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pAAV-hSyn-DIO-hM3D(Gq)-mCherry Citations (109)

Plasmid Article: Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.
Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB J Clin Invest. 2011 Apr;121(4):1424-8. doi: 10.1172/JCI46229.
PubMed Journal

Articles Citing pAAV-hSyn-DIO-hM3D(Gq)-mCherry

Articles
Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Neuropharmacology. 2014 Oct;85:451-60. doi: 10.1016/j.neuropharm.2014.06.015. Epub 2014 Jun 18. PubMed
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Penagarikano O, Lazaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH. Sci Transl Med. 2015 Jan 21;7(271):271ra8. doi: 10.1126/scitranslmed.3010257. PubMed

Associated Plasmids

Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha2 adrenergic agonists. Zhang Z, Ferretti V, Guntan I, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP. Nat Neurosci. 2015 Apr;18(4):553-61. doi: 10.1038/nn.3957. Epub 2015 Feb 23. PubMed

Associated Plasmids

Wakefulness Is Governed by GABA and Histamine Cotransmission. Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W. Neuron. 2015 Jun 17. pii: S0896-6273(15)00516-4. doi: 10.1016/j.neuron.2015.06.003. PubMed

Associated Plasmids

Insular neural system controls decision-making in healthy and methamphetamine-treated rats. Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3930-9. doi: 10.1073/pnas.1418014112. Epub 2015 Jul 6. PubMed
A viral strategy for targeting and manipulating interneurons across vertebrate species. Dimidschstein J, Chen Q, Tremblay R, Rogers SL, Saldi GA, Guo L, Xu Q, Liu R, Lu C, Chu J, Avery MC, Rashid MS, Baek M, Jacob AL, Smith GB, Wilson DE, Kosche G, Kruglikov I, Rusielewicz T, Kotak VC, Mowery TM, Anderson SA, Callaway EM, Dasen JS, Fitzpatrick D, Fossati V, Long MA, Noggle S, Reynolds JH, Sanes DH, Rudy B, Feng G, Fishell G. Nat Neurosci. 2016 Oct 31. doi: 10.1038/nn.4430. PubMed

Associated Plasmids

A reliable and flexible gene manipulation strategy in posthatch zebra finch brain. Ahmadiantehrani S, London SE. Sci Rep. 2017 Feb 24;7:43244. doi: 10.1038/srep43244. PubMed
AgRP Neurons Can Increase Food Intake during Conditions of Appetite Suppression and Inhibit Anorexigenic Parabrachial Neurons. Essner RA, Smith AG, Jamnik AA, Ryba AR, Trutner ZD, Carter ME. J Neurosci. 2017 Sep 6;37(36):8678-8687. doi: 10.1523/JNEUROSCI.0798-17.2017. Epub 2017 Aug 7. PubMed
Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Resch JM, Fenselau H, Madara JC, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-Toth G, Naray-Fejes-Toth A, Geerling JC, Lowell BB. Neuron. 2017 Sep 27;96(1):190-206.e7. doi: 10.1016/j.neuron.2017.09.014. PubMed
Activation of endogenous arginine vasopressin neurons inhibit food intake: by using a novel transgenic rat line with DREADDs system. Yoshimura M, Nishimura K, Nishimura H, Sonoda S, Ueno H, Motojima Y, Saito R, Maruyama T, Nonaka Y, Ueta Y. Sci Rep. 2017 Nov 16;7(1):15728. doi: 10.1038/s41598-017-16049-2. PubMed
Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation. Gelegen C, Miracca G, Ran MZ, Harding EC, Ye Z, Yu X, Tossell K, Houston CM, Yustos R, Hawkins ED, Vyssotski AL, Dong HL, Wisden W, Franks NP. Curr Biol. 2018 Feb 19;28(4):580-587.e5. doi: 10.1016/j.cub.2017.12.050. Epub 2018 Feb 1. PubMed
Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Zelikowsky M, Hui M, Karigo T, Choe A, Yang B, Blanco MR, Beadle K, Gradinaru V, Deverman BE, Anderson DJ. Cell. 2018 May 17;173(5):1265-1279.e19. doi: 10.1016/j.cell.2018.03.037. PubMed
Adeno-associated Virus-mediated Transgene Expression in Genetically Defined Neurons of the Spinal Cord. Haenraets K, Albisetti GW, Foster E, Wildner H. J Vis Exp. 2018 May 12;(135). doi: 10.3791/57382. PubMed
Pyramidal cell regulation of interneuron survival sculpts cortical networks. Wong FK, Bercsenyi K, Sreenivasan V, Portales A, Fernandez-Otero M, Marin O. Nature. 2018 May;557(7707):668-673. doi: 10.1038/s41586-018-0139-6. Epub 2018 May 30. PubMed
Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone. Noble EE, Hahn JD, Konanur VR, Hsu TM, Page SJ, Cortella AM, Liu CM, Song MY, Suarez AN, Szujewski CC, Rider D, Clarke JE, Darvas M, Appleyard SM, Kanoski SE. Cell Metab. 2018 Jul 3;28(1):55-68.e7. doi: 10.1016/j.cmet.2018.05.001. Epub 2018 May 31. PubMed
Four Key Steps Control Glycolytic Flux in Mammalian Cells. Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD. Cell Syst. 2018 Jul 25;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. Epub 2018 Jun 27. PubMed
A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus. Harding EC, Yu X, Miao A, Andrews N, Ma Y, Ye Z, Lignos L, Miracca G, Ba W, Yustos R, Vyssotski AL, Wisden W, Franks NP. Curr Biol. 2018 Jul 23;28(14):2263-2273.e4. doi: 10.1016/j.cub.2018.05.054. Epub 2018 Jul 12. PubMed

