408 results

Showing: 301 - 320 of 408 results

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CHyMErA Large-Scale Exon Deletion hgRNA Library

Pooled library

#209736

Purpose

CHyMErA Exon Deletion hgRNA Library allows identification of frame-preserving exons that affect cell fitness in human cells using the CHyMErA screening platform.

Depositor

Thomas Gonatopoulos-Pournatzis

Publication

Xiao et al Mol Cell. 2024 Jul 11;84(13):2553-2572.e

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

June 20, 2024

Availability

Academic Institutions and Nonprofits only
PBbtCRISPRko.v1

Pooled library

#213928

Purpose

Uses the PiggyBac transposon system to deliver the library into hard to transduce cells

Depositor

Wenfang Spring Tan

Publication

Tan et al PLoS Pathog. 2023 Dec 6;19(12):e1011822.

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

April 9, 2024

Availability

Academic Institutions and Nonprofits only
scQers promoter control #2 (low: no promoter, p029)

Pooled library

#217421

Purpose

scQers promoter control #2 (low: no promoter, p029)

Depositor

Jay Shendure

Publication

Lalanne et al bioRxiv 2022.12.10.519236

Expression

Bacterial and Mammalian

Use

RNAi

Available since

April 3, 2024

Availability

Academic Institutions and Nonprofits only
scQers promoter control #3 (intermediate: UBC promoter, p041)

Pooled library

#217422

Purpose

scQers promoter control #3 (intermediate: UBC promoter, p041)

Depositor

Jay Shendure

Publication

Lalanne et al bioRxiv 2022.12.10.519236

Expression

Bacterial and Mammalian

Use

RNAi

Available since

April 3, 2024

Availability

Academic Institutions and Nonprofits only
scQers promoter control #4 (intermediate: Pgk1 promoter, p042)

Pooled library

#217423

Purpose

scQers promoter control #4 (intermediate: Pgk1 promoter, p042)

Depositor

Jay Shendure

Publication

Lalanne et al bioRxiv 2022.12.10.519236

Expression

Bacterial and Mammalian

Use

RNAi

Available since

April 3, 2024

Availability

Academic Institutions and Nonprofits only
lentiGuide-Puro-pKO-library

Pooled library

#190744

Purpose

Targets proximal poly(A) signal sequences in genes identified to be differentially polyadenylated in the mouse B16-F10 melanoma system.

Depositor

Robert Bradley

Publication

Gabel et al Nat Commun. 2024 Feb 1;15(1):959. doi: 1

Expression

Mammalian

Species

Mus musculus

Use

CRISPR, Lentiviral, and Mouse Targeting

Available since

Feb. 2, 2024

Availability

Academic Institutions and Nonprofits only
plIG-109_CD19-BBz_CAR_SR_Library

Pooled library

#207476

Purpose

CD19-BBz CAR in combination with 129 surface receptors and 2 controls (GFP/RFP). Library can be used to generate HDR templates for modular pooled knockin (ModPoKI) into the TRAC locus of human T cells

Depositor

Alexander Marson

Publication

Blaeschke et al Cell. 2023 Sep 14;186(19):4216-4234.e33.

Use

CRISPR

Available since

Jan. 26, 2024

Availability

Academic Institutions and Nonprofits only
plIG-123_HA-GD2-28z_CAR_TF_Library

Pooled library

#207478

Purpose

HA-GD2-28z CAR in combination with 100 transcription factors (and related proteins) and 2 controls (GFP/RFP). Library can be used to generate HDR templates for modular pooled knockin (ModPoKI) into th

Depositor

Alexander Marson

Publication

Blaeschke et al Cell. 2023 Sep 14;186(19):4216-4234.e33.

Species

Homo sapiens

Use

CRISPR

Available since

Jan. 26, 2024

Availability

Academic Institutions and Nonprofits only
plIG-128_HA-GD2-28z_CAR_TFxTF_Library

Pooled library

#207480

Purpose

HA-GD2-28z CAR in combination with ~10,000 transcription factor combinations (and related proteins) and controls (GFP/RFP combinations). Library can be used to generate HDR templates for modular poole

Depositor

Alexander Marson

Publication

Blaeschke et al Cell. 2023 Sep 14;186(19):4216-4234.e33.

Use

CRISPR

Available since

Jan. 26, 2024

Availability

Academic Institutions and Nonprofits only
TRE-MPRA_minTK Library

Pooled library

#201014

Purpose

Massively parallel reporter assay (MPRA) library with minTK promoter

Depositor

Justin English

Publication

Zahm et al Nat Commun. 2024 Nov 28;15(1):10353. doi

Expression

Mammalian

Use

Luciferase

Available since

Oct. 31, 2023

Availability

Academic Institutions and Nonprofits only
mU6-CR1-CRISPRiv2_hU6-CR3-EMC2-guide_EF1a-PuroR-T2A-BFP

Pooled library

#197349

Purpose

To allow for genome-wide genetic modifier screening, the library has a second fixed guide targeting EMC2.

Depositor

Rebecca Voorhees, Jonathan Weissman

Publication

Guna et al BMC Genomics. 2023 Oct 30;24(1):651. doi

Species

Homo sapiens

Use

Lentiviral

Available since

May 25, 2023

Availability

Academic Institutions and Nonprofits only

Cited by

1 Article
APA Variant and Reference Libraries

Pooled library

#1000000214

Depositor

Georg Seelig

Available since

March 31, 2023

Availability

Academic Institutions and Nonprofits only
iSPI_pSer_Subpool#2

Pooled library

#188527

Purpose

Express a library of MBP-Fusion proteins containing phosphoserine at a defined position in the fusion protein

Depositor

Jesse Rinehart

Publication

Gassaway et al Nat Methods. 2022 Oct 24. pii: 10.1038/s

Expression

Bacterial

Species

Homo sapiens

Available since

Dec. 14, 2022

Availability

Academic Institutions and Nonprofits only
hCRISPRa_dual_3_4

Pooled library

#187250

Purpose

Ultra-compact, human genome-wide CRISPRa library targeting each gene with a single element encoding a dual sgRNA cassette.

Depositor

Marco Jost, Jonathan Weissman

Publication

Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

Species

Synthetic

Use

Lentiviral

Available since

Sept. 30, 2022

Availability

Academic Institutions and Nonprofits only
hCRISPRa_dual_5_6

Pooled library

#187251

Purpose

Ultra-compact, human genome-wide CRISPRa library targeting each gene with a single element encoding a dual sgRNA cassette.

Depositor

Marco Jost, Jonathan Weissman

Publication

Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

Species

Synthetic

Use

Lentiviral

Available since

Sept. 30, 2022

Availability

Academic Institutions and Nonprofits only
SARS-CoV-2 RBD Delta SSM Library

Pooled library

#1000000185

Depositor

Jesse Bloom

Available since

June 14, 2022

Availability

Academic Institutions and Nonprofits only
Liu Lab MusCK Library B

Pooled library

#174197

Purpose

MusCK library contains 23,622 unique sgRNAs targeting 4,787 gene locations in the genome. Sub-library MusCK M_b contains 5 gRNAs per gene.

Depositor

Xiaole Shirley Liu

Publication

Wang et al Cell. 2021 Oct 14;184(21):5357-5374.e22.

Expression

Mammalian

Species

Mus musculus

Use

CRISPR and Lentiviral

Available since

Oct. 29, 2021

Availability

Academic Institutions and Nonprofits only
SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 1

Pooled library

#168776

Purpose

Pooled library expressing barcoded SARS-CoV-2 RNA Binding Domain mutations

Depositor

Timothy Whitehead

Publication

Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

Expression

Yeast

Species

Sars-cov-2

Available since

Sept. 13, 2021

Availability

Academic Institutions and Nonprofits only
SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 2

Pooled library

#168777

Purpose

Pooled library expressing barcoded SARS-CoV-2 RNA Binding Domain mutations

Depositor

Timothy Whitehead

Publication

Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

Expression

Yeast

Species

Sars-cov-2

Available since

Sept. 13, 2021

Availability

Academic Institutions and Nonprofits only
SARS-CoV-2 Spike (S) Ectodomain Library C

Pooled library

#157973

Purpose

Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

Depositor

Timothy Whitehead

Publication

Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

Expression

Bacterial and Yeast

Species

Sars-cov-2

Available since

Sept. 13, 2021

Availability

Academic Institutions and Nonprofits only

Showing: 301 - 320 of 408 results

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More Filters

408 results

CHyMErA Large-Scale Exon Deletion hgRNA Library

PBbtCRISPRko.v1

scQers promoter control #2 (low: no promoter, p029)

scQers promoter control #3 (intermediate: UBC promoter, p041)

scQers promoter control #4 (intermediate: Pgk1 promoter, p042)

lentiGuide-Puro-pKO-library

plIG-109_CD19-BBz_CAR_SR_Library

plIG-123_HA-GD2-28z_CAR_TF_Library

plIG-128_HA-GD2-28z_CAR_TFxTF_Library

TRE-MPRA_minTK Library

mU6-CR1-CRISPRiv2_hU6-CR3-EMC2-guide_EF1a-PuroR-T2A-BFP

APA Variant and Reference Libraries

iSPI_pSer_Subpool#2

hCRISPRa_dual_3_4

hCRISPRa_dual_5_6

SARS-CoV-2 RBD Delta SSM Library

Liu Lab MusCK Library B

SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 1

SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 2

SARS-CoV-2 Spike (S) Ectodomain Library C

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