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pAAV-hSyn-DIO-hM3D(Gq)-mCherry Citations (55)

Plasmid Article: Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.
Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB J Clin Invest. 2011 Apr;121(4):1424-8. doi: 10.1172/JCI46229.
PubMed Journal

Articles Citing pAAV-hSyn-DIO-hM3D(Gq)-mCherry

Articles
Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons. Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M, Yamanaka A. Neuropharmacology. 2014 Oct;85:451-60. doi: 10.1016/j.neuropharm.2014.06.015. Epub 2014 Jun 18. PubMed
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Penagarikano O, Lazaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH. Sci Transl Med. 2015 Jan 21;7(271):271ra8. doi: 10.1126/scitranslmed.3010257. PubMed

Associated Plasmids

Neuronal ensembles sufficient for recovery sleep and the sedative actions of alpha2 adrenergic agonists. Zhang Z, Ferretti V, Guntan I, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP. Nat Neurosci. 2015 Apr;18(4):553-61. doi: 10.1038/nn.3957. Epub 2015 Feb 23. PubMed

Associated Plasmids

Wakefulness Is Governed by GABA and Histamine Cotransmission. Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W. Neuron. 2015 Jun 17. pii: S0896-6273(15)00516-4. doi: 10.1016/j.neuron.2015.06.003. PubMed

Associated Plasmids

Insular neural system controls decision-making in healthy and methamphetamine-treated rats. Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3930-9. doi: 10.1073/pnas.1418014112. Epub 2015 Jul 6. PubMed
A viral strategy for targeting and manipulating interneurons across vertebrate species. Dimidschstein J, Chen Q, Tremblay R, Rogers SL, Saldi GA, Guo L, Xu Q, Liu R, Lu C, Chu J, Avery MC, Rashid MS, Baek M, Jacob AL, Smith GB, Wilson DE, Kosche G, Kruglikov I, Rusielewicz T, Kotak VC, Mowery TM, Anderson SA, Callaway EM, Dasen JS, Fitzpatrick D, Fossati V, Long MA, Noggle S, Reynolds JH, Sanes DH, Rudy B, Feng G, Fishell G. Nat Neurosci. 2016 Oct 31. doi: 10.1038/nn.4430. PubMed

Associated Plasmids

A reliable and flexible gene manipulation strategy in posthatch zebra finch brain. Ahmadiantehrani S, London SE. Sci Rep. 2017 Feb 24;7:43244. doi: 10.1038/srep43244. PubMed
AgRP Neurons Can Increase Food Intake during Conditions of Appetite Suppression and Inhibit Anorexigenic Parabrachial Neurons. Essner RA, Smith AG, Jamnik AA, Ryba AR, Trutner ZD, Carter ME. J Neurosci. 2017 Sep 6;37(36):8678-8687. doi: 10.1523/JNEUROSCI.0798-17.2017. Epub 2017 Aug 7. PubMed
Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Resch JM, Fenselau H, Madara JC, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-Toth G, Naray-Fejes-Toth A, Geerling JC, Lowell BB. Neuron. 2017 Sep 27;96(1):190-206.e7. doi: 10.1016/j.neuron.2017.09.014. PubMed
Activation of endogenous arginine vasopressin neurons inhibit food intake: by using a novel transgenic rat line with DREADDs system. Yoshimura M, Nishimura K, Nishimura H, Sonoda S, Ueno H, Motojima Y, Saito R, Maruyama T, Nonaka Y, Ueta Y. Sci Rep. 2017 Nov 16;7(1):15728. doi: 10.1038/s41598-017-16049-2. PubMed
Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation. Gelegen C, Miracca G, Ran MZ, Harding EC, Ye Z, Yu X, Tossell K, Houston CM, Yustos R, Hawkins ED, Vyssotski AL, Dong HL, Wisden W, Franks NP. Curr Biol. 2018 Feb 19;28(4):580-587.e5. doi: 10.1016/j.cub.2017.12.050. Epub 2018 Feb 1. PubMed
Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed
The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Zelikowsky M, Hui M, Karigo T, Choe A, Yang B, Blanco MR, Beadle K, Gradinaru V, Deverman BE, Anderson DJ. Cell. 2018 May 17;173(5):1265-1279.e19. doi: 10.1016/j.cell.2018.03.037. PubMed
Adeno-associated Virus-mediated Transgene Expression in Genetically Defined Neurons of the Spinal Cord. Haenraets K, Albisetti GW, Foster E, Wildner H. J Vis Exp. 2018 May 12;(135). doi: 10.3791/57382. PubMed
Pyramidal cell regulation of interneuron survival sculpts cortical networks. Wong FK, Bercsenyi K, Sreenivasan V, Portales A, Fernandez-Otero M, Marin O. Nature. 2018 May;557(7707):668-673. doi: 10.1038/s41586-018-0139-6. Epub 2018 May 30. PubMed
Control of Feeding Behavior by Cerebral Ventricular Volume Transmission of Melanin-Concentrating Hormone. Noble EE, Hahn JD, Konanur VR, Hsu TM, Page SJ, Cortella AM, Liu CM, Song MY, Suarez AN, Szujewski CC, Rider D, Clarke JE, Darvas M, Appleyard SM, Kanoski SE. Cell Metab. 2018 Jul 3;28(1):55-68.e7. doi: 10.1016/j.cmet.2018.05.001. Epub 2018 May 31. PubMed
Four Key Steps Control Glycolytic Flux in Mammalian Cells. Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD. Cell Syst. 2018 Jul 25;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. Epub 2018 Jun 27. PubMed
A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus. Harding EC, Yu X, Miao A, Andrews N, Ma Y, Ye Z, Lignos L, Miracca G, Ba W, Yustos R, Vyssotski AL, Wisden W, Franks NP. Curr Biol. 2018 Jul 23;28(14):2263-2273.e4. doi: 10.1016/j.cub.2018.05.054. Epub 2018 Jul 12. PubMed

