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pLKO.1 puro Citations (217)

Plasmid Article: Lentivirus-delivered stable gene silencing by RNAi in primary cells.
Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD RNA 2003 Apr;9(4):493-501.
PubMed Journal

Articles Citing pLKO.1 puro

Articles
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. Wang L, Harris TE, Roth RA, Lawrence JC. J Biol Chem. 2007 Jul 6. 282(27):20036-44. PubMed

Associated Plasmids

Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR. Tzatsos A. J Biol Chem. 2009 Aug 21;284(34):22525-34. doi: 10.1074/jbc.M109.027748. Epub 2009 Jun 26. PubMed
Identification of prospective factors promoting osteotropism in breast cancer: a potential role for CITED2. Lau WM, Weber KL, Doucet M, Chou YT, Brady K, Kowalski J, Tsai HL, Yang J, Kominsky SL. Int J Cancer. 2010 Feb 15;126(4):876-84. doi: 10.1002/ijc.24780. PubMed
Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1beta release in human macrophages. Petrovski G, Ayna G, Majai G, Hodrea J, Benko S, Madi A, Fesus L. Autophagy. 2011 Mar;7(3):321-30. PubMed
Scavenger receptor WC1 contributes to the gammadelta T cell response to Leptospira. Wang F, Herzig CT, Chen C, Hsu H, Baldwin CL, Telfer JC. Mol Immunol. 2011 Mar;48(6-7):801-9. doi: 10.1016/j.molimm.2010.12.001. Epub 2011 Jan 11. PubMed
JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Delta716) mice. Fujishita T, Aoki M, Taketo MM. Gastroenterology. 2011 May;140(5):1556-63.e6. doi: 10.1053/j.gastro.2011.02.007. Epub 2011 Feb 12. PubMed
Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H. PLoS One. 2011 Mar 18;6(3):e17830. doi: 10.1371/journal.pone.0017830. PubMed
The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E. PLoS One. 2011 Apr 29;6(4):e19151. doi: 10.1371/journal.pone.0019151. PubMed
Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP. Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ. Oncogene. 2012 Jan 12;31(2):238-50. doi: 10.1038/onc.2011.224. Epub 2011 Jun 13. PubMed

Associated Plasmids

Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest. Daviau A, Couture JP, Blouin R. Biochem Biophys Res Commun. 2011 Sep 23;413(2):282-7. doi: 10.1016/j.bbrc.2011.08.086. Epub 2011 Aug 27. PubMed
Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. Belyea BC, Naini S, Bentley RC, Linardic CM. Clin Cancer Res. 2011 Dec 1;17(23):7324-36. doi: 10.1158/1078-0432.CCR-11-1004. Epub 2011 Sep 23. PubMed
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M, Parenti AR, Poletti A, Daidone MG, Dupont S, Basso G, Bicciato S, Piccolo S. Cell. 2011 Nov 11;147(4):759-72. doi: 10.1016/j.cell.2011.09.048. PubMed
FGF signalling inhibits neural induction in human embryonic stem cells. Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Arauzo-Bravo MJ, Han DW, Pape HC, Scholer HR. EMBO J. 2011 Nov 15;30(24):4874-84. doi: 10.1038/emboj.2011.407. PubMed
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI. Cell. 2011 Nov 23;147(5):1066-79. doi: 10.1016/j.cell.2011.10.039. PubMed
gamma-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis. Vinopal S, Cernohorska M, Sulimenko V, Sulimenko T, Vosecka V, Flemr M, Draberova E, Draber P. PLoS One. 2012;7(1):e29919. doi: 10.1371/journal.pone.0029919. Epub 2012 Jan 3. PubMed
The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer. Al Sorkhy M, Ferraiuolo RM, Jalili E, Malysa A, Fratiloiu AR, Sloane BF, Porter LA. BMC Cancer. 2012 Jan 26;12:45. doi: 10.1186/1471-2407-12-45. PubMed
Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Lee DF, Su J, Sevilla A, Gingold J, Schaniel C, Lemischka IR. Nat Protoc. 2012 Mar 22;7(4):729-48. doi: 10.1038/nprot.2012.018. PubMed
KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals. Moleirinho S, Chang N, Sims AH, Tilston-Lunel AM, Angus L, Steele A, Boswell V, Barnett SC, Ormandy C, Faratian D, Gunn-Moore FJ, Reynolds PA. Oncogene. 2012 May 21. doi: 10.1038/onc.2012.196. PubMed

Associated Plasmids

FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. Crose LE, Etheridge KT, Chen C, Belyea B, Talbot LJ, Bentley RC, Linardic CM. Clin Cancer Res. 2012 Jul 15;18(14):3780-90. doi: 10.1158/1078-0432.CCR-10-3063. Epub 2012 May 30. PubMed
Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing. Capshew CR, Dusenbury KL, Hundley HA. Nucleic Acids Res. 2012 Sep 1;40(17):8637-45. Epub 2012 Jun 25. PubMed
New insight into the SDF-1/CXCR4 axis in a breast carcinoma model: hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation. Jin F, Brockmeier U, Otterbach F, Metzen E. Mol Cancer Res. 2012 Aug;10(8):1021-31. doi: 10.1158/1541-7786.MCR-11-0498. Epub 2012 Jul 5. PubMed
The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance. Kumari R, Li H, Haudenschild DR, Fierro F, Carlson CS, Overn P, Gupta L, Gupta K, Nolta J, Yik JH, Di Cesare PE. Carcinogenesis. 2012 Nov;33(11):2076-83. doi: 10.1093/carcin/bgs254. Epub 2012 Jul 30. PubMed
High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell. Shin YJ, Kim MS, Kim MS, Lee J, Kang M, Jeong JH. Cancer Biol Ther. 2013 Mar;14(3):213-21. doi: 10.4161/cbt.23292. Epub 2012 Dec 19. PubMed
Gene transduction in human monocyte-derived dendritic cells using lentiviral vectors. Satoh T, Manel N. Methods Mol Biol. 2013;960:401-9. doi: 10.1007/978-1-62703-218-6_30. PubMed
alpha-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKalpha in vitro. Wang L, Brautigan DL. Nat Commun. 2013;4:1559. doi: 10.1038/ncomms2565. PubMed
Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease. Tang Z, Bereczki E, Zhang H, Wang S, Li C, Ji X, Branca RM, Lehtio J, Guan Z, Filipcik P, Xu S, Winblad B, Pei JJ. J Biol Chem. 2013 May 31;288(22):15556-70. doi: 10.1074/jbc.M112.435123. Epub 2013 Apr 12. PubMed
Cadherin-17 interacts with alpha2beta1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis. Bartolome RA, Barderas R, Torres S, Fernandez-Acenero MJ, Mendes M, Garcia-Foncillas J, Lopez-Lucendo M, Casal JI. Oncogene. 2014 Mar 27;33(13):1658-69. doi: 10.1038/onc.2013.117. Epub 2013 Apr 22. PubMed
Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbaurl H, Metzen E. J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40. doi: 10.1242/jcs.117564. Epub 2013 Apr 19. PubMed
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, Schmitt A, Poulain L, Green AS, Uzunov M, Kosmider O, Radford-Weiss I, Moura IC, Auberger P, Ifrah N, Bardet V, Chapuis N, Lacombe C, Mayeux P, Tamburini J, Bouscary D. Blood. 2013 Nov 14;122(20):3521-32. doi: 10.1182/blood-2013-03-493163. Epub 2013 Sep 6. PubMed
miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis. Fu X, Meng Z, Liang W, Tian Y, Wang X, Han W, Lou G, Wang X, Lou F, Yen Y, Yu H, Jove R, Huang W. Oncogene. 2014 Aug 21;33(34):4296-306. doi: 10.1038/onc.2013.385. Epub 2013 Sep 23. PubMed
Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4. Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y. Biochem Biophys Res Commun. 2013 Nov 1;440(4):623-9. doi: 10.1016/j.bbrc.2013.09.119. Epub 2013 Oct 5. PubMed
Lentiviral overexpression of miRNAs. Zollner H, Hahn SA, Maghnouj A. Methods Mol Biol. 2014;1095:177-90. doi: 10.1007/978-1-62703-703-7_15. PubMed
PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y. Development. 2014 Jan;141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11. PubMed
microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Offer SM, Butterfield GL, Jerde CR, Fossum CC, Wegner NJ, Diasio RB. Mol Cancer Ther. 2014 Mar;13(3):742-51. doi: 10.1158/1535-7163.MCT-13-0878. Epub 2014 Jan 8. PubMed
Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling. Spindler V, Dehner C, Hubner S, Waschke J. J Invest Dermatol. 2014 Jun;134(6):1655-64. doi: 10.1038/jid.2014.21. Epub 2014 Jan 17. PubMed
Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. Arthritis Rheumatol. 2014 Jun;66(6):1537-46. doi: 10.1002/art.38378. PubMed
Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Niu Y, Shen B, Cui Y, Chen Y, Wang J, Wang L, Kang Y, Zhao X, Si W, Li W, Xiang AP, Zhou J, Guo X, Bi Y, Si C, Hu B, Dong G, Wang H, Zhou Z, Li T, Tan T, Pu X, Wang F, Ji S, Zhou Q, Huang X, Ji W, Sha J. Cell. 2014 Feb 13;156(4):836-43. doi: 10.1016/j.cell.2014.01.027. Epub 2014 Jan 30. PubMed
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Shen B, Zhang W, Zhang J, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC. Nat Methods. 2014 Mar 2. doi: 10.1038/nmeth.2857. PubMed