Associated Plasmids

Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure. Farzi A, Lau J, Ip CK, Qi Y, Shi YC, Zhang L, Tasan R, Sperk G, Herzog H. Elife. 2018 Aug 21;7. pii: 36494. doi: 10.7554/eLife.36494. PubMed
Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons. Wang L, Chen SR, Ma H, Chen H, Hittelman WN, Pan HL. J Neurochem. 2018 Nov;147(4):526-540. doi: 10.1111/jnc.14588. Epub 2018 Oct 31. PubMed
Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress. Alpar A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, Bakker J, Miklosi AG, Tretiakov E, Keimpema E, Arque G, Tasan RO, Sperk G, Malenczyk K, Mate Z, Erdelyi F, Szabo G, Lubec G, Palkovits M, Giordano A, Hokfelt TG, Romanov RA, Horvath TL, Harkany T. EMBO J. 2018 Nov 2;37(21). pii: embj.2018100087. doi: 10.15252/embj.2018100087. Epub 2018 Sep 12. PubMed
Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity. Calin A, Stancu M, Zagrean AM, Jefferys JGR, Ilie AS, Akerman CJ. Front Cell Neurosci. 2018 Sep 5;12:293. doi: 10.3389/fncel.2018.00293. eCollection 2018. PubMed
Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories. Chen JY, Campos CA, Jarvie BC, Palmiter RD. Neuron. 2018 Nov 21;100(4):891-899.e5. doi: 10.1016/j.neuron.2018.09.032. Epub 2018 Oct 18. PubMed
Convergent Inputs from the Hippocampus and Thalamus to the Nucleus Accumbens Regulate Dopamine Neuron Activity. Perez SM, Lodge DJ. J Neurosci. 2018 Dec 12;38(50):10607-10618. doi: 10.1523/JNEUROSCI.2629-16.2018. Epub 2018 Oct 24. PubMed
Hypothalamic Neurons that Regulate Feeding Can Influence Sleep/Wake States Based on Homeostatic Need. Goldstein N, Levine BJ, Loy KA, Duke WL, Meyerson OS, Jamnik AA, Carter ME. Curr Biol. 2018 Dec 3;28(23):3736-3747.e3. doi: 10.1016/j.cub.2018.09.055. Epub 2018 Nov 21. PubMed
Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State. Li C, Navarrete J, Liang-Guallpa J, Lu C, Funderburk SC, Chang RB, Liberles SD, Olson DP, Krashes MJ. Cell Metab. 2019 Mar 5;29(3):681-694.e5. doi: 10.1016/j.cmet.2018.10.016. Epub 2018 Nov 21. PubMed
GABA and glutamate neurons in the VTA regulate sleep and wakefulness. Yu X, Li W, Ma Y, Tossell K, Harris JJ, Harding EC, Ba W, Miracca G, Wang D, Li L, Guo J, Chen M, Li Y, Yustos R, Vyssotski AL, Burdakov D, Yang Q, Dong H, Franks NP, Wisden W. Nat Neurosci. 2019 Jan;22(1):106-119. doi: 10.1038/s41593-018-0288-9. Epub 2018 Dec 17. PubMed

