We narrowed to 96 results for: REP

1. sgRNA pool for Streptococcus pneumoniae

   Pooled Library

   #170432

   Purpose

   Concise library targeting the whole genome of S. pneumoniae D39V with one sgRNA per operon or gene.

   Depositor

   Jan-Willem Veening

   Article

   Liu et al Cell Host Microbe. 2021 Jan 13;29(1):107

   Expression

   Bacterial

   Use

   CRISPR

   Available Since

   Aug. 31, 2021

   Availability

   Academic Institutions and Nonprofits only

2. DNA repair library with 1,573 sgRNAs

   Pooled Library

   #177663

   Purpose

   CRISPR-interference (CRISPRi) library of 1,573 sgRNAs targeting 476 genes encoding factors involved in DNA repair and associated processes

   Depositor

   Brittany Adamson

   Article

   Hussmann et al Cell. 2021 Oct 28;184(22):5653-5669.e25.

   Species

   Homo sapiens

   Use

   CRISPR

   Available Since

   July 11, 2023

   Availability

   Academic Institutions and Nonprofits only

3. DNA repair library with 336 sgRNAs

   Pooled Library

   #177664

   Purpose

   CRISPR-interference (CRISPRi) library of 366 sgRNAs targeting 118 genes encoding factors involved in DNA repair and associated processes

   Depositor

   Brittany Adamson

   Article

   Hussmann et al Cell. 2021 Oct 28;184(22):5653-5669.e25.

   Species

   Homo sapiens

   Use

   CRISPR

   Available Since

   Nov. 29, 2023

   Availability

   Academic Institutions and Nonprofits only

4. pCMV-Rep78/68 Scanning Saturation Mutagenesis (SSM)

   Pooled Library

   #198050

   Purpose

   By supplying an AAV cap gene of interest in trans, researchers can use this library to investigate the effects of rep mutations on production of a wide range of AAV capsid serotypes

   Depositor

   George Church

   Article

   Jain et al Elife. 2024 Mar 27;12:RP87730. doi: 10.7

   Expression

   Mammalian

   Use

   AAV

   Available Since

   May 4, 2023

   Availability

   Academic Institutions and Nonprofits only

5. pRep-Cap Scanning Saturation Mutagenesis (SSM) pooled library

   Pooled Library

   #199601

   Purpose

   pRep-Cap SSM library enables VP1, VP2, and VP3 expression under the control of the endogenous p40 promoter

   Depositor

   George Church

   Article

   Ogden et al Science. 2019 Nov 29;366(6469):1139-1143

   Expression

   Mammalian

   Species

   Aav2

   Use

   AAV

   Available Since

   June 13, 2023

   Availability

   Academic Institutions and Nonprofits only

6. Human Paralog Knockout Library (pgPEN)

   Pooled Library

   #171172

   Purpose

   Induces knockouts of paralogous gene pairs. Plasmids express a pair of guide RNAs targeting either individual genes or a pair of paralogs.

   Depositor

   Alice Berger

   Article

   Parrish et al Cell Rep. 2021 Aug 31;36(9):109597. doi:

   Expression

   Mammalian

   Species

   Homo sapiens and Synthetic

   Use

   CRISPR and Lentiviral

   Available Since

   Sept. 28, 2021

   Availability

   Academic Institutions and Nonprofits only

7. Human lentiviral CRISPR library_v1

   Pooled Library

   #69763

   Purpose

   Used for genome scale lentiviral CRISPR screening. Target sites were chosen in a region close to the translation initiation site.

   Depositor

   Haoquan Wu

   Article

   Ma et al Cell Rep. 2015 Jul 28;12(4):673-83. doi:

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available Since

   Feb. 9, 2016

   Availability

   Academic Institutions and Nonprofits only

8. pLCKO2::TKOv3

   Pooled Library

   #125517

   Purpose

   Human CRISPR lentiviral library containing 70,948 guides (4-5 guides/gene) targeting 18,053 human protein-coding genes, in a non-Cas9 containing backbone

   Depositor

   Jason Moffat

   Article

   Mair et al Cell Rep. 2019 Apr 9;27(2):599-615.e12.

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available Since

   Aug. 1, 2019

   Availability

   Academic Institutions and Nonprofits only

9. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 1

   Pooled Library

   #168776

   Purpose

   Pooled library expressing barcoded SARS-CoV-2 RNA Binding Domain mutations

   Depositor

   Timothy Whitehead

   Article

   Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

   Expression

   Yeast

   Species

   Sars-cov-2

   Available Since

   Sept. 13, 2021

   Availability

   Academic Institutions and Nonprofits only

10. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 2

    Pooled Library

    #168777

    Purpose

    Pooled library expressing barcoded SARS-CoV-2 RNA Binding Domain mutations

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Species

    Sars-cov-2

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

11. SARS-CoV-2 Spike (S) Ectodomain Library C

    Pooled Library

    #157973

    Purpose

    Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Bacterial and Yeast

    Species

    Sars-cov-2

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

12. SARS-CoV-2 Spike (S) Ectodomain Library B

    Pooled Library

    #157972

    Purpose

    Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Bacterial and Yeast

    Species

    Sars-cov-2

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

13. SARS-CoV-2 Spike (S) Ectodomain Library A

    Pooled Library

    #157971

    Purpose

    Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Bacterial and Yeast

    Species

    Sars-cov-2

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

14. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library N501Y Tile 2 (positions 437-527)

    Pooled Library

    #174296

    Purpose

    This library contains mutations to SARS-CoV-2 Spike RBD N501Y variant in which all surface exposed residues on S RBD (Tile 2, positions 437-527) were mutated to every other amino acid.

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

15. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library N501Y Tile 1 (positions 333-436)

    Pooled Library

    #174295

    Purpose

    This library contains mutations to SARS-CoV-2 Spike RBD N501Y variant in which all surface exposed residues on S RBD (Tile 1, positions 333-436) were mutated to every other amino acid.

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

16. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library E484K Tile 2 (positions 437-527)

    Pooled Library

    #174294

    Purpose

    This library contains mutations to SARS-CoV-2 Spike RBD E484K variant in which all surface exposed residues on S RBD (Tile 2, positions 437-527) were mutated to every other amino acid.

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

17. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library E484K Tile 1 (positions 333-436)

    Pooled Library

    #174293

    Purpose

    This library contains mutations to SARS-CoV-2 Spike RBD E484K variant in which all surface exposed residues on S RBD (Tile 1, positions 333-436) were mutated to every other amino acid.

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

18. Human genome-wide lentiviral CRISPR gRNA library version 1

    Pooled Library

    #67989

    Purpose

    Knockout library targeting 18,010 human genes. gRNAs were improved using a new design pipeline and improved gRNA scaffold.

    Depositor

    Kosuke Yusa

    Article

    Tzelepis et al Cell Rep. 2016 Oct 18;17(4):1193-1205. d

    Species

    Homo sapiens, Mus musculus, and Synthetic

    Use

    CRISPR and Lentiviral

    Available Since

    Oct. 14, 2016

    Availability

    Academic Institutions and Nonprofits only

19. Mouse genome-wide lentiviral CRISPR gRNA library version 2

    Pooled Library

    #67988

    Purpose

    Knockout library targeting 18,424 mouse genes. gRNAs were improved using a new design pipeline and improved gRNA scaffold.

    Depositor

    Kosuke Yusa

    Article

    Tzelepis et al Cell Rep. 2016 Oct 18;17(4):1193-1205. d

    Species

    Homo sapiens, Mus musculus, and Synthetic

    Use

    CRISPR and Lentiviral

    Available Since

    Oct. 14, 2016

    Availability

    Academic Institutions and Nonprofits only

20. DDR_MKOv4

    Pooled Library

    #140219

    Purpose

    Knockout library targeting human DNA damage response and DNA repair genes.

    Depositor

    Junjie Chen

    Article

    Su et al DNA Repair (Amst). 2020 Jan 16;87:102803

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available Since

    Aug. 20, 2021

    Availability

    Academic Institutions and Nonprofits only