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pCMV-PEmax Citations (22)

Originally described in: Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.
Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. PubMed Journal

Articles Citing pCMV-PEmax

Articles
Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy. Nishiyama T, Zhang Y, Cui M, Li H, Sanchez-Ortiz E, McAnally JR, Tan W, Kim J, Chen K, Xu L, Bassel-Duby R, Olson EN. Sci Transl Med. 2022 Nov 23;14(672):eade1633. doi: 10.1126/scitranslmed.ade1633. Epub 2022 Nov 23. PubMed
Development of a versatile nuclease prime editor with upgraded precision. Li X, Zhang G, Huang S, Liu Y, Tang J, Zhong M, Wang X, Sun W, Yao Y, Ji Q, Wang X, Liu J, Zhu S, Huang X. Nat Commun. 2023 Jan 19;14(1):305. doi: 10.1038/s41467-023-35870-0. PubMed
Future Perspectives of Prime Editing for the Treatment of Inherited Retinal Diseases. Hansen S, McClements ME, Corydon TJ, MacLaren RE. Cells. 2023 Jan 29;12(3):440. doi: 10.3390/cells12030440. PubMed
Chromatin context-dependent regulation and epigenetic manipulation of prime editing. Li X, Chen W, Martin BK, Calderon D, Lee C, Choi J, Chardon FM, McDiarmid T, Kim H, Lalanne JB, Nathans JF, Shendure J. bioRxiv. 2023 Apr 12:2023.04.12.536587. doi: 10.1101/2023.04.12.536587. Preprint. PubMed
Genotoxic effects of base and prime editing in human hematopoietic stem cells. Fiumara M, Ferrari S, Omer-Javed A, Beretta S, Albano L, Canarutto D, Varesi A, Gaddoni C, Brombin C, Cugnata F, Zonari E, Naldini MM, Barcella M, Gentner B, Merelli I, Naldini L. Nat Biotechnol. 2023 Sep 7. doi: 10.1038/s41587-023-01915-4. PubMed
Development of a highly efficient prime editor system in mice and rabbits. Qian Y, Wang D, Niu W, Shi Z, Wu M, Zhao D, Li J, Gao X, Zhang Z, Lai L, Li Z. Cell Mol Life Sci. 2023 Nov 4;80(11):346. doi: 10.1007/s00018-023-05003-3. PubMed
One-pot DTECT enables rapid and efficient capture of genetic signatures for precision genome editing and clinical diagnostics. Baudrier L, Benamozig O, Langley J, Chopra S, Kalashnikova T, Benaoudia S, Singh G, Mahoney DJ, Wright NAM, Billon P. Cell Rep Methods. 2024 Feb 26;4(2):100698. doi: 10.1016/j.crmeth.2024.100698. Epub 2024 Jan 31. PubMed
Enhancing prime editor activity by directed protein evolution in yeast. Weber Y, Bock D, Ivascu A, Mathis N, Rothgangl T, Ioannidi EI, Blaudt AC, Tidecks L, Vadovics M, Muramatsu H, Reichmuth A, Marquart KF, Kissling L, Pardi N, Jinek M, Schwank G. Nat Commun. 2024 Mar 7;15(1):2092. doi: 10.1038/s41467-024-46107-z. PubMed
Improving prime editing with an endogenous small RNA-binding protein. Yan J, Oyler-Castrillo P, Ravisankar P, Ward CC, Levesque S, Jing Y, Simpson D, Zhao A, Li H, Yan W, Goudy L, Schmidt R, Solley SC, Gilbert LA, Chan MM, Bauer DE, Marson A, Parsons LR, Adamson B. Nature. 2024 Apr 3. doi: 10.1038/s41586-024-07259-6. PubMed

Associated Plasmids
Chromatin context-dependent regulation and epigenetic manipulation of prime editing. Li X, Chen W, Martin BK, Calderon D, Lee C, Choi J, Chardon FM, McDiarmid TA, Daza RM, Kim H, Lalanne JB, Nathans JF, Lee DS, Shendure J. Cell. 2024 May 9;187(10):2411-2427.e25. doi: 10.1016/j.cell.2024.03.020. Epub 2024 Apr 11. PubMed
Precise editing of pathogenic nucleotide repeat expansions in iPSCs using paired prime editor. Hwang HY, Gim D, Yi H, Jung H, Lee J, Kim D. Nucleic Acids Res. 2024 Jun 10;52(10):5792-5803. doi: 10.1093/nar/gkae310. PubMed
Development and testing of a versatile genome editing application reporter (V-GEAR) system. Kleinboehl EW, Laoharawee K, Lahr WS, Jensen JD, Peterson JJ, Bell JB, Webber BR, Moriarity BS. Mol Ther Methods Clin Dev. 2024 Apr 24;32(2):101253. doi: 10.1016/j.omtm.2024.101253. eCollection 2024 Jun 13. PubMed
Creation of de novo cryptic splicing for ALS and FTD precision medicine. Wilkins OG, Chien MZYJ, Wlaschin JJ, Barattucci S, Harley P, Mattedi F, Mehta PR, Pisliakova M, Ryadnov E, Keuss MJ, Thompson D, Digby H, Knez L, Simkin RL, Diaz JA, Zanovello M, Brown AL, Darbey A, Karda R, Fisher EMC, Cunningham TJ, Le Pichon CE, Ule J, Fratta P. Science. 2024 Oct 4;386(6717):61-69. doi: 10.1126/science.adk2539. Epub 2024 Oct 3. PubMed

