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COVID-19 and Coronavirus Plasmids & Resources

The global research community is moving quickly to expand the knowledge and understanding of COVID-19 and related coronaviruses. To assist with this effort Addgene will maintain this plasmid collection page, which highlights plasmids available that may be useful for COVID-19 related research. Additionally, we have linked to collections of open-access articles, protocols, and other resource collections related to COVID-19 that may be of use to scientists.


The Coronavirus Disease-2019 (COVID-19) pandemic is caused by a novel virus strain from the Coronaviridae family called SARS-CoV-2. Scientists have been working at lightning speed to elucidate as much as they can about this novel virus. It is now known that SARS-CoV-2 entry, like that of SARS-CoV and MERS CoV, depends on binding of the viral spike (S) protein to cellular receptors. The cellular receptor for SARS-CoV-2 and SARS-CoV is hACE2, an angiotensin receptor. Another key step is the priming of the S protein by host cell proteases. The S protein of SARS-CoV-2 is primed by the serine protease TMPRSS2.

Image credit: Maya Kostman for the Innovative Genomics Institute
Single virion with all parts labeled

Addgene COVID-19 Resources

The following types of resources can be found on this page:

  • SARS-CoV-2 Antibodies: Recombinant monoclonal antibodies that target SARS-CoV-2 nucleocapsid protein.
  • SARS-CoV-2 Plasmids: Plasmids that are available or coming soon containing SARS-CoV-2 sequences.
  • SARS-CoV Plasmids: Plasmids that are available containing SARS-CoV (SARS classic) sequences.
  • Mammalian Targets: Plasmids containing mammalian sequences linked to SARS-CoV-2 infection.
  • General Tools: Plasmids expressing Cas12a/Cas13a, Reverse Transcriptases, etc. that may be useful for detection assays and more.
  • Pooled Libraries: Pooled libraries of spike protein mutations.
  • Research Articles: A list of free access articles on COVID-19 research.
  • Protocols: Protocols that may be useful for COVID-19 research.



SARS-CoV-2 Plasmids