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Showing: 61 - 80 of 918 results
  1. Seeing Red: Simple GFP Photoconversion

    Type
    Blog Post
    ...Sattarzadeh et al. found that only the protonated form of GFP is photoconverted, so this technique may ...been encountered by some investigators when using forms of mEos." The ability to repurpose GFP is great ...
  2. Viral Vectors 101: Parts of the AAV Packaging Plasmid

    Type
    Blog Post
    ...and ATPase domains. To function, the Rep proteins form oligomers of Rep 78/68 or Rep52/40. Rep78/68 play...capsid proteins VP1, VP2, and VP3, which together form the outer capsid shell that protects the viral genome...
  3. Supporting Rare Disease Research with BeHeard 2017

    Type
    Blog Post
    ...team of physicians and scientists.  Although the form of malignant mesothelioma that affects the lining...widely understood and often misdiagnosed. Like other forms of mesothelioma, there are currently no targeted...model to identify SMN1 interacting partners and perform whole animal screens for small molecules that block...this little-known disease. You can find more information about the disease on the Meothelioma Cancer Alliance...
  4. AAVs in Retinal Gene Therapy

    Type
    Blog Post
    ... an autosomal recessive, severe, childhood-onset form of blindness name Leber’s Congenital Amaurosis (...years to obtain FDA approval and make history in the form of Luxturna™. A better vector for ocular gene therapy...non-dividing cells because they remain in episomal form in the cell’s nucleus. But since nothing’s ever...
  5. Data Freedom: The Expansion of Data Sharing in Research Publications

    Type
    Blog Post
    ...stored in a retrievable format, we too rarely preserve “raw” data of any sort in a form that can be parsed ...underlying data easily available, organized in a form that can be understood by others, balanced against...should recognize that storing data in a sharable form is indeed a significant effort. Our standards of...publications must contain enough information (or links to information) for assessment of veracity of the...unprocessed and in capture format. This raises another issue of proprietary data formats. Many instruments store... raise the alpha isoform of GSK-3 to the same (deserved) stature as the beta isoform. Follow him on Twitter...Not quite. The PLOS policy on data access is a formal statement that is already practiced or required...
  6. Sleeping Beauty Awakens for Genome Engineering

    Type
    Blog Post
    ...applications of genome engineering - such as certain forms of gene therapy - avoiding the use of viruses is...different fish species in a variety of non-functional forms and is believed to be millions of years old. The... is one such system which has been designed to perform gene transfer in vertebrates. The system is comprised...
  7. The Strength of Story Telling

    Type
    Blog Post
    ...designed to pay attention and enjoy anecdotal forms of information — identifying with a character, building...you can leave out. Start viewing your work in the form of a story, and you’ll very quickly get better at...Here’s an example of storytelling to answer an informational interview question: Interviewer: “Tell me about...
  8. Bricking Science: Portraying Scientific Reality Through LEGO

    Type
    Blog Post
    ...movement, and assembling the many pictures together to form the full movement. Producing stop motion videos ...quirky lab story you’d like to see portrayed in LEGO form, feel free to share with us at [email protected] Science” was born. We chose the stop motion format for our videos as it is the most approachable for...
  9. What Good Citizenship Can Do for Reproducibility in Science

    Type
    Blog Post
    ...something differently. Communication comes in many forms—from transparency about data to allow others to ...good scientific citizenship in all its different forms as part of graduation, hiring, funding, and promotion... again, the problem comes down to inadequate information about what the original researchers actually ...ourselves having to ask authors for additional information (accession numbers, reagent details, author contributions...published. To a scientist, all of this checking and formatting can feel like yet another hurdle in front of ...transparency of methods sections, including clear information about reagents, and why other publishers and ...
Showing: 61 - 80 of 918 results