374 results

1. mTF-CRISPRai

   Pooled Library

   #122131

   Purpose

   Expresses gRNAs for mouse transcription factor-CRISPR activation

   Depositor

   Stanley Qi

   Article

   Liu et al Cell Stem Cell. 2018 Sep 28. pii: S1934-

   Expression

   Mammalian

   Species

   Mus musculus

   Use

   CRISPR and Lentiviral

   Available since

   April 25, 2019

   Availability

   Academic Institutions and Nonprofits only

2. Human Genome-Wide Reduced Double-gRNA library

   Pooled Library

   #137999

   Purpose

   This gRNA library targets the human coding genome, aimed to reduce the scale of genome-wide perturbation screens up to fivefold compared to conventional methods, without sacrificing performance.

   Depositor

   Leopold Parts

   Article

   Peets et al bioRxiv 859652

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Oct. 15, 2020

   Availability

   Academic Institutions and Nonprofits only

3. pUC57kan-T7-mt-gRNA library

   Pooled Library

   #82480

   Purpose

   Pool of sgRNAs to remove mouse mitochondrial DNA reads in the sequencing of genomic libraries

   Depositor

   Wei Xie

   Article

   Wu et al Nature. 2016 Jun 30;534(7609):652-7.

   Available since

   April 5, 2017

   Availability

   Academic Institutions and Nonprofits only

4. Pan-Druggable Cancer Library

   Pooled Library

   #182133

   Purpose

   All-in-one CRISPR/Cas system with 74 individual elements. 63 elements target cancer-related genes with FDA-approved drug treatments, and 3 elements target key medulloblastoma driver genes.

   Depositor

   Prashant Mali

   Article

   Hu et al Biomaterials. 2022 Jan;280:121276. doi:

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Aug. 26, 2022

   Availability

   Academic Institutions and Nonprofits only

5. p11-5’_10xN_PAM-site4 (RTW574)

   Pooled Library

   #160135

   Purpose

   Plasmid library harboring a randomized 10nt PAM 5’ of target site 4. Can be used to profile CRISPR-Cas PAM requirements of enzymes that recognize 5’ PAMs (e.g. Cas12a)

   Depositor

   Keith Joung, Benjamin Kleinstiver

   Article

   Walton et al Nat Protoc. 2021 Feb 5. pii: 10.1038/s41

   Species

   Synthetic

   Use

   CRISPR

   Available since

   Feb. 8, 2021

   Availability

   Academic Institutions and Nonprofits only

6. Human CRISPRi sgRNA library Dolcetto in backbone XPR_050, Set B

   Pooled Library

   #92386

   Purpose

   Crispri

   Depositor

   David Root, John Doench

   Article

   Sanson et al Nat Commun. 2018 Dec 21;9(1):5416. doi:

   Use

   Lentiviral

   Available since

   July 13, 2018

   Availability

   Academic Institutions and Nonprofits only

7. BARBEKO sgRNA library

   Pooled Library

   #174163

   Purpose

   iBARed cytosine Base Editing-mediated gene KnockOut (BARBEKO) sgRNA library; This library leverages CRISPR cytosine base editors for genome-scale knockout screens.

   Depositor

   Wensheng Wei

   Article

   Xu et al Nat Biotechnol. 2021 Jun 21. pii: 10.103

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Aug. 31, 2021

   Availability

   Academic Institutions and Nonprofits only

8. Human Lentiviral sgRNA Library - Ribosomal Proteins

   Pooled Library

   #51045

   Purpose

   Sub-pool of Sabatini/Lander sgRNA library enriched for ribosomal gene targets.

   Depositor

   David Sabatini, Eric Lander

   Article

   Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Feb. 7, 2014

   Availability

   Academic Institutions and Nonprofits only

9. Human Lentiviral sgRNA Library - Unknown Function

   Pooled Library

   #51043

   Purpose

   Sub-pool of Sabatini/Lander sgRNA library enriched for gene targets of unknown function.

   Depositor

   David Sabatini, Eric Lander

   Article

   Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Feb. 7, 2014

   Availability

   Academic Institutions and Nonprofits only

10. CRISPRi non-coding library (CRiNCL) - iPSC & HFF

    Pooled Library

    #86550

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

11. scQers promoter control series (p027, p028, p029, p041, p042)

    Pooled Library

    #1000000239

    Depositor

    Jay Shendure

    Available since

    April 3, 2024

    Availability

    Academic Institutions and Nonprofits only

12. Human Transporter Knockout Library with UMIs

    Pooled Library

    #221409

    Purpose

    gRNA library to test the impact of transporters on biological processes

    Depositor

    Giulio Superti-Furga, RESOLUTE Consortium

    Article

    Wolf et al Cell Chem Biol. 2024 Dec 24:S2451-9456(2

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    Sept. 13, 2024

    Availability

    Academic Institutions and Nonprofits only

13. SARS-CoV-2_RBD_DMS_Library

    Pooled Library

    #1000000172

    Depositor

    Jesse Bloom

    Available since

    March 29, 2021

    Availability

    Academic Institutions and Nonprofits only

14. Lourido Toxoplasma CRISPR Library V1

    Pooled Library

    #80636

    Purpose

    Plasmid sgRNA library containing ten guides against each of the 8,158 predicted Toxoplasma gondii protein coding genes.

    Depositor

    Sebastian Lourido

    Article

    Sidik et al Cell. 2016 Sep 8;166(6):1423-1435.e12. d

    Available since

    Sept. 19, 2016

    Availability

    Academic Institutions and Nonprofits only

15. CRISPRi non-coding library (CRiNCL) - Unique to HFF

    Pooled Library

    #86541

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

16. SARS-CoV-2 RBD Omicron BA.1 SSM Library

    Pooled Library

    #1000000187

    Depositor

    Jesse Bloom

    Available since

    June 14, 2022

    Availability

    Academic Institutions and Nonprofits only

17. lentiGuide-Puro-pKO-library

    Pooled Library

    #190744

    Purpose

    CRISPR/Cas9 paired-guide RNA library to delete proximal poly(A) sites in mouse melanoma.

    Depositor

    Robert Bradley

    Article

    Gabel et al Nat Commun. 2024 Feb 1;15(1):959. doi: 1

    Expression

    Mammalian

    Species

    Mus musculus

    Use

    CRISPR, Lentiviral, and Mouse Targeting

    Available since

    Feb. 2, 2024

    Availability

    Academic Institutions and Nonprofits only

18. Liu Lab MusCK Library B

    Pooled Library

    #174197

    Purpose

    MusCK library contains 23,622 unique sgRNAs targeting 4,787 gene locations in the genome. Sub-library MusCK M_b contains 5 gRNAs per gene.

    Depositor

    Xiaole Shirley Liu

    Article

    Wang et al Cell. 2021 Oct 14;184(21):5357-5374.e22.

    Expression

    Mammalian

    Species

    Mus musculus

    Use

    CRISPR and Lentiviral

    Available since

    Oct. 29, 2021

    Availability

    Academic Institutions and Nonprofits only

19. Human Brunello kinome pooled library, guides 5-8 in lentiCRISPRv2 backbone

    Pooled Library

    #75315

    Purpose

    Human sgRNA library in backbone lentiCRISPRv2 targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

    Depositor

    David Root, John Doench

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    June 27, 2016

    Availability

    Academic Institutions and Nonprofits only

20. CRISPRi non-coding library (CRiNCL) - Unique to K562

    Pooled Library

    #86544

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only