Associated Plasmids

hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. Perez-Gonzalez A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A, Nieto A. PLoS One. 2014 Mar 7;9(3):e90957. doi: 10.1371/journal.pone.0090957. eCollection 2014. PubMed
Anoctamin 6 regulates C2C12 myoblast proliferation. Zhao P, Torcaso A, Mariano A, Xu L, Mohsin S, Zhao L, Han R. PLoS One. 2014 Mar 24;9(3):e92749. doi: 10.1371/journal.pone.0092749. eCollection 2014. PubMed

Associated Plasmids

ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. Yang Y, Ahn YH, Chen Y, Tan X, Guo L, Gibbons DL, Ungewiss C, Peng DH, Liu X, Lin SH, Thilaganathan N, Wistuba II, Rodriguez-Canales J, McLendon G, Creighton CJ, Kurie JM. J Clin Invest. 2014 Jun;124(6):2696-708. doi: 10.1172/JCI72171. Epub 2014 Apr 24. PubMed
MS4A8B promotes cell proliferation in prostate cancer. Ye L, Yao XD, Wan FN, Qu YY, Liu ZY, Shen XX, Li S, Liu XJ, Yue F, Wang N, Dai B, Ye DW. Prostate. 2014 Jun;74(9):911-22. doi: 10.1002/pros.22802. Epub 2014 Apr 30. PubMed
Murine norovirus: propagation, quantification, and genetic manipulation. Hwang S, Alhatlani B, Arias A, Caddy SL, Christodoulou C, Cunha JB, Emmott E, Gonzalez-Hernandez M, Kolawole A, Lu J, Rippinger C, Sorgeloos F, Thorne L, Vashist S, Goodfellow I, Wobus CE. Curr Protoc Microbiol. 2014 May 1;33:15K.2.1-61. doi: 10.1002/9780471729259.mc15k02s33. PubMed
SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma. Siegle JM, Basin A, Sastre-Perona A, Yonekubo Y, Brown J, Sennett R, Rendl M, Tsirigos A, Carucci JA, Schober M. Nat Commun. 2014 Jul 31;5:4511. doi: 10.1038/ncomms5511. PubMed
Goat activin receptor type IIB knockdown by muscle specific promoter driven artificial microRNAs. Patel AK, Shah RK, Patel UA, Tripathi AK, Joshi CG. J Biotechnol. 2014 Oct 10;187:87-97. doi: 10.1016/j.jbiotec.2014.07.450. Epub 2014 Aug 7. PubMed
Regulation of mitochondrial function and cellular energy metabolism by protein kinase C-lambda/iota: a novel mode of balancing pluripotency. Mahato B, Home P, Rajendran G, Paul A, Saha B, Ganguly A, Ray S, Roy N, Swerdlow RH, Paul S. Stem Cells. 2014 Nov;32(11):2880-92. doi: 10.1002/stem.1817. PubMed
ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells. Plotnik JP, Budka JA, Ferris MW, Hollenhorst PC. Nucleic Acids Res. 2014 Oct 29;42(19):11928-40. doi: 10.1093/nar/gku929. Epub 2014 Oct 7. PubMed
An optical labeling-based proliferation assay system reveals the paracrine effect of interleukin-6 in breast cancer. Itou J, Tanaka S, Sato F, Akiyama R, Kawakami Y, Toi M. Biochim Biophys Acta. 2015 Jan;1853(1):27-40. doi: 10.1016/j.bbamcr.2014.10.004. Epub 2014 Oct 12. PubMed
JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress. Kostecka A, Sznarkowska A, Meller K, Acedo P, Shi Y, Mohammad Sakil HA, Kawiak A, Lion M, Krolicka A, Wilhelm M, Inga A, Zawacka-Pankau J. Cell Death Dis. 2014 Oct 23;5:e1484. doi: 10.1038/cddis.2014.408. PubMed
MicroRNA-29c/PTEN pathway is involved in mice brain development and modulates neurite outgrowth in PC12 cells. Zou H, Ding Y, Shi W, Xu X, Gong A, Zhang Z, Liu J. Cell Mol Neurobiol. 2015 Apr;35(3):313-22. doi: 10.1007/s10571-014-0126-x. Epub 2014 Oct 29. PubMed
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Mitter SK, Song C, Qi X, Mao H, Rao H, Akin D, Lewin A, Grant M, Dunn W Jr, Ding J, Bowes Rickman C, Boulton M. Autophagy. 2014;10(11):1989-2005. doi: 10.4161/auto.36184. PubMed
YAP-mediated induction of monoacylglycerol lipase restrains oncogenic transformation. Tang ED, Wang CY. Cell Signal. 2015 Apr;27(4):836-40. doi: 10.1016/j.cellsig.2015.01.011. Epub 2015 Jan 28. PubMed
GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells. Bilal MY, Zhang EY, Dinkel B, Hardy D, Yankee TM, Houtman JC. Cell Signal. 2015 Apr;27(4):841-50. doi: 10.1016/j.cellsig.2015.01.012. Epub 2015 Jan 28. PubMed
EWI-2 negatively regulates TGF-beta signaling leading to altered melanoma growth and metastasis. Wang HX, Sharma C, Knoblich K, Granter SR, Hemler ME. Cell Res. 2015 Mar;25(3):370-85. doi: 10.1038/cr.2015.17. Epub 2015 Feb 6. PubMed
MicroRNA-29A/PTEN pathway modulates neurite outgrowth in PC12 cells. Zou H, Ding Y, Wang K, Xiong E, Peng W, Du F, Zhang Z, Liu J, Gong A. Neuroscience. 2015 Apr 16;291:289-300. doi: 10.1016/j.neuroscience.2015.01.055. Epub 2015 Feb 7. PubMed
miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta. Zhang XF, Li KK, Gao L, Li SZ, Chen K, Zhang JB, Wang D, Tu RF, Zhang JX, Tao KX, Wang G, Zhang XD. Oncotarget. 2015 Feb 28;6(6):4144-58. PubMed
GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-gamma1 Activation and Cytokine Production. Bilal MY, Houtman JC. Front Immunol. 2015 Mar 30;6:141. doi: 10.3389/fimmu.2015.00141. eCollection 2015. PubMed
Leukemia stem cells in T-ALL require active Hif1alpha and Wnt signaling. Giambra V, Jenkins CE, Lam SH, Hoofd C, Belmonte M, Wang X, Gusscott S, Gracias D, Weng AP. Blood. 2015 Jun 18;125(25):3917-27. doi: 10.1182/blood-2014-10-609370. Epub 2015 May 1. PubMed
Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia. Sujobert P, Poulain L, Paubelle E, Zylbersztejn F, Grenier A, Lambert M, Townsend EC, Brusq JM, Nicodeme E, Decrooqc J, Nepstad I, Green AS, Mondesir J, Hospital MA, Jacque N, Christodoulou A, Desouza TA, Hermine O, Foretz M, Viollet B, Lacombe C, Mayeux P, Weinstock DM, Moura IC, Bouscary D, Tamburini J. Cell Rep. 2015 Jun 9;11(9):1446-57. doi: 10.1016/j.celrep.2015.04.063. Epub 2015 May 21. PubMed
Optimization of methods for the genetic modification of human T cells. Bilal MY, Vacaflores A, Houtman JC. Immunol Cell Biol. 2015 Nov;93(10):896-908. doi: 10.1038/icb.2015.59. Epub 2015 Jun 1. PubMed
Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. Kephart JJ, Tiller RG, Crose LE, Slemmons KK, Chen PH, Hinson AR, Bentley RC, Chi JT, Linardic CM. Clin Cancer Res. 2015 Nov 1;21(21):4868-80. doi: 10.1158/1078-0432.CCR-14-1797. Epub 2015 Jun 12. PubMed
Critical role of Wnt/beta-catenin signaling in driving epithelial ovarian cancer platinum resistance. Nagaraj AB, Joseph P, Kovalenko O, Singh S, Armstrong A, Redline R, Resnick K, Zanotti K, Waggoner S, DiFeo A. Oncotarget. 2015 Sep 15;6(27):23720-34. PubMed
Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition. Jacque N, Ronchetti AM, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Thiago TT, Lambert M, Poulain L, Hospital MA, Sujobert P, Joseph L, Chapuis N, Lacombe C, Moura IC, Demo S, Sarry JE, Recher C, Mayeux P, Tamburini J, Bouscary D. Blood. 2015 Sep 10;126(11):1346-56. doi: 10.1182/blood-2015-01-621870. Epub 2015 Jul 17. PubMed
The Glycogen Synthase Kinase 3alpha and beta Isoforms Differentially Regulates Interleukin-12p40 Expression in Endothelial Cells Stimulated with Peptidoglycan from Staphylococcus aureus. Cortes-Vieyra R, Silva-Garcia O, Oviedo-Boyso J, Huante-Mendoza A, Bravo-Patino A, Valdez-Alarcon JJ, Finlay BB, Baizabal-Aguirre VM. PLoS One. 2015 Jul 22;10(7):e0132867. doi: 10.1371/journal.pone.0132867. eCollection 2015. PubMed
