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pcDNA3/Myc-DNMT3A Citations (26)

Plasmid Article: Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family.
Chen ZX, Mann JR, Hsieh CL, Riggs AD, Chedin F J Cell Biochem. 2005 Aug 1;95(5):902-17.
PubMed Journal

Articles Citing pcDNA3/Myc-DNMT3A

Repurposing the CRISPR-Cas9 system for targeted DNA methylation. Vojta A, Dobrinic P, Tadic V, Bockor L, Korac P, Julg B, Klasic M, Zoldos V. Nucleic Acids Res. 2016 Mar 11. pii: gkw159. PubMed

Associated Plasmids

Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors. Garella D, Atlante S, Borretto E, Cocco M, Giorgis M, Costale A, Stevanato L, Miglio G, Cencioni C, Fernandez-de Gortari E, Medina-Franco JL, Spallotta F, Gaetano C, Bertinaria M. Chem Biol Drug Des. 2016 May 26. doi: 10.1111/cbdd.12794. PubMed
Optogenetic regulation of site-specific subtelomeric DNAmethylation. Choudhury SR, Cui Y, Narayanan A, Gilley DP, Huda N, Lo CL, Zhou FC, Yernool D, Irudayaraj J. Oncotarget. 2016 Jul 4. doi: 10.18632/oncotarget.10394. PubMed

Associated Plasmids

Editing DNA Methylation in the Mammalian Genome. Liu XS, Wu H, Ji X, Stelzer Y, Wu X, Czauderna S, Shu J, Dadon D, Young RA, Jaenisch R. Cell. 2016 Sep 22;167(1):233-247.e17. doi: 10.1016/j.cell.2016.08.056. PubMed

Associated Plasmids

20(S)-Rg3 blocked epithelial-mesenchymal transition through DNMT3A/miR-145/FSCN1 in ovarian cancer. Li J, Lu J, Ye Z, Han X, Zheng X, Hou H, Chen W, Li X, Zhao L. Oncotarget. 2017 Jun 15;8(32):53375-53386. doi: 10.18632/oncotarget.18482. eCollection 2017 Aug 8. PubMed
Epigenetic Toxicity of Trichloroethylene: A Single-Molecule Perspective. Cui Y, Choudhury SR, Irudayaraj J. Toxicol Res (Camb). 2016;5(2):641-650. doi: 10.1039/C5TX00454C. Epub 2016 Jan 27. PubMed
Ginsenoside 20(S)-Rg3 Inhibits the Warburg Effect Via Modulating DNMT3A/ MiR-532-3p/HK2 Pathway in Ovarian Cancer Cells. Zhou Y, Zheng X, Lu J, Chen W, Li X, Zhao L. Cell Physiol Biochem. 2018;45(6):2548-2559. doi: 10.1159/000488273. Epub 2018 Mar 16. PubMed
Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases. Lin L, Liu Y, Xu F, Huang J, Daugaard TF, Petersen TS, Hansen B, Ye L, Zhou Q, Fang F, Yang L, Li S, Floe L, Jensen KT, Shrock E, Chen F, Yang H, Wang J, Liu X, Xu X, Bolund L, Nielsen AL, Luo Y. Gigascience. 2018 Mar 1;7(3):1-19. doi: 10.1093/gigascience/giy011. PubMed

