We narrowed to 85,561 results for: Son

1. pLenti-LmoCascade-IL1RNcrRNA

   Plasmid

   #126493

   Purpose

   Encodes lentivirus expression of L. monocytogenes CRISPR Type I-B crRNA targeting IL1RN

   Depositor

   Charles Gersbach

   Article

   Pickar-Oliver et al Nat Biotechnol. 2019 Sep 23. pii: 10.103

   Insert

   Lmo IL1RN cr03
   

   Use

   CRISPR and Lentiviral

   Tags

   Expression

   Mammalian

   Mutation

   Promoter

   U6

   Available since

   Sept. 30, 2019

   Availability

   Academic Institutions and Nonprofits only

   

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2. pLenti-LmoCascade-HBE1crRNA

   Plasmid

   #126494

   Purpose

   Encodes lentivirus expression of L. monocytogenes CRISPR Type I-B crRNA targeting HBE1

   Depositor

   Charles Gersbach

   Article

   Pickar-Oliver et al Nat Biotechnol. 2019 Sep 23. pii: 10.103

   Insert

   Lmo HBE1 cr06
   

   Use

   CRISPR and Lentiviral

   Tags

   Expression

   Mammalian

   Mutation

   Promoter

   U6

   Available since

   Sept. 30, 2019

   Availability

   Academic Institutions and Nonprofits only

   

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3. sg resistant gamma-tubulin

   Plasmid

   #104433

   Purpose

   For expressing gamma-tubulin in cells expressing γTUBULIN single guide RNA

   Depositor

   Maria Alvarado-Kristensson

   Article

   Lindstrom et al Biochim Biophys Acta. 2017 Oct 16. pii:

   Insert

   gamma-tubulin 1 (TUBG1 Human)
   

   Use

   Tags

   None

   Expression

   Mammalian

   Mutation

   changed t bp28 to c; g bp30 to a; c bp33 to a; …

   Promoter

   Available since

   Feb. 13, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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4. pmTol-InsUAS-6MTnlstdTomato2A-Dusp6DM-CC

   Plasmid

   #67687

   Purpose

   UAS-driven 6xMyc nuclear localized tdTomato-2A-activated Dusp6 in minTol backbone; also with cry:cfp cassette

   Depositor

   Nathan Lawson

   Article

   Shin et al Development. 2016 Oct 15;143(20):3796-38

   Insert

   dusp6 (dusp6 Zebrafish)
   

   Use

   Tags

   6xmyc-NLS-tdTomato-2A

   Expression

   Mutation

   S159A, S196A

   Promoter

   Available since

   Oct. 22, 2015

   Availability

   Academic Institutions and Nonprofits only

   

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5. pJ02B2Gm:Rm_AF

   Plasmid

   #66061

   Purpose

   MoClo Device: FACS Standard Color Controls - High GFP (first unit) & RFP (second unit) expression cassette - Ampicillin plasmid [A:J23102:B:BCD2:C:E0040m:D:B0015:E:J23102:B:BCD2:C:E1010m:D:B0015:F]

   Depositor

   Douglas Densmore

   Article

   Iverson et al ACS Synth Biol. 2016 Jan 15;5(1):99-103.

   Insert

   FACS Controls
   

   Use

   Synthetic Biology

   Tags

   Expression

   Mutation

   Promoter

   Available since

   Jan. 21, 2016

   Availability

   Academic Institutions and Nonprofits only

   

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6. pJ02B2Rm:Gm_AF

   Plasmid

   #66062

   Purpose

   MoClo Device: FACS Standard Color Controls - High RFP (first unit) & GFP (second unit) expression cassette - Ampicillin plasmid [A:J23102:B:BCD2:C:E1010m:D:B0015:E:J23102:B:BCD2:C:E0040m:D:B0015:F]

   Depositor

   Douglas Densmore

   Article

   Iverson et al ACS Synth Biol. 2016 Jan 15;5(1):99-103.