Associated Plasmids

NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice. Fergani C, Leon S, Padilla SL, Verstegen AM, Palmiter RD, Navarro VM. Elife. 2018 Dec 19;7. pii: 40476. doi: 10.7554/eLife.40476. PubMed
Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton JEV, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z. Nat Neurosci. 2019 Feb;22(2):205-217. doi: 10.1038/s41593-018-0311-1. Epub 2019 Jan 21. PubMed
The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits. Li MM, Madara JC, Steger JS, Krashes MJ, Balthasar N, Campbell JN, Resch JM, Conley NJ, Garfield AS, Lowell BB. Neuron. 2019 May 8;102(3):653-667.e6. doi: 10.1016/j.neuron.2019.02.028. Epub 2019 Mar 14. PubMed
Pathway specific activation of ventral hippocampal cells projecting to the prelimbic cortex diminishes fear renewal. Vasquez JH, Leong KC, Gagliardi CM, Harland B, Apicella AJ, Muzzio IA. Neurobiol Learn Mem. 2019 May;161:63-71. doi: 10.1016/j.nlm.2019.03.003. Epub 2019 Mar 18. PubMed
Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions. Ip CK, Zhang L, Farzi A, Qi Y, Clarke I, Reed F, Shi YC, Enriquez R, Dayas C, Graham B, Begg D, Bruning JC, Lee NJ, Hernandez-Sanchez D, Gopalasingam G, Koller J, Tasan R, Sperk G, Herzog H. Cell Metab. 2019 Jul 2;30(1):111-128.e6. doi: 10.1016/j.cmet.2019.04.001. Epub 2019 Apr 25. PubMed
Innervation of thermogenic adipose tissue via a calsyntenin 3beta-S100b axis. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Nature. 2019 May;569(7755):229-235. doi: 10.1038/s41586-019-1156-9. Epub 2019 May 1. PubMed
A Specialized Neural Circuit Gates Social Vocalizations in the Mouse. Tschida K, Michael V, Takatoh J, Han BX, Zhao S, Sakurai K, Mooney R, Wang F. Neuron. 2019 Aug 7;103(3):459-472.e4. doi: 10.1016/j.neuron.2019.05.025. Epub 2019 Jun 13. PubMed
The Lateral Hypothalamic and BNST GABAergic Projections to the Anterior Ventrolateral Periaqueductal Gray Regulate Feeding. Hao S, Yang H, Wang X, He Y, Xu H, Wu X, Pan L, Liu Y, Lou H, Xu H, Ma H, Xi W, Zhou Y, Duan S, Wang H. Cell Rep. 2019 Jul 16;28(3):616-624.e5. doi: 10.1016/j.celrep.2019.06.051. PubMed
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward. Parker KE, Pedersen CE, Gomez AM, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Kash TJ, Dougherty JD, Stuber GD, Bruchas MR. Cell. 2019 Jul 25;178(3):653-671.e19. doi: 10.1016/j.cell.2019.06.034. PubMed
Neuronal Activation Stimulates Cytomegalovirus Promoter-Driven Transgene Expression. Back S, Dossat A, Parkkinen I, Koivula P, Airavaara M, Richie CT, Chen YH, Wang Y, Harvey BK. Mol Ther Methods Clin Dev. 2019 Jul 3;14:180-188. doi: 10.1016/j.omtm.2019.06.006. eCollection 2019 Sep 13. PubMed
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. Cell Metab. 2019 Nov 5;30(5):987-996.e6. doi: 10.1016/j.cmet.2019.07.013. Epub 2019 Aug 22. PubMed
Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca(2+) channels. Bavley CC, Fetcho RN, Burgdorf CE, Walsh AP, Fischer DK, Hall BS, Sayles NM, Contoreggi NH, Hackett JE, Antigua SA, Babij R, De Marco Garcia NV, Kash TL, Milner TA, Liston C, Rajadhyaksha AM. Mol Psychiatry. 2019 Sep 9. pii: 10.1038/s41380-019-0513-2. doi: 10.1038/s41380-019-0513-2. PubMed
Galanin Neurons Unite Sleep Homeostasis and alpha2-Adrenergic Sedation. Ma Y, Miracca G, Yu X, Harding EC, Miao A, Yustos R, Vyssotski AL, Franks NP, Wisden W. Curr Biol. 2019 Oct 7;29(19):3315-3322.e3. doi: 10.1016/j.cub.2019.07.087. Epub 2019 Sep 19. PubMed
Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning. Pomrenze MB, Giovanetti SM, Maiya R, Gordon AG, Kreeger LJ, Messing RO. Cell Rep. 2019 Oct 1;29(1):13-21.e4. doi: 10.1016/j.celrep.2019.08.083. PubMed

