Human sgRNA library Brunello in lentiGuide-Puro Citations (110)

Originally described in: Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.
Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE Nat Biotechnol. 2016 Jan 18. doi: 10.1038/nbt.3437. PubMed Journal

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Articles Citing Human sgRNA library Brunello in lentiGuide-Puro

Articles
Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries. Ong SH, Li Y, Koike-Yusa H, Yusa K. Sci Rep. 2017 Aug 7;7(1):7384. doi: 10.1038/s41598-017-07827-z. PubMed
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Gaidt MM, Ebert TS, Chauhan D, Ramshorn K, Pinci F, Zuber S, O'Duill F, Schmid-Burgk JL, Hoss F, Buhmann R, Wittmann G, Latz E, Subklewe M, Hornung V. Cell. 2017 Nov 16;171(5):1110-1124.e18. doi: 10.1016/j.cell.2017.09.039. Epub 2017 Oct 12. PubMed
Next-Generation Sequencing of Genome-Wide CRISPR Screens. Yau EH, Rana TM. Methods Mol Biol. 2018;1712:203-216. doi: 10.1007/978-1-4939-7514-3_13. PubMed
Pooled Lentiviral-Delivery Genetic Screens. Piccioni F, Younger ST, Root DE. Curr Protoc Mol Biol. 2018 Jan 16;121:32.1.1-32.1.21. doi: 10.1002/cpmb.52. PubMed
CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J. Nat Med. 2018 Jul;24(7):927-930. doi: 10.1038/s41591-018-0049-z. Epub 2018 Jun 11. PubMed
Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. Nakagawa M, Shaffer AL 3rd, Ceribelli M, Zhang M, Wright G, Huang DW, Xiao W, Powell J, Petrus MN, Yang Y, Phelan JD, Kohlhammer H, Dubois SP, Yoo HM, Bachy E, Webster DE, Yang Y, Xu W, Yu X, Zhao H, Bryant BR, Shimono J, Ishio T, Maeda M, Green PL, Waldmann TA, Staudt LM. Cancer Cell. 2018 Aug 13;34(2):286-297.e10. doi: 10.1016/j.ccell.2018.06.014. Epub 2018 Jul 26. PubMed
Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma. Tomska K, Kurilov R, Lee KS, Hullein J, Lukas M, Sellner L, Walther T, Wagner L, Oles M, Brors B, Huber W, Zenz T. Sci Rep. 2018 Aug 13;8(1):12046. doi: 10.1038/s41598-018-30509-3. PubMed
Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A. Cell. 2018 Dec 13;175(7):1958-1971.e15. doi: 10.1016/j.cell.2018.10.024. Epub 2018 Nov 15. PubMed
NP220 mediates silencing of unintegrated retroviral DNA. Zhu Y, Wang GZ, Cingoz O, Goff SP. Nature. 2018 Dec;564(7735):278-282. doi: 10.1038/s41586-018-0750-6. Epub 2018 Nov 28. PubMed
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities. Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG. Nat Commun. 2018 Dec 21;9(1):5416. doi: 10.1038/s41467-018-07901-8. PubMed Associated Plasmids Human CRISPRa sgRNA library Calabrese in backbone XPR_502 (P65 HSF), Set A Human CRISPRa sgRNA library Calabrese in backbone XPR_502 (P65 HSF), Set B Mouse CRISPRa sgRNA library Caprano in backbone XPR_502 (P65 HSF), Set A Mouse CRISPRa sgRNA library Caprano in backbone XPR_502 (P65 HSF), Set B Human CRISPRi sgRNA library Dolcetto in backbone XPR_050, Set A More ...
Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells. Bakke J, Wright WC, Zamora AE, Oladimeji P, Crawford JC, Brewer CT, Autry RJ, Evans WE, Thomas PG, Chen T. BMC Cancer. 2019 Mar 21;19(1):253. doi: 10.1186/s12885-019-5455-1. PubMed
Functional and Mechanistic Interrogation of BET Bromodomain Degraders for the Treatment of Metastatic Castration-resistant Prostate Cancer. Kregel S, Malik R, Asangani IA, Wilder-Romans K, Rajendiran T, Xiao L, Vo JN, Soni T, Cieslik M, Fernadez-Salas E, Zhou B, Cao X, Speers C, Wang S, Chinnaiyan AM. Clin Cancer Res. 2019 Jul 1;25(13):4038-4048. doi: 10.1158/1078-0432.CCR-18-3776. Epub 2019 Mar 27. PubMed
CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor. Shoemaker CJ, Huang TQ, Weir NR, Polyakov NJ, Schultz SW, Denic V. PLoS Biol. 2019 Apr 1;17(4):e2007044. doi: 10.1371/journal.pbio.2007044. eCollection 2019 Apr. PubMed
Genome-wide CRISPR-based gene knockout screens reveal cellular factors and pathways essential for nasopharyngeal carcinoma. Wang C, Jiang S, Ke L, Zhang L, Li D, Liang J, Narita Y, Hou I, Chen CH, Wang L, Zhong Q, Ling Y, Lv X, Xiang Y, Guo X, Teng M, Tsao SW, Gewurz BE, Zeng MS, Zhao B. J Biol Chem. 2019 Jun 21;294(25):9734-9745. doi: 10.1074/jbc.RA119.008793. Epub 2019 May 9. PubMed
Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dundar F, Zumbo P, Witkin M, Koche R, Betel D, Chen S, Massague J, Garippa R, Evans T, Beer MA, Huangfu D. Nat Genet. 2019 Jun;51(6):999-1010. doi: 10.1038/s41588-019-0408-9. Epub 2019 May 20. PubMed
Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking and activity of the nonselective cation channel TRPC6. Talbot BE, Vandorpe DH, Stotter BR, Alper SL, Schlondorff JS. J Biol Chem. 2019 Jul 2. pii: RA119.008299. doi: 10.1074/jbc.RA119.008299. PubMed
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE. Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013. PubMed
CRISPR Cas9 in Pancreatic Cancer Research. Yang H, Bailey P, Pilarsky C. Front Cell Dev Biol. 2019 Oct 18;7:239. doi: 10.3389/fcell.2019.00239. eCollection 2019. PubMed
Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer. Xu S, Zhan M, Jiang C, He M, Yang L, Shen H, Huang S, Huang X, Lin R, Shi Y, Liu Q, Chen W, Mohan M, Wang J. Nat Commun. 2019 Dec 2;10(1):5492. doi: 10.1038/s41467-019-13420-x. PubMed
KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion. Oladimeji PO, Bakke J, Wright WC, Chen T. Sci Rep. 2020 Jan 30;10(1):1485. doi: 10.1038/s41598-020-58448-y. PubMed
Genome-wide CRISPR screening identifies new regulators of glycoprotein secretion. Popa S, Villeneuve J, Stewart S, Perez Garcia E, Petrunkina Harrison A, Moreau K. Wellcome Open Res. 2019 Aug 9;4:119. doi: 10.12688/wellcomeopenres.15232.2. eCollection 2019. PubMed
Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication. Ardeljan D, Steranka JP, Liu C, Li Z, Taylor MS, Payer LM, Gorbounov M, Sarnecki JS, Deshpande V, Hruban RH, Boeke JD, Fenyo D, Wu PH, Smogorzewska A, Holland AJ, Burns KH. Nat Struct Mol Biol. 2020 Feb;27(2):168-178. doi: 10.1038/s41594-020-0372-1. Epub 2020 Feb 10. PubMed Associated Plasmids pDA007 pDA025 pDA027 pDA034 pDA056 More ...
Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAF(V600) -Wild-Type Colorectal Cancer. Georgiou A, Stewart A, Cunningham D, Banerji U, Whittaker SR. Mol Cancer Res. 2020 Jun;18(6):835-846. doi: 10.1158/1541-7786.MCR-19-1201. Epub 2020 Feb 25. PubMed
A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications. Wright GW, Huang DW, Phelan JD, Coulibaly ZA, Roulland S, Young RM, Wang JQ, Schmitz R, Morin RD, Tang J, Jiang A, Bagaev A, Plotnikova O, Kotlov N, Johnson CA, Wilson WH, Scott DW, Staudt LM. Cancer Cell. 2020 Apr 13;37(4):551-568.e14. doi: 10.1016/j.ccell.2020.03.015. PubMed
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. Tang M, Xie Q, Gimple RC, Zhong Z, Tam T, Tian J, Kidwell RL, Wu Q, Prager BC, Qiu Z, Yu A, Zhu Z, Mesci P, Jing H, Schimelman J, Wang P, Lee D, Lorenzini MH, Dixit D, Zhao L, Bhargava S, Miller TE, Wan X, Tang J, Sun B, Cravatt BF, Muotri AR, Chen S, Rich JN. Cell Res. 2020 Jun 4. pii: 10.1038/s41422-020-0338-1. doi: 10.1038/s41422-020-0338-1. PubMed
A pooled genome-wide screening strategy to identify and rank influenza host restriction factors in cell-based vaccine production platforms. Sharon DM, Nesdoly S, Yang HJ, Gelinas JF, Xia Y, Ansorge S, Kamen AA. Sci Rep. 2020 Jul 22;10(1):12166. doi: 10.1038/s41598-020-68934-y. PubMed
Rational discovery of molecular glue degraders via scalable chemical profiling. Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Muller AC, Zuber J, Geyer M, Thoma NH, Kubicek S, Winter GE. Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. PubMed
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex. Bailey PSJ, Ortmann BM, Martinelli AW, Houghton JW, Costa ASH, Burr SP, Antrobus R, Frezza C, Nathan JA. Nat Commun. 2020 Aug 13;11(1):4046. doi: 10.1038/s41467-020-17862-6. PubMed
Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiation. Park JW, Kang JY, Hahm JY, Kim HJ, Seo SB. Commun Biol. 2020 Aug 21;3(1):462. doi: 10.1038/s42003-020-01186-8. PubMed
Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy. Ohnstad AE, Delgado JM, North BJ, Nasa I, Kettenbach AN, Schultz SW, Shoemaker CJ. EMBO J. 2020 Dec 15;39(24):e104948. doi: 10.15252/embj.2020104948. Epub 2020 Nov 23. PubMed
Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas. Dersh D, Phelan JD, Gumina ME, Wang B, Arbuckle JH, Holly J, Kishton RJ, Markowitz TE, Seedhom MO, Fridlyand N, Wright GW, Huang DW, Ceribelli M, Thomas CJ, Lack JB, Restifo NP, Kristie TM, Staudt LM, Yewdell JW. Immunity. 2021 Jan 12;54(1):116-131.e10. doi: 10.1016/j.immuni.2020.11.002. Epub 2020 Dec 2. PubMed
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. Evans LT, Anglen T, Scott P, Lukasik K, Loncarek J, Holland AJ. EMBO J. 2021 Feb 15;40(4):e105106. doi: 10.15252/embj.2020105106. Epub 2020 Dec 22. PubMed
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks. Schneider WM, Luna JM, Hoffmann HH, Sanchez-Rivera FJ, Leal AA, Ashbrook AW, Le Pen J, Ricardo-Lax I, Michailidis E, Peace A, Stenzel AF, Lowe SW, MacDonald MR, Rice CM, Poirier JT. Cell. 2021 Jan 7;184(1):120-132.e14. doi: 10.1016/j.cell.2020.12.006. Epub 2020 Dec 9. PubMed
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry. Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R. Nat Commun. 2021 Feb 11;12(1):961. doi: 10.1038/s41467-021-21213-4. PubMed
Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING. Fang R, Jiang Q, Guan Y, Gao P, Zhang R, Zhao Z, Jiang Z. Immunity. 2021 May 11;54(5):962-975.e8. doi: 10.1016/j.immuni.2021.03.011. Epub 2021 Apr 14. PubMed
Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Pettinato AM, Yoo D, VanOudenhove J, Chen YS, Cohn R, Ladha FA, Yang X, Thakar K, Romano R, Legere N, Meredith E, Robson P, Regnier M, Cotney JL, Murry CE, Hinson JT. Cell Rep. 2021 May 4;35(5):109088. doi: 10.1016/j.celrep.2021.109088. PubMed
Non-invasive and high-throughput interrogation of exon-specific isoform expression. Truong DJ, Phlairaharn T, Esswein B, Gruber C, Tumen D, Baligacs E, Armbrust N, Vaccaro FL, Lederer EM, Beck EM, Geilenkeuser J, Goppert S, Krumwiede L, Gratz C, Raffl G, Schwarz D, Zirngibl M, Zivanic M, Beyer M, Korner JD, Santl T, Evsyukov V, Strauss T, Schwarz SC, Hoglinger GU, Heutink P, Doll S, Conrad M, Giesert F, Wurst W, Westmeyer GG. Nat Cell Biol. 2021 Jun;23(6):652-663. doi: 10.1038/s41556-021-00678-x. Epub 2021 Jun 3. PubMed Associated Plasmids pEXSISERS_NLuc_FRT-PuroR pEXSISERS_FLuc_loxP-PuroR pEXSISERS_BSD_FRT-PuroR pEXSISERS_mGreenLantern_FRT-PuroR-HSV-TK pEXSISERS_SurfaceHaloTag_FRT-PuroR
Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity. Sapp V, Aguirre A, Mainkar G, Ding J, Adler E, Liao R, Sharma S, Jain M. Sci Rep. 2021 Jul 6;11(1):13866. doi: 10.1038/s41598-021-92988-1. PubMed
Negative Regulation of Erythroid Differentiation via the CBX8-TRIM28 Axis. Kim HJ, Park JW, Kang JY, Seo SB. Mol Cells. 2021 Jul 31;44(7):444-457. doi: 10.14348/molcells.2021.0012. PubMed
SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia. Wei Y, Huang YH, Skopelitis DS, Iyer SV, Costa ASH, Yang Z, Kramer M, Adelman ER, Klingbeil O, Demerdash OE, Polyanskaya SA, Chang K, Goodwin S, Hodges E, McCombie WR, Figueroa ME, Vakoc CR. Cancer Discov. 2022 Feb;12(2):450-467. doi: 10.1158/2159-8290.CD-20-1849. Epub 2021 Sep 16. PubMed
SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, Haupl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schnutgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, Schmitz R, Hodson DJ, Stegmaier K, Urlaub H, Serve H, Schmitt CA, Kreuz F, Knittel G, Rabinowitz JD, Reinhardt HC, Vander Heiden MG, Thomas C, Staudt LM, Zenz T, Oellerich T. Blood. 2022 Jan 27;139(4):538-553. doi: 10.1182/blood.2021012081. PubMed
Translational repression of NMD targets by GIGYF2 and EIF4E2. Zinshteyn B, Sinha NK, Enam SU, Koleske B, Green R. PLoS Genet. 2021 Oct 19;17(10):e1009813. doi: 10.1371/journal.pgen.1009813. eCollection 2021 Oct. PubMed
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB 3rd, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher P. Nat Commun. 2021 Nov 9;12(1):6468. doi: 10.1038/s41467-021-26640-x. PubMed