   Insert

   FACS Controls
   

   Use

   Synthetic Biology

   Tags

   Expression

   Mutation

   Promoter

   Available since

   Jan. 21, 2016

   Availability

   Academic Institutions and Nonprofits only

   

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7. pCSD_SpCas9MT3-NLS-3xHA-NLS-SaCas9WT-2xNLS

   Plasmid

   #107322

   Purpose

   Expresses SpCas9 (R1335K) fused to SaCas9 in mammalian cells

   Depositor

   Scot Wolfe

   Article

   Bolukbasi et al Nat Commun. 2018 Nov 19;9(1):4856. doi:

   Insert

   SpCas9-SaCas9 fusion
   

   Use

   CRISPR

   Tags

   NLS

   Expression

   Mammalian

   Mutation

   SpCas9 (R1335K) is fused to SaCas9

   Promoter

   CMV IE93

   Available since

   Nov. 15, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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8. pCSD_2XNLS-SpCas9MT3-NLS-3xHA-2XNLS-NmCas9WT-2XNLS

   Plasmid

   #107325

   Purpose

   Expresses SpCas9 (R1335K) fused to NmCas9 in mammalian cells

   Depositor

   Scot Wolfe

   Article

   Bolukbasi et al Nat Commun. 2018 Nov 19;9(1):4856. doi:

   Insert

   SpCas9-NmCas9 fusion
   

   Use

   CRISPR

   Tags

   NLS

   Expression

   Mammalian

   Mutation

   SpCas9 (R1335K) is fused to NmCas9

   Promoter

   CMV IE94

   Available since

   Nov. 15, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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9. pCSD_2XNLS-SpCas9MT2-NLS-3xHA-2XNLS-NmCas9WT-2XNLS

   Plasmid

   #107326

   Purpose

   Expresses SpCas9 (R1333S) fused to NmCas9 in mammalian cells

   Depositor

   Scot Wolfe

   Article

   Bolukbasi et al Nat Commun. 2018 Nov 19;9(1):4856. doi:

   Insert

   SpCas9-NmCas9 fusion
   

   Use

   CRISPR

   Tags

   NLS

   Expression

   Mammalian

   Mutation

   SpCas9 (R1333S) is fused to NmCas9

   Promoter

   CMV IE93

   Available since

   Nov. 15, 2018

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

10. p5M-PR-B-1-688

    Plasmid

    #89115

    Purpose

    mammalian expression of human progesterone receptor amino acid residues 1-688 in pCMV5 with 5 restriction sites deleted in polylinker

    Depositor

    Elizabeth Wilson

    Article

    Liu et al J Biol Chem. 2011 Aug 26;286(34):29951-6

    Insert

    human progesterone receptor-B N-term+DNA binding domain (PGR Human)
    

    Use

    Tags

    Expression

    Mammalian

    Mutation

    5 restriction sites deleted in polylinker, contai…

    Promoter

    CMV

    Available since

    April 21, 2017

    Availability

    Academic Institutions and Nonprofits only

    

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11. pEGFP-N2-RIPK3 4KR

    Plasmid

    #78825

    Purpose

    To detect localization of RIPK3 4KR protein in live mammalian cells

    Depositor

    Jaewhan Song

    Article

    Seo et al Nat Cell Biol. 2016 Mar;18(3):291-302. d

    Insert

    RIPK3 (RIPK3 Human)
    

    Use

    Tags

    GFP

    Expression

    Mammalian

    Mutation

    K55R, K89R, K363R, K501R

    Promoter

    CMV

    Available since

    June 14, 2016

    Availability

    Academic Institutions and Nonprofits only

12. pcDNA3-HA-RIPK1 K627R

    Plasmid

    #78840

    Purpose

    To overexpress RIPK1 K627R in Mammalian Cells

    Depositor

    Jaewhan Song

    Article

    Seo et al Nat Cell Biol. 2016 Mar;18(3):291-302. d

    Insert

    RIPK1 (RIPK1 Human)
    