Associated Plasmids

Activity of Insula to Basolateral Amygdala Projecting Neurons is Necessary and Sufficient for Taste Valence Representation. Kayyal H, Yiannakas A, Kolatt Chandran S, Khamaisy M, Sharma V, Rosenblum K. J Neurosci. 2019 Nov 20;39(47):9369-9382. doi: 10.1523/JNEUROSCI.0752-19.2019. Epub 2019 Oct 9. PubMed
High-potency ligands for DREADD imaging and activation in rodents and monkeys. Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M. Nat Commun. 2019 Oct 11;10(1):4627. doi: 10.1038/s41467-019-12236-z. PubMed
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, Umpierre AD, Zhu J, Bosco DB, Dong H, Wu LJ. Nat Neurosci. 2019 Nov;22(11):1771-1781. doi: 10.1038/s41593-019-0511-3. Epub 2019 Oct 21. PubMed
Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an alpha-synuclein based rat model for Parkinson's disease. Torre-Muruzabal T, Devoght J, Van den Haute C, Brone B, Van der Perren A, Baekelandt V. Acta Neuropathol Commun. 2019 Oct 22;7(1):160. doi: 10.1186/s40478-019-0814-3. PubMed
Contribution of the Retrotrapezoid Nucleus and Carotid Bodies to Hypercapnia- and Hypoxia-induced Arousal from Sleep. Souza GMPR, Stornetta RL, Stornetta DS, Abbott SBG, Guyenet PG. J Neurosci. 2019 Dec 4;39(49):9725-9737. doi: 10.1523/JNEUROSCI.1268-19.2019. Epub 2019 Oct 22. PubMed
Prefrontal Corticotectal Neurons Enhance Visual Processing through the Superior Colliculus and Pulvinar Thalamus. Hu F, Kamigaki T, Zhang Z, Zhang S, Dan U, Dan Y. Neuron. 2019 Dec 18;104(6):1141-1152.e4. doi: 10.1016/j.neuron.2019.09.019. Epub 2019 Oct 23. PubMed
An Excitatory and Epileptogenic Effect of Dentate Gyrus Mossy Cells in a Mouse Model of Epilepsy. Botterill JJ, Lu YL, LaFrancois JJ, Bernstein HL, Alcantara-Gonzalez D, Jain S, Leary P, Scharfman HE. Cell Rep. 2019 Nov 26;29(9):2875-2889.e6. doi: 10.1016/j.celrep.2019.10.100. PubMed
Kisspeptin neuron-specific and self-sustained calcium oscillation in the hypothalamic arcuate nucleus of neonatal mice: Regulatory factors of its synchronization. Kim D, Jang S, Kim J, Park I, Ku K, Choi M, Lee S, Heo WD, Son GH, Choe HK, Kim K. Neuroendocrinology. 2020 Jan 15. pii: 000505922. doi: 10.1159/000505922. PubMed
Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice. Lee Y, Han NE, Kim W, Kim JG, Lee IB, Choi SJ, Chun H, Seo M, Lee CJ, Koh HY, Kim JH, Baik JH, Bear MF, Choi SY, Yoon BJ. Mol Cells. 2020 Apr 30;43(4):360-372. doi: 10.14348/molcells.2019.0279. PubMed
DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats. Sharma PK, Wells L, Rizzo G, Elson JL, Passchier J, Rabiner EA, Gunn RN, Dexter DT, Pienaar IS. Neurotherapeutics. 2020 Jul;17(3):1120-1141. doi: 10.1007/s13311-019-00830-4. PubMed
Pituitary Adenylate Cyclase Activating Polypeptide Excites Proopiomelanocortin Neurons: Implications for the Regulation of Energy Homeostasis. Chang R, Hernandez J, Gastelum C, Guadagno K, Perez L, Wagner EJ. Neuroendocrinology. 2020 Feb 7. pii: 000506367. doi: 10.1159/000506367. PubMed
A Novel Next-Generation Sequencing and Analysis Platform to Assess the Identity of Recombinant Adeno-Associated Viral Preparations from Viral DNA Extracts. Guerin K, Rego M, Bourges D, Ersing I, Haery L, Harten DeMaio K, Sanders E, Tasissa M, Kostman M, Tillgren M, Makana Hanley L, Mueller I, Mitsopoulos A, Fan M. Hum Gene Ther. 2020 Jun;31(11-12):664-678. doi: 10.1089/hum.2019.277. Epub 2020 Apr 15. PubMed
The Role of Dorsal Raphe Serotonin Neurons in the Balance between Reward and Aversion. Nagai Y, Takayama K, Nishitani N, Andoh C, Koda M, Shirakawa H, Nakagawa T, Nagayasu K, Yamanaka A, Kaneko S. Int J Mol Sci. 2020 Mar 21;21(6). pii: ijms21062160. doi: 10.3390/ijms21062160. PubMed
Memory trace interference impairs recall in a mouse model of Alzheimer's disease. Poll S, Mittag M, Musacchio F, Justus LC, Giovannetti EA, Steffen J, Wagner J, Zohren L, Schoch S, Schmidt B, Jackson WS, Ehninger D, Fuhrmann M. Nat Neurosci. 2020 Aug;23(8):952-958. doi: 10.1038/s41593-020-0652-4. Epub 2020 Jun 8. PubMed
Neurons that regulate mouse torpor. Hrvatin S, Sun S, Wilcox OF, Yao H, Lavin-Peter AJ, Cicconet M, Assad EG, Palmer ME, Aronson S, Banks AS, Griffith EC, Greenberg ME. Nature. 2020 Jul;583(7814):115-121. doi: 10.1038/s41586-020-2387-5. Epub 2020 Jun 11. PubMed
Complex Movement Control in a Rat Model of Parkinsonian Falls: Bidirectional Control by Striatal Cholinergic Interneurons. Avila C, Kucinski A, Sarter M. J Neurosci. 2020 Jul 29;40(31):6049-6067. doi: 10.1523/JNEUROSCI.0220-20.2020. Epub 2020 Jun 18. PubMed
Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. Yu X, Ba W, Zhao G, Ma Y, Harding EC, Yin L, Wang D, Li H, Zhang P, Shi Y, Yustos R, Vyssotski AL, Dong H, Franks NP, Wisden W. Mol Psychiatry. 2020 Jun 17. pii: 10.1038/s41380-020-0810-9. doi: 10.1038/s41380-020-0810-9. PubMed
Immunohistochemical amplification of mCherry fusion protein is necessary for proper visualization. Falcy BA, Mohr MA, Micevych PE. MethodsX. 2020 Jun 2;7:100946. doi: 10.1016/j.mex.2020.100946. eCollection 2020. PubMed
Regulation of Pv-specific interneurons in the medial prefrontal cortex and reward-seeking behaviors. Nahar L, Grant CA, Hewett C, Cortes D, Reker AN, Kang S, Choi DS, Nam HW. J Neurochem. 2021 Jan;156(2):212-224. doi: 10.1111/jnc.15106. Epub 2020 Jul 20. PubMed
Chronic nicotine impairs sparse motor learning via striatal fast-spiking parvalbumin interneurons. Kim B, Im HI. Addict Biol. 2021 May;26(3):e12956. doi: 10.1111/adb.12956. Epub 2020 Aug 6. PubMed
Hypothalamic-vagal oxytocinergic neurocircuitry modulates gastric emptying and motility following stress. Jiang Y, Travagli RA. J Physiol. 2020 Nov;598(21):4941-4955. doi: 10.1113/JP280023. Epub 2020 Sep 7. PubMed
5-HT1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function. Han L, Wu KL, Kwan PY, Chua OW, Shum DK, Chan YS. J Physiol. 2021 Jan;599(1):253-267. doi: 10.1113/JP280610. Epub 2020 Oct 23. PubMed
Septal GABAergic inputs to CA1 govern contextual memory retrieval. Sans-Dublanc A, Razzauti A, Desikan S, Pascual M, Monyer H, Sindreu C. Sci Adv. 2020 Oct 30;6(44). pii: 6/44/eaba5003. doi: 10.1126/sciadv.aba5003. Print 2020 Oct. PubMed
Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats. Strong CE, Hagarty DP, Brea Guerrero A, Schoepfer KJ, Cajuste SM, Kabbaj M. Sci Rep. 2020 Nov 5;10(1):19178. doi: 10.1038/s41598-020-76183-2. PubMed
Central Amygdala Projections to Lateral Hypothalamus Mediate Avoidance Behavior in Rats. Weera MM, Shackett RS, Kramer HM, Middleton JW, Gilpin NW. J Neurosci. 2021 Jan 6;41(1):61-72. doi: 10.1523/JNEUROSCI.0236-20.2020. Epub 2020 Nov 13. PubMed
Activation of Preoptic Arginine Vasopressin Neurons Induces Hyperthermia in Male Mice. Tabarean IV. Endocrinology. 2021 Feb 1;162(2). pii: 6010022. doi: 10.1210/endocr/bqaa217. PubMed
An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake. Zhang J, Chen D, Sweeney P, Yang Y. Nat Commun. 2020 Dec 10;11(1):6326. doi: 10.1038/s41467-020-20093-4. PubMed
Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice. Zhang Z, Reis FMCV, He Y, Park JW, DiVittorio JR, Sivakumar N, van Veen JE, Maesta-Pereira S, Shum M, Nichols I, Massa MG, Anderson S, Paul K, Liesa M, Ajijola OA, Xu Y, Adhikari A, Correa SM. Nat Commun. 2020 Dec 11;11(1):6378. doi: 10.1038/s41467-020-20050-1. PubMed
Anatomically and functionally distinct locus coeruleus efferents mediate opposing effects on anxiety-like behavior. Borodovitsyna O, Duffy BC, Pickering AE, Chandler DJ. Neurobiol Stress. 2020 Dec 5;13:100284. doi: 10.1016/j.ynstr.2020.100284. eCollection 2020 Nov. PubMed
Discrete TrkB-expressing neurons of the dorsomedial hypothalamus regulate feeding and thermogenesis. Houtz J, Liao GY, An JJ, Xu B. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). pii: 2017218118. doi: 10.1073/pnas.2017218118. PubMed
Bidirectional Regulation of Cognitive and Anxiety-like Behaviors by Dentate Gyrus Mossy Cells in Male and Female Mice. Botterill JJ, Vinod KY, Gerencer KJ, Teixeira CM, LaFrancois JJ, Scharfman HE. J Neurosci. 2021 Mar 17;41(11):2475-2495. doi: 10.1523/JNEUROSCI.1724-20.2021. Epub 2021 Jan 20. PubMed
Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury. Brommer B, He M, Zhang Z, Yang Z, Page JC, Su J, Zhang Y, Zhu J, Gouy E, Tang J, Williams P, Dai W, Wang Q, Solinsky R, Chen B, He Z. Nat Commun. 2021 Feb 3;12(1):781. doi: 10.1038/s41467-021-20980-4. PubMed
Addition of angled rungs to the horizontal ladder walking task for more sensitive probing of sensorimotor changes. Eisdorfer JT, Phelan MA, Keefe KM, Rollins MM, Campion TJ 3rd, Rauscher KM, Sobotka-Briner H, Senior M, Gordon G, Smith GM, Spence AJ. PLoS One. 2021 Feb 5;16(2):e0246298. doi: 10.1371/journal.pone.0246298. eCollection 2021. PubMed
Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior. Kato Y, Katsumata H, Inutsuka A, Yamanaka A, Onaka T, Minami S, Orikasa C. Sci Rep. 2021 Feb 8;11(1):3348. doi: 10.1038/s41598-021-82773-5. PubMed
Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments. Cai Y, Nielsen BE, Boxer EE, Aoto J, Ford CP. Neuron. 2021 Apr 7;109(7):1137-1149.e5. doi: 10.1016/j.neuron.2021.01.028. Epub 2021 Feb 17. PubMed

Associated Plasmids

Control of wakefulness by lateral hypothalamic glutamatergic neurons in male mice. Wang RF, Guo H, Jiang SY, Liu ZL, Qu WM, Huang ZL, Wang L. J Neurosci Res. 2021 Jun;99(6):1689-1703. doi: 10.1002/jnr.24828. Epub 2021 Mar 13. PubMed
Activation of Basolateral Amygdala to Nucleus Accumbens Projection Neurons Attenuates Chronic Corticosterone-Induced Behavioral Deficits in Male Mice. Dieterich A, Floeder J, Stech K, Lee J, Srivastava P, Barker DJ, Samuels BA. Front Behav Neurosci. 2021 Feb 24;15:643272. doi: 10.3389/fnbeh.2021.643272. eCollection 2021. PubMed
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome. Achilly NP, Wang W, Zoghbi HY. Nature. 2021 Apr;592(7855):596-600. doi: 10.1038/s41586-021-03369-7. Epub 2021 Mar 24. PubMed
Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist-induced orofacial dyskinesia. Nagaoka K, Nagashima T, Asaoka N, Yamamoto H, Toda C, Kayanuma G, Siswanto S, Funahashi Y, Kuroda K, Kaibuchi K, Mori Y, Nagayasu K, Shirakawa H, Kaneko S. JCI Insight. 2021 May 24;6(10). pii: 145632. doi: 10.1172/jci.insight.145632. PubMed
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis. Picard A, Metref S, Tarussio D, Dolci W, Berney X, Croizier S, Labouebe G, Thorens B. Diabetes. 2021 Jul;70(7):1443-1457. doi: 10.2337/db20-1121. Epub 2021 Apr 21. PubMed
Protocol for behavioral tests using chemogenetically manipulated mice. Horii-Hayashi N, Nishi M. STAR Protoc. 2021 Apr 1;2(2):100418. doi: 10.1016/j.xpro.2021.100418. eCollection 2021 Jun 18. PubMed
Somatostatin-expressing parafacial neurons are CO2/H(+) sensitive and regulate baseline breathing. Cleary CM, Milla BM, Kuo FS, James S, Flynn WF, Robson P, Mulkey DK. Elife. 2021 May 20;10. pii: 60317. doi: 10.7554/eLife.60317. PubMed
An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice. Siemian JN, Arenivar MA, Sarsfield S, Borja CB, Erbaugh LJ, Eagle AL, Robison AJ, Leinninger G, Aponte Y. Elife. 2021 May 27;10. pii: 66446. doi: 10.7554/eLife.66446. PubMed
Regulation of perineuronal nets in the adult cortex by the activity of the cortical network. Devienne G, Picaud S, Cohen I, Piquet J, Tricoire L, Testa D, Di Nardo AA, Rossier J, Cauli B, Lambolez B. J Neurosci. 2021 May 27. pii: JNEUROSCI.0434-21.2021. doi: 10.1523/JNEUROSCI.0434-21.2021. PubMed
Neural basis of opioid-induced respiratory depression and its rescue. Liu S, Kim DI, Oh TG, Pao GM, Kim JH, Palmiter RD, Banghart MR, Lee KF, Evans RM, Han S. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23). pii: 2022134118. doi: 10.1073/pnas.2022134118. PubMed

Associated Plasmids

NPY Released From GABA Neurons of the Dentate Gyrus Specially Reduces Contextual Fear Without Affecting Cued or Trace Fear. Comeras LB, Hormer N, Mohan Bethuraj P, Tasan RO. Front Synaptic Neurosci. 2021 May 26;13:635726. doi: 10.3389/fnsyn.2021.635726. eCollection 2021. PubMed
Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery. Smit RD, Campion TJ 3rd, Stingel RL, Shah PH, Chen J, Smith GM. J Vis Exp. 2021 Jun 30;(172). doi: 10.3791/62698. PubMed
Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states. Koralek AC, Costa RM. Sci Adv. 2021 Jul 23;7(30). pii: 7/30/eabh2059. doi: 10.1126/sciadv.abh2059. Print 2021 Jul. PubMed
A common limiter circuit for opioid choice and relapse identified in a rodent addiction model. Heinsbroek JA, Giannotti G, Mandel MR, Josey M, Aston-Jones G, James MH, Peters J. Nat Commun. 2021 Aug 9;12(1):4788. doi: 10.1038/s41467-021-25080-x. PubMed
Chemogenetic inhibition of corticostriatal circuits reduces cued reinstatement of methamphetamine seeking. Kearns AM, Siemsen BM, Hopkins JL, Weber RA, Scofield MD, Peters J, Reichel CM. Addict Biol. 2022 Jan;27(1):e13097. doi: 10.1111/adb.13097. Epub 2021 Aug 25. PubMed
Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors. Siemian JN, Arenivar MA, Sarsfield S, Borja CB, Russell CN, Aponte Y. Cell Rep. 2021 Aug 24;36(8):109615. doi: 10.1016/j.celrep.2021.109615. PubMed
Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions. Smith ACW, Jonkman S, Difeliceantonio AG, O'Connor RM, Ghoshal S, Romano MF, Everitt BJ, Kenny PJ. Nat Commun. 2021 Aug 25;12(1):5121. doi: 10.1038/s41467-021-25460-3. PubMed
Bottom-up inputs are required for establishment of top-down connectivity onto cortical layer 1 neurogliaform cells. Ibrahim LA, Huang S, Fernandez-Otero M, Sherer M, Qiu Y, Vemuri S, Xu Q, Machold R, Pouchelon G, Rudy B, Fishell G. Neuron. 2021 Nov 3;109(21):3473-3485.e5. doi: 10.1016/j.neuron.2021.08.004. Epub 2021 Sep 2. PubMed
Activation of septal OXTr neurons induces anxiety- but not depressive-like behaviors. Huang T, Guan F, Licinio J, Wong ML, Yang Y. Mol Psychiatry. 2021 Dec;26(12):7270-7279. doi: 10.1038/s41380-021-01283-y. Epub 2021 Sep 6. PubMed
Glucagon-like peptide-1 (GLP-1) signalling in the brain: From neural circuits and metabolism to therapeutics. Kabahizi A, Wallace B, Lieu L, Chau D, Dong Y, Hwang ES, Williams KW. Br J Pharmacol. 2022 Feb;179(4):600-624. doi: 10.1111/bph.15682. Epub 2021 Nov 4. PubMed
Oestrogen engages brain MC4R signalling to drive physical activity in female mice. Krause WC, Rodriguez R, Gegenhuber B, Matharu N, Rodriguez AN, Padilla-Roger AM, Toma K, Herber CB, Correa SM, Duan X, Ahituv N, Tollkuhn J, Ingraham HA. Nature. 2021 Nov;599(7883):131-135. doi: 10.1038/s41586-021-04010-3. Epub 2021 Oct 13. PubMed
Regulation of Brain Primary Cilia Length by MCH Signaling: Evidence from Pharmacological, Genetic, Optogenetic, and Chemogenic Manipulations. Alhassen W, Kobayashi Y, Su J, Robbins B, Nguyen H, Myint T, Yu M, Nauli SM, Saito Y, Alachkar A. Mol Neurobiol. 2022 Jan;59(1):245-265. doi: 10.1007/s12035-021-02511-w. Epub 2021 Oct 19. PubMed
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes. Kim A, Knudsen JG, Madara JC, Benrick A, Hill TG, Abdul Kadir L, Kellard JA, Mellander L, Miranda C, Lin H, James T, Suba K, Spigelman AF, Wu Y, MacDonald PE, Wernstedt Asterholm I, Magnussen T, Christensen M, Vilsboll T, Salem V, Knop FK, Rorsman P, Lowell BB, Briant LJ. Elife. 2021 Nov 17;10. pii: 72919. doi: 10.7554/eLife.72919. PubMed
Distinct Roles for Prefrontal Dopamine D1 and D2 Neurons in Social Hierarchy. Xing B, Mack NR, Zhang YX, McEachern EP, Gao WJ. J Neurosci. 2022 Jan 12;42(2):313-324. doi: 10.1523/JNEUROSCI.0741-21.2021. Epub 2021 Nov 29. PubMed
A fast, aqueous, reversible three-day tissue clearing method for adult and embryonic mouse brain and whole body. Kosmidis S, Negrean A, Dranovsky A, Losonczy A, Kandel ER. Cell Rep Methods. 2021 Nov 22;1(7):100090. doi: 10.1016/j.crmeth.2021.100090. Epub 2021 Oct 11. PubMed
Edinger-Westphal peptidergic neurons enable maternal preparatory nesting. Topilko T, Diaz SL, Pacheco CM, Verny F, Rousseau CV, Kirst C, Deleuze C, Gaspar P, Renier N. Neuron. 2022 Apr 20;110(8):1385-1399.e8. doi: 10.1016/j.neuron.2022.01.012. Epub 2022 Feb 4. PubMed
VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors. Baek SJ, Park JS, Kim J, Yamamoto Y, Tanaka-Yamamoto K. Elife. 2022 Feb 14;11. pii: 72981. doi: 10.7554/eLife.72981. PubMed
Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy. Jovanovic P, Wang Y, Vit JP, Novinbakht E, Morones N, Hogg E, Tagliati M, Riera CE. PLoS One. 2022 Mar 22;17(3):e0263074. doi: 10.1371/journal.pone.0263074. eCollection 2022. PubMed
Neurons in the Dorsomedial Hypothalamus Promote, Prolong, and Deepen Torpor in the Mouse. Ambler M, Hitrec T, Wilson A, Cerri M, Pickering A. J Neurosci. 2022 May 25;42(21):4267-4277. doi: 10.1523/JNEUROSCI.2102-21.2022. Epub 2022 Apr 19. PubMed
The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding. Pascal M, Kazakov A, Chevalier G, Dubrule L, Deyrat J, Dupin A, Saha S, Jagot F, Sailor K, Dulauroy S, Moigneu C, Belkaid Y, Lepousez G, Lledo PM, Wilhelm C, Eberl G. Mucosal Immunol. 2022 Apr;15(4):629-641. doi: 10.1038/s41385-022-00516-9. Epub 2022 May 2. PubMed
Daily changes in light influence mood via inhibitory networks within the thalamic perihabenular nucleus. Weil T, Daly KM, Yarur Castillo H, Thomsen MB, Wang H, Mercau ME, Hattar S, Tejeda H, Fernandez DC. Sci Adv. 2022 Jun 10;8(23):eabn3567. doi: 10.1126/sciadv.abn3567. Epub 2022 Jun 10. PubMed
Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue. Ojima K, Kakegawa W, Yamasaki T, Miura Y, Itoh M, Michibata Y, Kubota R, Doura T, Miura E, Nonaka H, Mizuno S, Takahashi S, Yuzaki M, Hamachi I, Kiyonaka S. Nat Commun. 2022 Jun 16;13(1):3167. doi: 10.1038/s41467-022-30828-0. PubMed
Single-scan volumetric imaging throughout thick tissue specimens by one-touch installable light-needle creating device. Chang CP, Otomo K, Kozawa Y, Ishii H, Yamasaki M, Watanabe M, Sato S, Enoki R, Nemoto T. Sci Rep. 2022 Jun 21;12(1):10468. doi: 10.1038/s41598-022-14647-3. PubMed

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