405 results

#179217

sgRNAs that target frequently occurring cancer associated mutations identified in the MSK IMPACT dataset that can be modeled with cytosine base editing.

Lukas Dow

Sanchez-Rivera et al Nat Biotechnol. 2022 Feb 14. pii: 10.103

June 16, 2022

Academic Institutions and Nonprofits only

#86550

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#79153

Library of protospacer flanking sites (PFS) inserted at the 5' end of the β-lactamase gene for screening PFS preference for Cas13a/C2c2.

Feng Zhang

Abudayyeh et al Science. 2016 Jun 2. pii: aaf5573.

Oct. 26, 2017

Academic Institutions and Nonprofits only

#227707

CRISPR guide RNA library for prime editing

Brittany Adamson

Cirincione et al Nat Methods. 2024 Nov 19. doi: 10.1038/s

Jan. 23, 2025

Academic Institutions and Nonprofits only

#187248

Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

Marco Jost, Jonathan Weissman

Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

Sept. 30, 2022

Academic Institutions and Nonprofits only

#198050

By supplying an AAV cap gene of interest in trans, researchers can use this library to investigate the effects of rep mutations on production of a wide range of AAV capsid serotypes

George Church

Jain et al Elife. 2024 Mar 27;12:RP87730. doi: 10.7

May 4, 2023

Academic Institutions and Nonprofits only

#86541

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#217744

Targets 56 transcription factors in Yarrowia lipolytica, enabling the knockout or modulation of expression levels for these factors.

Irina Borodina

Jiang et al Proc Natl Acad Sci U S A. 2025 Jun 10;12

May 20, 2025

Academic Institutions and Nonprofits only

#1000000187

Jesse Bloom

June 14, 2022

Academic Institutions and Nonprofits only

#86540

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#138015

AAV library targeting transcriptional regulators expressed in cardiomyocytes.

William Pu

VanDusen et al Nat Commun. 2021 Jul 21;12(1):4442. doi:

April 17, 2020

Academic Institutions and Nonprofits only

#160133

Plasmid library harboring a randomized 8nt PAM 3’ of target site 2. Can be used to profile CRISPR-Cas PAM requirements of enzymes that recognize 3’ PAMs (e.g. Cas9)

Keith Joung, Benjamin Kleinstiver

Walton et al Nat Protoc. 2021 Feb 5. pii: 10.1038/s41

Feb. 8, 2021

Academic Institutions and Nonprofits only

#113585

AAV-CRISPR library for pool mutagenesis of top tumor suppressor genes in mouse liver

Sidi Chen

Wang et al Sci Adv. 2018 Feb 28;4(2):eaao5508. doi:

July 23, 2019

Academic Institutions and Nonprofits only

#138084

Targets 3' splice sites with paired gRNAs. Induces skipping of poison cassette exons and matching upstream constitutive exons. Compare loss of a constitutive coding exon with loss of a poison exon.

Robert Bradley

Thomas et al Nat Genet. 2020 Jan;52(1):84-94. doi: 10

March 6, 2020

Academic Institutions and Nonprofits only

#153101

CRISPR library targets all non-essential and conditionally essential transporter genes in S. cerevisiae

Irina Borodina

Wang et al Metab Eng. 2021 Jan 16. pii: S1096-7176(

Jan. 20, 2021

Academic Institutions and Nonprofits only

#86542

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#92352

Focused gRNA library that targets synthetic lethal candidate and control genes with oncogenic Ras.

Eric Lander, David Sabatini

Wang et al Cell. 2017 Feb 1. pii: S0092-8674(17)300

June 7, 2017

Academic Institutions and Nonprofits only

#1000000232

Tyler Starr

Oct. 25, 2023

Academic Institutions and Nonprofits only

#113584

AAV-CRISPR library for pool mutagenesis of top tumor suppressor genes

Sidi Chen

Wang et al Sci Adv. 2018 Feb 28;4(2):eaao5508. doi:

July 23, 2019

Academic Institutions and Nonprofits only

#216134

Library of intron-targeting sgRNAs for pooled tagging of proteins with GFP or other protein tags at their endogenous genomic locus using an intron tagging approach.

Stefan Kubicek

Reicher et al Nat Cell Biol. 2024 May;26(5):745-756. d

April 19, 2024

Academic Institutions and Nonprofits only

#216133

Library of intron-targeting sgRNAs for pooled tagging of proteins with GFP or other protein tags at their endogenous genomic locus using an intron tagging approach.

Stefan Kubicek

Reicher et al Nat Cell Biol. 2024 May;26(5):745-756. d

April 19, 2024

Academic Institutions and Nonprofits only

#86546

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#83977

Human CRISPRi Pooled Library targeting unassigned genes

Jonathan Weissman

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Dec. 14, 2016

Academic Institutions and Nonprofits only

#1000000188

Jesse Bloom

June 14, 2022

Academic Institutions and Nonprofits only

#86547

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#86549

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#180272

Tiles the entire ~154 kb of the BAC16 Kaposi’s Sarcoma-associated Herpes Virus genome. A guide every ~8 bp allows pooled screening of the viral genome.

Britt Glaunsinger

Morgens et al PLoS Pathog. 2022 Jan 18;18(1):e1010236.

Feb. 11, 2022

Academic Institutions and Nonprofits only

#86548

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#221409

gRNA library to test the impact of transporters on biological processes

RESOLUTE Consortium, Giulio Superti-Furga

Wolf et al Cell Chem Biol. 2024 Dec 24:S2451-9456(2

Sept. 13, 2024

Academic Institutions and Nonprofits only

#190744

Targets proximal poly(A) signal sequences in genes identified to be differentially polyadenylated in the mouse B16-F10 melanoma system.

Robert Bradley

Gabel et al Nat Commun. 2024 Feb 1;15(1):959. doi: 1

Feb. 2, 2024

Academic Institutions and Nonprofits only