We narrowed to 115 results for: mutant p53

1. pEGFP-WRAP53beta-DC-mutant-G435R

   Plasmid

   #64684

   Purpose

   expresses single mutated WRAP53beta at G435R, found in Dyskeratosis congenita patients

   Depositor

   Marianne Farnebo

   Article

   Henriksson et al Genes Dev. 2014 Dec 15;28(24):2726-38. d

   Insert

   WD40-encoding RNA antisense to P53 (WRAP53 Human)
   

   Use

   Tags

   GFP

   Expression

   Mammalian

   Mutation

   mutation at G435R

   Promoter

   CMV

   Available since

   May 21, 2015

   Availability

   Academic Institutions and Nonprofits only

2. pEGFP-WRAP53beta-DC-mutant-R398W

   Plasmid

   #64683

   Purpose

   expresses single mutated WRAP53beta at R398W, found in Dyskeratosis congenita patients

   Depositor

   Marianne Farnebo

   Article

   Henriksson et al Genes Dev. 2014 Dec 15;28(24):2726-38. d

   Insert

   WD40-encoding RNA antisense to P53 (WRAP53 Human)
   

   Use

   Tags

   GFP

   Expression

   Mammalian

   Mutation

   mutation at R398W

   Promoter

   CMV

   Available since

   May 21, 2015

   Availability

   Academic Institutions and Nonprofits only

3. pEGFP-WRAP53beta-DC-mutant-F164L

   Plasmid

   #64681

   Purpose

   expresses single mutated WRAP53beta at F164L, found in Dyskeratosis congenita patients

   Depositor

   Marianne Farnebo

   Article

   Henriksson et al Genes Dev. 2014 Dec 15;28(24):2726-38. d

   Insert

   WD40-encoding RNA antisense to P53 (WRAP53 Human)
   

   Use

   Tags

   GFP

   Expression

   Mammalian

   Mutation

   mutation at F164L

   Promoter

   CMV

   Available since

   May 21, 2015

   Availability

   Academic Institutions and Nonprofits only

4. pEGFP-WRAP53beta-DC-mutant-H376Y

   Plasmid

   #64682

   Purpose

   expresses single mutated WRAP53beta at H376Y, found in Dyskeratosis congenita patients

   Depositor

   Marianne Farnebo

   Article

   Henriksson et al Genes Dev. 2014 Dec 15;28(24):2726-38. d

   Insert

   WD40-encoding RNA antisense to P53 (WRAP53 Human)
   

   Use

   Tags

   GFP

   Expression

   Mammalian

   Mutation

   mutation at H376Y

   Promoter

   CMV

   Available since

   May 21, 2015

   Availability

   Academic Institutions and Nonprofits only

5. p53 (dominant negative R175H mutant)-pcw107-V5

   Plasmid

   #64638

   Purpose

   3rd generation lentiviral transfer plasmid. When used to produce lentivirus, express physiological levels of insert

   Depositor

   David Sabatini, Kris Wood

   Article

   Martz et al Sci Signal. 2014 Dec 23;7(357):ra121. do

   Insert

   TP53 (transcript variant 3) (TP53 Human)
   

   Use

   Lentiviral

   Tags

   V5

   Expression

   Mutation

   R175H

   Promoter

   PGK

   Available since

   Dec. 1, 2015

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

6. pLenti6/V5-p53_wt p53

   Plasmid

   #22945

   Purpose

   3rd generation lentiviral vector encoding human p53 with a C-terminal V5 tag

   Depositor

   Bernard Futscher

   Article

   Junk et al Neoplasia. 2008 May . 10(5):450-61.

   Insert

   tumor protein 53 (TP53 Human)
   

   Use

   Lentiviral

   Tags

   V5

   Expression

   Mammalian

   Mutation

   Promoter

   Available since

   Jan. 27, 2010

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

7. pLenti6/V5-p53_R175H

   Plasmid

   #22936

   Depositor

   Bernard Futscher

   Article

   Junk et al Neoplasia. 2008 May . 10(5):450-61.

   Insert

   tumor protein 53 (TP53 Human)
   

   Use

   Lentiviral

   Tags

   V5

   Expression

   Mammalian

   Mutation

   R175H Mutant

   Promoter

   Available since

   March 8, 2010

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

8. pLenti6/V5-p53_R273H

   Plasmid

   #22934

   Depositor

   Bernard Futscher

   Article

   Junk et al Neoplasia. 2008 May . 10(5):450-61.

   Insert

   tumor protein 53 (TP53 Human)
   

   Use

   Lentiviral

   Tags

   V5

   Expression

   Mammalian

   Mutation

   R273H Mutant

   Promoter

   Available since

   Jan. 27, 2010

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

9. pLenti6/V5-p53_R249S

   Plasmid

   #22935

   Depositor

   Bernard Futscher

   Article

   Junk et al Neoplasia. 2008 May . 10(5):450-61.

   Insert

   tumor protein 53 (TP53 Human)
   

   Use

   Lentiviral

   Tags

   V5

   Expression

   Mammalian

   Mutation

   R249S Mutant

   Promoter

   Available since

   Jan. 27, 2010

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

10. pLenti6/V5-p53_R280K

    Plasmid

    #22933

    Depositor

    Bernard Futscher

    Article

    Junk et al Neoplasia. 2008 May . 10(5):450-61.

    Insert

    tumor protein 53 (TP53 Human)
    

    Use

    Lentiviral

    Tags

    v5

    Expression

    Mammalian

    Mutation

    R280K mutant

    Promoter

    Available since

    Jan. 27, 2010

    Availability

    Academic Institutions and Nonprofits only

11. pLentiCRISPR_Puro_sgTP53

    Plasmid

    #187819

    Purpose

    pLentiCRISPR that is selectable with puromycin with an sgRNA targeting TP53

    Depositor

    William Kaelin

    Article

    Stransky et al Proc Natl Acad Sci U S A. 2022 Apr 5;119

    Insert

    sgTP53
    

    Use

    CRISPR and Lentiviral

    Tags

    Expression

    Mammalian

    Mutation

    Promoter

    U6

    Available since

    Aug. 24, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

12. pLentiCRISPR_zeo_sgTP53

    Plasmid

    #183180

    Purpose

    pLentiCRISPR that is selectable with zeocin with an sgRNA targeting TP53

    Depositor

    William Kaelin

    Article

    Stransky et al Proc Natl Acad Sci U S A. 2022 Apr 5;119

    Insert

    sgTP53 (TP53 Human)
    

    Use

    CRISPR and Lentiviral

    Tags

    Expression

    Mammalian

    Mutation

    Promoter

    U6

    Available since

    Oct. 31, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

13. Lox-stop-Lox p53 R172H

    Plasmid

    #14854

    Depositor

    Tyler Jacks

    Article

    Olive et al Cell. 2004 Dec 17. 119(6):847-60.

    Insert

    p53 R172H (Trp53 Mouse)
    

    Use

    Cre/Lox

    Tags

    Lox-STOP-lox

    Expression

    Mammalian

    Mutation

    Structural mutant R172H. (Murine p53 codon 172 co…

    Promoter

    Available since

    April 27, 2007

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

14. Lox-stop-Lox p53 R270H

    Plasmid

    #14853

    Depositor

    Tyler Jacks

    Article

    Olive et al Cell. 2004 Dec 17. 119(6):847-60.

    Insert

    p53 R270H (Trp53 Mouse)
    

    Use

    Cre/Lox

    Tags

    Lox-STOP-lox

    Expression

    Mammalian

    Mutation

    Contact mutant R270H. (Murine p53 codon 270 corre…

    Promoter

    Available since

    April 27, 2007

    Availability

    Academic Institutions and Nonprofits only

15. pLenti_EF1a_Flag_TP53_WT

    Plasmid

    #183112

    Purpose

    Expresses flag-tagged p53 in mammalian cells

    Depositor

    William Kaelin

    Article

    Stransky et al Proc Natl Acad Sci U S A. 2022 Apr 5;119

    Insert

    TP53 (TP53 Human)
    

    Use

    CRISPR and Lentiviral

    Tags

    Expression

    Mammalian

    Mutation

    See Depositor Comments Below

    Promoter

    EF1a

    Available since

    Aug. 24, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

16. pLenti_EF1a_Flag_TP53_R248W

    Plasmid

    #183114

    Purpose

    Expresses flag-tagged p53 with R248W mutation in mammalian cells

    Depositor

    William Kaelin

    Article

    Stransky et al Proc Natl Acad Sci U S A. 2022 Apr 5;119

    Insert

    TP53 (TP53 Human)
    

    Use

    CRISPR and Lentiviral

    Tags

    FLAG

    Expression

    Mammalian

    Mutation

    changed arginine 248 to tryptophan

    Promoter

    EF1a

    Available since

    April 25, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

17. pLenti_EF1a_Flag_TP53_P278A

    Plasmid

    #183113

    Purpose

    Expresses flag-tagged p53 with P278A mutation in mammalian cells

    Depositor

    William Kaelin

    Article

    Stransky et al Proc Natl Acad Sci U S A. 2022 Apr 5;119

    Insert

    TP53 (TP53 Human)
    

    Use

    CRISPR and Lentiviral

    Tags

    FLAG

    Expression

    Mammalian

    Mutation

    changed proline 278 to alanine, see depositor com…

    Promoter

    EF1a

    Available since

    Aug. 24, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

18. pLenti_EF1a_Flag_TP53_R248W+P278A

    Plasmid

    #183115

    Purpose

    Expresses flag-tagged p53 with both R248W and P278A mutations in mammalian cells

    Depositor

    William Kaelin

    Article

    Stransky et al Proc Natl Acad Sci U S A. 2022 Apr 5;119

    Insert

    TP53 (TP53 Human)
    

    Use

    CRISPR and Lentiviral

    Tags

    FLAG

    Expression

    Mammalian

    Mutation

    changed proline 278 to alanine and arginine 248 t…

    Promoter

    EF1a

    Available since

    Aug. 24, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

19. pCDF RBP-FL P53

    Plasmid

    #174042

    Purpose

    Express Full length P53 in E.coli with cleavable expression/purification tag (ribose binding protein)

    Depositor

    Stewart Loh

    Article

    Blanden et al Elife. 2020 Dec 2;9. pii: 61487. doi: 10

    Insert

    P53 gene (TP53 Human)
    

    Use

    Tags

    Thermoanaerobacter Tencongenesis ribose binding p…

    Expression

    Bacterial

    Mutation

    Promoter

    T7

    Available since

    Oct. 7, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

20. pKan cpRBP-FL P53

    Plasmid

    #174504

    Purpose

    Express Full-length P53 in E.coli with cleavable expression/purification tag (ribose binding protein circular permutant)

    Depositor

    Stewart Loh

    Article

    Ha et al Bio Protoc. 2021 Oct 20;11(20):e4188. do

    Insert

    P53 gene (TP53 Human)
    

    Use

    Tags

    20 amino acid linker containing HRV3C protease si…

    Expression

    Bacterial

    Mutation

    Promoter

    T7

    Available since

    Oct. 7, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

21. pIVT-p53DD

    Plasmid

    #232751

    Purpose

    IVT template for making modRNA encoding p53DD, a mutant p53 that lacks DNA binding ability

    Depositor

    Kate Galloway

    Article

    Blanch-Asensio et al bioRxiv [Preprint]. 2024 Oct 17:2024.10.

    Insert

    p53DD
    

    Use

    In vitro transcription

    Tags

    Expression

    Mutation

    deletion of DNA binding domain

    Promoter

    Available since

    March 17, 2025

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

22. pAc-HT-Dmp53KRKR

    Plasmid

    #85699

    Purpose

    expression of Drosophila p53 KRKR mutant in Drosophila cells

    Depositor

    Licio Collavin, Giannino Del Sal

    Article

    Mauri et al J Biol Chem. 2008 Jul 25. 283(30):20848-

    Insert

    Dmp53 (p53 Fly)
    

    Use

    Tags

    His

    Expression

    Insect

    Mutation

    K26R K302R

    Promoter

    Ac5

    Available since

    March 21, 2017

    Availability

    Academic Institutions and Nonprofits only

23. pcDNA3 p53 S15D

    Plasmid

    #69005

    Purpose

    mammalian expression of human p53 S15D mutant

    Depositor

    David Meek

    Article

    Loughery et al Nucleic Acids Res. 2014 Jul;42(12):7666-

    Insert

    p53 (TP53 Human)
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    S15D

    Promoter

    CMV

    Available since

    Oct. 9, 2015

    Availability

    Academic Institutions and Nonprofits only

24. pcDNA3 p53 S15A

    Plasmid

    #69004

    Purpose

    mammalian expression of human p53 S15A mutant.

    Depositor

    David Meek

    Article

    Loughery et al Nucleic Acids Res. 2014 Jul;42(12):7666-

    Insert

    p53 (TP53 Human)
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    S15A

    Promoter

    CMV

    Available since

    Oct. 9, 2015

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

25. pCI-Neo-p53mut

    Plasmid

    #99239

    Purpose

    Mutant p53 encoded by AS-30D rat hepatoma cell line

    Depositor

    Peter Pedersen

    Article

    Mathupala et al J Biol Chem. 1997 Sep 5;272(36):22776-80

    Insert

    p53 (Tp53 Rat)
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    Silent mutations in translated protein at Gly (10…

    Promoter

    CMV immediate/early enhancer/promoter

    Available since

    Aug. 30, 2017

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

26. T7-p53DD-pcDNA3

    Plasmid

    #25989

    Depositor

    William Kaelin

    Article

    Irwin et al Nature. 2000 Oct 5. 407(6804):645-8.

    Insert

    tumor protein p53 (TP53 Human)
    

    Use

    Tags

    T7

    Expression

    Mammalian

    Mutation

    truncated cDNA encodes truncated protein (aa 300-…

    Promoter

    Available since

    Oct. 21, 2010

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

27. pAAV2-sgTrp53-sgAtrx-EFS-Cre

    Plasmid

    #189977

    Purpose

    Expresses Cre cDNA and sgRNAs targeting murine Trp53 and Atrx

    Depositor

    William Kaelin

    Article

    Shi et al Cancer Cell. 2022 Sep 12;40(9):939-956.e

    Insert

    sgTrp53, sgAtrx, Cre recombinase
    

    Use

    AAV, Cre/Lox, and Mouse Targeting

    Tags

    Expression

    Mutation

    Promoter

    Available since

    Dec. 12, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

28. pBABE-hygro p53 DD

    Plasmid

    #9058

    Depositor

    Bob Weinberg

    Article

    Hahn et al Mol Cell Biol 2002 Apr;22(7):2111-23.

    Insert

    p53 DD (Trp53 Mouse)
    

    Use

    Retroviral

    Tags

    Expression

    Mammalian

    Mutation

    DD. Dominant negative mutant carries deletion of…

    Promoter

    Available since

    Dec. 7, 2005

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

29. NSK021 CMV-TO-p53R248Q (FLP-IN)

    Plasmid

    #191167

    Purpose

    Expression of human p53 mutant R248Q in mammalian cells

    Depositor

    Xiaojing Gao

    Article

    Kaseniit et al Nat Biotechnol. 2022 Oct 5. pii: 10.1038

    Insert

    p53(R248Q) (TP53 Human)
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    R248Q

    Promoter

    CMV-TO

    Available since

    Oct. 26, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

30. NSK026 CMV-TO-p53R248W (FLP-IN)

    Plasmid

    #191168

    Purpose

    Expression of human p53 mutant R248W in mammalian cells

    Depositor

    Xiaojing Gao

    Article

    Kaseniit et al Nat Biotechnol. 2022 Oct 5. pii: 10.1038

    Insert

    p53(R248W) (TP53 Human)
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    R248W

    Promoter

    CMV-TO

    Available since

    Oct. 26, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge