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pAAV-FLEXfrt-SaCas9-U6-sgGabrg3

Plasmid

#124872

Purpose

Mutagenesis of Gabrg3

Depositor

Larry Zweifel

Article

Hunker et al Cell Rep. 2020 Mar 24;30(12):4303-4316.e

Insert

Gabrg3 (Gabrg3 Mouse)

Use

AAV, CRISPR, and Mouse Targeting

Tags

Expression

Mutation

Promoter

Available since

May 6, 2019

Availability

Academic Institutions and Nonprofits only

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pAAV-FLEXfrt-SaCas9-U6-sgGabrg2

Plasmid

#124871

Purpose

Mutagenesis of Gabrg2

Depositor

Larry Zweifel

Article

Hunker et al Cell Rep. 2020 Mar 24;30(12):4303-4316.e

Insert

Gabrg2 (Gabrg2 Mouse)

Use

AAV, CRISPR, and Mouse Targeting

Tags

Expression

Mutation

Promoter

Available since

May 3, 2019

Availability

Academic Institutions and Nonprofits only

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AAV-KrasG12A/sgKras/Cre

Plasmid

#99849

Purpose

Expresses Cre-recombinase, a barcoded HDR template to introduce a G12A mutation into the endogenous Kras locus, and a Kras-targeting sgRNA to enhance HDR.

Depositor

Monte Winslow

Article

Winters et al Nat Commun. 2017 Dec 12;8(1):2053. doi:

Insert

Kras (Kras Mouse)

Use

AAV and Cre/Lox

Tags

Expression

Mammalian

Mutation

AvrII site (CAAAGG>CCTAGG), PAM/sgRNA mutation…

Promoter

Available since

Dec. 13, 2017

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-FLEX-splitTVA950

Plasmid

#59329

Purpose

Expresses splitTVA950

Depositor

Ian Wickersham

Insert

splitTVA950

Use

AAV and Cre/Lox

Tags

Expression

Mammalian

Mutation

Promoter

CAG

Available since

Oct. 1, 2014

Availability

Academic Institutions and Nonprofits only

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pAAV-S5E8-dTom-nlsdTom

Plasmid

#135643

Purpose

AAV vector to drive the expression of dTomato in PV cortical interneuronsunder the control of the E8 regulatory element

Depositor

Jordane Dimidschstein

Article

Vormstein-Schneider et al Nat Neurosci. 2020 Dec;23(12):1629-1636.

Insert

dTom-nlsdTom

Use

AAV

Tags

Expression

Mutation

None

Promoter

Available since

Aug. 17, 2020

Availability

Academic Institutions and Nonprofits only

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AAV_3xgRNA;PTENA, p53B,SMAD4A_CAG_FlPO_synthPA

Plasmid

#68346

Purpose

Used to produce AAV expressing the FlpO recombinase and pig gRNA towards 3 tumor suppressors: PTEN, p53 and SMAD4

Depositor

Jannik Elverløv-Jakobsen

Article

Berthelsen et al Cancers (Basel). 2021 Jun 16;13(12). pii

Inserts

3xgRNA;PTENA, p53B,SMAD4A
FlPO

Use

AAV; Flp/frt

Tags

Expression

Mammalian

Mutation

Promoter

CAG and U6

Available since

Dec. 2, 2015

Availability

Academic Institutions and Nonprofits only

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AAV-Flex-rev-GFPFANACfullWT

Plasmid

#126551

Purpose

AAV Flex reverse plasmid with the coding sequence of eGFP fused to the N-term of the FMRFamide gated Na channel

Depositor

Rory McQuiston

Article

Schanuel et al Neuroscience. 2008 Aug 13;155(2):374-86.

Insert

eGFP N-terminal fused to FMRFamide gate sodium channel

Use

AAV

Tags

Expression

Mutation

Promoter

Available since

July 2, 2019

Availability

Academic Institutions and Nonprofits only

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pAAV-APLP1ICD-IRES-hrGFP

Plasmid

#107546

Purpose

AAV-mediated expression of last 50 amino acids of APLP1 protein (APLP1ICD) and IRES-mediated co-expression of hrGFP to recognize labelled cells

Depositor

Hélène Marie

Article

Pousinha et al Elife. 2017 Jul 6;6. doi: 10.7554/eLife.

Insert

APLP1ICD (APLP1 Human)

Use

AAV

Tags

Expression

Mutation

None

Promoter

CMV

Available since

May 1, 2018

Availability

Academic Institutions and Nonprofits only

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AAV-hSyn-REX-GECO0.9

Plasmid

#61249

Purpose

Expresses REX-GECO0.9 in neurons

Depositor

Robert Campbell

Article

Wu et al Nat Commun. 2014 Oct 31;5:5262. doi: 10.

Insert

REX-GECO0.9

Use

AAV

Tags

Expression

Mammalian

Mutation

Substitutions relative to R-GECO1: P60R, V61W, R6…

Promoter

hSyn

Available since

March 27, 2015

Availability

Academic Institutions and Nonprofits only

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AAV-KrasG13V/sgKras/Cre

Plasmid

#99860

Purpose

Expresses Cre-recombinase, a barcoded HDR template to introduce a G13V mutation into the endogenous Kras locus, and a Kras-targeting sgRNA to enhance HDR.

