400 results

#1000000083

CRISPR gRNA knockout pooled library for targeting the human kinome

John Doench, David Root

June 27, 2016

Academic Institutions and Nonprofits only

#159391

Targets 182 immune evasion genes. Designed for loss-of-function screening against genes shown to increase sensistivity or resistance of cancer cells to cytotoxic T lymphocyte-mediated toxicity.

Jason Moffat

Lawson et al Nature. 2020 Oct;586(7827):120-126. doi:

Nov. 9, 2020

Academic Institutions and Nonprofits only

#83994

Mouse CRISPRi Pooled Library targeting membrane proteins

Jonathan Weissman

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Jan. 12, 2017

Academic Institutions and Nonprofits only

#163966

Knockout library targeting mouse metabolic genes.

Alec Kimmelman

Biancur et al Cell Metab. 2020 Oct 28. pii: S1550-4131

July 1, 2021

Academic Institutions and Nonprofits only

#163954

Targets open reading frames and non-coding RNAs in M. tuberculosis.

Jeremy Rock

Bosch et al Cell. 2021 Jul 16. pii: S0092-8674(21)00

Oct. 1, 2021

Academic Institutions and Nonprofits only

#206248

The lipid metabolism library contains guide RNAs against 295 genes targeting mouse genes encoding enzymes that directly impact lipid metabolism.

Kivanc Birsoy

Soula et al Nature. 2024 Aug 7. doi: 10.1038/s41586-

Aug. 29, 2024

Academic Institutions and Nonprofits only

#171531

Knockout library targeting ubiquitination and de-ubiquitination complex genes.

Chunliang Li

Wright et al Proc Natl Acad Sci U S A. 2023 Apr 18;12

June 22, 2021

Academic Institutions and Nonprofits only

#174592

Targets human ubiquitation-related proteins and deubiquitinating enzymes.

Juan Bonifacino

Jia et al Elife. 2019 Nov 6;8. pii: 50034. doi: 10

Nov. 30, 2021

Academic Institutions and Nonprofits only

#209552

The human, genome-wide, CRISPR knockout enAsCas12a gRNA library targets single genes and paralog pairs, triples, and quads with arrays of 4 gRNAs.

John Doench

Esmaeili Anvar et al Nat Commun. 2024 Apr 27;15(1):3577. doi:

Dec. 5, 2023

Academic Institutions and Nonprofits only

#1000000239

Jay Shendure

April 3, 2024

Academic Institutions and Nonprofits only

#172650

Set C contains best-ranked guides 1 and 4.

John Doench, David Root

DeWeirdt et al Nat Biotechnol. 2020 Jul 13. pii: 10.103

Nov. 10, 2021

Academic Institutions and Nonprofits only

#1000000075

Genome-wide CRISPR gRNA pooled library for activation of mouse genes

Feng Zhang

March 17, 2016

Academic Institutions and Nonprofits only

#212966

Genome-scale library for pan-cancer interrogation of lncRNA dependencies using CasRx.

Roland Rad

Montero et al Nat Methods. 2024 Feb 26. doi: 10.1038/s

Feb. 21, 2024

Academic Institutions and Nonprofits only

#115644

Viral barcoding library to combinatorially index cells for single-cell analysis of clonal dynamics

Samantha Morris

Biddy et al Nature. 2018 Dec;564(7735):219-224. doi:

Dec. 5, 2018

Academic Institutions and Nonprofits only

#187249

Ultra-compact, human genome-wide CRISPRa library targeting each gene with a single element encoding a dual sgRNA cassette.

Marco Jost, Jonathan Weissman

Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

Sept. 30, 2022

Academic Institutions and Nonprofits only

#226117

Contains 748 traditional and newly predicted epigenetic regulators using epigenetic network analyses that integrated gene codependency (DepMap) and protein-protein interaction data (BioPlex).

Rui Lu

Zhou et al Blood. 2024 Aug 16:blood.2023023644. doi

Oct. 29, 2024

Academic Institutions and Nonprofits only

#1000000131

Genome-wide CRISPR gRNA pooled library for inhibition of mouse genes

John Doench, David Root

July 13, 2018

Academic Institutions and Nonprofits only

#115645

Viral barcoding library to combinatorially index cells for single-cell analysis of clonal dynamics

Samantha Morris

Biddy et al Nature. 2018 Dec;564(7735):219-224. doi:

Dec. 5, 2018

Academic Institutions and Nonprofits only

#83985

Human CRISPRa Pooled Library targeting membrane proteins

Jonathan Weissman

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Jan. 12, 2017

Academic Institutions and Nonprofits only

#177663

CRISPR-interference (CRISPRi) library of 1,573 sgRNAs targeting 476 genes encoding factors involved in DNA repair and associated processes

Brittany Adamson

Hussmann et al Cell. 2021 Oct 28;184(22):5653-5669.e25.

July 11, 2023

Academic Institutions and Nonprofits only