388 results

1. Mouse CRISPRa sgRNA library Caprano in backbone XPR_502 (P65 HSF), Set B

   Pooled Library

   #92384

   Purpose

   CRISPRa

   Depositor

   John Doench, David Root

   Article

   Sanson et al Nat Commun. 2018 Dec 21;9(1):5416. doi:

   Expression

   Mammalian

   Use

   CRISPR and Lentiviral

   Available Since

   July 13, 2018

   Availability

   Academic Institutions and Nonprofits only

2. S. rosetta Col+ cDNA amplified library

   Pooled Library

   #62844

   Purpose

   amplified library of Salpingoeca rosetta from a colony rich culture which included the colony inducing bacteria Algoriphagus machipongonensis

   Depositor

   Nicole King

   Article

   Fairclough et al Genome Biol. 2013 Feb 18;14(2):R15. doi:

   Expression

   Bacterial

   Species

   Salpingoeca rosetta

   Available Since

   June 16, 2015

   Availability

   Academic Institutions and Nonprofits only

3. hCRISPRa_dual_3_4

   Pooled Library

   #187250

   Purpose

   Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

   Depositor

   Marco Jost, Jonathan Weissman

   Article

   Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

   Species

   Synthetic

   Use

   Lentiviral

   Available Since

   Sept. 30, 2022

   Availability

   Academic Institutions and Nonprofits only

4. hCRISPRa_dual_5_6

   Pooled Library

   #187251

   Purpose

   Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

   Depositor

   Marco Jost, Jonathan Weissman

   Article

   Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

   Species

   Synthetic

   Use

   Lentiviral

   Available Since

   Sept. 30, 2022

   Availability

   Academic Institutions and Nonprofits only

5. SARS-CoV-2 RBD Delta SSM Library

   Pooled Library

   #1000000185

   Depositor

   Jesse Bloom

   Available Since

   June 14, 2022

   Availability

   Academic Institutions and Nonprofits only

6. APA Variant and Reference Libraries

   Pooled Library

   #1000000214

   Depositor

   Georg Seelig

   Available Since

   March 31, 2023

   Availability

   Academic Institutions and Nonprofits only

7. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 1

   Pooled Library

   #168776

   Purpose

   Pooled library expressing barcoded SARS-CoV-2 RNA Binding Domain mutations

   Depositor

   Timothy Whitehead

   Article

   Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

   Expression

   Yeast

   Species

   Sars-cov-2

   Available Since

   Sept. 13, 2021

   Availability

   Academic Institutions and Nonprofits only

8. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 2

   Pooled Library

   #168777

   Purpose

   Pooled library expressing barcoded SARS-CoV-2 RNA Binding Domain mutations

   Depositor

   Timothy Whitehead

   Article

   Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

   Expression

   Yeast

   Species

   Sars-cov-2

   Available Since

   Sept. 13, 2021

   Availability

   Academic Institutions and Nonprofits only

9. SARS-CoV-2 Spike (S) Ectodomain Library C

   Pooled Library

   #157973

   Purpose

   Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

   Depositor

   Timothy Whitehead

   Article

   Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

   Expression

   Bacterial and Yeast

   Species

   Sars-cov-2

   Available Since

   Sept. 13, 2021

   Availability

   Academic Institutions and Nonprofits only

10. SARS-CoV-2 Spike (S) Ectodomain Library B

    Pooled Library

    #157972

    Purpose

    Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Bacterial and Yeast

    Species

    Sars-cov-2

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

11. SARS-CoV-2 Spike (S) Ectodomain Library A

    Pooled Library

    #157971

    Purpose

    Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Bacterial and Yeast

    Species

    Sars-cov-2

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

12. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library N501Y Tile 2 (positions 437-527)

    Pooled Library

    #174296

    Purpose

    This library contains mutations to SARS-CoV-2 Spike RBD N501Y variant in which all surface exposed residues on S RBD (Tile 2, positions 437-527) were mutated to every other amino acid.

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

13. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library N501Y Tile 1 (positions 333-436)

    Pooled Library

    #174295

    Purpose

    This library contains mutations to SARS-CoV-2 Spike RBD N501Y variant in which all surface exposed residues on S RBD (Tile 1, positions 333-436) were mutated to every other amino acid.

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

14. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library E484K Tile 2 (positions 437-527)

    Pooled Library

    #174294

    Purpose

    This library contains mutations to SARS-CoV-2 Spike RBD E484K variant in which all surface exposed residues on S RBD (Tile 2, positions 437-527) were mutated to every other amino acid.

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

15. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library E484K Tile 1 (positions 333-436)

    Pooled Library

    #174293

    Purpose

    This library contains mutations to SARS-CoV-2 Spike RBD E484K variant in which all surface exposed residues on S RBD (Tile 1, positions 333-436) were mutated to every other amino acid.

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Available Since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

16. Large-scale mismatched sgRNA library for gene titration (human essential genes, CRISPRi)

    Pooled Library

    #136478

    Purpose

    Expresses gRNAs for gene titration of ~2400 human genes using CRISPRi

    Depositor

    Jonathan Weissman

    Article

    Jost et al Nat Biotechnol. 2020 Jan 13. pii: 10.103

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available Since

    Feb. 25, 2020

    Availability

    Academic Institutions and Nonprofits only

17. scCHyMErA-Seq Exon Deletion Library 1

    Pooled Library

    #237473

    Purpose

    Enables high-throughput identification of frame-preserving exons that influence transcriptional phenotypes, building on the CHyMErA system (Nature Biotechnology, 2020; PMID: 32249828).

    Depositor

    Thomas Gonatopoulos-Pournatzis

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available Since

    Oct. 28, 2025

    Availability

    Academic Institutions and Nonprofits only

18. CRASP-Seq CBC Backbone

    Pooled Library

    #232068

    Purpose

    The CRASP-Seq backbone is designed to accommodate the cloning of diverse gRNA libraries. It includes a cell barcode (CBC), which enhances its functionality by enabling library preparation.

    Depositor

    Thomas Gonatopoulos-Pournatzis

    Article

    Behera et al bioRxiv [Preprint]. 2025 Apr 26:2025.04.

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available Since

    Oct. 28, 2025

    Availability

    Academic Institutions and Nonprofits only

19. CRASP-Seq Gene KO v1 empty

    Pooled Library

    #232069

    Purpose

    Knockout library for use in CRASP-Seq experiments. Provides a flexible platform for studying splicing regulation.

    Depositor

    Thomas Gonatopoulos-Pournatzis

    Article

    Behera et al bioRxiv [Preprint]. 2025 Apr 26:2025.04.

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available Since

    Oct. 28, 2025

    Availability

    Academic Institutions and Nonprofits only

20. CRASP-Seq BE Tiling v1 empty

    Pooled Library

    #232070

    Purpose

    Tiling library to conduct CRASP-Seq experiments combined with high-throughput base editing for precise and scalable investigations into protein regions that affect splicing regulation.

    Depositor

    Thomas Gonatopoulos-Pournatzis

    Article

    Behera et al bioRxiv [Preprint]. 2025 Apr 26:2025.04.

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available Since

    Oct. 28, 2025

    Availability

    Academic Institutions and Nonprofits only