Associated Plasmids

Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure. Farzi A, Lau J, Ip CK, Qi Y, Shi YC, Zhang L, Tasan R, Sperk G, Herzog H. Elife. 2018 Aug 21;7. pii: 36494. doi: 10.7554/eLife.36494. PubMed
Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons. Wang L, Chen SR, Ma H, Chen H, Hittelman WN, Pan HL. J Neurochem. 2018 Nov;147(4):526-540. doi: 10.1111/jnc.14588. Epub 2018 Oct 31. PubMed
Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress. Alpar A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, Bakker J, Miklosi AG, Tretiakov E, Keimpema E, Arque G, Tasan RO, Sperk G, Malenczyk K, Mate Z, Erdelyi F, Szabo G, Lubec G, Palkovits M, Giordano A, Hokfelt TG, Romanov RA, Horvath TL, Harkany T. EMBO J. 2018 Nov 2;37(21). pii: embj.2018100087. doi: 10.15252/embj.2018100087. Epub 2018 Sep 12. PubMed
Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity. Calin A, Stancu M, Zagrean AM, Jefferys JGR, Ilie AS, Akerman CJ. Front Cell Neurosci. 2018 Sep 5;12:293. doi: 10.3389/fncel.2018.00293. eCollection 2018. PubMed
Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories. Chen JY, Campos CA, Jarvie BC, Palmiter RD. Neuron. 2018 Nov 21;100(4):891-899.e5. doi: 10.1016/j.neuron.2018.09.032. Epub 2018 Oct 18. PubMed
Convergent Inputs from the Hippocampus and Thalamus to the Nucleus Accumbens Regulate Dopamine Neuron Activity. Perez SM, Lodge DJ. J Neurosci. 2018 Dec 12;38(50):10607-10618. doi: 10.1523/JNEUROSCI.2629-16.2018. Epub 2018 Oct 24. PubMed
Hypothalamic Neurons that Regulate Feeding Can Influence Sleep/Wake States Based on Homeostatic Need. Goldstein N, Levine BJ, Loy KA, Duke WL, Meyerson OS, Jamnik AA, Carter ME. Curr Biol. 2018 Dec 3;28(23):3736-3747.e3. doi: 10.1016/j.cub.2018.09.055. Epub 2018 Nov 21. PubMed
Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State. Li C, Navarrete J, Liang-Guallpa J, Lu C, Funderburk SC, Chang RB, Liberles SD, Olson DP, Krashes MJ. Cell Metab. 2019 Mar 5;29(3):681-694.e5. doi: 10.1016/j.cmet.2018.10.016. Epub 2018 Nov 21. PubMed
GABA and glutamate neurons in the VTA regulate sleep and wakefulness. Yu X, Li W, Ma Y, Tossell K, Harris JJ, Harding EC, Ba W, Miracca G, Wang D, Li L, Guo J, Chen M, Li Y, Yustos R, Vyssotski AL, Burdakov D, Yang Q, Dong H, Franks NP, Wisden W. Nat Neurosci. 2019 Jan;22(1):106-119. doi: 10.1038/s41593-018-0288-9. Epub 2018 Dec 17. PubMed
NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice. Fergani C, Leon S, Padilla SL, Verstegen AM, Palmiter RD, Navarro VM. Elife. 2018 Dec 19;7. pii: 40476. doi: 10.7554/eLife.40476. PubMed
Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton JEV, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z. Nat Neurosci. 2019 Feb;22(2):205-217. doi: 10.1038/s41593-018-0311-1. Epub 2019 Jan 21. PubMed
The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits. Li MM, Madara JC, Steger JS, Krashes MJ, Balthasar N, Campbell JN, Resch JM, Conley NJ, Garfield AS, Lowell BB. Neuron. 2019 May 8;102(3):653-667.e6. doi: 10.1016/j.neuron.2019.02.028. Epub 2019 Mar 14. PubMed
