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Showing: 101 - 120 of 129 results

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Inzolia library in pRDA_550

Pooled Library

#209552

Purpose

The human, genome-wide, CRISPR knockout enAsCas12a gRNA library targets single genes and paralog pairs, triples, and quads with arrays of 4 gRNAs.

Depositor

John Doench

Article

Esmaeili Anvar et al Nat Commun. 2024 Apr 27;15(1):3577. doi:

Use

CRISPR and Lentiviral

Available Since

Dec. 5, 2023

Availability

Academic Institutions and Nonprofits only
Mouse Metabolic Gene CRISPRa sgRNA library

Pooled Library

#187081

Purpose

Library targeting 2,989 mouse metabolic genes for activation of gene expression.

Depositor

Kivanc Birsoy

Article

Unlu et al Mol Cell. 2022 Aug 4;82(15):2832-2843.e7

Expression

Mammalian

Species

Mus musculus

Use

Lentiviral

Available Since

Oct. 26, 2022

Availability

Academic Institutions and Nonprofits only
Mouse Brie kinome pooled library, guides 1-4 in lentiCRISPRv2 backbone

Pooled Library

#75317

Purpose

Mouse sgRNA library in backbone lentiCRISPRv2 targeting 713 kinase genes and containing 2,852 unique sgRNAs along with 100 non-targeting controls

Depositor

John Doench, David Root

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Available Since

June 27, 2016

Availability

Academic Institutions and Nonprofits only
Human Lipid Droplet and Metabolism Library

Pooled Library

#191535

Purpose

Targets 1,196 genes related to lipid droplet biology and cell metabolism.

Depositor

James Olzmann

Article

Roberts et al Dev Cell. 2023 Jul 18:S1534-5807(23)0033

Expression

Mammalian

Use

CRISPR and Lentiviral

Available Since

March 1, 2023

Availability

Academic Institutions and Nonprofits only
Inzolia library in pRDA_052

Pooled Library

#209551

Purpose

The human, genome-wide, CRISPR knockout enAsCas12a gRNA library targets single genes and paralog pairs, triples, and quads with arrays of 4 gRNAs.

Depositor

John Doench

Article

Esmaeili Anvar et al Nat Commun. 2024 Apr 27;15(1):3577. doi:

Use

CRISPR and Lentiviral

Available Since

Dec. 5, 2023

Availability

Academic Institutions and Nonprofits only
Mini-human AsCpf1-based human genome-wide knockout library

Pooled Library

#130630

Purpose

Knockout library targeting 16,977 genes. Each gene is targeted by an AsCpf1(AsCas12a)-based array containing 3-4 guides concatenated in one vector.

Depositor

Giulio Draetta

Article

Liu et al Nat Commun. 2019 Jul 17;10(1):3144. doi:

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available Since

Sept. 9, 2019

Availability

Academic Institutions and Nonprofits only
mTORC1 Focused library

Pooled Library

#164084

Purpose

Knockout library targeting human genes required for mTORC1 activation and inhibition.

Depositor

David Sabatini

Article

Condon et al Proc Natl Acad Sci U S A. 2021 Jan 26;11

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available Since

Jan. 11, 2021

Availability

Academic Institutions and Nonprofits only
Human Paralog Knockout Library (pgPEN)

Pooled Library

#171172

Purpose

Induces knockouts of paralogous gene pairs. Plasmids express a pair of guide RNAs targeting either individual genes or a pair of paralogs.

Depositor

Alice Berger

Article

Parrish et al Cell Rep. 2021 Aug 31;36(9):109597. doi:

Expression

Mammalian

Species

Homo sapiens and Synthetic

Use

CRISPR and Lentiviral

Available Since

Sept. 28, 2021

Availability

Academic Institutions and Nonprofits only
Sabatini/Lander Lab Ras synthetic lethal candidate focused human sgRNA library in lentiCRISPRv1

Pooled Library

#92352

Purpose

Focused gRNA library that targets synthetic lethal candidate and control genes with oncogenic Ras.

Depositor

Eric Lander, David Sabatini

Article

Wang et al Cell. 2017 Feb 1. pii: S0092-8674(17)300

Species

Homo sapiens

Available Since

June 7, 2017

Availability

Academic Institutions and Nonprofits only
lentiGuide-Puro-pKO-library

Pooled Library

#190744

Purpose

Targets proximal poly(A) signal sequences in genes identified to be differentially polyadenylated in the mouse B16-F10 melanoma system.

Depositor

Robert Bradley

Article

Gabel et al Nat Commun. 2024 Feb 1;15(1):959. doi: 1

Expression

Mammalian

Species

Mus musculus

Use

CRISPR, Lentiviral, and Mouse Targeting

Available Since

Feb. 2, 2024

Availability

Academic Institutions and Nonprofits only
DNA repair library with 336 sgRNAs

Pooled Library

#177664

Purpose

CRISPR-interference (CRISPRi) library of 366 sgRNAs targeting 118 genes encoding factors involved in DNA repair and associated processes

Depositor

Brittany Adamson

Article

Hussmann et al Cell. 2021 Oct 28;184(22):5653-5669.e25.

Species

Homo sapiens

Use

CRISPR

Available Since

Nov. 29, 2023

Availability

Academic Institutions and Nonprofits only
Human sgRNA library Brunello in lentiCRISPRv2

Pooled Library

#73179

Purpose

Human sgRNA library in backbone lentiCRISPRv2 targeting 19,114 genes and containing 76,441 unique sgRNAs along with 1000 non-targeting controls

Depositor

John Doench, David Root

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Has Service

Lentiviral Prep

Expression

Mammalian

Use

CRISPR and Lentiviral

Available Since

Feb. 9, 2016

Availability

Academic Institutions and Nonprofits only
Human Epigenetic Knockout Library

Pooled Library

#162256

Purpose

Knockout library that targets human epigenetic genes.

Depositor

Kivanc Birsoy

Article

Williams et al Cell Metab. 2020 Apr 7;31(4):852-861.e6.

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available Since

Nov. 17, 2020

Availability

Academic Institutions and Nonprofits only
Mouse metabolism knockout library

Pooled Library

#160129

Purpose

Targets mouse metabolic genes and includes most metabolic enzymes and transporters.

Depositor

Kivanc Birsoy

Article

Zhu et al Cell Metab. 2020 Oct 28. pii: S1550-4131

Expression

Mammalian

Species

Mus musculus

Use

CRISPR and Lentiviral

Available Since

Nov. 10, 2020

Availability

Academic Institutions and Nonprofits only
Bison sgRNA library

Pooled Library

#169942

Purpose

Knockout library targeting ubiquitin ligases, deubiquitinases, and control genes.

Depositor

Benjamin Ebert

Article

Slabicki et al Nature. 2020 Sep;585(7824):293-297. doi:

Use

Lentiviral

Available Since

Sept. 9, 2021

Availability

Academic Institutions and Nonprofits only
Murine cell surface protein knockout (McspKO) library

Pooled Library

#200445

Purpose

Knockout library targeting mouse cell surface genes.

Depositor

Junjie Chen

Article

Wang et al Proc Natl Acad Sci U S A. 2022 Jun 21;11

Expression

Mammalian

Species

Mus musculus

Use

CRISPR, Lentiviral, and Mouse Targeting

Available Since

Oct. 26, 2023

Availability

Academic Institutions and Nonprofits only
Mouse sgRNA library Brie in lentiCRISPRv2

Pooled Library

#73632

Purpose

Mouse sgRNA library in backbone lentiCRISPRv2 containing 78,637 unique sgRNAs targeting 19,674 genes along with 1000 non-targeting controls

Depositor

John Doench, David Root

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Expression

Mammalian

Use

CRISPR and Lentiviral

Available Since

Feb. 25, 2016

Availability

Academic Institutions and Nonprofits only
Mouse Brie kinome pooled library, guides 1-4 in lentiGuide-Puro backbone

Pooled Library

#75316

Purpose

Mouse sgRNA library in backbone lentiGuide-Puro targeting 713 kinase genes and containing 2,852 unique sgRNAs along with 100 non-targeting controls

Depositor

John Doench, David Root

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Available Since

June 27, 2016

Availability

Academic Institutions and Nonprofits only
mTF-CRISPRai

Pooled Library

#122131

Purpose

Increases transcriptional repression of genes encoding transcription factors in combination with dCas9 repression systems, such as the dCas9-KRAB system.

Depositor

Stanley Qi

Article

Liu et al Cell Stem Cell. 2018 Sep 28. pii: S1934-

Expression

Mammalian

Species

Mus musculus

Use

CRISPR and Lentiviral

Available Since

April 25, 2019

Availability

Academic Institutions and Nonprofits only
Human Brunello kinome pooled library, guides 1-4 in lentiCRISPRv2 backbone

Pooled Library

#75314

Purpose

Human sgRNA library in backbone lentiCRISPRv2 targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

Depositor

John Doench, David Root

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Expression

Mammalian

Use

CRISPR and Lentiviral

Available Since

June 27, 2016

Availability

Academic Institutions and Nonprofits only

Showing: 101 - 120 of 129 results

Results per page:

Sort results by:

More Filters

We narrowed to 129 results for: nes

Inzolia library in pRDA_550

Mouse Metabolic Gene CRISPRa sgRNA library

Mouse Brie kinome pooled library, guides 1-4 in lentiCRISPRv2 backbone

Human Lipid Droplet and Metabolism Library

Inzolia library in pRDA_052

Mini-human AsCpf1-based human genome-wide knockout library

mTORC1 Focused library

Human Paralog Knockout Library (pgPEN)

Sabatini/Lander Lab Ras synthetic lethal candidate focused human sgRNA library in lentiCRISPRv1

lentiGuide-Puro-pKO-library

DNA repair library with 336 sgRNAs

Human sgRNA library Brunello in lentiCRISPRv2

Human Epigenetic Knockout Library

Mouse metabolism knockout library

Bison sgRNA library

Murine cell surface protein knockout (McspKO) library

Mouse sgRNA library Brie in lentiCRISPRv2

Mouse Brie kinome pooled library, guides 1-4 in lentiGuide-Puro backbone

mTF-CRISPRai

Human Brunello kinome pooled library, guides 1-4 in lentiCRISPRv2 backbone

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