We narrowed to 24,459 results for: Spr

1. pLKO5-SgHottip-GFP-CRISPRa

   Plasmid

   #134990

   Purpose

   dCas9-mediated activation of HOTTIP in mammalian cells

   Depositor

   Suming Huang

   Article

   Luo et al Cancer Cell. 2019 Dec 9;36(6):645-659.e8

   Insert

   HOTTIP (HOTTIP Human)
   

   Use

   Lentiviral

   Tags

   GFP

   Expression

   Bacterial and Mammalian

   Promoter

   U6

   Available Since

   May 31, 2022

   Availability

   Academic Institutions and Nonprofits only

   

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2. LentiCRISPR v2-sgAMPK alpha1 clone2

   Plasmid

   #162120

   Purpose

   Lentiviral sgRNA plasmid targeting human AMPK alpha1

   Depositor

   Boyi Gan

   Article

   Lee et al Nat Cell Biol. 2020 Feb;22(2):225-234. d

   Insert

   sgAMPK alpha1 (PRKAA1 Human)
   

   Use

   Lentiviral

   Available Since

   Jan. 26, 2021

   Availability

   Academic Institutions and Nonprofits only

   

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3. pCRISPR-Cas9/CD4-TK2

   Plasmid

   #104397

   Purpose

   The designed sgRNA cloned into this plasmid directs the specific DNA cleavage exerted by Cas9 nuclease in a region of exon 5 of the human TK2 gene. The plasmid also includes the Cas9 nuclease and CD4.

   Depositor

   Jeronimo Blanco

   Article

   Meca-Cortes et al Mol Ther Nucleic Acids. 2017 Sep 15;8:39

   Insert

   TK2 (TK2 Human)
   

   Expression

   Mammalian

   Promoter

   U6

   Available Since

   April 13, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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4. pFRT/TO/GFP-SCAF8 (CRISPR_resistant)

   Plasmid

   #122472

   Purpose

   Dox-inducible GFP (N-terminal tag) SCAF8 expression

   Depositor

   Jesper Svejstrup

   Article

   Gregersen et al Cell. 2019 May 10. pii: S0092-8674(19)30

   Insert

   SCAF8 (SCAF8 Human)
   

   Tags

   GFP

   Expression

   Mammalian

   Mutation

   Synonymous mutations conferring resistance to gRN…

   Promoter

   CMV

   Available Since

   May 16, 2019

   Availability

   Academic Institutions and Nonprofits only

   

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5. CASPR/Neurexin IV scFv [K65/35]

   Plasmid

   #182068

   Purpose

   Mammalian Expression of CASPR/Neurexin IV scFv. Derived from hybridoma K65/35.

   Depositor

   James Trimmer

   Article

   Mitchell et al Sci Rep. 2023 Sep 27;13(1):16200. doi: 1

   Insert

   recombinant mouse scFv targeting CASPR/Neurexin IV (Rattus norvegicus) (Cntnap1 Mouse)
   

   Tags

   Sortase, His

   Expression

   Mammalian

   Promoter

   CMV

   Available Since

   March 24, 2022

   Availability

   Academic Institutions and Nonprofits only

   

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6. pCDNA3-Flag-SPRTN-Y117C

   Plasmid

   #110216

   Purpose

   Expression in mammalian cells of of full-length SPRTN protein carrying Y117C mutation, a catalytically-impaired mutant, and Flag-tag at N-terminus.

   Depositor

   Kristijan Ramadan, Ivana Marinovic-Terzic

   Article

   Vaz et al Mol Cell. 2016 Nov 17;64(4):704-719. doi

   Insert

   SPRTN (SPRTN Human)
   

   Tags

   Flag

   Expression

   Mammalian

   Mutation

   Y117C, P296L (see depositor comments below)

   Available Since

   May 23, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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7. lentiCRISPR - Amplicon, JAK2 sgRNA 1

   Plasmid

   #70679

   Purpose

   Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and an intergenic JAK2 amplicon-targeting sgRNA element from U6 promoter. Lentiviral backbone

   Depositor

   David Sabatini

   Article

   Wang et al Science. 2015 Oct 15. pii: aac7041.

   Insert

   sgRNA against JAK2 amplicon found in AML-derived HEL cell line (JAK2 )
   

   Use

   CRISPR and Lentiviral

   Expression

   Mammalian

   Available Since

   Oct. 29, 2015

   Availability

   Academic Institutions and Nonprofits only

8. Non-targeting CRISPRi plasmid

   Plasmid

   #154891

   Purpose

   Human non-targeting CRISPRi gRNA

   Depositor

   Joseph Dougherty, Rob Mitra

   Article

   Lalli et al Genome Res. 2020 Sep;30(9):1317-1331. do

   Insert

   Nontargeting gRNA
   

   Use

   CRISPR and Lentiviral

   Available Since

   Nov. 18, 2020

   Availability

   Academic Institutions and Nonprofits only

   

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9. LentiCRISPR v2-sgAMPK alpha1 clone3

   Plasmid

   #162121

   Purpose

   Lentiviral sgRNA plasmid targeting human AMPK alpha1

   Depositor

   Boyi Gan

   Article

   Lee et al Nat Cell Biol. 2020 Feb;22(2):225-234. d

   Insert

   sgAMPK alpha1 (PRKAA1 Human)
   

   Use

   Lentiviral

   Available Since

   Jan. 26, 2021

   Availability

   Academic Institutions and Nonprofits only

   

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10. pBW1997_pExpr-hU6-CRISPR-DECODER

    Plasmid

    #87549

    Purpose

    Expresses NGN2, MIAT, ACTC1, and TTN gRNAs in response to combinations of Cre and Flp recombinases

    Depositor

    Wilson Wong

    Article

    Weinberg et al Nat Biotechnol. 2017 Mar 27. doi: 10.103

    Insert

    gRNAs targeting NGN2, MIAT, ACTC1, TTN
    

    Use

    CRISPR, Cre/Lox, and Synthetic Biology

    Expression

    Mammalian

    Available Since

    April 24, 2017

    Availability

    Academic Institutions and Nonprofits only

    

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11. lentiCRISPR - Amplicon, JAK2 sgRNA 2

    Plasmid

    #70660

    Purpose

    Expresses human codon-optimized Cas9 protein and puromycin resistance from EFS promoter and an intergenic JAK2 amplicon-targeting sgRNA element from U6 promoter. Lentiviral backbone

    Depositor

    David Sabatini

    Article

    Wang et al Science. 2015 Oct 15. pii: aac7041.

    Insert

    sgRNA against JAK2 amplicon found in AML-derived HEL cell line (JAK2 )
    

    Use

    CRISPR and Lentiviral

    Expression

    Mammalian

    Available Since

    Oct. 29, 2015

    Availability

    Academic Institutions and Nonprofits only

12. pEffector-LaTranC-CRISPR RNA

    Plasmid

    #246928

    Purpose

    for E.coli plasmid interference and PAM depletion assays

    Depositor

    Caixia Gao

    Article

    Jin et al Cell. 2025 Sep 29:S0092-8674(25)01035-9.

    Insert

    LaTranC
    

    Use

    Unspecified

    Available Since

    Oct. 16, 2025

    Availability

    Academic Institutions and Nonprofits only

    

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13. pLentiCRISPR V2 puro HTRA2 sg2

    Plasmid

    #244864

    Purpose

    Knockout of human HTRA2

    Depositor

    Alexis Jourdain

    Article

    Harhai et al Cell Rep. 2025 Jul 25;44(8):116069. doi:

    Insert

    HTRA2 sgRNA (HTRA2 Human)
    

    Use

    CRISPR and Lentiviral

    Promoter

    U6

    Available Since

    Oct. 15, 2025

    Availability

    Academic Institutions and Nonprofits only

    

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14. pLentiCRISPR V2 puro HTRA2 sg1

    Plasmid

    #244863

    Purpose

    Knockout of human HTRA2

    Depositor

    Alexis Jourdain

    Article

    Harhai et al Cell Rep. 2025 Jul 25;44(8):116069. doi:

    Insert

    HTRA2 sgRNA (HTRA2 Human)
    

    Use

    CRISPR and Lentiviral

    Promoter

    U6

    Available Since

    Oct. 15, 2025

    Availability

    Academic Institutions and Nonprofits only

    

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15. pYJ39-PB-CRISPR-NKX3.1-E2-gRNA2

    Plasmid

    #131082

    Purpose

    NKX3-1 knock out

    Depositor

    Xiaojun Lian

    Insert

    NKX3.1 Exon2 gRNA2 (NKX3-1 Human)
    

    Use

    CRISPR

    Expression

    Mammalian

    Available Since

    Oct. 3, 2025

    Availability

    Academic Institutions and Nonprofits only

    

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16. pYJ40-PB-CRISPR-NKX3.1-E2-gRNA3

    Plasmid

    #131083

    Purpose

    NKX3-1 knock out

    Depositor

    Xiaojun Lian

    Insert

    NKX3.1 Exon2 gRNA3 (NKX3-1 Human)
    

    Use

    CRISPR

    Expression

    Mammalian

    Available Since

    Oct. 3, 2025

    Availability

    Academic Institutions and Nonprofits only

    

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17. pYJ36-PB-CRISPR-NKX3.1-E1-gRNA1

    Plasmid

    #131079

    Purpose

    NKX3-1 knock out

    Depositor

    Xiaojun Lian

    Insert

    NKX3.1 Exon1 gRNA1 (NKX3-1 Human)
    

    Use

    CRISPR

    Expression

    Mammalian

    Available Since

    Oct. 3, 2025

    Availability

    Academic Institutions and Nonprofits only

    

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18. pYJ37-PB-CRISPR-NKX3.1-E1-gRNA2

    Plasmid

    #131080

    Purpose

    NKX3-1 knock out

    Depositor

    Xiaojun Lian

    Insert

    NKX3.1 Exon1 gRNA2 (NKX3-1 Human)
    

    Use

    CRISPR

    Expression

    Mammalian

    Available Since

    Oct. 3, 2025

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

19. pYJ38-PB-CRISPR-NKX3.1-E2-gRNA1

    Plasmid

    #131081

    Purpose

    NKX3-1 knock out

    Depositor

    Xiaojun Lian

    Insert

    NKX3.1 Exon2 gRNA1 (NKX3-1 Human)
    

    Use

    CRISPR

    Expression

    Mammalian

    Available Since

    Oct. 3, 2025

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

20. pYJ06-CRISPR-SOX17-E2-gRNA1

    Plasmid

    #131051

    Purpose

    SOX17 Knock out

    Depositor

    Xiaojun Lian

    Insert

    SOX17 Exon2 gRNA1 (SOX17 Human)
    

    Use

    CRISPR

    Expression

    Mammalian

    Available Since

    Oct. 3, 2025

    Availability

    Academic Institutions and Nonprofits only

    

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