Purpose
This G protein alpha-s mutant exhibits increased affinity for and decreased ability to be activated by Gs-protein-coupled receptors as well as decreased ability to activate adenylyl cyclase.
Insert
G protein alpha-s with alpha-i2 substitutions in alpha3/beta5 loop (
Gnas Rat)
Tags
internal EE epitope (residues 189-194 in alpha-s …
Mutation
N271K, K274D, R280K, T284D, I285T in alpha-s sequ…
Available Since
July 23, 2015
Availability
Academic Institutions and Nonprofits only