

    Article

    Hirani et al BMC Biotechnol. 2013 Jan 3;13(1):1.

    Insert

    mTFP1-RT-::[(G4S)3]::C-TAP Tag
    

    Use

    Tags

    Expression

    Mutation

    Promoter

    Available since

    March 14, 2013

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

19. pNH090

    Plasmid

    #42166

    Depositor

    Colin Dolphin

    Article

    Hirani et al BMC Biotechnol. 2013 Jan 3;13(1):1.

    Insert

    mTFP1::[(G4S)3]::C-TAP Tag
    

    Use

    Tags

    Expression

    Mutation

    Promoter

    Available since

    Feb. 6, 2013

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

20. Hox B8b

    Plasmid

    #36465

    Depositor

    Robert Ho

    Article

    Ahn et al Dev Biol. 2008 Oct 1;322(1):220-33. Epub

    Insert

    hoxB8b (hoxb8b Zebrafish)
    

    Use

    Riboprobe synthesis

    Tags

    Expression

    Mutation

    Promoter

    T7

    Available since

    Sept. 28, 2012

    Availability

    Academic Institutions and Nonprofits only

21. Hox A9b

    Plasmid

    #36464

    Depositor

    Robert Ho

    Article

    Ahn et al Dev Biol. 2008 Oct 1;322(1):220-33. Epub

    Insert

    hoxA9b (hoxa9b Zebrafish)
    

    Use

    Riboprobe synthesis

    Tags

    Expression

    Mutation

    S46G

    Promoter

    T7

    Available since

    Sept. 28, 2012

    Availability

    Academic Institutions and Nonprofits only

22. sankE3_5

    Plasmid

    #24893

    Depositor

    David Baker

    Article

    Karanicolas et al Mol Cell. 2011 Apr 22;42(2):250-60. Epub

    Insert

    sank E3_5
    

    Use

    Tags

    His

    Expression

    Bacterial

    Mutation

    Promoter

    Available since

    Aug. 24, 2011

    Availability

    Academic Institutions and Nonprofits only

23. PrbC5

    Plasmid

    #24787

    Depositor

    David Baker

    Article

    Karanicolas et al Mol Cell. 2011 Apr 22;42(2):250-60. Epub

    Insert

    Prb
    

    Use

    Tags

    His

    Expression

    Bacterial

    Mutation

    Asp11Gly, Asp83Asn, Val92Ala, Glu119Gly, and Glu1…

    Promoter

    Available since

    July 11, 2011

    Availability

    Academic Institutions and Nonprofits only

24. His-tagged-SF1 (antisense)

    Plasmid

    #28183

    Depositor

    Bernard Schimmer

    Article

    Frigeri et al Mol Endocrinol. 2000 Apr . 14(4):535-44.

    Insert

    SF1 (Nr5a1 Mouse)
    

    Use

    Tags

    His

    Expression

    Mammalian

    Mutation

    Reverse Orientation

    Promoter

    Available since

    May 24, 2011

    Availability

    Academic Institutions and Nonprofits only

25. pcasper4 p [7-Gr66a-]

    Plasmid

    #26860

    Depositor

    Craig Montell

    Article

    Moon et al Curr Biol. 2006 Sep 19. 16(18):1812-7.

    Insert

    Gr66 gustatory receptor (Gr66a Fly)
    

    Use

    Tags

    Expression

    Insect

    Mutation

    Partial deletion of Gr66a (see associated paper l…

    Promoter

    Available since

    May 18, 2011

    Availability

    Academic Institutions and Nonprofits only

26. ninaE-norpA

    Plasmid

    #26854

    Depositor

    Craig Montell

    Article

    Wang et al Neuron. 2008 Jan 10. 57(1):56-68.

    Insert

    no receptor potential A (norpA Fly)
    

    Use

    Tags

    Expression

    Insect

    Mutation

    V963A

    Promoter

    Available since

    April 5, 2011

    Availability

    Academic Institutions and Nonprofits only

27. ninaE-stops m3-myc

    Plasmid

    #26855

    Depositor

    Craig Montell

    Article

    Wang et al Neuron. 2008 Jan 10. 57(1):56-68.

    Insert

    Slow Termination of Phototransduction (stops Fly)
    

    Use

    Tags

    myc

    Expression

    Insect

    Mutation

    Amino acids 296-299 (SLRH in wild-type) are mutat…

    Promoter

    Available since

    April 5, 2011

    Availability

    Academic Institutions and Nonprofits only

28. GFP-D1a_W1-2(aa270-346)

    Plasmid

    #21524

    Depositor

    Edward Chan

    Article

    Lian et al RNA. 2009 May . 15(5):804-13.

    Insert

    TNRC6A (TNRC6A Human)
    

    Use

    Tags

    GFP

    Expression

    Mammalian

    Mutation

    contain aa270-346

    Promoter

    Available since

    Sept. 28, 2009

    Availability

    Academic Institutions and Nonprofits only

29. GFP-D1a_W2-3(aa318-399)

    Plasmid

    #21525

    Depositor

    Edward Chan

    Article

    Lian et al RNA. 2009 May . 15(5):804-13.