Genome-wide CRISPR screen identifies CDK6 as a therapeutic target in adult T-cell leukemia/lymphoma. Ishio T, Kumar S, Shimono J, Daenthanasanmak A, Dubois S, Lin Y, Bryant B, Petrus MN, Bachy E, Huang DW, Yang Y, Green PL, Hasegawa H, Maeda M, Goto H, Endo T, Yokota T, Hatanaka KC, Hatanaka Y, Tanaka S, Matsuno Y, Yang Y, Hashino S, Teshima T, Waldmann TA, Staudt LM, Nakagawa M. Blood. 2022 Mar 10;139(10):1541-1556. doi: 10.1182/blood.2021012734. PubMed
MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase. Sooraj D, Sun C, Doan A, Garama DJ, Dannappel MV, Zhu D, Chua HK, Mahara S, Wan Hassan WA, Tay YK, Guanizo A, Croagh D, Prodanovic Z, Gough DJ, Wan C, Firestein R. Mol Cell. 2022 Jan 6;82(1):123-139.e7. doi: 10.1016/j.molcel.2021.11.015. Epub 2021 Dec 14. PubMed
Genome-scale CRISPR screens identify host factors that promote human coronavirus infection. Grodzki M, Bluhm AP, Schaefer M, Tagmount A, Russo M, Sobh A, Rafiee R, Vulpe CD, Karst SM, Norris MH. Genome Med. 2022 Jan 27;14(1):10. doi: 10.1186/s13073-022-01013-1. PubMed
A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments. Zhao B, Rao Y, Leighow S, O'Brien EP, Gilbert L, Pritchard JR. Nat Commun. 2022 Feb 2;13(1):625. doi: 10.1038/s41467-022-28045-w. PubMed
PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production. Srinivas US, Tay NSC, Jaynes P, Anbuselvan A, Ramachandran GK, Wardyn JD, Hoppe MM, Hoang PM, Peng Y, Lim S, Lee MY, Peethala PC, An O, Shendre A, Tan BWQ, Jemimah S, Lakshmanan M, Hu L, Jakhar R, Sachaphibulkij K, Lim LHK, Pervaiz S, Crasta K, Yang H, Tan P, Liang C, Ho L, Khanchandani V, Kappei D, Yong WP, Tan DSP, Bordi M, Campello S, Tam WL, Frezza C, Jeyasekharan AD. Oncogene. 2022 Mar;41(13):1986-2002. doi: 10.1038/s41388-022-02219-8. Epub 2022 Mar 2. PubMed
Genes Involved in Maintaining Mitochondrial Membrane Potential Upon Electron Transport Chain Disruption. Vasan K, Clutter M, Fernandez Dunne S, George MD, Luan CH, Chandel NS, Martinez-Reyes I. Front Cell Dev Biol. 2022 Feb 16;10:781558. doi: 10.3389/fcell.2022.781558. eCollection 2022. PubMed
Molecular Virology of SARS-CoV-2 and Related Coronaviruses. Kung YA, Lee KM, Chiang HJ, Huang SY, Wu CJ, Shih SR. Microbiol Mol Biol Rev. 2022 Jun 15;86(2):e0002621. doi: 10.1128/mmbr.00026-21. Epub 2022 Mar 28. PubMed
VCP suppresses proteopathic seeding in neurons. Zhu J, Pittman S, Dhavale D, French R, Patterson JN, Kaleelurrrahuman MS, Sun Y, Vaquer-Alicea J, Maggiore G, Clemen CS, Buscher WJ, Bieschke J, Kotzbauer P, Ayala Y, Diamond MI, Davis AA, Weihl C. Mol Neurodegener. 2022 Apr 12;17(1):30. doi: 10.1186/s13024-022-00532-0. PubMed
A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor. Chen H, Diolaiti ME, O'Leary PC, Rojc A, Krogan NJ, Kim M, Ashworth A. Mol Cancer Ther. 2022 Jul 5;21(7):1076-1089. doi: 10.1158/1535-7163.MCT-21-0841. PubMed
Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms. Ernst P, Schnoder TM, Huber N, Perner F, Jayavelu AK, Eifert T, Hsu CJ, Tubio-Santamaria N, Crodel CC, Ungelenk M, Hubner CA, Clement JH, Hochhaus A, Heidel FH. Leukemia. 2022 Jul;36(7):1843-1849. doi: 10.1038/s41375-022-01611-3. Epub 2022 Jun 2. PubMed
Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress. Liu X, Viswanadhapalli S, Kumar S, Lee TK, Moore A, Ma S, Chen L, Hsieh M, Li M, Sareddy GR, Parra K, Blatt EB, Reese TC, Zhao Y, Chang A, Yan H, Xu Z, Pratap UP, Liu Z, Roggero CM, Tan Z, Weintraub ST, Peng Y, Tekmal RR, Arteaga CL, Lippincott-Schwartz J, Vadlamudi RK, Ahn JM, Raj GV. Nat Cancer. 2022 Jul;3(7):866-884. doi: 10.1038/s43018-022-00389-8. Epub 2022 Jun 2. PubMed
Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors. Dieter SM, Lovecchio D, Pataskar A, Zowada MK, Korner PR, Khalizieva A, van Tellingen O, Jager D, Glimm H, Agami R. Oncogene. 2022 Aug;41(32):3953-3968. doi: 10.1038/s41388-022-02400-z. Epub 2022 Jul 7. PubMed
TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection. Yousefi M, Lee WS, Yan B, Cui L, Yong CL, Yap X, Tay KSL, Qiao W, Tan D, Nurazmi NI, Linster M, Smith GJD, Lee YH, Carette JE, Ooi EE, Chan KR, Ooi YS. PLoS Pathog. 2022 Aug 8;18(8):e1010763. doi: 10.1371/journal.ppat.1010763. eCollection 2022 Aug. PubMed
Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Michaelis JB, Brunstein ME, Bozkurt S, Alves L, Wegner M, Kaulich M, Pohl C, Munch C. Nat Commun. 2022 Sep 2;13(1):5164. doi: 10.1038/s41467-022-32564-x. PubMed
Ligand Identification for Orphan MHC-Agnostic T-Cell Receptors by Whole Genome CRISPR-Cas9 Screening. Crowther MD, Legut M, Sewell AK. Methods Mol Biol. 2022;2574:3-14. doi: 10.1007/978-1-0716-2712-9_1. PubMed
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M. Nat Commun. 2022 Sep 12;13(1):5351. doi: 10.1038/s41467-022-33025-1. PubMed
Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction. Fujihara KM, Zhang BZ, Jackson TD, Ogunkola MO, Nijagal B, Milne JV, Sallman DA, Ang CS, Nikolic I, Kearney CJ, Hogg SJ, Cabalag CS, Sutton VR, Watt S, Fujihara AT, Trapani JA, Simpson KJ, Stojanovski D, Leimkuhler S, Haupt S, Phillips WA, Clemons NJ. Sci Adv. 2022 Sep 16;8(37):eabm9427. doi: 10.1126/sciadv.abm9427. Epub 2022 Sep 14. PubMed
Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma. Yang Y, Bolomsky A, Oellerich T, Chen P, Ceribelli M, Haupl B, Wright GW, Phelan JD, Huang DW, Lord JW, Van Winkle CK, Yu X, Wisniewski J, Wang JQ, Tosto FA, Beck E, Wilson K, McKnight C, Travers J, Klumpp-Thomas C, Smith GA, Pittaluga S, Maric I, Kazandjian D, Thomas CJ, Young RM. Nat Commun. 2022 Sep 17;13(1):5469. doi: 10.1038/s41467-022-33142-x. PubMed
Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency. Irwan ID, Bogerd HP, Cullen BR. Nat Microbiol. 2022 Dec;7(12):2101-2113. doi: 10.1038/s41564-022-01264-z. Epub 2022 Nov 14. PubMed
Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress. Yang R, Yang C, Ma L, Zhao Y, Guo Z, Niu J, Chu Q, Ma Y, Li B. Nat Commun. 2022 Nov 17;13(1):7031. doi: 10.1038/s41467-022-34850-0. PubMed Associated Plasmids mito-EcSTH mito-EcSTH-LbNOX EcSTH EcSTH-LbNOX
Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia. Ling VY, Straube J, Godfrey W, Haldar R, Janardhanan Y, Cooper L, Bruedigam C, Cooper E, Tavakoli Shirazi P, Jacquelin S, Tey SK, Baell J, Huang F, Jin J, Zhao Y, Bullinger L, Bywater MJ, Lane SW. Leukemia. 2023 Jan;37(1):143-153. doi: 10.1038/s41375-022-01755-2. Epub 2022 Nov 18. PubMed
Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins. Tsai PL, Cameron CJF, Forni MF, Wasko RR, Naughton BS, Horsley V, Gerstein MB, Schlieker C. Cell Rep. 2022 Nov 22;41(8):111675. doi: 10.1016/j.celrep.2022.111675. PubMed
The PNUTS-PP1 complex acts as an intrinsic barrier to herpesvirus KSHV gene expression and replication. Devlin AM, Shukla A, Ruiz JC, Barnes SD, Govindan A, Hunter OV, Scarborough AM, D'Orso I, Conrad NK. Nat Commun. 2022 Dec 2;13(1):7447. doi: 10.1038/s41467-022-35268-4. PubMed
Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate. Kriachkov V, Ormsby AR, Kusnadi EP, McWilliam HEG, Mintern JD, Amarasinghe SL, Ritchie ME, Furic L, Hatters DM. J Biol Chem. 2023 Jan;299(1):102774. doi: 10.1016/j.jbc.2022.102774. Epub 2022 Dec 5. PubMed
Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ-focal adhesion kinase signaling circuitry. Arang N, Lubrano S, Rigiracciolo DC, Nachmanson D, Lippman SM, Mali P, Harismendy O, Gutkind JS. J Biol Chem. 2023 Feb;299(2):102866. doi: 10.1016/j.jbc.2022.102866. Epub 2022 Dec 31. PubMed
Genome-wide CRISPR screen reveals genetic modifiers of Ca (2+) -mediated cell death. Reyes Gaido OE, Schole KL, Anderson ME, Luczak ED. bioRxiv. 2023 Jan 14:2023.01.13.523980. doi: 10.1101/2023.01.13.523980. Preprint. PubMed
A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase. Jin DY, Chen X, Liu Y, Williams CM, Pedersen LC, Stafford DW, Tie JK. Nat Commun. 2023 Feb 14;14(1):828. doi: 10.1038/s41467-023-36446-8. PubMed
Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication. Ohlson MB, Eitson JL, Wells AI, Kumar A, Jang S, Ni C, Xing C, Buszczak M, Schoggins JW. mBio. 2023 Apr 25;14(2):e0012723. doi: 10.1128/mbio.00127-23. Epub 2023 Feb 21. PubMed
Thymidine nucleotide metabolism controls human telomere length. Mannherz W, Agarwal S. Nat Genet. 2023 Apr;55(4):568-580. doi: 10.1038/s41588-023-01339-5. Epub 2023 Mar 23. PubMed
The ER membrane protein complex governs lysosomal turnover of a mitochondrial tail-anchored protein, BNIP3, to restrict mitophagy. Delgado JM, Wallace Shepard L, Lamson SW, Liu SL, Shoemaker CJ. bioRxiv [Preprint]. 2023 Mar 24:2023.03.22.533681. doi: 10.1101/2023.03.22.533681. PubMed
Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas. Scheich S, Chen J, Liu J, Schnutgen F, Enssle JC, Ceribelli M, Thomas CJ, Choi J, Morris V, Hsiao T, Nguyen H, Wang B, Bolomsky A, Phelan JD, Corcoran S, Urlaub H, Young RM, Haupl B, Wright GW, Huang DW, Ji Y, Yu X, Xu W, Yang Y, Zhao H, Muppidi J, Pan KT, Oellerich T, Staudt LM. Cancer Discov. 2023 Aug 4;13(8):1862-1883. doi: 10.1158/2159-8290.CD-22-1401. PubMed
Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors. van der Noord VE, van der Stel W, Louwerens G, Verhoeven D, Kuiken HJ, Lieftink C, Grandits M, Ecker GF, Beijersbergen RL, Bouwman P, Le Devedec SE, van de Water B. Breast Cancer Res. 2023 May 5;25(1):51. doi: 10.1186/s13058-023-01648-x. PubMed
Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hurthle Cell Carcinoma of the Thyroid. Frank AR, Li V, Shelton SD, Kim J, Stott GM, Neckers LM, Xie Y, Williams NS, Mishra P, McFadden DG. Cancer Discov. 2023 Aug 4;13(8):1884-1903. doi: 10.1158/2159-8290.CD-22-0982. PubMed
Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening. Haldrup J, Weiss S, Schmidt L, Sorensen KD. Sci Rep. 2023 Jun 3;13(1):9043. doi: 10.1038/s41598-023-35950-7. PubMed
Estrogen Therapy Induces Receptor-Dependent DNA Damage Enhanced by PARP Inhibition in ER+ Breast Cancer. Traphagen NA, Schwartz GN, Tau S, Roberts AM, Jiang A, Hosford SR, Marotti JD, Goen AE, Romo BA, Johnson AL, Duffy EK, Demidenko E, Heverly P, Mosesson Y, Soucy SM, Kolling F, Miller TW. Clin Cancer Res. 2023 Sep 15;29(18):3717-3728. doi: 10.1158/1078-0432.CCR-23-0488. PubMed
Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang Y, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto J, Akamatsu H, Napolitano F, Mani R, Cescon D, Xu L, Xie Y, Mendell J, Hanker A, Arteaga C. Res Sq. 2023 Jul 10:rs.3.rs-2966905. doi: 10.21203/rs.3.rs-2966905/v1. Preprint. PubMed
Fucosylated glycoproteins and fucosylated glycolipids play opposing roles in cholera intoxication. Ghorashi AC, Boucher A, Archer-Hartmann SA, Murray NB, Konada RSR, Zhang X, Xing C, Azadi P, Yrlid U, Kohler JJ. bioRxiv [Preprint]. 2023 Aug 3:2023.08.02.551727. doi: 10.1101/2023.08.02.551727. PubMed
Whole genome CRISPR screening strategy to identify genes contributing to SARS-CoV-2 spike and VSV-G mediated entry. Hossain MS, Kerkvliet JG, Hoppe AD. J Med Virol. 2023 Sep;95(9):e29087. doi: 10.1002/jmv.29087. PubMed
A genome-wide CRISPR/Cas9 screen identifies DNA-PK as a sensitiser to (177)Lutetium-DOTA-octreotate radionuclide therapy. Waldeck K, Van Zuylekom J, Cullinane C, Gulati T, Simpson KJ, Tothill RW, Blyth B, Hicks RJ. Theranostics. 2023 Aug 28;13(14):4745-4761. doi: 10.7150/thno.84628. eCollection 2023. PubMed
Balanced Epigenetic Regulation of MHC Class I Expression in Tumor Cells by the Histone Ubiquitin Modifiers BAP1 and PCGF1. Wijdeven RH, Luk SJ, Schoufour TAW, van der Zanden SY, Cabezuelo M, Heemskerk MHM, Neefjes J. J Immunol. 2024 Feb 1;212(3):446-454. doi: 10.4049/jimmunol.2300263. PubMed
Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer. Murayama T, Nakayama J, Jiang X, Miyata K, Morris AD, Cai KQ, Prasad RM, Ma X, Efimov A, Belani N, Gerstein ER, Tan Y, Zhou Y, Kim W, Maruyama R, Campbell KS, Chen L, Yang Y, Balachandran S, Canadas I. Cancer Discov. 2024 Mar 1;14(3):468-491. doi: 10.1158/2159-8290.CD-23-0486. PubMed
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. Sweeney KM, Chantarawong S, Barbieri EM, Cajka G, Liu M, Spruce L, Fazelinia H, Portz B, Copley K, Lapidot T, Duhamel L, Greenwald P, Saida N, Shalgi R, Shorter J, Shalem O. PLoS Genet. 2024 Feb 5;20(2):e1011138. doi: 10.1371/journal.pgen.1011138. eCollection 2024 Feb. PubMed Associated Plasmids TRE-TDP-43ΔNLS-mClover3 TRE-mClover3-TDP-43ΔNLS EF1a-SRRD-HA (in pLEX_307) EF1a-SRRD-noTag (in pLEX_307) TRE-SRRD-mRuby3 More ...