Pathway specific activation of ventral hippocampal cells projecting to the prelimbic cortex diminishes fear renewal. Vasquez JH, Leong KC, Gagliardi CM, Harland B, Apicella AJ, Muzzio IA. Neurobiol Learn Mem. 2019 May;161:63-71. doi: 10.1016/j.nlm.2019.03.003. Epub 2019 Mar 18. PubMed
Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions. Ip CK, Zhang L, Farzi A, Qi Y, Clarke I, Reed F, Shi YC, Enriquez R, Dayas C, Graham B, Begg D, Bruning JC, Lee NJ, Hernandez-Sanchez D, Gopalasingam G, Koller J, Tasan R, Sperk G, Herzog H. Cell Metab. 2019 Jul 2;30(1):111-128.e6. doi: 10.1016/j.cmet.2019.04.001. Epub 2019 Apr 25. PubMed
Innervation of thermogenic adipose tissue via a calsyntenin 3beta-S100b axis. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Nature. 2019 May;569(7755):229-235. doi: 10.1038/s41586-019-1156-9. Epub 2019 May 1. PubMed
A Specialized Neural Circuit Gates Social Vocalizations in the Mouse. Tschida K, Michael V, Takatoh J, Han BX, Zhao S, Sakurai K, Mooney R, Wang F. Neuron. 2019 Aug 7;103(3):459-472.e4. doi: 10.1016/j.neuron.2019.05.025. Epub 2019 Jun 13. PubMed
The Lateral Hypothalamic and BNST GABAergic Projections to the Anterior Ventrolateral Periaqueductal Gray Regulate Feeding. Hao S, Yang H, Wang X, He Y, Xu H, Wu X, Pan L, Liu Y, Lou H, Xu H, Ma H, Xi W, Zhou Y, Duan S, Wang H. Cell Rep. 2019 Jul 16;28(3):616-624.e5. doi: 10.1016/j.celrep.2019.06.051. PubMed
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward. Parker KE, Pedersen CE, Gomez AM, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Kash TJ, Dougherty JD, Stuber GD, Bruchas MR. Cell. 2019 Jul 25;178(3):653-671.e19. doi: 10.1016/j.cell.2019.06.034. PubMed
Neuronal Activation Stimulates Cytomegalovirus Promoter-Driven Transgene Expression. Back S, Dossat A, Parkkinen I, Koivula P, Airavaara M, Richie CT, Chen YH, Wang Y, Harvey BK. Mol Ther Methods Clin Dev. 2019 Jul 3;14:180-188. doi: 10.1016/j.omtm.2019.06.006. eCollection 2019 Sep 13. PubMed
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. Cell Metab. 2019 Nov 5;30(5):987-996.e6. doi: 10.1016/j.cmet.2019.07.013. Epub 2019 Aug 22. PubMed
Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type Ca(2+) channels. Bavley CC, Fetcho RN, Burgdorf CE, Walsh AP, Fischer DK, Hall BS, Sayles NM, Contoreggi NH, Hackett JE, Antigua SA, Babij R, De Marco Garcia NV, Kash TL, Milner TA, Liston C, Rajadhyaksha AM. Mol Psychiatry. 2019 Sep 9. pii: 10.1038/s41380-019-0513-2. doi: 10.1038/s41380-019-0513-2. PubMed
Galanin Neurons Unite Sleep Homeostasis and alpha2-Adrenergic Sedation. Ma Y, Miracca G, Yu X, Harding EC, Miao A, Yustos R, Vyssotski AL, Franks NP, Wisden W. Curr Biol. 2019 Oct 7;29(19):3315-3322.e3. doi: 10.1016/j.cub.2019.07.087. Epub 2019 Sep 19. PubMed
Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning. Pomrenze MB, Giovanetti SM, Maiya R, Gordon AG, Kreeger LJ, Messing RO. Cell Rep. 2019 Oct 1;29(1):13-21.e4. doi: 10.1016/j.celrep.2019.08.083. PubMed

Associated Plasmids

High-potency ligands for DREADD imaging and activation in rodents and monkeys. Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M. Nat Commun. 2019 Oct 11;10(1):4627. doi: 10.1038/s41467-019-12236-z. PubMed
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, Umpierre AD, Zhu J, Bosco DB, Dong H, Wu LJ. Nat Neurosci. 2019 Nov;22(11):1771-1781. doi: 10.1038/s41593-019-0511-3. Epub 2019 Oct 21. PubMed
Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an alpha-synuclein based rat model for Parkinson's disease. Torre-Muruzabal T, Devoght J, Van den Haute C, Brone B, Van der Perren A, Baekelandt V. Acta Neuropathol Commun. 2019 Oct 22;7(1):160. doi: 10.1186/s40478-019-0814-3. PubMed
Prefrontal Corticotectal Neurons Enhance Visual Processing through the Superior Colliculus and Pulvinar Thalamus. Hu F, Kamigaki T, Zhang Z, Zhang S, Dan U, Dan Y. Neuron. 2019 Dec 18;104(6):1141-1152.e4. doi: 10.1016/j.neuron.2019.09.019. Epub 2019 Oct 23. PubMed
An Excitatory and Epileptogenic Effect of Dentate Gyrus Mossy Cells in a Mouse Model of Epilepsy. Botterill JJ, Lu YL, LaFrancois JJ, Bernstein HL, Alcantara-Gonzalez D, Jain S, Leary P, Scharfman HE. Cell Rep. 2019 Nov 26;29(9):2875-2889.e6. doi: 10.1016/j.celrep.2019.10.100. PubMed
Kisspeptin neuron-specific and self-sustained calcium oscillation in the hypothalamic arcuate nucleus of neonatal mice: Regulatory factors of its synchronization. Kim D, Jang S, Kim J, Park I, Ku K, Choi M, Lee S, Heo WD, Son GH, Choe HK, Kim K. Neuroendocrinology. 2020 Jan 15. pii: 000505922. doi: 10.1159/000505922. PubMed
Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice. Lee Y, Han NE, Kim W, Kim JG, Lee IB, Choi SJ, Chun H, Seo M, Lee CJ, Koh HY, Kim JH, Baik JH, Bear MF, Choi SY, Yoon BJ. Mol Cells. 2020 Apr 30;43(4):360-372. doi: 10.14348/molcells.2019.0279. PubMed
Pituitary Adenylate Cyclase Activating Polypeptide Excites Proopiomelanocortin Neurons: Implications for the Regulation of Energy Homeostasis. Chang R, Hernandez J, Gastelum C, Guadagno K, Perez L, Wagner EJ. Neuroendocrinology. 2020 Feb 7. pii: 000506367. doi: 10.1159/000506367. PubMed
A Novel Next-Generation Sequencing and Analysis Platform to Assess the Identity of Recombinant Adeno-Associated Viral Preparations from Viral DNA Extracts. Guerin K, Rego M, Bourges D, Ersing I, Haery L, Harten DeMaio K, Sanders E, Tasissa M, Kostman M, Tillgren M, Makana Hanley L, Mueller I, Mitsopoulos A, Fan M. Hum Gene Ther. 2020 Jun;31(11-12):664-678. doi: 10.1089/hum.2019.277. Epub 2020 Apr 15. PubMed
The Role of Dorsal Raphe Serotonin Neurons in the Balance between Reward and Aversion. Nagai Y, Takayama K, Nishitani N, Andoh C, Koda M, Shirakawa H, Nakagawa T, Nagayasu K, Yamanaka A, Kaneko S. Int J Mol Sci. 2020 Mar 21;21(6). pii: ijms21062160. doi: 10.3390/ijms21062160. PubMed
Memory trace interference impairs recall in a mouse model of Alzheimer's disease. Poll S, Mittag M, Musacchio F, Justus LC, Giovannetti EA, Steffen J, Wagner J, Zohren L, Schoch S, Schmidt B, Jackson WS, Ehninger D, Fuhrmann M. Nat Neurosci. 2020 Aug;23(8):952-958. doi: 10.1038/s41593-020-0652-4. Epub 2020 Jun 8. PubMed
Complex Movement Control in a Rat Model of Parkinsonian Falls: Bidirectional Control by Striatal Cholinergic Interneurons. Avila C, Kucinski A, Sarter M. J Neurosci. 2020 Jul 29;40(31):6049-6067. doi: 10.1523/JNEUROSCI.0220-20.2020. Epub 2020 Jun 18. PubMed
Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. Yu X, Ba W, Zhao G, Ma Y, Harding EC, Yin L, Wang D, Li H, Zhang P, Shi Y, Yustos R, Vyssotski AL, Dong H, Franks NP, Wisden W. Mol Psychiatry. 2020 Jun 17. pii: 10.1038/s41380-020-0810-9. doi: 10.1038/s41380-020-0810-9. PubMed
Immunohistochemical amplification of mCherry fusion protein is necessary for proper visualization. Falcy BA, Mohr MA, Micevych PE. MethodsX. 2020 Jun 2;7:100946. doi: 10.1016/j.mex.2020.100946. eCollection 2020. PubMed

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