Showing: 21 - 40 of 100 results
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Plasmid#22661DepositorInsertLamin A (LMNA Human)
UseLentiviralTagsOnestrep TagExpressionMammalianMutationPromoterAvailabilityAcademic Institutions and Nonprofits only -
pCDHblast MCSNard OST-LMNAd50
Plasmid#22662DepositorInsertLaminAd50 (=Progerin)
UseLentiviralTagsOnestrep TagExpressionMammalianMutation50AA deletion creating Progerin instead of mature…PromoterAvailabilityAcademic Institutions and Nonprofits only -
pUC CBA-SpCas9.EF1a-BFP.sgLMNA
Plasmid#98971PurposeCas9 Homologous Recombination Reporter. SpCas9 and a sgRNA targeting LMNA. TagBFP.DepositorInsertLMNA sgRNA and spCas9
UseTagsExpressionMammalianMutationPromoterAvailabilityAcademic Institutions and Nonprofits only -
pCMS-dsRed2-WT LMNA-GFP minigene
Plasmid#128230PurposeLamin A splicing reporterDepositorInsertlamin A (LMNA Human)
UseTagsGFP and SV40-driven dsRed2 to identify transfecte…ExpressionMammalianMutationPromoterCMVAvailabilityAcademic Institutions and Nonprofits only -
PHY98-LMNA 5'HA-TriTag (mTagBFP)-3'HA (HDR donor)
Plasmid#164046PurposeCRISPR donor plasmid to insert TriTag (mTagBFP) into the N-terminus of human LMNA geneDepositorInsertmTagBFG-TriTag
UseCRISPRTagsExpressionMammalianMutationPromoterAvailabilityAcademic Institutions and Nonprofits only -
PW124-LMNA 5'HA-TriTag (mCherry)-3'HA (HDR donor)
Plasmid#164047PurposeCRISPR donor plasmid to insert TriTag (mCherry) into the N-terminus of human LMNA geneDepositorInsertmCherry-TriTag
UseCRISPRTagsExpressionMammalianMutationPromoterAvailabilityAcademic Institutions and Nonprofits only -
pCMS-dsRed2-C1824U LMNA-GFP minigene
Plasmid#128231PurposeC1824U mutation Lamin A splicing reporterDepositorInsertlamin A (LMNA Human)
UseTagsGFP and SV40-driven dsRed2 to identify transfecte…ExpressionMammalianMutationC1824UPromoterCMVAvailabilityAcademic Institutions and Nonprofits only -
pAAV-EFS-TadA8e-Sauri-U6-Lmna sgRNA
Plasmid#206979PurposeExpresses SauriABE8e by EFS promoter and sgRNA targeting murine Lmna c.1621T mutation by U6 promoterDepositorInsertLmna sgRNA
UseAAV; Adenine base editorTagsExpressionMutationPromoterU6AvailabilityAcademic Institutions and Nonprofits only -
pcDNA5-FRT/TO-3*Flag-APEX2 N-term LMNA
Plasmid#187576PurposeExpress FLAG epitope and APEX2-tagged LMNA fusion protein in mammalian cellsDepositorInsertLMNA (LMNA Human)
UseTagsAPEX2-FLAGExpressionMammalianMutationPromoterCMVAvailabilityAcademic Institutions and Nonprofits only -
BC1455-LMNA 5'HA-mCherry-CRISPR-Tag_V2-3'HA (HDR donor)
Plasmid#164042PurposeCRISPR donor plasmid to insert mCherry-harboring CRISPR-TagV2 into the N-terminus of human LMNA geneDepositorInsertmCherry-CRISPR-TagV2
UseCRISPRTagsExpressionMammalianMutationPromoterAvailabilityAcademic Institutions and Nonprofits only -
pAAV-CASI-InteinC-NG C aa714-1368-U6-Lmna sgRNA1
Plasmid#206974PurposeExpresses NG cas9C by the constitutive CASI promoter and sgRNA targeting murine Lmna c.1621T mutation by U6 promoterDepositorInsertNG aa714-1368, U6, Lmna sgRNA1