Associated Plasmids

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG. Mol Cell. 2018 Jun 7;70(5):825-841.e6. doi: 10.1016/j.molcel.2018.04.028. Epub 2018 May 31. PubMed
miR-603 targeted hexokinase-2 to inhibit the malignancy of ovarian cancer cells. Lu J, Wang L, Chen W, Wang Y, Zhen S, Chen H, Cheng J, Zhou Y, Li X, Zhao L. Arch Biochem Biophys. 2019 Jan;661:1-9. doi: 10.1016/ Epub 2018 Oct 23. PubMed
Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition. Huang MH, Chou YW, Li MH, Shih TE, Lin SZ, Chuang HM, Chiou TW, Su HL, Harn HJ. Pharmacol Res. 2019 Jan;139:50-61. doi: 10.1016/j.phrs.2018.10.015. Epub 2018 Oct 29. PubMed
Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness. Kim GC, Kwon HK, Lee CG, Verma R, Rudra D, Kim T, Kang K, Nam JH, Kim Y, Im SH. Oncogenesis. 2018 Nov 23;7(11):91. doi: 10.1038/s41389-018-0101-3. PubMed
Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation. Lyu G, Zong L, Zhang C, Huang X, Xie W, Fang J, Guan Y, Zhang L, Ni T, Gu J, Tao W. J Mol Cell Biol. 2019 Jan 1;11(1):78-90. doi: 10.1093/jmcb/mjy023. PubMed
Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro. Brezgin S, Kostyusheva A, Bayurova E, Gordeychuk I, Isaguliants M, Goptar I, Nikiforova A, Smirnov V, Volchkova E, Glebe D, Kostyushev D, Chulanov V. Microorganisms. 2019 Nov 6;7(11). pii: microorganisms7110533. doi: 10.3390/microorganisms7110533. PubMed
Epigenetic engineering of yeast reveals dynamic molecular adaptation to methylation stress and genetic modulators of specific DNMT3 family members. Finnegan AI, Kim S, Jin H, Gapinske M, Woods WS, Perez-Pinera P, Song JS. Nucleic Acids Res. 2020 May 7;48(8):4081-4099. doi: 10.1093/nar/gkaa161. PubMed
Ginsenoside 20(S)-Rg3 upregulates HIF-1alpha-targeting miR-519a-5p to inhibit the Warburg effect in ovarian cancer cells. Lu J, Chen H, He F, You Y, Feng Z, Chen W, Li X, Zhao L. Clin Exp Pharmacol Physiol. 2020 Aug;47(8):1455-1463. doi: 10.1111/1440-1681.13321. Epub 2020 May 4. PubMed
Perfluorooctanoic acid (PFOA) exposure inhibits DNA methyltransferase activities and alters constitutive heterochromatin organization. Liu W, Irudayaraj J. Food Chem Toxicol. 2020 Jul;141:111358. doi: 10.1016/j.fct.2020.111358. Epub 2020 Apr 18. PubMed
Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus. Bayraktar G, Yuanxiang P, Confettura AD, Gomes GM, Raza SA, Stork O, Tajima S, Suetake I, Karpova A, Yildirim F, Kreutz MR. Neuropsychopharmacology. 2020 Nov;45(12):2120-2130. doi: 10.1038/s41386-020-0780-2. Epub 2020 Jul 29. PubMed
The DNA methyltransferase DNMT3A contributes to autophagy long-term memory. Gonzalez-Rodriguez P, Cheray M, Fullgrabe J, Salli M, Engskog-Vlachos P, Keane L, Cunha V, Lupa A, Li W, Ma Q, Dreij K, Rosenfeld MG, Joseph B. Autophagy. 2021 May;17(5):1259-1277. doi: 10.1080/15548627.2020.1816664. Epub 2020 Sep 14. PubMed
The negative feedback between miR-143 and DNMT3A regulates cisplatin resistance in ovarian cancer. Han X, Liu D, Zhou Y, Wang L, Hou H, Chen H, Zhang L, Chen W, Li X, Zhao L. Cell Biol Int. 2021 Jan;45(1):227-237. doi: 10.1002/cbin.11486. Epub 2020 Oct 22. PubMed
De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands. Masalmeh RHA, Taglini F, Rubio-Ramon C, Musialik KI, Higham J, Davidson-Smith H, Kafetzopoulos I, Pawlicka KP, Finan HM, Clark R, Wills J, Finch AJ, Murphy L, Sproul D. Nat Commun. 2021 Jan 29;12(1):694. doi: 10.1038/s41467-020-20716-w. PubMed
miR-770-5p regulates EMT and invasion in TNBC cells by targeting DNMT3A. Noyan S, Andac Ozketen A, Gurdal H, Gur Dedeoglu B. Cell Signal. 2021 Jul;83:109996. doi: 10.1016/j.cellsig.2021.109996. Epub 2021 Mar 31. PubMed
TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Zhang X, Zhao S, Yuan Q, Zhu L, Li F, Wang H, Kong D, Hao J. Cell Death Dis. 2021 Jun 23;12(7):642. doi: 10.1038/s41419-021-03930-2. PubMed
Kaiso Regulates DNA Methylation Homeostasis. Kaplun D, Starshin A, Sharko F, Gainova K, Filonova G, Zhigalova N, Mazur A, Prokhortchouk E, Zhenilo S. Int J Mol Sci. 2021 Jul 15;22(14). pii: ijms22147587. doi: 10.3390/ijms22147587. PubMed
Inhibition of DNA methylation during chronic obstructive bladder disease (COBD) improves function, pathology and expression. Sidler M, Aitken KJ, Jiang JX, Yadav P, Lloyd E, Ibrahim M, Choufani S, Weksberg R, Bagli D. Sci Rep. 2021 Aug 27;11(1):17307. doi: 10.1038/s41598-021-96155-4. PubMed
Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3. Huang X, Zhang X, Zong L, Gao Q, Zhang C, Wei R, Guan Y, Huang L, Zhang L, Lyu G, Tao W. J Biol Chem. 2021 Oct;297(4):101195. doi: 10.1016/j.jbc.2021.101195. Epub 2021 Sep 11. PubMed

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