Associated Plasmids
Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles. Halegua T, Risson V, Carras J, Rouyer M, Coudert L, Jacquier A, Schaeffer L, Ohlmann T, Mangeot PE. Nat Commun. 2025 Jan 4;16(1):397. doi: 10.1038/s41467-024-55604-0. PubMed

Associated Plasmids
EXPERT expands prime editing efficiency and range of large fragment edits. Xiong Y, Su Y, He R, Han X, Li S, Liu M, Xi X, Liu Z, Wang H, Xie S, Xu X, Li K, Zhang J, Xu J, Li X, Zhao S, Ruan J. Nat Commun. 2025 Feb 13;16(1):1592. doi: 10.1038/s41467-025-56734-9. PubMed
Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers. Caragine CM, Le VT, Mustafa M, Diaz BJ, Morris JA, Muller S, Mendez-Mancilla A, Geller E, Liscovitch-Brauer N, Sanjana NE. Nat Commun. 2025 Feb 13;16(1):1611. doi: 10.1038/s41467-025-56568-5. PubMed

Associated Plasmids
Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning. Silverstein RA, Kim N, Kroell AS, Walton RT, Delano J, Butcher RM, Pacesa M, Smith BK, Christie KA, Ha LL, Meis RJ, Clark AB, Spinner AD, Lazzarotto CR, Li Y, Matsubara A, Urbina EO, Dahl GA, Correia BE, Marks DS, Tsai SQ, Pinello L, De Ravin SS, Liu Q, Kleinstiver BP. Nature. 2025 Apr 22. doi: 10.1038/s41586-025-09021-y. PubMed

Associated Plasmids
Insights into pegRNA design from editing of the cardiomyopathy-associated phospholamban R14del mutation. Yao B, Yang Q, Snijders Blok CJB, Daniels MA, Doevendans PA, Schiffelers R, Sluijter JPG, Lei Z. FEBS Lett. 2025 Sep;599(17):2543-2554. doi: 10.1002/1873-3468.70097. Epub 2025 Jun 24. PubMed
In vivo prime editing rescues alternating hemiplegia of childhood in mice. Sousa AA, Terrey M, Sakai HA, Simmons CQ, Arystarkhova E, Morsci NS, Anderson LC, Xie J, Suri-Payer F, Laux LC, Roze E, Forlani S, Gao G, Frost S, Frost N, Sweadner KJ, George AL Jr, Lutz CM, Liu DR. Cell. 2025 Aug 7;188(16):4275-4294.e23. doi: 10.1016/j.cell.2025.06.038. Epub 2025 Jul 21. PubMed
AI-generated MLH1 small binder improves prime editing efficiency. Park JC, Uhm H, Kim YW, Oh YE, Lee JH, Yang J, Kim K, Bae S. Cell. 2025 Aug 1:S0092-8674(25)00799-8. doi: 10.1016/j.cell.2025.07.010. PubMed

Associated Plasmids
Prime Editing Modification with FEN1 Improves F508del Variant Editing in the CFTR Gene in Airway Basal Cells. Volodina OV, Demchenko AG, Anuchina AA, Ryzhkova OP, Kovalskaya VA, Kondrateva EV, Artemova EV, Tabakov VY, Ignatov MA, Vorobyeva NY, Osipov AN, Lavrov AV, Smirnikhina SA. Int J Mol Sci. 2025 Aug 18;26(16):7943. doi: 10.3390/ijms26167943. PubMed
Double-stranded DNA deaminase DddA(E1347A) can increase the efficiency and targeting range of cytidine base editors. Qian Y, Hui F, Niu W, Wang D, Hao Y, Meng Q, Ren S, Kong D, Gong H, Wu J, Chen K, Alariqi M, Gao J, Li Z, Jin S. Genome Biol. 2025 Nov 17;26(1):391. doi: 10.1186/s13059-025-03849-3. PubMed

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