    Use

    Tags

    HA

    Expression

    Mammalian

    Mutation

    K627R

    Promoter

    CMV

    Available since

    June 8, 2016

    Availability

    Academic Institutions and Nonprofits only

    

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13. pcDNA3-HA-RIPK1 K571R

    Plasmid

    #78838

    Purpose

    To overexpress RIPK1 K571R in Mammalian Cells

    Depositor

    Jaewhan Song

    Article

    Seo et al Nat Cell Biol. 2016 Mar;18(3):291-302. d

    Insert

    RIP-1 (RIPK1 Human)
    

    Use

    Tags

    HA

    Expression

    Mammalian

    Mutation

    K571R

    Promoter

    CMV

    Available since

    June 8, 2016

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

14. pcDNA3-HA-RIPK1 K604R

    Plasmid

    #78839

    Purpose

    To overexpress RIPK1 K604R in Mammalian Cells

    Depositor

    Jaewhan Song

    Article

    Seo et al Nat Cell Biol. 2016 Mar;18(3):291-302. d

    Insert

    RIPK1 (RIPK1 Human)
    

    Use

    Tags

    HA

    Expression

    Mammalian

    Mutation

    K604R

    Promoter

    CMV

    Available since

    June 8, 2016

    Availability

    Academic Institutions and Nonprofits only

    

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15. pcDNA3-HA-RIPK1 K163R

    Plasmid

    #78836

    Purpose

    To overexpress RIPK1 K163R in Mammalian Cells

    Depositor

    Jaewhan Song

    Article

    Seo et al Nat Cell Biol. 2016 Mar;18(3):291-302. d

    Insert

    RIPK1 (RIPK1 Human)
    

    Use

    Tags

    HA

    Expression

    Mammalian

    Mutation

    K163R

    Promoter

    CMV

    Available since

    June 8, 2016

    Availability

    Academic Institutions and Nonprofits only

    

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16. pBABEpuro-ARAF_S214F

    Plasmid

    #51078

    Purpose

    mammalian expression of ARAF S214F

    Depositor

    Matthew Meyerson

    Article

    Imielinski et al J Clin Invest. 2014 Apr;124(4):1582-6. d

    Insert

    ARAF (ARAF Human)
    

    Use

    Retroviral

    Tags

    Expression

    Mammalian

    Mutation

    S214F

    Promoter

    Available since

    Feb. 14, 2014

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

17. pUAS-Tum

    Plasmid

    #37304

    Depositor

    Norbert Perrimon

    Article

    Harrison et al EMBO J. 1995 Jun 15;14(12):2857-65.

    Insert

    hopTum-1 (hop Fly)
    

    Use

    Tags

    Expression

    Insect

    Mutation

    Tul-l mutation is a G to A transversion at nucleo…

    Promoter

    Hsp70

    Available since

    July 23, 2012

    Availability

    Academic Institutions and Nonprofits only

18. pEMS2075

    Plasmid

    #158098

    Purpose

    High Copy number plasmid containing smCBA insert.

    Depositor

    Elizabeth Simpson

    Article

    de Moura Gomes et al Sci Rep. 2024 Nov 15;14(1):28194. doi: 1

    Insert

    smCBA
    

    Use

    Tags

    Expression

    Mutation

    Promoter

    smCBA

    Available since

    Nov. 18, 2024

    Availability

    Industry, Academic Institutions, and Nonprofits

    

    Enlarge

19. pGEX-PML B-box1 WT

    Plasmid

    #185632

    Purpose

    expression of GST-tagged wild-type PML B-box1 domain in bacterial cells

    Depositor

    Irina Bezsonova

    Article

    Bregnard et al Structure. 2023 Sep 7;31(9):1086-1099.e6

    Insert

    promyelocytic leukemia protein (PML Human)
    