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Santhosh Kumar S, Naseri NN, Pather SR, Hallacli E, Ndayisaba A, Buenaventura C, Acosta K, Roof J, Fazelinia H, Spruce LA, Luk K, Khurana V, Rhoades E, Shalem O. Sci Adv. 2024 Feb 9;10(6):eadj4767. doi: 10.1126/sciadv.adj4767. Epub 2024 Feb 9. PubMed Associated Plasmids FUW-hSNCA-NE FUW-hSNCA(D2R)-NE FUW-hSNCA(D2E)-NE FUW-hSNCA-GFP FUW-hSNCA(D2R)-GFP More ...
A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells. Mondal P, Alyateem G, Mitchell AV, Gottesman MM. bioRxiv [Preprint]. 2024 Feb 15:2024.02.15.580539. doi: 10.1101/2024.02.15.580539. PubMed
PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang YV, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto JJ, Akamatsu H, Napolitano F, Mani R, Cescon DW, Xu L, Xie Y, Mendell JT, Hanker AB, Arteaga CL. Nat Commun. 2024 Mar 13;15(1):2287. doi: 10.1038/s41467-024-46495-2. PubMed
Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer. Mishra AK, Ye T, Banday S, Thakare RP, Su CT, Pham NNH, Ali A, Kulshreshtha A, Chowdhury SR, Simone TM, Hu K, Zhu LJ, Eisenhaber B, Deibler SK, Simin K, Thompson PR, Kelliher MA, Eisenhaber F, Malonia SK, Green MR. Cell Rep. 2024 Apr 23;43(4):114041. doi: 10.1016/j.celrep.2024.114041. Epub 2024 Apr 3. PubMed
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies. Xiang M, Li H, Zhan Y, Ma D, Gao Q, Fang Y. Mol Cancer. 2024 Apr 5;23(1):73. doi: 10.1186/s12943-024-01987-z. PubMed
GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies. Benbarche S, Pineda JMB, Galvis LB, Biswas J, Liu B, Wang E, Zhang Q, Hogg SJ, Lyttle K, Dahi A, Lewis AM, Sarchi M, Rahman J, Fox N, Ai Y, Mehta S, Garippa R, Ortiz-Pacheco J, Li Z, Monetti M, Stanley RF, Doulatov S, Bradley RK, Abdel-Wahab O. Mol Cell. 2024 May 16;84(10):1886-1903.e10. doi: 10.1016/j.molcel.2024.04.006. Epub 2024 Apr 29. PubMed
Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas. Choi J, Ceribelli M, Phelan JD, Haupl B, Huang DW, Wright GW, Hsiao T, Morris V, Ciccarese F, Wang B, Corcoran S, Scheich S, Yu X, Xu W, Yang Y, Zhao H, Zhou J, Zhang G, Muppidi J, Inghirami GG, Oellerich T, Wilson WH, Thomas CJ, Staudt LM. Cancer Cell. 2024 May 13;42(5):833-849.e12. doi: 10.1016/j.ccell.2024.04.007. Epub 2024 May 2. PubMed
A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells. Bulanova D, Akimov Y, Senkowski W, Oikkonen J, Gall-Mas L, Timonen S, Elmadani M, Hynninen J, Hautaniemi S, Aittokallio T, Wennerberg K. Sci Adv. 2024 May 24;10(21):eadj1564. doi: 10.1126/sciadv.adj1564. Epub 2024 May 23. PubMed
CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy. Qin M, Deng C, Wen L, Luo G, Meng Y. J Transl Med. 2024 May 30;22(1):516. doi: 10.1186/s12967-024-05235-2. PubMed
A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans. Lin J, Miao J, Schaefer KG, Russell CM, Pyron RJ, Zhang F, Phan QT, Solis-Swidergall NV, Liu H, Tashiro M, Dordick JS, Linhardt RJ, Yeaman MR, King GM, Barrera FN, Peters BM, Filler SG. bioRxiv [Preprint]. 2024 May 23:2024.05.23.595417. doi: 10.1101/2024.05.23.595417. PubMed
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma. Bolomsky A, Ceribelli M, Scheich S, Rinaldi K, Huang DW, Chakraborty P, Pham L, Wright GW, Hsiao T, Morris V, Choi J, Phelan JD, Holewinski RJ, Andresson T, Wisniewski J, Riley D, Pittaluga S, Hill E, Thomas CJ, Muppidi J, Young RM. Cancer Cell. 2024 Jul 8;42(7):1185-1201.e14. doi: 10.1016/j.ccell.2024.05.026. Epub 2024 Jun 20. PubMed
CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition. Schoufour TAW, van der Plas-van Duijn A, Derksen I, Melgers M, van Veenendaal JMF, Lensen C, Heemskerk MHM, Neefjes J, Wijdeven RHM, Scheeren FA. iScience. 2024 May 27;27(6):110120. doi: 10.1016/j.isci.2024.110120. eCollection 2024 Jun 21. PubMed
Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction. Wang C, Liu Y, Xiong J, Xie K, Wang T, Hu Y, Fu H, Zhang B, Huang X, Bao H, Cai H, Dong B, Li Z. PLoS Pathog. 2024 Jul 8;20(7):e1012344. doi: 10.1371/journal.ppat.1012344. eCollection 2024 Jul. PubMed
Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis. Feng YY, Li YC, Liu HM, Xu R, Liu YT, Zhang W, Yang HY, Chen G. Cell Rep. 2024 Jul 23;43(7):114477. doi: 10.1016/j.celrep.2024.114477. Epub 2024 Jul 11. PubMed
Galpha13 restricts nutrient driven proliferation in mucosal germinal centers. Nguyen HT, Li M, Vadakath R, Henke KA, Tran TC, Li H, Yamadi M, Darbha S, Yang Y, Kabat J, Albright AR, Centeno EG, Phelan JD, Roulland S, Huang DW, Kelly MC, Young RM, Pittaluga S, Difilippantonio S, Muppidi JR. Nat Immunol. 2024 Sep;25(9):1718-1730. doi: 10.1038/s41590-024-01910-0. Epub 2024 Jul 18. PubMed
Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection. Gong M, Peng C, Yang C, Wang Z, Qian H, Hu X, Zhou P, Shan C, Ding Q. PLoS Pathog. 2024 Aug 22;20(8):e1012444. doi: 10.1371/journal.ppat.1012444. eCollection 2024 Aug. PubMed
A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation. Padmanabhan A, de Soysa TY, Pelonero A, Sapp V, Shah PP, Wang Q, Li L, Lee CY, Sadagopan N, Nishino T, Ye L, Yang R, Karnay A, Poleshko A, Bolar N, Linares-Saldana R, Ranade SS, Alexanian M, Morton SU, Jain M, Haldar SM, Srivastava D, Jain R. Nat Cardiovasc Res. 2024 Mar;3(3):317-331. doi: 10.1038/s44161-024-00431-1. Epub 2024 Feb 23. PubMed
TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells. Truong P, Shen S, Joshi S, Islam MI, Zhong L, Raftery MJ, Afrasiabi A, Alinejad-Rokny H, Nguyen M, Zou X, Bhuyan GS, Sarowar CH, Ghodousi ES, Stonehouse O, Mohamed S, Toscan CE, Connerty P, Kakadia PM, Bohlander SK, Michie KA, Larsson J, Lock RB, Walkley CR, Thoms JAI, Jolly CJ, Pimanda JE. Nat Commun. 2024 Aug 28;15(1):7360. doi: 10.1038/s41467-024-51646-6. PubMed
SLC35A2 modulates paramyxovirus fusion events during infection. Yang Y, Wang Y, Campbell DE, Lee HW, Wang L, Baldridge M, Lopez CB. bioRxiv [Preprint]. 2024 Aug 27:2024.08.27.609835. doi: 10.1101/2024.08.27.609835. PubMed
Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus. Franz H, Rathod M, Zimmermann A, Studle C, Beyersdorfer V, Leal-Fischer K, Hanns P, Cunha T, Didona D, Hertl M, Scheibe M, Butter F, Schmidt E, Spindler V. Nat Commun. 2024 Sep 14;15(1):8044. doi: 10.1038/s41467-024-51747-2. PubMed
GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes. Yousefi M, See WR, Aw-Yong KL, Lee WS, Yong CL, Fanusi F, Smith GJD, Ooi EE, Li S, Ghosh S, Ooi YS. Brief Bioinform. 2024 Jul 25;25(5):bbae452. doi: 10.1093/bib/bbae452. PubMed
Endocrine persistence in ER+ breast cancer is accompanied by metabolic vulnerability in oxidative phosphorylation. Tau S, Chamberlin MD, Yang H, Marotti JD, Roberts AM, Carmichael MM, Cressey L, Dragnev C, Demidenko E, Hampsch RA, Soucy SM, Kolling F, Samkoe KS, Alvarez JV, Kettenbach AN, Miller TW. bioRxiv [Preprint]. 2024 Sep 27:2024.09.26.615177. doi: 10.1101/2024.09.26.615177. PubMed
SLC35A2 gene product modulates paramyxovirus fusion events during infection. Yang Y, Wang Y, Campbell DE, Lee HW, Beatty W, Wang L, Baldridge M, Lopez CB. PLoS Pathog. 2025 Jan 10;21(1):e1012531. doi: 10.1371/journal.ppat.1012531. eCollection 2025 Jan. PubMed
The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma. Banday S, Mishra AK, Rashid R, Ye T, Ali A, Li J, Yustein JT, Kelliher MA, Zhu LJ, Deibler SK, Malonia SK, Green MR. Nat Commun. 2025 Feb 2;16(1):1267. doi: 10.1038/s41467-025-56632-0. PubMed
CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production. O'Driscoll EE, Arora S, Lang JF, Davidson BL, Shalem O. Mol Ther Methods Clin Dev. 2025 Jan 17;33(1):101408. doi: 10.1016/j.omtm.2025.101408. eCollection 2025 Mar 13. PubMed

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