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Plasmid#160996PurposeSplicing reporter backboneDepositorInserthemoglobin subunit beta (HBB Human)
UseTagsExpressionMammalianMutationRepeated intron 1 with 40 nucelotide deletionPromoterCAGAvailable sinceJan. 13, 2021AvailabilityAcademic Institutions and Nonprofits only -
pOTTC1761 - pAAV SYN1 DIO HA-hM3D(Gq)
Plasmid#125147PurposeAn adeno-associated viral vector expressing Cre-dependent HA-tagged inhibitory DREADD (hM3D(Gq)) from a synapsin promoterDepositorInsertHA-tagged hM3D(Gq) (CHRM3 Human)
UseAAV and Cre/LoxTagsHAExpressionMammalianMutationPromoterSYN1Available sinceMay 13, 2019AvailabilityAcademic Institutions and Nonprofits only -
pAAV-hSyn-DIO-HA-rM3D(Gs)-IRES-mCitrine
Plasmid#50456PurposeDouble floxed Gs-coupled rM3D-IRES-mCitrine under the control of human synapsin promoterDepositorInsertrM3D-IRES-mCitrine (CHRM3 Human)
UseAAVTagsHAExpressionMutationSee supplemental documents for DREADD mutationsPromoterhuman Synapsin 1Available sinceApril 16, 2014AvailabilityAcademic Institutions and Nonprofits only -
pAAV-CBA-DIO-hM4Di-mCherry
Plasmid#81008PurposeCre-dependent expression of hM4Di-mCherry under CBA promoterDepositorInserthM4D(Gi)-mCherry
UseAAVTagsmCherryExpressionMutationPromoterCBAAvailable sinceAug. 15, 2016AvailabilityAcademic Institutions and Nonprofits only -
CAG::PSAML141F,Y115F:5HT3HC-IRES-GFP
Plasmid#32476PurposeExpresses PSAM-5HT3 HC (L141F,Y115F) neuronal activator, with IRES-EGFP markerDepositorInsertPSAM Y115F,L141F-5HT3 HC
UseTagsIRES-GFPExpressionMammalianMutationPromoterCAGAvailable sinceApril 10, 2012AvailabilityAcademic Institutions and Nonprofits only -
CAG::PSAMQ79G,Q139G:5HT3HC-IRES-GFP
Plasmid#32474PurposeExpresses PSAM-5HT3 HC (Q79G,Q139G) neuronal activator, with IRES-EGFP markerDepositorInsertPSAMQ79G,Q139G-5HT3 HC
UseTagsIRES-EGFPExpressionMammalianMutationPromoterCAGAvailable sinceApril 10, 2012AvailabilityAcademic Institutions and Nonprofits only -
MTK3_016
Plasmid#123731PurposeEncodes Gs-coupled rM3D as a Type 3 part to be used in the MTK systemDepositorInsertrM3D(Gs)
UseTagsExpressionMammalianMutationPromoterAvailable sinceDec. 13, 2019AvailabilityAcademic Institutions and Nonprofits only -
pAAV-hSyn-flx-fDIO-HA-Rpl10a-T2A-myc-hM3D(Gq)
Plasmid#223654PurposeExpresses vTRAP and hM3D(Gq) in a FlpON-CreOFF dependent mannerDepositorInsertvTRAP-T2A-hM3D(Gq)
UseAAVTagsHAExpressionMutationPromoterhSynAvailable sinceApril 30, 2025AvailabilityAcademic Institutions and Nonprofits only -
MTK3_014
Plasmid#123729PurposeEncodes Gq-coupled hM3D as a Type 3 part to be used in the MTK systemDepositorInserthM3D(Gq)
UseTagsExpressionMammalianMutationPromoterAvailable sinceDec. 13, 2019AvailabilityAcademic Institutions and Nonprofits only -
MTK3_015
Plasmid#123730PurposeEncodes Gi-coupled hM4D as a Type 3 part to be used in the MTK systemDepositorInserthM4D(Gi)
UseTagsExpressionMammalianMutationPromoterAvailable sinceDec. 13, 2019AvailabilityAcademic Institutions and Nonprofits only -
pLV.CMV.flex.hM3Dq.Cherry
Plasmid#170360PurposeCre-inducible lentiviral vector expressing hM3DqDepositorInsertflex.hM3Dq.Cherry
UseLentiviralTagsExpressionMutationPromoterCMVAvailable sinceJan. 4, 2022AvailabilityAcademic Institutions and Nonprofits only -
pAAV Ef1a DIO GeNL_SS hGtACR1
Plasmid#233511PurposeLuciferase opsin fusion protein for bioluminescent optogeneticsDepositorInsertsmNeonGreen
ISN-IE
hGtACR1
UseAAVTagsGaussia luciferase signal sequenceExpressionMutationPromoterAvailable sinceApril 1, 2025AvailabilityAcademic Institutions and Nonprofits only -
pAAV hSyn FLEx-OFF hM4Di-mCherry
Plasmid#161579PurposeTo express hM4Di in cells not expressing Cre.DepositorInserthM4Di-mCherry
UseAAVTagsExpressionMutationNAPromoterhSynAvailable sinceNov. 20, 2020AvailabilityAcademic Institutions and Nonprofits only -
pZac2.1 GfaABC1D rM3D mCherry SV40
Plasmid#92285PurposeAAV DREADD expressionDepositorInsertrM3D
UseAAVTagsmCherryExpressionMutationPromoterGfaABC1DAvailable sinceJune 26, 2017AvailabilityAcademic Institutions and Nonprofits only -
pAAV hSyn FLEx-OFF hM3Dq-mCherry
Plasmid#161578PurposeTo express hM3Dq in cells not expressing Cre.DepositorInserthM3Dq-mCherry
UseAAVTagsExpressionMutationNAPromoterhSynAvailable sinceNov. 20, 2020AvailabilityAcademic Institutions and Nonprofits only -
pOTTC1740 - pAAV SYN1 DIO HA-hM4D(Gi)
Plasmid#125146PurposeAn adeno-associated viral vector expressing Cre-dependent HA-tagged inhibitory DREADD (hM4D(Gi)) from a synapsin promoterDepositorInsertHA-tagged hM4D(Gi) (CHRM4 Human)
UseAAV and Cre/LoxTagsHAExpressionMammalianMutationPromoterSYN1Available sinceMay 13, 2019AvailabilityAcademic Institutions and Nonprofits only -
pAAV-TRE-DIO-hM3Dq-mCherry (Cre-OFF)
Plasmid#166609PurposeEncodes Cre-inactivated hM3Dq-mCherry under control of the TREDepositorInserthM3Dq-mCherry
UseAAVTagsExpressionMutationPromotertetracycline response elementAvailable sinceApril 5, 2021AvailabilityAcademic Institutions and Nonprofits only -
rAAV-syn::FLEX-rev::PSAML141F,Y115F:GlyR-IRES-GFP
Plasmid#32481PurposeCre-dependent expression of PSAM-GlyR (L141F,Y115F) neuronal inhibitor, with IRES-EGFP markerDepositorInsertPSAML141F,Y115F-GlyR
UseAAV and Cre/Lox; Adeno-associated virus, flex swi…TagsIRES-EGFPExpressionMutationPromoterSynapsinAvailable sinceJan. 13, 2012AvailabilityAcademic Institutions and Nonprofits only -
pAAV-Dlx-FLEX-hM4Di-mCherry
Plasmid#209701PurposeExpresses hM4Di-mCherry under the control of distalless homeobox 5 and 6 (mDlx) enhancer in Cre-recombinase-dependent mannerDepositorInserthM4D(Gi)
UseAAVTagsmCherryExpressionMutationPromoterAvailable sinceApril 24, 2024AvailabilityAcademic Institutions and Nonprofits only -
pAAV-hSyn-LMO11 (GeNL_SS-ChRmine)
Plasmid#213034Purposefusion protein of mNeonGreen, SSLuc, and ChRmine for bioluminescent optogeneticsDepositorInsertmNeonGreen, ISN-IE, ChRmine
UseAAVTagsGaussia luciferase signal sequenceExpressionMutationPromoterhSynAvailable sinceJune 3, 2024AvailabilityAcademic Institutions and Nonprofits only