    Use

    Tags

    GST

    Expression

    Bacterial

    Mutation

    none

    Promoter

    Available since

    Sept. 19, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

20. pGEX-PML B-box1 C4C4

    Plasmid

    #185640

    Purpose

    expression of GST-tagged mutant PML B-box1 H155C/H161C domain in bacterial cells

    Depositor

    Irina Bezsonova

    Article

    Bregnard et al Structure. 2023 Sep 7;31(9):1086-1099.e6

    Insert

    promyelocytic leukemia protein (PML Human)
    

    Use

    Tags

    GST

    Expression

    Bacterial

    Mutation

    H155C H161C

    Promoter

    Available since

    Sept. 19, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

21. pGEX-PML B-box1 W157E

    Plasmid

    #185641

    Purpose

    expression of GST-tagged mutant PML B-box1 W157E domain in bacterial cells

    Depositor

    Irina Bezsonova

    Article

    Bregnard et al Structure. 2023 Sep 7;31(9):1086-1099.e6

    Insert

    promyelocytic leukemia protein (PML Human)
    

    Use

    Tags

    GST

    Expression

    Bacterial

    Mutation

    W157E

    Promoter

    Available since

    Sept. 19, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

22. pGEX-PML B-box1 F158E

    Plasmid

    #185642

    Purpose

    expression of GST-tagged mutant PML B-box1 F158E domain in bacterial cells

    Depositor

    Irina Bezsonova

    Article

    Bregnard et al Structure. 2023 Sep 7;31(9):1086-1099.e6

    Insert

    promyelocytic leukemia protein (PML Human)
    

    Use

    Tags

    GST

    Expression

    Bacterial

    Mutation

    F158E

    Promoter

    Available since

    Sept. 19, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

23. pAAV-hSyn-FRISZ-GPI

    Plasmid

    #177264

    Purpose

    AAV transfer plasmid for cell-surface-localized FRISZ (via CD59 GPI) under hSyn promoter

    Depositor

    Huiwang Ai

    Article

    Wu et al Sci Adv. 2023 Mar;9(9):eadd2058. doi: 10

    Insert

    CD59 leader-FRISZ-GPI
    

    Use

    AAV

    Tags

    CD59 GPI and CD59 leader sequence

    Expression

    Mutation

    Promoter

    hSyn

    Available since

    Feb. 1, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

24. pJH4253

    Plasmid

    #191539

    Purpose

    Prig-3-LoxP::EBFP::LoxP::Chrimson::wCherry unc-54 3' UTR C.elegans AVA neuron expression of Chrimson RFP

    Depositor

    Mei Zhen

    Article

    Lu et al Curr Biol. 2022 Nov 7;32(21):4631-4644.e

    Insert

    Chrimson
    

    Use

    Tags

    wCherry

    Expression

    Worm

    Mutation

    Promoter

    Prig-3

    Available since

    Nov. 30, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

25. mU6-sgCebpa_v1-hu6-sgCebpb_v1

    Plasmid

    #177251

    Purpose

    Expresses Cebpa_v1 (mU6), Cebpb_v1 (hU6) gRNAs and Cre-recombinase

    Depositor

    Monte Winslow

    Article

    Murray et al Nat Commun. 2022 Feb 28;13(1):1090. doi:

    Insert

    sgCebpa_v1/sgCebpb_v1
    

    Use

    Lentiviral

    Tags

    Expression

    Mutation

    Promoter

    mU6/hU6

    Available since

    Oct. 3, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

26. mU6-sgCebpa_v2-hu6-sgCebpb_v2

    Plasmid

    #177252

    Purpose

    Expresses Cebpa_v2 (mU6), Cebpb_v2(hU6) gRNAs and Cre-recombinase

    Depositor

    Monte Winslow

    Article

    Murray et al Nat Commun. 2022 Feb 28;13(1):1090. doi:

