We narrowed to 32,277 results for: uros

1. pDonor-FMR1-dCGG0

   Plasmid

   #222965

   Purpose

   To create 0CGG FMR1 cell line

   Depositor

   Xinyu Zhao

   Article

   Sirois et al Cell Rep. 2024 Jun 11;43(6):114330. doi:

   Insert

   FMR1 homologous template no CGG repeats (FMR1 Human)
   

   Use

   CRISPR

   Mutation

   CGG repeats deleted from 5' UTR

   Available Since

   Sept. 12, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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2. pcDNA5-FRT/TO-FLAG-msMMS22L

   Plasmid

   #221015

   Purpose

   mammalian expression vector of Flag tagged mouse MMS22L

   Depositor

   Daniel Durocher

   Article

   O'Donnell et al Mol Cell. 2010 Nov 24;40(4):619-31. doi:

   Insert

   MMS22L (Mms22l Mouse)
   

   Tags

   Flag

   Expression

   Mammalian

   Mutation

   naturally siResistant to siMMS22L (human) aagacuu…

   Promoter

   CMV

   Available Since

   Sept. 5, 2024

   Availability

   Industry, Academic Institutions, and Nonprofits

   

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3. pMRX-IP-muGFP-hATG2A mLIR

   Plasmid

   #215506

   Purpose

   Expresses GFP tagged human ATG2A with the mutation in LC3 interacting region.

   Depositor

   Noboru Mizushima

   Article

   Shimizu et al Hum Mol Genet. 2023 Aug 7;32(16):2623-26

   Insert

   Autophagy related 2A (ATG2A Human)
   

   Use

   Retroviral

   Tags

   muGFP

   Expression

   Mammalian

   Mutation

   P656R (natural variant with no functional relevan…

   Available Since

   June 17, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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4. pAAVss-U6-sgHTT51-7sk-Cas9

   Plasmid

   #190901

   Purpose

   AAV-KamiCas9 vector expressing sgGFP and mouse HTT sgRNA

   Depositor

   Nicole Déglon

   Article

   Duarte et al Mol Ther Methods Clin Dev. 2023 Mar 27;2

   Insert

   sgRNA (Htt Mouse)
   

   Use

   AAV and CRISPR

   Promoter

   U6 and 7sk

   Available Since

   March 27, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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5. pAAV2ss-EFS-GFP-synPolyA-U6-sgHTT1

   Plasmid

   #190902

   Purpose

   AAV vector expressing thew GFP reporter gene and human sgHTT

   Depositor

   Nicole Déglon

   Article

   Duarte et al Mol Ther Methods Clin Dev. 2023 Mar 27;2

   Insert

   GFP and sgHTT (HTT Human)
   

   Use

   AAV and CRISPR

   Promoter

   EFS and U6

   Available Since

   March 27, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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6. pCS2plus-TDP-43

   Plasmid

   #162608

   Purpose

   Allows for transcription of TDP-43 mRNA for injection into zebrafish embryos for BiFC assays

   Depositor

   Marco Morsch

   Article

   Don et al Mol Neurobiol. 2021 May;58(5):2061-2074.

   Insert

   TARDBP (TARDBP Human)
   

   Expression

   Mammalian

   Available Since

   June 10, 2021

   Availability

   Academic Institutions and Nonprofits only

   

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7. pCMV ShadowG-AURKA K162M-mTurq2

   Plasmid

   #157769

   Purpose

   Expression of AuroraA kinase-dead biosensor under CMV promoter

   Depositor

   Marc Tramier

   Article

   Bertolin et al eLife. 2018 Aug 2;7. pii: 38111. doi: 10

   Insert

   AURKA (AURKA Human)
   

   Tags

   mTurquoise2 and shadowG

   Expression

   Mammalian

   Mutation

   AURKA K162M is a kinase-dead version of AURKA

   Promoter

   CMV

   Available Since

   Feb. 10, 2021

   Availability

   Academic Institutions and Nonprofits only

   

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8. pCMV ShadowY-AURKA K162M-mTurq2

   Plasmid

   #157771

   Purpose

   Expression of AuroraA kinase-dead biosensor under CMV promoter

   Depositor

   Marc Tramier

   Article

   Bertolin et al eLife. 2018 Aug 2;7. pii: 38111. doi: 10

   Insert

   AURKA (AURKA Human)
   

   Tags

   mTurquoise2 and shadowY

   Expression

   Mammalian

   Mutation

   AURKA K162M is a kinase-dead version of AURKA

   Promoter

   CMV

   Available Since

   Feb. 10, 2021

   Availability

   Academic Institutions and Nonprofits only

   

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9. 61427-sgHtt_10

   Plasmid

   #157861

   Purpose

   Expresses a sgRNA targeting mouse Htt promoter for gene activation using the SAM system

   Depositor

   Xinyu Zhao

   Article

   Shen et al Nat Neurosci. 2019 Mar;22(3):386-400. do

   Insert

   Htt (Htt Mouse)
   

   Use

   CRISPR and Lentiviral

   Expression

   Mammalian

   Available Since

   Feb. 10, 2021

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

10. 61427-sgHtt_6

    Plasmid

    #157860

    Purpose

    Expresses a sgRNA targeting mouse Htt promoter for gene activation using the SAM system

    Depositor

    Xinyu Zhao

    Article

    Shen et al Nat Neurosci. 2019 Mar;22(3):386-400. do

    Insert

    Htt (Htt Mouse)
    

    Use

    CRISPR and Lentiviral

    Expression

    Mammalian

    Available Since

    Feb. 10, 2021

    Availability

    Academic Institutions and Nonprofits only

    

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11. sgRNA targeting human SLC12A5 gene stop codon

    Plasmid

    #158577

    Purpose

    For generate double-strand DNA break near the stop codon of the human SLC12A5 gene that encodes neuronal chloride transporter KCC2 protein.

    Depositor

    Rudolf Jaenisch

    Article

    Tang et al Sci Transl Med. 2019 Jul 31;11(503). pii

    Insert

    sgRNA targeting human SLC12A5 gene stop codon
    

    Use

    CRISPR

    Tags

    Cas9 and GFP

    Expression

    Mammalian

    Available Since

    Sept. 29, 2020

    Availability

    Academic Institutions and Nonprofits only

    

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12. pcDNA5-eGFP-FRT-T0-RNF168 delta MIU1/MIU2

    Plasmid

    #133980

    Purpose

    inducible mammalian expression vector of eGFP tagged RNF168 where both motifs interacting with ubiquitin have been deleted

    Depositor

    Daniel Durocher

    Article

    Stewart et al Cell. 2009 Feb 6;136(3):420-34. doi: 10.

    Insert

    RNF168 (RNF168 Human)
    

    Tags

    eGFP

    Expression

    Mammalian

    Mutation

    deletion of MIU1 and MIU2

    Promoter

    CMV

    Available Since

    Nov. 4, 2019

    Availability

    Industry, Academic Institutions, and Nonprofits

    

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13. pBABE-RSLID1(WT)

    Plasmid

    #122296

    Purpose

    expresses RSL1D1 protein in mammalian cells (puro resistance)

    Depositor

    Gerardo Ferbeyre

    Article

    Lessard et al Nat Cell Biol. 2018 Jul;20(7):789-799. d

    Insert

    RSL1D1 (RSL1D1 Human)
    

    Use

    Retroviral

    Expression

    Mammalian

    Promoter

    vector's LTR

    Available Since

    March 19, 2019

    Availability

    Academic Institutions and Nonprofits only

    

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14. AURKC gRNA (BRDN0001146500)

    Plasmid

    #78054

    Purpose

    3rd generation lentiviral gRNA plasmid targeting human AURKC

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Insert

    AURKC (AURKC Human)
    

    Use

    CRISPR and Lentiviral

    Expression

    Mammalian

    Promoter

    hU6

    Available Since

    July 6, 2016

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

15. AURKC gRNA (BRDN0001487140)

    Plasmid

    #78055

    Purpose

    3rd generation lentiviral gRNA plasmid targeting human AURKC

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Insert

    AURKC (AURKC Human)
    

    Use

    CRISPR and Lentiviral

    Expression

    Mammalian

    Promoter

    hU6

    Available Since

    July 6, 2016

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

16. AURKC gRNA (BRDN0001148441)

    Plasmid

    #78056

    Purpose

    3rd generation lentiviral gRNA plasmid targeting human AURKC

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Insert

    AURKC (AURKC Human)
    

    Use

    CRISPR and Lentiviral

    Expression

    Mammalian

    Promoter

    hU6

    Available Since

    July 6, 2016

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

17. LRRK2 gRNA (BRDN0001144775)

    Plasmid

    #77331

    Purpose

    3rd generation lentiviral gRNA plasmid targeting human LRRK2

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Insert

    LRRK2 (LRRK2 Human)
    

    Use

    CRISPR and Lentiviral

    Expression

    Mammalian

    Promoter

    hU6

    Available Since

    July 6, 2016

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

18. GAK gRNA (BRDN0001146263)

    Plasmid

    #76471

    Purpose

    3rd generation lentiviral gRNA plasmid targeting human GAK

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Insert

    GAK (GAK Human)
    

    Use

    CRISPR and Lentiviral

    Expression

    Mammalian

    Promoter

    hU6

    Available Since

    July 6, 2016

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

19. GAK gRNA (BRDN0001148048)

    Plasmid

    #76472

    Purpose

    3rd generation lentiviral gRNA plasmid targeting human GAK

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Insert

    GAK (GAK Human)
    

    Use

    CRISPR and Lentiviral

    Expression

    Mammalian

    Promoter

    hU6

    Available Since

    July 6, 2016

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

20. AURKC gRNA (BRDN0001147545)

    Plasmid

    #78053

    Purpose

    3rd generation lentiviral gRNA plasmid targeting human AURKC

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Insert

    AURKC (AURKC Human)
    

    Use

    CRISPR and Lentiviral

    Expression

    Mammalian

    Promoter

    hU6

    Available Since

    June 24, 2016

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge