We narrowed to 10 results for: RAP

...ideal for gene therapy, neuroscience research, and other biomedical fields. Gene Therapy One of the major...AAV) as novel vectors for human gene therapy . Current Gene Therapy, 3 (4), 281–304. https://doi.org/10.2174...serotypes: vector toolkit for human gene therapy . Molecular Therapy, 14 (3), 316–327. https://doi.org/10.1016...preferred choice to be used as viral vectors for gene therapy applications. This guide contains many viral vector-specific...applications of rAAV vectors is in the field of gene therapy to treat genetic disorders. rAAV vectors are favored...insertional mutagenesis. Several AAV-based gene therapies have been approved by the US Food and Drug Administration...dystrophy. Many clinical trials of AAV-based gene therapies are underway and are promising for the treatment...

...order to facilitate immunotherapy and gene therapy. Biomedicine & Pharmacotherapy , 128 , 110276. https...predict. In therapeutic applications, like chimeric antigen receptor T cell (CAR-T) therapy, the location...delivery of gene therapies. Lentiviral vectors are particularly effective for stem cell therapies, which rely...are common in clinical applications, like gene therapy, as you can more specifically dictate the target...oncogenes and other disease-associated genes. Gene Therapy Due to their relative safety and ability to transduce...transduce by other means. A concern with gene therapies is the possibility of transducing healthy tissues... of nonspecific transduction, lentiviral gene therapies have been shown to be relatively safe and effective...

...platforms within the gene therapy landscape . Signal Transduction and Targeted Therapy, 6 (1), 53. https://...The immune system recognizes adenoviral elements rapidly and can mount a strong immune response quickly,...quickly, which has limited their use in therapeutic applications. However, this has also made them the most ...disadvantage for the use of rAdV vectors in gene therapy but has, however, proven to be very useful for ...adenoviral vectors are also being used in cancer therapy to stimulate anti-tumor immune response in different...implications and circumvention strategies . Current Gene Therapy, 11 (4), 307–320. https://doi.org/10.2174/156652311796150372...for outbreak pathogens . Human Vaccines & Immunotherapeutics, 13 (12), 3020–3032. https://doi.org/10.1080...

...used in gene therapy applications to more specifically direct delivery of gene therapies. Common Uses ...gamma-retroviral vectors. Gene Therapy Gamma-retroviral vectors are a popular choice in gene therapy applications. There...There are many approved gamma-retroviral gene therapies to treat disease like cancer or immunodeficiency...Delivery of chimeric antigen receptor T cell (CAR-T) therapy is a particularly popular application of gamma-...and provide stable integration of the intended therapeutic. While similar to lentiviral vectors, they offer...centrifugation for CAR T cell manufacturing. Molecular Therapy — Methods & Clinical Development , 28 , 116–128...

...modular plasmids and enhanced MoClo protocols for rapid one-pot, multipart assembly, combinatorial design...library of constructs expressing GFP at 18 levels for rapid characterization in new organisms. Mobius Assembly...Mammalian Expression Stephan Gruber Platform for rapid assembly of expression vectors for multi-subunit... Drosophila John Doench 180-plasmid toolkit for rapid creation of CRISPR vectors compatible with various...

...entry vectors deposited with Addgene), it can be rapidly shuttled into any compatible Gateway destination...entry plasmids are also available, allowing for rapid cloning of PCR products into donor plasmids without... a ligation step, making it an easy, cheap, and rapid cloning method. LIC depends on the addition of only...

... 4 ). Additional varenicline analogs, termed ultrapotent PSEMs (or uPSEMs), have also been developed as..., Basu J, Michaelides M, Sternson SM (2019). Ultrapotent chemogenetics for research and potential clinical...potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and ...

...comparative simplicity and adaptability, CRISPR rapidly became the most popular genome engineering approach...regulate known phenotypes, including resistances to chemotherapy drugs and toxins, cell viability, and tumor ...natural and engineered CjCas9 orthologs. Molecular Therapy , 31 (4), 1177–1187. PMID: 36733251 Harrington,...

... frequently use AAVs to develop CRISPR-based therapeutics. One limitation of AAV vectors is that the packaging...

... the LOV2 domain of Avena sativa phototropin 1 LOVETRAP reversibly sequester and release proteins from...