    Insert

    sgCebpa_v2/sgCebpb_v2
    

    Use

    Lentiviral

    Tags

    Expression

    Mutation

    Promoter

    mU6/hU6

    Available since

    Oct. 3, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

27. mU6-sgCebpa_v1-hu6-sgCebpd_v1

    Plasmid

    #177253

    Purpose

    Expresses Cebpa_v1 (mU6), Cebpd_v1 (hU6) gRNAs and Cre-recombinase

    Depositor

    Monte Winslow

    Article

    Murray et al Nat Commun. 2022 Feb 28;13(1):1090. doi:

    Insert

    sgCebpa_v1/sgCebpd_v1
    

    Use

    Lentiviral

    Tags

    Expression

    Mutation

    Promoter

    mU6/hU6

    Available since

    Oct. 3, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

28. mU6-sgCebpa_v2-hu6-sgCebpd_v2

    Plasmid

    #177254

    Purpose

    Expresses Cebpa_v2 (mU6), Cebpd_v2(hU6) gRNAs and Cre-recombinase

    Depositor

    Monte Winslow

    Article

    Murray et al Nat Commun. 2022 Feb 28;13(1):1090. doi:

    Insert

    sgCebpa_v2/sgCebpd_v2
    

    Use

    Lentiviral

    Tags

    Expression

    Mutation

    Promoter

    mU6/hU6

    Available since

    Oct. 3, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

29. mU6-sgCebpb_v1-hu6-sgCebpd_v1

    Plasmid

    #177255

    Purpose

    Expresses Cebpb_v1 (mU6), Cebpd_v1 (hU6) gRNAs and Cre-recombinase

    Depositor

    Monte Winslow

    Article

    Murray et al Nat Commun. 2022 Feb 28;13(1):1090. doi:

    Insert

    sgCebpb_v1/sgCebpd_v1
    

    Use

    Lentiviral

    Tags

    Expression

    Mutation

    Promoter

    mU6/hU6

    Available since

    Oct. 3, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

30. mU6-sgCebpb_v2-hu6-sgCebpd_v2

    Plasmid

    #177256

    Purpose

    Expresses Cebpb_v2 (mU6), Cebpd_v2(hU6) gRNAs and Cre-recombinase

    Depositor

    Monte Winslow

    Article

    Murray et al Nat Commun. 2022 Feb 28;13(1):1090. doi:

    Insert

    sgCebpb_v2/sgCebpd_v2
    

    Use

    Lentiviral

    Tags

    Expression

    Mutation

    Promoter

    mU6/hU6

    Available since

    Oct. 3, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

31. pLL5.0-EGFP-HRasC20

    Plasmid

    #187252

    Purpose

    Lenticiral expression of EGFP-HRasC20

    Depositor

    Alpha Yap

    Article

    Katsuno-Kambe et al Elife. 2021 Oct 18;10. pii: 67915. doi:

    Insert

    HRasC20 (HRAS Human)
    

    Use

    Lentiviral

    Tags

    EGFP

    Expression

    Mutation

    Promoter

    5' LTR

    Available since

    Sept. 22, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

32. pAc-His-zfCsf1b

    Plasmid

    #168104

    Purpose

    Express soluble His-tagged zebrafish Csf1b in insect cells

    Depositor

    Petr Bartunek

    Article

    Hason et al Blood Adv. 2022 Jan 3. pii: 483305. doi:

    Insert

    Csf1b (csf1b Zebrafish)
    

    Use

    Tags

    6x His

    Expression

    Insect

    Mutation

    Promoter

    Available since

    Aug. 15, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

33. pmRE-Tn5-142

    Plasmid

    #118531

    Purpose

    miniTn5 plasmid to deliver constitutively expressed fluorescent protein genes in bacteria