    Insert

    TNRC6A (TNRC6A Human)
    

    Use

    Tags

    GFP

    Expression

    Mammalian

    Mutation

    contain aa318-399

    Promoter

    Available since

    Sept. 28, 2009

    Availability

    Academic Institutions and Nonprofits only

30. GFP-D1a_W3-4(aa340-439)

    Plasmid

    #21526

    Depositor

    Edward Chan

    Article

    Lian et al RNA. 2009 May . 15(5):804-13.

    Insert

    TNRC6A (TNRC6A Human)
    

    Use

    Tags

    GFP

    Expression

    Mammalian

    Mutation

    contain aa340-439

    Promoter

    Available since

    Sept. 28, 2009

    Availability

    Academic Institutions and Nonprofits only

31. GFP-D1a_W4-5(aa409-495)

    Plasmid

    #21527

    Depositor

    Edward Chan

    Article

    Lian et al RNA. 2009 May . 15(5):804-13.

    Insert

    TNRC6A (TNRC6A Human)
    

    Use

    Tags

    GFP

    Expression

    Mammalian

    Mutation

    contain aa409-495

    Promoter

    Available since

    Sept. 28, 2009

    Availability

    Academic Institutions and Nonprofits only

32. pcDNA3-rB50

    Plasmid

    #18957

    Depositor

    Mariano Viapiano

    Article

    Viapiano et al J Neurooncol. 2008 Jul . 88(3):261-72.

    Insert

    Brevican N-terminus (Bcan Rat)
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    Brevican N-terminus, aminoacids 1-395

    Promoter

    Available since

    Dec. 12, 2008

    Availability

    Academic Institutions and Nonprofits only

33. pAW

    Plasmid

    #133893

    Purpose

    Expression of Gal4AD-Prey hybrid protein

    Depositor

    Sebastian Maurer

    Article

    Yang et al Nat Commun. 2018 Sep 14;9(1):3747. doi:

    Type

    Empty backbone

    Use

    Tags

    Expression

    Yeast

    Mutation

    Promoter

    Available since

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

34. pBW

    Plasmid

    #133897

    Purpose

    Expression of Gal4BD-Bait hybrid protein.

    Depositor

    Sebastian Maurer

    Article

    Yang et al Nat Commun. 2018 Sep 14;9(1):3747. doi:

    Type

    Empty backbone

    Use

    Tags

    Expression

    Yeast

    Mutation

    Promoter

    Available since

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

35. GFP-p53

    Plasmid

    #12091

    Depositor

    Tyler Jacks

    Article

    Boyd et al Nat Cell Biol. 2000 Sep . 2(9):563-8.

    Insert

    p53 (TP53 Human)
    

    Use

    Tags

    GFP

    Expression

    Mammalian

    Mutation

    72R variant of p53

    Promoter

    Available since

    July 5, 2006

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

36. pMSP1D1

    Plasmid

    #20061

    Purpose

    Bacterial expression of membrane scaffold protein (MSP1D1) for Nanodisc formation

    Depositor

    Stephen Sligar

    Article

    Denisov et al J Am Chem Soc. 2004 Mar 24. 126(11):3477

    Insert

    MSP1D1
    

    Use

    Tags

    7-His tag

    Expression

    Bacterial

    Mutation

    deletion mutant (1-11) of MSP1; His-tag on N-term…

    Promoter

    Available since

    March 16, 2009

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

37. pEGFP-SUN1_916

    Plasmid

    #125850

    Purpose

    Expresses SUN1_916 tagged with GFP in mammalian cells

    Depositor

    Miki Hieda

    Article

    Nishioka et al Nucleus. 2016 Nov;7(6):572-584. doi: 10.

    Insert

    SUN1_916 (SUN1 Human)
    

    Use

    Tags

    GFP

    Expression

    Mammalian

    Mutation

    stop codon

    Promoter

    Available since

    June 5, 2019

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

38. lenti-pegRNA-puro backbone

    Plasmid

    #214085

    Purpose

    Lentiviral backbone plasmid to insert pegRNAs of interest. The cloning site is BsmbI.

    Depositor

    Ting Zhou

    Article

    Wu et al Nat Commun. 2024 Dec 30;15(1):10824. doi

    Type

    Empty backbone

    Use

    Lentiviral

    Tags

    Expression

    Mammalian

    Mutation

    Promoter

    hU6, EF1a

    Available since

    June 6, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

39. pcDNA3-Flag mTOR wt

    Plasmid

    #26603

    Purpose

    Mammalian expression of human flag-tagged mTor

    Depositor

    Jie Chen

    Article

    Vilella-Bach et al J Biol Chem. 1999 Feb 12. 274(7):4266-72

    Insert

    mTOR (MTOR Human)
    

    Use

    Tags

    Flag

    Expression

    Mammalian

    Mutation

    Promoter

    Available since

    Oct. 28, 2010

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

40. lenti-tmpknot-epegRNA-puro backbone

    Plasmid

    #214089

    Purpose

    Lentiviral backbone plasmid to insert epegRNAs (mpknot) of interest. The cloning site is BsmbI.