Myosin 1b Regulates Amino Acid Transport by Associating Transporters with the Apical Plasma Membrane of Kidney Cells. Komaba S, Coluccio LM. PLoS One. 2015 Sep 11;10(9):e0138012. doi: 10.1371/journal.pone.0138012. eCollection 2015. PubMed
LDL suppresses angiogenesis through disruption of the HIF pathway via NF-kappaB inhibition which is reversed by the proteasome inhibitor BSc2118. Yao G, Zhang Q, Doeppner TR, Niu F, Li Q, Yang Y, Kuckelkorn U, Hagemann N, Li W, Hermann DM, Dai Y, Zhou W, Jin F. Oncotarget. 2015 Oct 6;6(30):30251-62. doi: 10.18632/oncotarget.4943. PubMed
Paclitaxel-induced transcriptional regulation of Fas signaling pathway is antagonized by dexamethasone. Crozier M, Porter LA. Breast Cancer Res Treat. 2015 Nov;154(1):33-44. PubMed
Transcription factor CREB3L1 mediates cAMP and glucocorticoid regulation of arginine vasopressin gene transcription in the rat hypothalamus. Greenwood M, Greenwood MP, Mecawi AS, Loh SY, Rodrigues JA, Paton JF, Murphy D. Mol Brain. 2015 Oct 26;8(1):68. doi: 10.1186/s13041-015-0159-1. PubMed
Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-beta/RUNX axis. Anderson BD, Harris RS. Sci Adv. 2015 Sep 18;1(8):e1500296. doi: 10.1126/sciadv.1500296. eCollection 2015 Sep. PubMed
Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins. Koh S, Kim N, Yin HH, Harris IR, Dejneka NS, Eroglu C. J Neurosci. 2015 Nov 25;35(47):15649-65. doi: 10.1523/JNEUROSCI.1364-15.2015. PubMed
Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation. Greenwood MP, Greenwood M, Mecawi AS, Antunes-Rodrigues J, Paton JF, Murphy D. Mol Brain. 2016 Jan 7;9(1):1. doi: 10.1186/s13041-015-0182-2. PubMed
WNT/beta-catenin signaling mediates human neural crest induction via a pre-neural border intermediate. Leung AW, Murdoch B, Salem AF, Prasad MS, Gomez GA, Garcia-Castro MI. Development. 2016 Feb 1;143(3):398-410. doi: 10.1242/dev.130849. PubMed
Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL. Le Pen J, Laurent M, Sarosiek K, Vuillier C, Gautier F, Montessuit S, Martinou JC, Letai A, Braun F, Juin PP. Cell Death Dis. 2016 Feb 4;7:e2083. doi: 10.1038/cddis.2015.400. PubMed
CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Wright HJ, Arulmoli J, Motazedi M, Nelson LJ, Heinemann FS, Flanagan LA, Razorenova OV. Oncogene. 2016 Feb 15. doi: 10.1038/onc.2016.7. PubMed
Increased risk of interstitial lung disease in children with a single R288K variant of ABCA3. Wittmann T, Frixel S, Hoppner S, Schindlbeck U, Schams A, Kappler MV, Hegermann J, Wrede C, Liebisch G, Vierzig A, Zacharasiewicz A, Kopp M, Poets CF, Baden W, Hartl D, Van Kaam AH, Lohse P, Aslanidis C, Zarbock R, Griese M. Mol Med. 2016 Feb 26. pii: molmed.2015.00244. doi: 10.2119/molmed.2015.00244. PubMed
E-Cadherin repression increases amount of cancer stem cells in human A549 lung adenocarcinoma and stimulates tumor growth. Farmakovskaya M, Khromova N, Rybko V, Dugina V, Kopnin B, Kopnin P. Cell Cycle. 2016 Apr 17;15(8):1084-92. doi: 10.1080/15384101.2016.1156268. PubMed
Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates. Song HY, Park SH, Kang HJ, Vassilopoulos A. J Vis Exp. 2016 Feb 27;(108). doi: 10.3791/53563. PubMed
A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells. Li W, Itou J, Tanaka S, Nishimura T, Sato F, Toi M. Exp Cell Res. 2016 May 1;343(2):177-89. doi: 10.1016/j.yexcr.2016.03.023. Epub 2016 Mar 28. PubMed
A CRISPR-Based Toolbox for Studying T Cell Signal Transduction. Chi S, Weiss A, Wang H. Biomed Res Int. 2016;2016:5052369. doi: 10.1155/2016/5052369. Epub 2016 Feb 1. PubMed
ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells. Wang Y, Li Y, Guo C, Lu Q, Wang W, Jia Z, Chen P, Ma K, Reinberg D, Zhou C. Nucleic Acids Res. 2016 Apr 21. pii: gkw301. PubMed
Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness. Nguyen A, Yoshida M, Goodarzi H, Tavazoie SF. Nat Commun. 2016 May 3;7:11246. doi: 10.1038/ncomms11246. PubMed
KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification. Tetreault MP, Weinblatt D, Shaverdashvili K, Yang Y, Katz JP. Sci Rep. 2016 May 17;6:26130. doi: 10.1038/srep26130. PubMed
Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells. Tilston-Lunel AM, Haley KE, Schlecht NF, Wang Y, Chatterton AL, Moleirinho S, Watson A, Hundal HS, Prystowsky MB, Gunn-Moore FJ, Reynolds PA. J Mol Cell Biol. 2016 Apr 18. pii: mjw020. PubMed
CITED2 Modulates Breast Cancer Metastatic Ability Through Effects on IKKalpha. Jayaraman S, Doucet M, Lau WM, Kominsky SL. Mol Cancer Res. 2016 May 23. pii: molcanres.0081.2016. PubMed
Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CW, Ma VW, Yip TT, Au JS, Hao Q, Cheung KH, Wu W, Li GR, Yue J. Autophagy. 2016 Aug 2;12(8):1340-54. doi: 10.1080/15548627.2016.1187365. Epub 2016 May 31. PubMed
MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10. Lin J, He S, Sun X, Franck G, Deng Y, Yang D, Haemmig S, Wara AK, Icli B, Li D, Feinberg MW. FASEB J. 2016 Jun 13. pii: fj.201500163R. PubMed
Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma. Benhamou Y, Picco V, Raybaud H, Sudaka A, Chamorey E, Brolih S, Monteverde M, Merlano M, Lo Nigro C, Ambrosetti D, Pages G. Oncotarget. 2016 Jul 12;7(28):44236-44251. doi: 10.18632/oncotarget.10005. PubMed
Regulation of Laminin gamma2 Expression by CDX2 in Colonic Epithelial Cells Is Impaired During Active Inflammation. Coskun M, Soendergaard C, Joergensen S, Dahlgaard K, Riis LB, Nielsen OH, Sandelin A, Troelsen JT. J Cell Biochem. 2016 Jun 23. doi: 10.1002/jcb.25636. PubMed
Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration. Xu JY, Lee YK, Ran X, Liao SY, Yang J, Au KW, Lai WH, Esteban MA, Tse HF. Stem Cells. 2016 Jun 22. doi: 10.1002/stem.2438. PubMed
Screening of Human cDNA Library Reveals Two differentiation-Related Genes, HHEX and HLX, as Promoters of Early Phase Reprogramming toward Pluripotency. Yamakawa T, Sato Y, Matsumura Y, Kobayashi Y, Kawamura Y, Goshima N, Yamanaka S, Okita K. Stem Cells. 2016 Jun 22. doi: 10.1002/stem.2436. PubMed
Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1. Chen G, Gong R, Shi X, Yang D, Zhang G, Lu A, Yue J, Bian Z. Oncotarget. 2016 Aug 2;7(31):50302-50314. doi: 10.18632/oncotarget.10367. PubMed
Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/beta-catenin inhibition. De Pauw A, Massion P, Sekkali B, Andre E, Dubroca C, Kmecova J, Bouzin C, Friart A, Sibille C, Gilon P, De Mulder D, Esfahani H, Strapart A, Martherus R, Payen V, Sonveaux P, Brouckaert P, Janssens S, Balligand JL. Cardiovasc Res. 2016 Oct;112(1):478-90. doi: 10.1093/cvr/cvw196. Epub 2016 Aug 12. PubMed
Adipose- and muscle-derived Wnts trigger pancreatic beta-cell adaptation to systemic insulin resistance. Kozinski K, Jazurek M, Dobrzyn P, Janikiewicz J, Kolczynska K, Gajda A, Dobrzyn A. Sci Rep. 2016 Aug 16;6:31553. doi: 10.1038/srep31553. PubMed
Directing cellular information flow via CRISPR signal conductors. Liu Y, Zhan Y, Chen Z, He A, Li J, Wu H, Liu L, Zhuang C, Lin J, Guo X, Zhang Q, Huang W, Cai Z. Nat Methods. 2016 Nov;13(11):938-944. doi: 10.1038/nmeth.3994. Epub 2016 Sep 5. PubMed
MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. Chanda D, Li J, Oligschlaeger Y, Jeurissen ML, Houben T, Walenbergh SM, Shiri-Sverdlov R, Neumann D. Exp Mol Med. 2016 Sep 9;48:e258. doi: 10.1038/emm.2016.79. PubMed
An alternative splicing program promotes adipose tissue thermogenesis. Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. Elife. 2016 Sep 16;5. pii: e17672. doi: 10.7554/eLife.17672. PubMed
Localized translation regulates cell adhesion and transendothelial migration. Bergeman J, Caillier A, Houle F, Gagne LM, Huot ME. J Cell Sci. 2016 Nov 1;129(21):4105-4117. Epub 2016 Sep 16. PubMed
CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling. Narayanaswamy PB, Tkachuk S, Haller H, Dumler I, Kiyan Y. Cell Death Dis. 2016 Sep 29;7(9):e2383. doi: 10.1038/cddis.2016.291. PubMed
Serum starvation induces anti-apoptotic cIAP1 to promote mitophagy through ubiquitination. Mukhopadhyay S, Naik PP, Panda PK, Sinha N, Das DN, Bhutia SK. Biochem Biophys Res Commun. 2016 Oct 28;479(4):940-946. doi: 10.1016/j.bbrc.2016.09.143. Epub 2016 Sep 28. PubMed
HOXB4 Gene Expression Is Regulated by CDX2 in Intestinal Epithelial Cells. Jorgensen S, Coskun M, Homburg KM, Pedersen OB, Troelsen JT. PLoS One. 2016 Oct 18;11(10):e0164555. doi: 10.1371/journal.pone.0164555. eCollection 2016. PubMed
SIKs control osteocyte responses to parathyroid hormone. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. Nat Commun. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176. PubMed
The Sal-like 4 - integrin alpha6beta1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells. Itou J, Tanaka S, Li W, Iida A, Sehara-Fujisawa A, Sato F, Toi M. Biochim Biophys Acta. 2017 Jan;1864(1):76-88. doi: 10.1016/j.bbamcr.2016.10.012. Epub 2016 Oct 20. PubMed
PAR1 Scaffolds TGFbetaRII to Downregulate TGF-beta Signaling and Activate ESC Differentiation to Endothelial Cells. Gong H, An S, Sassmann A, Liu M, Mastej V, Mittal M, Zhang W, Hong Z, Offermanns S, Rehman J, Malik AB. Stem Cell Reports. 2016 Dec 13;7(6):1050-1058. doi: 10.1016/j.stemcr.2016.10.006. Epub 2016 Nov 17. PubMed
PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency. Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, Kawaguchi M, Kashida H, Nakajima A, Tachibana M, Seki Y. Stem Cell Reports. 2016 Dec 13;7(6):1072-1086. doi: 10.1016/j.stemcr.2016.10.007. Epub 2016 Nov 17. PubMed
SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Shi B, Huang QQ, Birkett R, Doyle R, Dorfleutner A, Stehlik C, He C, Pope RM. Autophagy. 2016 Dec 8:1-17. doi: 10.1080/15548627.2016.1261238. PubMed
Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1334-1340. doi: 10.1016/j.bbrc.2016.12.037. Epub 2016 Dec 7. PubMed
Down-regulation of CITED2 attenuates breast tumor growth, vessel formation and TGF-beta-induced expression of VEGFA. Jayaraman S, Doucet M, Kominsky SL. Oncotarget. 2017 Jan 24;8(4):6169-6178. doi: 10.18632/oncotarget.14048. PubMed
Small Interfering RNA Targeting Dickkopf-1 Contributes to Neuroprotection After Intracerebral Hemorrhage in Rats. Li Z, Chen X, Zhang X, Ren X, Chen X, Cao J, Zang W, Liu X, Guo F. J Mol Neurosci. 2017 Feb;61(2):279-288. doi: 10.1007/s12031-017-0883-3. Epub 2017 Jan 17. PubMed
Interaction with ZMYND11 mediates opposing roles of Ras-responsive transcription factors ETS1 and ETS2. Plotnik JP, Hollenhorst PC. Nucleic Acids Res. 2017 May 5;45(8):4452-4462. doi: 10.1093/nar/gkx039. PubMed
Requirement of Hsp105 in CoCl2-induced HIF-1alpha accumulation and transcriptional activation. Mikami H, Saito Y, Okamoto N, Kakihana A, Kuga T, Nakayama Y. Exp Cell Res. 2017 Mar 15;352(2):225-233. doi: 10.1016/j.yexcr.2017.02.004. Epub 2017 Feb 6. PubMed
CBX3 promotes colon cancer cell proliferation by CDK6 kinase-independent function during cell cycle. Fan Y, Li H, Liang X, Xiang Z. Oncotarget. 2017 Mar 21;8(12):19934-19946. doi: 10.18632/oncotarget.15253. PubMed
Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer. Zhang XF, Tu R, Li K, Ye P, Cui X. J Cell Biochem. 2017 Mar 18. doi: 10.1002/jcb.25995. PubMed
The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner. Ota K, Tong KI, Goto K, Tomida S, Komuro A, Wang Z, Nishio K, Okada H. PLoS One. 2017 Mar 20;12(3):e0173713. doi: 10.1371/journal.pone.0173713. eCollection 2017. PubMed
2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes. Chanda D, Oligschlaeger Y, Geraets I, Liu Y, Zhu X, Li J, Nabben M, Coumans W, Luiken JJFP, Glatz JFC, Neumann D. J Biol Chem. 2017 Apr 28;292(17):7105-7114. doi: 10.1074/jbc.M116.767384. Epub 2017 Mar 20. PubMed
The cyclin-like protein, SPY1, regulates the ERalpha and ERK1/2 pathways promoting tamoxifen resistance. Ferraiuolo RM, Tubman J, Sinha I, Hamm C, Porter LA. Oncotarget. 2017 Apr 4;8(14):23337-23352. doi: 10.18632/oncotarget.15578. PubMed
Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression. Liu Y, Zhang Z, Liang H, Zhao X, Liang L, Wang G, Yang J, Jin Y, McNutt MA, Yin Y. Sci Rep. 2017 May 9;7(1):1630. doi: 10.1038/s41598-017-01915-w. PubMed
SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways. Tang F, Hu P, Yang Z, Xue C, Gong J, Sun S, Shi L, Zhang S, Li Z, Yang C, Zhang J, Xie C. Oncol Rep. 2017 Jun;37(6):3449-3458. doi: 10.3892/or.2017.5635. Epub 2017 May 10. PubMed
Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. Balasubramaniam SL, Gopalakrishnapillai A, Petrelli NJ, Barwe SP. J Biol Chem. 2017 Jul 7;292(27):11388-11399. doi: 10.1074/jbc.M116.752352. Epub 2017 May 26. PubMed
SOD2 Facilitates the Antiviral Innate Immune Response by Scavenging Reactive Oxygen Species. Wang W, Jin Y, Zeng N, Ruan Q, Qian F. Viral Immunol. 2017 Jun 2. doi: 10.1089/vim.2017.0043. PubMed
A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer. Zhao X, Wang X, Fang L, Lan C, Zheng X, Wang Y, Zhang Y, Han X, Liu S, Cheng K, Zhao Y, Shi J, Guo J, Hao J, Ren H, Nie G. Cancer Lett. 2017 Aug 28;402:61-70. doi: 10.1016/j.canlet.2017.05.015. Epub 2017 May 30. PubMed
Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Deb Roy A, Yin T, Choudhary S, Rodionov V, Pilbeam CC, Wu YI. Nat Commun. 2017 Jun 21;8:15831. doi: 10.1038/ncomms15831. PubMed
KIBRA attains oncogenic activity by repressing RASSF1A. Anuj, Arivazhagan L, Surabhi RP, Kanakarajan A, Sundaram S, Pitani RS, Mudduwa L, Kremerskothen J, Venkatraman G, Rayala SK. Br J Cancer. 2017 Jun 29. pii: bjc2017192. doi: 10.1038/bjc.2017.192. PubMed
Role of transient receptor potential channel 6 in the odontogenic differentiation of human dental pulp cells. Yang X, Song Z, Chen L, Wang R, Huang S, Qin W, Guo J, Lin Z. Exp Ther Med. 2017 Jul;14(1):73-78. doi: 10.3892/etm.2017.4471. Epub 2017 May 18. PubMed
DeltaNp73 regulates the expression of the multidrug-resistance genes ABCB1 and ABCB5 in breast cancer and melanoma cells - a short report. Sakil HAM, Stantic M, Wolfsberger J, Brage SE, Hansson J, Wilhelm MT. Cell Oncol (Dordr). 2017 Dec;40(6):631-638. doi: 10.1007/s13402-017-0340-x. Epub 2017 Jul 4. PubMed
A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a 'self-cleaving' GFP-expression plasmid. Talas A, Kulcsar PI, Weinhardt N, Borsy A, Toth E, Szebenyi K, Krausz SL, Huszar K, Vida I, Sturm A, Gordos B, Hoffmann OI, Bencsura P, Nyeste A, Ligeti Z, Fodor E, Welker E. DNA Res. 2017 Jun 30. doi: 10.1093/dnares/dsx029. PubMed