Depositor

Monte Winslow

Article

Winters et al Nat Commun. 2017 Dec 12;8(1):2053. doi:

Insert

Kras (Kras Mouse)

Use

AAV and Cre/Lox

Tags

Expression

Mammalian

Mutation

AvrII site (CAAAGG>CCTAGG), PAM/sgRNA mutation…

Promoter

Available since

Dec. 13, 2017

Availability

Academic Institutions and Nonprofits only

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1184_pAAV-U6-ApoB-gRNA2-CB-EmGFP

Plasmid

#89062

Purpose

AAV-gRNA targeting the murine Apob gene

Depositor

William Lagor

Article

Jarrett et al Sci Rep. 2017 Mar 16;7:44624. doi: 10.10

Insert

EmGFP

Use

AAV and CRISPR

Tags

Expression

Mammalian

Mutation

Promoter

Chicken beta actin with partial CMV enhancer

Available since

April 11, 2017

Availability

Academic Institutions and Nonprofits only

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pAAV-SMVP-Cas9N-U6-gRNA M4

Plasmid

#80937

Purpose

Expresses Cas9N in mammalian cells; expresses gRNA M4 for Mstn cleavage.

Depositor

George Church

Article

Chew et al Nat Methods. 2016 Sep 5. doi: 10.1038/nm

Insert

Cas9N

Use

AAV, CRISPR, and Synthetic Biology

Tags

Expression

Mammalian

Mutation

Promoter

Available since

Oct. 3, 2016

Availability

Academic Institutions and Nonprofits only

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pAAV-SEPT_Cdk2-T160E-siR

Plasmid

#73976

Purpose

HDR template to generate Cdk2-T160E-siR

Depositor

Manuel Kaulich, Steven Dowdy

Article

Kaulich et al Nucleic Acids Res. 2015 Apr 20;43(7):e45

Inserts

Cdk2-LHA-siR (CDK2 Human)
Cdk2-RHA-T160E (CDK2 Human)

Use

AAV

Tags

Expression

Mutation

T160 mutated to Glu and siRNA target site mutated

Promoter

Available since

March 18, 2016

Availability

Academic Institutions and Nonprofits only

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pAAV asyn S87D/S129A

Plasmid

#36071

Depositor

Hilal Lashuel, Patrick Aebischer

Insert

alpha-synuclein S87D/S129A (SNCA Human)

Use

AAV

Tags

Expression

Mammalian

Mutation

S87D/S129A

Promoter

CMV

Available since

Sept. 10, 2012

Availability

Academic Institutions and Nonprofits only
pAAV-CAG-Lck-mTagBFP2

Plasmid

#234537

Purpose

to label the membrane of cells with a fluorescent protein (mTagBFP2)

Depositor

Hajime Hirase

Article

Wang et al Anatomical Science International. 2025 (

Insert

Lck-mTagBFP2

Use

AAV

Tags

Expression

Mutation

None

Promoter

Short CAG

Available since

June 11, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-Lck-mCerulean3

Plasmid

#234538

Purpose

to label the membrane of cells with a fluorescent protein (mCerulean3)

Depositor

Hajime Hirase

Article

Wang et al Anatomical Science International. 2025 (

Insert

Lck-mCerulean3

Use

AAV

Tags

Expression

Mutation

None

Promoter

Short CAG

Available since

June 11, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-Lck-mStayGold

Plasmid

#234539

Purpose

to label the membrane of cells with a fluorescent protein (mStayGold)

Depositor

Hajime Hirase

Article

Wang et al Anatomical Science International. 2025 (

Insert

Lck-mStayGold(E138D)

Use

AAV

Tags

Expression

Mutation

None

Promoter

Short CAG

Available since

June 11, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-Lck-mScarlet3

Plasmid

#234540

Purpose

to label the membrane of cells with a fluorescent protein (mScarlet3)

Depositor

Hajime Hirase

Article

Wang et al Anatomical Science International. 2025 (

Insert

Lck-mScarlet3

Use

AAV

Tags

Expression

Mutation

None

Promoter

Short CAG

Available since

June 11, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV.RMacL3-01.ChR2(H134R)-GFP.BCC10

Plasmid

#229639

Purpose

L3 pyramidal neuron Enhancer to drive transgene expression

Depositor

William Stauffer

Article

He et al Neuron. 2025 May 21;113(10):1548-1561.e8

Insert

RMacL3-01.ChR2(H134R)-GFP.BCC10

Use

AAV

Tags

Expression

Mammalian

Mutation

Promoter

Available since

June 11, 2025

Availability

Academic Institutions and Nonprofits only

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PP_072_pAAV_hSyn_DIO-LR-Voltron2-P2A-LR-CheRiff-HA

Plasmid

#230988

Purpose

Co-expressing membrane-localized Voltron2 and membrane-localized CheRiff.

Depositor

Adam Cohen

Article

Wong-Campos et al bioRxiv [Preprint]. 2023 May 26:2023.05.

Insert

Cre-dependent, membrane-localized optopatch for neuronal dendrites

Use

AAV

Tags

Expression

Mammalian

Mutation

Promoter

hSyn

Available since

June 5, 2025

Availability

Academic Institutions and Nonprofits only

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