    Depositor

    Mitja Remus-Emsermann

    Article

    Schlechter et al Front Microbiol. 2018 Dec 12;9:3052. doi

    Insert

    mClover3
    

    Use

    Minitn5 delivery vector

    Tags

    Expression

    Bacterial

    Mutation

    Promoter

    Available since

    July 26, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

34. pCS2-foxd4l1.1-deltaRII-Cterm-myc

    Plasmid

    #185505

    Purpose

    Expression of Xenopus laevis foxd4

    Depositor

    Sally Moody

    Article

    Neilson et al Dev Biol. 2012 May 15;365(2):363-75. doi

    Insert

    foxd4l1.1
    

    Use

    In vitro transcription

    Tags

    myc

    Expression

    Mutation

    RII domain and C-term deleted

    Promoter

    Available since

    July 12, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

35. pBtPIPLC_N168C His

    Plasmid

    #173809

    Purpose

    Expression and purification of the mature form of Bacillus thuringiensis phosphaatidyl inositol specific phospholipase C (PI-PLC), UniProt ID P08954 from E. coli BL21 CodonPlus (DE3) RIL cells

    Depositor

    Anne Gershenson, Mary F Roberts

    Article

    He et al J Biol Chem. 2015 Jul 31;290(31):19334-4

    Insert

    Bacillus thuringiensis 1-phosphatidylinositol phosphodiesterase
    

    Use

    Tags

    6XHis

    Expression

    Bacterial

    Mutation

    Asn168Cys for labeling

    Promoter

    T7

    Available since

    Aug. 25, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

36. pMiniT:myc-GluA2 TKIT donor

    Plasmid

    #169423

    Purpose

    Donor DNA for TKIT knockin of Myc to GluA2 in mouse

    Depositor

    Richard Huganir

    Article

    Fang et al Elife. 2021 Mar 10;10. pii: 65202. doi:

    Insert

    Myc (Myc Mouse)
    

    Use

    CRISPR

    Tags

    Expression

    Mammalian

    Mutation

    Promoter

    Available since

    June 10, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

37. GFP-MIOX only

    Plasmid

    #166683

    Purpose

    Yeast integrative plasmid for expressing mouse myo-inositol oxygenase fused to GFP (GAL10 promoter). Contains uracil auxotrophic marker (K. lactis URA3).

    Depositor

    Claudia Vickers

    Article

    Cheah et al ACS Synth Biol. 2021 Dec 17;10(12):3251-

    Insert

    GFP-MIOX
    

    Use

    Synthetic Biology

    Tags

    Expression

    Yeast

    Mutation

    Promoter

    GAL10

    Available since

    April 9, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

38. pTEF1-UDH

    Plasmid

    #166679

    Purpose

    Yeast integrative plasmid for expressing P. syringae uronate dehydrogenase, with TEF1 promoter. Contains leucine auxotrophic marker (K. lactis LEU2).

    Depositor

    Claudia Vickers

    Article

    Cheah et al ACS Synth Biol. 2021 Dec 17;10(12):3251-

    Insert

    UDH
    

    Use

    Synthetic Biology

    Tags

    Expression

    Yeast

    Mutation

    Promoter

    TEF1

    Available since

    April 8, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

39. wtVP1 only

    Plasmid

    #166673

    Purpose

    Yeast integrative plasmid for expressing wild-type Murine polyomavirus VP1, with GAL1 promoter. Contains uracil auxotrophic marker (K. lactis URA3).

    Depositor

    Claudia Vickers

    Article

    Cheah et al ACS Synth Biol. 2021 Dec 17;10(12):3251-

    Insert

    Wild-type Murine polyomavirus VP1
    

    Use

    Synthetic Biology

    Tags

    Expression

    Yeast

    Mutation

    Promoter

    GAL1

    Available since

    April 8, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

40. pEMS2267

    Plasmid

    #158392

    Purpose

    High Copy number plasmid containing Ple341 (PCP2 MiniPromoter) insert

    Depositor

    Elizabeth Simpson

    Article

    Korecki et al Gene Ther. 2021 Feb 2. pii: 10.1038/s414

    Insert

    Ple341 (PCP2 Human)
    

    Use

    Unspecified

    Tags

    Expression

    Mutation

    Promoter

    Ple341

    Available since

    Feb. 4, 2021

    Availability

    Industry, Academic Institutions, and Nonprofits

    

    Enlarge