Associated Plasmids

MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Abernathy DG, Kim WK, McCoy MJ, Lake AM, Ouwenga R, Lee SW, Xing X, Li D, Lee HJ, Heuckeroth RO, Dougherty JD, Wang T, Yoo AS. Cell Stem Cell. 2017 Sep 7;21(3):332-348.e9. doi: 10.1016/j.stem.2017.08.002. PubMed
A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. Slemmons KK, Crose LES, Riedel S, Sushnitha M, Belyea B, Linardic CM. Mol Cancer Res. 2017 Dec;15(12):1777-1791. doi: 10.1158/1541-7786.MCR-17-0004. Epub 2017 Sep 18. PubMed
Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment. Nagaraj AB, Wang QQ, Joseph P, Zheng C, Chen Y, Kovalenko O, Singh S, Armstrong A, Resnick K, Zanotti K, Waggoner S, Xu R, DiFeo A. Oncogene. 2018 Jan 18;37(3):403-414. doi: 10.1038/onc.2017.328. Epub 2017 Oct 2. PubMed
MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1. Idica A, Sevrioukov EA, Zisoulis DG, Hamdorf M, Daugaard I, Kadandale P, Pedersen IM. J Biol Chem. 2017 Dec 15;292(50):20494-20508. doi: 10.1074/jbc.M117.807677. Epub 2017 Oct 3. PubMed
Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice. Lee S, Kivimae S, Szoka FC. Mol Ther Methods Clin Dev. 2017 Sep 7;7:60-73. doi: 10.1016/j.omtm.2017.08.007. eCollection 2017 Dec 15. PubMed
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Shukla S, Cyrta J, Murphy DA, Walczak EG, Ran L, Agrawal P, Xie Y, Chen Y, Wang S, Zhan Y, Li D, Wong EWP, Sboner A, Beltran H, Mosquera JM, Sher J, Cao Z, Wongvipat J, Koche RP, Gopalan A, Zheng D, Rubin MA, Scher HI, Chi P, Chen Y. Cancer Cell. 2017 Dec 11;32(6):792-806.e7. doi: 10.1016/j.ccell.2017.10.008. Epub 2017 Nov 16. PubMed
Regulation of cAMP Responsive Element Binding Protein 3-Like 1 (Creb3l1) Expression by Orphan Nuclear Receptor Nr4a1. Greenwood MP, Greenwood M, Gillard BT, Chitra Devi R, Murphy D. Front Mol Neurosci. 2017 Dec 12;10:413. doi: 10.3389/fnmol.2017.00413. eCollection 2017. PubMed
SALL4 - KHDRBS3 network enhances stemness by modulating CD44 splicing in basal-like breast cancer. Matsumoto Y, Itou J, Sato F, Toi M. Cancer Med. 2018 Feb;7(2):454-462. doi: 10.1002/cam4.1296. Epub 2018 Jan 22. PubMed
CITED2 attenuates macrophage recruitment concordant with the downregulation of CCL20 in breast cancer cells. Jayaraman S, Doucet M, Kominsky SL. Oncol Lett. 2018 Jan;15(1):871-878. doi: 10.3892/ol.2017.7420. Epub 2017 Nov 15. PubMed
Picornavirus 2A protease regulates stress granule formation to facilitate viral translation. Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, Qin Y, Chen M. PLoS Pathog. 2018 Feb 7;14(2):e1006901. doi: 10.1371/journal.ppat.1006901. eCollection 2018 Feb. PubMed
Polycomb Protein Eed is Required for Neurogenesis and Cortical Injury Activation in the Subventricular Zone. Sun B, Chang E, Gerhartl A, Szele FG. Cereb Cortex. 2018 Apr 1;28(4):1369-1382. doi: 10.1093/cercor/bhx289. PubMed
The contribution of SP100 to cottontail rabbit papillomavirus transcription and replication. Wurdak M, Schneider M, Iftner T, Stubenrauch F. J Gen Virol. 2018 Jan 24. doi: 10.1099/jgv.0.001012. PubMed
A negative feedback regulation of MTORC1 activity by the lysosomal Ca(2+) channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism. Sun X, Yang Y, Zhong XZ, Cao Q, Zhu XH, Zhu X, Dong XP. Autophagy. 2018;14(1):38-52. doi: 10.1080/15548627.2017.1389822. Epub 2018 Feb 20. PubMed
Pre-B cell leukemia transcription factor 3 induces inflammatory responses in human umbilical vein endothelial cells and murine sepsis via acting a competing endogenous RNA for high mobility group box 1 protein. Zhang Y, Feng J, Cui J, Yang G, Zhu X. Mol Med Rep. 2018 Apr;17(4):5805-5813. doi: 10.3892/mmr.2018.8609. Epub 2018 Feb 15. PubMed
AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity. Brolih S, Parks SK, Vial V, Durivault J, Mostosi L, Pouyssegur J, Pages G, Picco V. BMC Cancer. 2018 Mar 5;18(1):249. doi: 10.1186/s12885-018-4169-0. PubMed
Sal-like 4 protein levels in breast cancer cells are post-translationally down-regulated by tripartite motif-containing 21. Itou J, Li W, Ito S, Tanaka S, Matsumoto Y, Sato F, Toi M. J Biol Chem. 2018 Apr 27;293(17):6556-6564. doi: 10.1074/jbc.RA117.000245. Epub 2018 Mar 6. PubMed
Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci. Amaral PP, Leonardi T, Han N, Vire E, Gascoigne DK, Arias-Carrasco R, Buscher M, Pandolfini L, Zhang A, Pluchino S, Maracaja-Coutinho V, Nakaya HI, Hemberg M, Shiekhattar R, Enright AJ, Kouzarides T. Genome Biol. 2018 Mar 15;19(1):32. doi: 10.1186/s13059-018-1405-5. PubMed
Impairment of an Endothelial NAD(+)-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Trevino-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. PubMed
Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid Atrophy. Lesovaya E, Agarwal S, Readhead B, Vinokour E, Baida G, Bhalla P, Kirsanov K, Yakubovskaya M, Platanias LC, Dudley JT, Budunova I. J Invest Dermatol. 2018 Sep;138(9):1935-1944. doi: 10.1016/j.jid.2018.02.045. Epub 2018 Mar 27. PubMed
Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Xu W, Chen C, Xu R, Li Y, Hu R, Li Z, Zhu X. Biomed Pharmacother. 2018 Jun;102:587-593. doi: 10.1016/j.biopha.2018.03.098. Epub 2018 Apr 5. PubMed