UseAAVTagsExpressionMutationPromoterU6AvailabilityAcademic Institutions and Nonprofits only -
pAAV-CASI-InteinC-SpG C aa714-1368-U6-Lmna sgRNA1
Plasmid#208110PurposeExpresses SpG cas9C by the constitutive CASI promoter and sgRNA targeting murine Lmna c.1621T mutation by U6 promoterDepositorInsertSpG C, U6, Lmna sgRNA1, scaffold
UseAAVTagsExpressionMutationPromoterU6AvailabilityAcademic Institutions and Nonprofits only -
Lamin A (R482Q)-mRFP
Plasmid#124273PurposeLamin A mutant (R482Q), C-terminally tagged with mRFP. Mutation associated with FPLD lipodystrophy.DepositorInsertLMNA (R482Q) (LMNA Human)
UseTagsmRFPExpressionMammalianMutationLMNA (R482Q)PromoterAvailabilityAcademic Institutions and Nonprofits only -
Lamin A (R435C)-mRFP
Plasmid#124274PurposeLamin A mutant (R435C), C-terminally tagged with mRFP. Mutation associated with Progeria.DepositorInsertLMNA (R435C) (LMNA Human)
UseTagsmRFPExpressionMammalianMutationLMNA (R435C)PromoterAvailabilityAcademic Institutions and Nonprofits only -
Lamin A (R298C)-mRFP
Plasmid#124269PurposeLamin A mutant (R298C), C-terminally tagged with Mrfp. Mutation associated with CMT neuropathy.DepositorInsertLMNA (R298C) (LMNA Human)
UseTagsmRFPExpressionMammalianMutationLMNA (R298C)PromoterAvailabilityAcademic Institutions and Nonprofits only -
Lamin A (R377H)-mRFP
Plasmid#124270PurposeLamin A mutant (R377H), C-terminally tagged with mRFP. Mutation associated with EDMD myopathy.DepositorInsertLMNA (R377H) (LMNA Human)
UseTagsmRFPExpressionMammalianMutationLMNA (R377H)PromoterAvailabilityAcademic Institutions and Nonprofits only -
Lamin A (G465D)-mRFP
Plasmid#124271PurposeLamin A mutant (G465D), C-terminally tagged with mRFP. Mutation associated with FPLD lipodystrophy.DepositorInsertLMNA (G465D) (LMNA Human)
UseTagsmRFPExpressionMammalianMutationLMNA (G465D)PromoterAvailabilityAcademic Institutions and Nonprofits only -
Lamin A (R527P)-mRFP
Plasmid#124272PurposeLamin A mutant (R527P), C-terminally tagged with mRFP. Mutation associated with EDMD myopathy.DepositorInsertLMNA (R527P) (LMNA Human)
UseTagsmRFPExpressionMammalianMutationLMNA (R527P)PromoterAvailabilityAcademic Institutions and Nonprofits only -
pAAV-AcGFP-progerin
Plasmid#86947PurposeConstruct used to synthesize progerin mRNA. Please note the plasmid contains LMNA gene with nucleotide C1824T mutation.DepositorInsertAcGFP-progerin (LMNA Human)
UseAAVTagsAcGFPExpressionMammalianMutationprogerin sequence is LMNA gene with nucleotide C1…PromoterCMV and T7AvailabilityAcademic Institutions and Nonprofits only -
pET3a-SF-LMNC-TS
Plasmid#169374PurposeE. coli expression plasmid for human LMNA residues 31-542, corresponding to the shorter lamin C isoform lacking the unstructured head, with an N-terminal splitFlAsH tag and a C-terminal TwinStrep tag.DepositorInsertLMNA residues 31-542 (LMNA Human)
UseTagsSplit-FlAsH Tag and TwinStrep TagExpressionBacterialMutationdeleted amino acid 1-30 (unstructured head domain…PromoterNative pET3a promotorAvailabilityAcademic Institutions and Nonprofits only
Showing: 21 - 40 of 100 results