    Depositor

    Ting Zhou

    Article

    Wu et al Nat Commun. 2024 Dec 30;15(1):10824. doi

    Type

    Empty backbone

    Use

    Lentiviral

    Tags

    Expression

    Mammalian

    Mutation

    Promoter

    hU6, EF1a

    Available since

    June 6, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

41. pLVX.TRE3G.AdProt

    Plasmid

    #131687

    Purpose

    A lentiviral vector for tTA-regulated expression of the adenovirus protease using the tetracycline transactivator transcription factor.

    Depositor

    Matthew D. Shoulders

    Article

    Berman et al J Am Chem Soc. 2018 Dec 26;140(51):18093

    Insert

    Adenovirus Protease
    

    Use

    Lentiviral

    Tags

    Expression

    Mutation

    Promoter

    TRE3GV

    Available since

    Feb. 27, 2020

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

42. E228Q Vps4A-HA

    Plasmid

    #200087

    Purpose

    3x HA-VPS4A with E228Q dominant negative mutation in Dox-inducible pInducer20 vector

    Depositor

    Jason MacGurn

    Article

    Qualls-Histed et al iScience. 2023 Feb 6;26(3):106150. doi:

    Insert

    VPS4A (VPS4A Human)
    

    Use

    Lentiviral

    Tags

    3xHA

    Expression

    Mammalian

    Mutation

    E228Q

    Promoter

    CMV

    Available since

    Aug. 29, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

43. pRN119

    Plasmid

    #176884

    Purpose

    Encodes STM and WUS2 for ectopic meristem induction in plants

    Depositor

    Daniel Voytas

    Article

    Cody et al Nat Protoc. 2022 Oct 17. pii: 10.1038/s4

    Insert

    CmYLCV:Luc+:HSP, Nos::WUS2:pinII, and 35:STM:35S
    

    Use

    Tags

    Expression

    Plant

    Mutation

    Promoter

    Available since

    May 9, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

44. pLV-tetO-mCherry

    Plasmid

    #70273

    Purpose

    Lentiviral plasmid for tetracycline/doxycycline dependent expression of mCherry

    Depositor

    Hubert Schorle

    Article

    Kubaczka et al Cell Stem Cell. 2015 Sep 22. pii: S1934-

    Insert

    mCherry
    

    Use

    Lentiviral

    Tags

    Expression

    Mammalian

    Mutation

    Promoter

    tetO

    Available since

    Nov. 16, 2015

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

45. pICH47742::p35S-ePEmax3::tEURb7

    Plasmid

    #227692

    Purpose

    Golden Gate level 1, position 2, ePEmax3 expression cassette.

    Depositor

    Jae-Yean Kim

    Article

    Vu et al Nat Plants. 2024 Sep 6. doi: 10.1038/s41

    Insert

    ePEmax3 being driven by long CaMV 35S (p35S) and terminated by a dual terminator (EURb7).
    

    Use

    CRISPR

    Tags

    Expression

    Plant

    Mutation

    Promoter

    CaMV 35S

    Available since

    Nov. 15, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

46. pNP566

    Plasmid

    #222724

    Purpose

    pNP561 - IS621 WT Target with T7 Inducible IS621 Recombinase

    Depositor

    Patrick Hsu

    Article

    Durrant et al Nature. 2024 Jun;630(8018):984-993. doi:

    Insert

    IS621 Recombinase
    

    Use

    Tags

    Expression

    Bacterial

    Mutation

    Promoter

    Available since

    July 24, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

47. pCAGGs-Foxp1

    Plasmid

    #45720

    Depositor

    Jeremy Dasen

    Article

    Dasen et al Cell. 2008 Jul 25;134(2):304-16. doi: 10

    Insert

    FoxP1 (Foxp1 Mouse)
    

    Use

    Tags

    Expression

    Mutation

    Promoter

    CMV / b-actin

    Available since

    Aug. 13, 2013

    Availability

    Academic Institutions and Nonprofits only

48. pBacPAK p110a WT

    Plasmid

    #55722

    Purpose

    His3 GST tagged WT p110 alpha

    Depositor

    Julian Downward

    Article

    Fritsch et al Cell. 2013 May 23;153(5):1050-63. doi: 1

    Insert

    p110 alpha (Pik3ca Mouse)
    

    Use

    Tags

    His3 GST

    Expression

    Mutation

    Promoter

    polyhedrin promoter

    Available since

    Sept. 30, 2014

    Availability

    Academic Institutions and Nonprofits only

49. Luciferase-pcDNA3

    Plasmid

    #18964

    Depositor

    William Kaelin

    Article

    Safran et al Proc Natl Acad Sci U S A. 2006 Jan 3. 10

    Insert

    Firefly Luciferase
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    Promoter

    Available since

    Aug. 20, 2008

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

50. pNP2157

    Plasmid

    #222732

    Purpose

    pNP1950 - J23119-IS621 bRNA TBL-WT, DBL-WT, HDV; T7-IS621 Recombinase

    Depositor

    Patrick Hsu

    Article

    Durrant et al Nature. 2024 Jun;630(8018):984-993. doi:

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