The Forkhead Transcription Factor FOXC2 Is Required for Maintaining Murine Spermatogonial Stem Cells. Wei C, Lin H, Cui S. Stem Cells Dev. 2018 May 1;27(9):624-636. doi: 10.1089/scd.2017.0233. Epub 2018 Apr 26. PubMed
A rare variant in MLKL confers susceptibility to ApoE varepsilon4-negative Alzheimer's disease in Hong Kong Chinese population. Wang B, Bao S, Zhang Z, Zhou X, Wang J, Fan Y, Zhang Y, Li Y, Chen L, Jia Y, Li J, Li M, Zheng W, Mu N, Wang L, Yu Z, Wong DSM, Zhang Y, Kwan J, Ka-Fung Mak H, Ambalavanan A, Zhou S, Cai W, Zheng J, Huang S, Rouleau GA, Yang W, Rogaeva E, Ma X, St George-Hyslop P, Chu LW, Song YQ. Neurobiol Aging. 2018 Aug;68:160.e1-160.e7. doi: 10.1016/j.neurobiolaging.2018.03.006. Epub 2018 Mar 10. PubMed
A novel heme oxygenase-1 splice variant, 14kDa HO-1, promotes cell proliferation and increases relative telomere length. Bian C, Zhong M, Nisar MF, Wu Y, Ouyang M, Bartsch JW, Zhong JL. Biochem Biophys Res Commun. 2018 Jun 2;500(2):429-434. doi: 10.1016/j.bbrc.2018.04.096. Epub 2018 Apr 19. PubMed
SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-kappaB p65. Li P, Jin Y, Qi F, Wu F, Luo S, Cheng Y, Montgomery RR, Qian F. Front Cell Infect Microbiol. 2018 Apr 9;8:113. doi: 10.3389/fcimb.2018.00113. eCollection 2018. PubMed
Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Wang Y, Wong CW, Yan M, Li L, Liu T, Or PM, Tsui SK, Waye MM, Chan AM. Cancer Lett. 2018 Aug 10;429:54-65. doi: 10.1016/j.canlet.2018.04.040. Epub 2018 May 3. PubMed
P1 promoter-driven HNF4alpha isoforms are specifically repressed by beta-catenin signaling in colorectal cancer cells. Babeu JP, Jones C, Geha S, Carrier JC, Boudreau F. J Cell Sci. 2018 Jul 6;131(13). pii: jcs.214734. doi: 10.1242/jcs.214734. PubMed
Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus. Wu CC, Jiang X, Wang XZ, Liu XJ, Li XJ, Yang B, Ye HQ, Harwardt T, Jiang M, Xia HM, Wang W, Britt WJ, Paulus C, Nevels M, Luo MH. J Virol. 2018 Aug 16;92(17). pii: JVI.00340-18. doi: 10.1128/JVI.00340-18. Print 2018 Sep 1. PubMed
The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression. Nikopoulou C, Panagopoulos G, Sianidis G, Psarra E, Ford E, Thanos D. Mol Cell. 2018 Jul 19;71(2):352-361.e5. doi: 10.1016/j.molcel.2018.06.019. Epub 2018 Jul 12. PubMed
Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus. Gao P, Xia JH, Sipeky C, Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SP, Zhang K, Zhu J, Lee HM, Suleman S, Giannareas N, Liu S, Tammela TLJ, Auvinen A, Wang X, Huang Q, Wang L, Manninen A, Vaarala MH, Wang L, Schleutker J, Wei GH. Cell. 2018 Jul 26;174(3):576-589.e18. doi: 10.1016/j.cell.2018.06.003. Epub 2018 Jul 19. PubMed
NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity. Kang HJ, Song HY, Ahmed MA, Guo Y, Zhang M, Chen C, Cristofanilli M, Horiuchi D, Vassilopoulos A. Free Radic Biol Med. 2018 Oct;126:358-371. doi: 10.1016/j.freeradbiomed.2018.08.009. Epub 2018 Aug 13. PubMed
BRMS1L suppresses ovarian cancer metastasis via inhibition of the beta-catenin-wnt pathway. Cao P, Zhao S, Sun Z, Jiang N, Shang Y, Wang Y, Gu J, Li S. Exp Cell Res. 2018 Oct 1;371(1):214-221. doi: 10.1016/j.yexcr.2018.08.013. Epub 2018 Aug 15. PubMed
Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism. Rakovic A, Domingo A, Grutz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Bruggemann N, Rosales R, Jamora D, Rolfs A, Seibler P, Westenberger A, Konig I, Klein C. Mov Disord. 2018 Jul;33(7):1108-1118. doi: 10.1002/mds.27441. PubMed
Growth inhibition and chemo-radiosensitization of esophageal squamous cell carcinoma by survivin-shRNA lentivirus transfection. Zhou C, Zhang L, Xu P. Oncol Lett. 2018 Oct;16(4):4813-4820. doi: 10.3892/ol.2018.9280. Epub 2018 Aug 8. PubMed
MiR-29a-Mediated CD133 Expression Contributes to Cisplatin Resistance in CD133(+) Glioblastoma Stem Cells. Yang L, Li N, Yan Z, Li C, Zhao Z. J Mol Neurosci. 2018 Nov;66(3):369-377. doi: 10.1007/s12031-018-1177-0. Epub 2018 Sep 29. PubMed
NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. Paul S, Ghosh S, Mandal S, Sau S, Pal M. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11. PubMed
Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma. Odabas G, Cetin M, Turhal S, Baloglu H, Sayan AE, Yagci T. Can J Gastroenterol Hepatol. 2018 Sep 19;2018:4040787. doi: 10.1155/2018/4040787. eCollection 2018. PubMed
Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness. Kim HY, Kim DK, Bae SH, Gwak H, Jeon JH, Kim JK, Lee BI, You HJ, Shin DH, Kim YH, Kim SY, Han SS, Shim JK, Lee JH, Kang SG, Jang H. Exp Mol Med. 2018 Oct 17;50(10):137. doi: 10.1038/s12276-018-0166-2. PubMed
Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. Koutsioumpa M, Hatziapostolou M, Polytarchou C, Tolosa EJ, Almada LL, Mahurkar-Joshi S, Williams J, Tirado-Rodriguez AB, Huerta-Yepez S, Karavias D, Kourea H, Poultsides GA, Struhl K, Dawson DW, Donahue TR, Fernandez-Zapico ME, Iliopoulos D. Gut. 2018 Oct 18. pii: gutjnl-2017-315690. doi: 10.1136/gutjnl-2017-315690. PubMed
Neuroendocrine differentiation of prostate cancer leads to PSMA suppression. Bakht MK, Derecichei I, Li Y, Ferraiuolo RM, Dunning M, Oh SW, Hussein A, Youn H, Stringer KF, Jeong CW, Cheon GJ, Kwak C, Kang KW, Lamb AD, Wang Y, Dong X, Porter LA. Endocr Relat Cancer. 2018 Nov 23;26(2):131-146. doi: 10.1530/ERC-18-0226. PubMed
The nucleosome remodeling and deacetylase complex protein CHD4 regulates neural differentiation of mouse embryonic stem cells by down-regulating p53. Hirota A, Nakajima-Koyama M, Ashida Y, Nishida E. J Biol Chem. 2019 Jan 4;294(1):195-209. doi: 10.1074/jbc.RA118.004086. Epub 2018 Nov 8. PubMed
FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer. Li L, Li W, Chen N, Zhao H, Xu G, Zhao Y, Pan X, Zhang X, Zhou L, Yu D, Li A, Hu JF, Cui J. Clin Cancer Res. 2019 Feb 15;25(4):1302-1317. doi: 10.1158/1078-0432.CCR-18-1447. Epub 2018 Nov 14. PubMed
GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment. Worley BL, Kim YS, Mardini J, Zaman R, Leon KE, Vallur PG, Nduwumwami A, Warrick JI, Timmins PF, Kesterson JP, Phaeton R, Lee NY, Walter V, Endres L, Mythreye K, Aird KM, Hempel N. Redox Biol. 2018 Nov 17. pii: S2213-2317(18)30891-7. doi: 10.1016/j.redox.2018.11.009. PubMed
Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells. Ojeda DS, Grasso D, Urquiza J, Till A, Vaccaro MI, Quarleri J. Front Immunol. 2018 Nov 20;9:2633. doi: 10.3389/fimmu.2018.02633. eCollection 2018. PubMed
Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2. Sanin DE, Matsushita M, Klein Geltink RI, Grzes KM, van Teijlingen Bakker N, Corrado M, Kabat AM, Buck MD, Qiu J, Lawless SJ, Cameron AM, Villa M, Baixauli F, Patterson AE, Hassler F, Curtis JD, O'Neill CM, O'Sullivan D, Wu D, Mittler G, Huang SC, Pearce EL, Pearce EJ. Immunity. 2018 Dec 18;49(6):1021-1033.e6. doi: 10.1016/j.immuni.2018.10.011. PubMed
IL-8 Secreted from M2 Macrophages Promoted Prostate Tumorigenesis via STAT3/MALAT1 Pathway. Zheng T, Ma G, Tang M, Li Z, Xu R. Int J Mol Sci. 2018 Dec 27;20(1). pii: ijms20010098. doi: 10.3390/ijms20010098. PubMed
Common ELF1 deletion in prostate cancer bolsters oncogenic ETS function, inhibits senescence and promotes docetaxel resistance. Budka JA, Ferris MW, Capone MJ, Hollenhorst PC. Genes Cancer. 2018 May;9(5-6):198-214. doi: 10.18632/genesandcancer.182. PubMed
SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists. Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y, Chen M. Cell Discov. 2019 Jan 1;5:1. doi: 10.1038/s41421-018-0068-4. eCollection 2019. PubMed
14-3-3zeta inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling. Song J, Zhang X, Liao Z, Liang H, Chu L, Dong W, Zhang X, Ge Q, Liu Q, Fan P, Zhang Z, Zhang B. J Exp Clin Cancer Res. 2019 Jan 3;38(1):3. doi: 10.1186/s13046-018-1007-9. PubMed
Heme oxygenase 1 facilitates cell proliferation via the B-Raf-ERK signaling pathway in melanoma. Liu L, Wu Y, Bian C, Nisar MF, Wang M, Hu X, Diao Q, Nian W, Wang E, Xu W, Zhong JL. Cell Commun Signal. 2019 Jan 11;17(1):3. doi: 10.1186/s12964-018-0313-3. PubMed
Exploitation of nuclear protein SFPQ by the encephalomyocarditis virus to facilitate its replication. Zhou B, Wu F, Han J, Qi F, Ni T, Qian F. Biochem Biophys Res Commun. 2019 Feb 26;510(1):65-71. doi: 10.1016/j.bbrc.2019.01.032. Epub 2019 Jan 18. PubMed
Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q. Cell Rep. 2019 Jan 22;26(4):884-892.e4. doi: 10.1016/j.celrep.2018.12.100. PubMed
Enhancer Associated Long Non-coding RNA Transcription and Gene Regulation in Experimental Models of Rickettsial Infection. Chowdhury IH, Narra HP, Sahni A, Khanipov K, Fofanov Y, Sahni SK. Front Immunol. 2019 Jan 9;9:3014. doi: 10.3389/fimmu.2018.03014. eCollection 2018. PubMed
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation. Kim J, Yu L, Chen W, Xu Y, Wu M, Todorova D, Tang Q, Feng B, Jiang L, He J, Chen G, Fu X, Xu Y. Cancer Cell. 2019 Feb 11;35(2):191-203.e8. doi: 10.1016/j.ccell.2018.12.012. Epub 2019 Jan 31. PubMed
De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma. Sastre-Perona A, Hoang-Phou S, Leitner MC, Okuniewska M, Meehan S, Schober M. Cell Stem Cell. 2019 Mar 7;24(3):390-404.e8. doi: 10.1016/j.stem.2019.01.003. Epub 2019 Jan 31. PubMed
L1 drives IFN in senescent cells and promotes age-associated inflammation. De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beausejour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. PubMed
ETS1 is coexpressed with ZEB2 and mediates ZEB2-induced epithelial-mesenchymal transition in human tumors. Yalim-Camci I, Balcik-Ercin P, Cetin M, Odabas G, Tokay N, Sayan AE, Yagci T. Mol Carcinog. 2019 Jun;58(6):1068-1081. doi: 10.1002/mc.22994. Epub 2019 Mar 6. PubMed
ROR1 Expression and Its Functional Significance in Hepatocellular Carcinoma Cells. Cetin M, Odabas G, Douglas LR, Duriez PJ, Balcik-Ercin P, Yalim-Camci I, Sayan AE, Yagci T. Cells. 2019 Mar 2;8(3). pii: cells8030210. doi: 10.3390/cells8030210. PubMed
The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways. Xu M, Almasi S, Yang Y, Yan C, Sterea AM, Rizvi Syeda AK, Shen B, Richard Derek C, Huang P, Gujar S, Wang J, Zong WX, Trebak M, El Hiani Y, Dong XP. Cell Calcium. 2019 May;79:80-88. doi: 10.1016/j.ceca.2019.02.010. Epub 2019 Mar 2. PubMed
Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Jung JW, Macalino SJY, Cui M, Kim JE, Kim HJ, Song DG, Nam SH, Kim S, Choi S, Lee JW. Cell Metab. 2019 Jun 4;29(6):1306-1319.e7. doi: 10.1016/j.cmet.2019.03.005. Epub 2019 Apr 4. PubMed
WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ. Nature. 2019 Apr 10. pii: 10.1038/s41586-019-1102-x. doi: 10.1038/s41586-019-1102-x. PubMed

Associated Plasmids

Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth. Wang Y, Gao B, Tan PY, Handoko YA, Sekar K, Deivasigamani A, Seshachalam VP, OuYang HY, Shi M, Xie C, Goh BKP, Ooi LL, Man Hui K. FASEB J. 2019 Aug;33(8):8759-8770. doi: 10.1096/fj.201802213RR. Epub 2019 Apr 25. PubMed
Wnt signaling regulates cytosolic translocation of connexin 43. Hou X, Khan MRA, Turmaine M, Thrasivoulou C, Becker DL, Ahmed A. Am J Physiol Regul Integr Comp Physiol. 2019 Aug 1;317(2):R248-R261. doi: 10.1152/ajpregu.00268.2018. Epub 2019 May 8. PubMed
APPBP2 enhances non-small cell lung cancer proliferation and invasiveness through regulating PPM1D and SPOP. Gong H, Liu F, Liu X, Min S, Wu N, Liu X, Liu Y, Han S, Zhang Y, Zhang Y, Hu Y, Liu X, Wang X. EBioMedicine. 2019 Jun;44:138-149. doi: 10.1016/j.ebiom.2019.05.028. Epub 2019 May 16. PubMed
Genome-wide target interactome profiling reveals a novel EEF1A1 epigenetic pathway for oncogenic lncRNA MALAT1 in breast cancer. Li X, Chen N, Zhou L, Wang C, Wen X, Jia L, Cui J, Hoffman AR, Hu JF, Li W. Am J Cancer Res. 2019 Apr 1;9(4):714-729. eCollection 2019. PubMed
MicroRNA-200b is downregulated and suppresses metastasis by targeting LAMA4 in renal cell carcinoma. Li Y, Guan B, Liu J, Zhang Z, He S, Zhan Y, Su B, Han H, Zhang X, Wang B, Li X, Zhou L, Zhao W. EBioMedicine. 2019 Jun;44:439-451. doi: 10.1016/j.ebiom.2019.05.041. Epub 2019 May 23. PubMed
Discovery of a Pathogenic Variant rs139379666 (p. P2974L) in ATM for Breast Cancer Risk in Chinese Populations. Guo X, Lin W, Bai M, Li H, Wen W, Zeng C, Chen Z, He J, Chen J, Cai Q, Long J, Jia WH, Shu XO, Zheng W. Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1308-1315. doi: 10.1158/1055-9965.EPI-18-1294. Epub 2019 Jun 3. PubMed
Hsp105alpha suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation. Yamane T, Saito Y, Teshima H, Hagino M, Kakihana A, Sato S, Shimada M, Kato Y, Kuga T, Yamagishi N, Nakayama Y. J Cell Biochem. 2019 Jun 7. doi: 10.1002/jcb.29062. PubMed
Abundance of d-2-hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1-expressing cells. Bala Bhaskara Rao K, Katragunta K, Sarma UM, Jain N. FEBS Lett. 2019 Jun 18. doi: 10.1002/1873-3468.13500. PubMed
The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity. Peng H, Yang F, Hu Q, Sun J, Peng C, Zhao Y, Huang C. Autophagy. 2020 Apr;16(4):698-708. doi: 10.1080/15548627.2019.1635381. Epub 2019 Jul 1. PubMed
CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. Yeung YT, Fan S, Lu B, Yin S, Yang S, Nie W, Wang M, Zhou L, Li T, Li X, Bode AM, Dong Z. Carcinogenesis. 2019 Jun 25. pii: 5523300. doi: 10.1093/carcin/bgz113. PubMed
DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction. Marivin A, Garcia-Marcos M. Mol Biol Cell. 2019 Jul 22;30(16):1900-1910. doi: 10.1091/mbc.E19-02-0091. Epub 2019 Jul 3. PubMed
Porphyromonas gingivalis-derived lipopolysaccharide causes excessive hepatic lipid accumulation via activating NF-kappaB and JNK signaling pathways. Ding LY, Liang LZ, Zhao YX, Yang YN, Liu F, Ding QR, Luo LJ. Oral Dis. 2019 Oct;25(7):1789-1797. doi: 10.1111/odi.13153. Epub 2019 Jul 28. PubMed
In silico analysis-based identification of the target residue of integrin alpha6 for metastasis inhibition of basal-like breast cancer. Tanaka S, Senda N, Iida A, Sehara-Fujisawa A, Ishii T, Sato F, Toi M, Itou J. Genes Cells. 2019 Sep;24(9):596-607. doi: 10.1111/gtc.12714. Epub 2019 Aug 5. PubMed
microRNA-183-3p Inhibits Progression of Human Prostate Cancer by Downregulating High-Mobility Group Nucleosome Binding Domain 5. Li Y, He S, Zhan Y, He A, Gong Y, Ji G, Huang C, Peng D, Guan B, Li X, Zhou L. DNA Cell Biol. 2019 Aug;38(8):840-848. doi: 10.1089/dna.2019.4642. Epub 2019 Jul 17. PubMed
Induced pluripotent stem cell generation from bovine somatic cells indicates unmet needs for pluripotency sustenance. Pillai VV, Kei TG, Reddy SE, Das M, Abratte C, Cheong SH, Selvaraj V. Anim Sci J. 2019 Sep;90(9):1149-1160. doi: 10.1111/asj.13272. Epub 2019 Jul 19. PubMed
Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer. Gao L, Zhang Z, Lu J, Pei G. Front Cell Neurosci. 2019 Jul 10;13:316. doi: 10.3389/fncel.2019.00316. eCollection 2019. PubMed
Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra SA, Zhang Y, Yankaskas CL, He S, Valverde MA, Sun SX, Konstantopoulos K. Sci Adv. 2019 Jul 24;5(7):eaaw7243. doi: 10.1126/sciadv.aaw7243. eCollection 2019 Jul. PubMed
The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. Nat Metab. 2019 Jan;1(1):98-110. doi: 10.1038/s42255-018-0004-9. Epub 2018 Dec 3. PubMed
Mitochondrial calcium uniporter regulates PGC-1alpha expression to mediate metabolic reprogramming in pulmonary fibrosis. Gu L, Larson Casey JL, Andrabi SA, Lee JH, Meza-Perez S, Randall TD, Carter AB. Redox Biol. 2019 Sep;26:101307. doi: 10.1016/j.redox.2019.101307. Epub 2019 Aug 25. PubMed
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKCepsilon activation and phosphorylation of XIAP. Baek HS, Kwon YJ, Ye DJ, Cho E, Kwon TU, Chun YJ. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118553. doi: 10.1016/j.bbamcr.2019.118553. Epub 2019 Sep 4. PubMed
TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer. Tan WX, Xu TM, Zhou ZL, Lv XJ, Liu J, Zhang WJ, Cui MH. Oncol Rep. 2019 Aug 2. doi: 10.3892/or.2019.7258. PubMed
Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells. Kim IK, Rao G, Zhao X, Fan R, Avantaggiati ML, Wang Y, Zhang YW, Giaccone G. Cell Death Differ. 2020 Jul;27(7):2263-2279. doi: 10.1038/s41418-020-0502-7. Epub 2020 Feb 7. PubMed
NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer. Zhou L, Wang D, Sheng D, Xu J, Chen W, Qin Y, Du R, Yang X, He X, Xie N, Liu S, Zhang L. Theranostics. 2020 Jan 19;10(5):2405-2421. doi: 10.7150/thno.38875. eCollection 2020. PubMed
Ligand-dependent internalization of Bombyx mori tachykinin-related peptide receptor is regulated by PKC, GRK5 and beta-arrestin2/BmKurtz. He X, Yan L, Wu Q, Zhang G, Zhou N. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118690. doi: 10.1016/j.bbamcr.2020.118690. Epub 2020 Feb 26. PubMed
YWHAE/14-3-3epsilon expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Xu Y, Fulciniti M, Samur MK, Ho M, Deng S, Liu L, Wen K, Yu T, Chyra Z, Dereibal S, Zhang L, Yao Y, Chakraborty C, Morelli E, Li N, Lopez MA, Perini T, Mu S, An G, Alonso R, Bianchi G, Tai YT, Anderson KC, Qiu L, Munshi NC. Blood. 2020 Jul 23;136(4):468-479. doi: 10.1182/blood.2019004147. PubMed
p75NTR(-/-) mice exhibit an alveolar bone loss phenotype and inhibited PI3K/Akt/beta-catenin pathway. Wang Y, Yang K, Li G, Liu R, Liu J, Li J, Tang M, Zhao M, Song J, Wen X. Cell Prolif. 2020 Apr;53(4):e12800. doi: 10.1111/cpr.12800. Epub 2020 Mar 25. PubMed
Ketamine promotes the neural differentiation of mouse embryonic stem cells by activating mTOR. Zhou X, Lv X, Zhang L, Yan J, Hu R, Sun Y, Xi S, Jiang H. Mol Med Rep. 2020 Jun;21(6):2443-2451. doi: 10.3892/mmr.2020.11043. Epub 2020 Mar 30. PubMed
LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR1261. Zhang Y, Zhou H. Int J Mol Med. 2020 Jul;46(1):159-166. doi: 10.3892/ijmm.2020.4586. Epub 2020 Apr 22. PubMed
Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation. Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R. PLoS One. 2020 May 4;15(5):e0231894. doi: 10.1371/journal.pone.0231894. eCollection 2020. PubMed
m(6) A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis. Nagaki Y, Motoyama S, Yamaguchi T, Hoshizaki M, Sato Y, Sato T, Koizumi Y, Wakita A, Kawakita Y, Imai K, Nanjo H, Watanabe H, Imai Y, Minamiya Y, Kuba K. Genes Cells. 2020 May 25. doi: 10.1111/gtc.12792. PubMed
The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Millar R, Kilbey A, Remak SJ, Severson TM, Dhayade S, Sandilands E, Foster K, Bryant DM, Blyth K, Coffelt SB. Mol Oncol. 2020 Aug;14(8):1868-1880. doi: 10.1002/1878-0261.12734. Epub 2020 Jun 17. PubMed
EXO1 Plays a Carcinogenic Role in Hepatocellular Carcinoma and is related to the regulation of FOXP3. Yang G, Dong K, Zhang Z, Zhang E, Liang B, Chen X, Huang Z. J Cancer. 2020 Jun 16;11(16):4917-4932. doi: 10.7150/jca.40673. eCollection 2020. PubMed

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