388 results

1. CRISPRi non-coding library (CRiNCL) - Unique to K562

   Pooled Library

   #86544

   Depositor

   Jonathan Weissman

   Article

   Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

   Available Since

   March 8, 2017

   Availability

   Academic Institutions and Nonprofits only

2. Human Whole Genome sgRNA iBAR Library

   Pooled Library

   #140633

   Purpose

   Enables genome-wide CRISPR screening at high MOI through use of barcoded gRNA plasmids.

   Depositor

   Wensheng Wei

   Article

   Zhu et al Genome Biol. 2019 Jan 24;20(1):20. doi:

   Use

   CRISPR and Lentiviral

   Available Since

   April 21, 2020

   Availability

   Academic Institutions and Nonprofits only

3. CRISPRi non-coding library (CRiNCL) - Common to all 5 cancer cell lines

   Pooled Library

   #86539

   Depositor

   Jonathan Weissman

   Article

   Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

   Available Since

   March 8, 2017

   Availability

   Academic Institutions and Nonprofits only

4. SARS-CoV-2 RBD Omicron BA.1 SSM Library

   Pooled Library

   #1000000187

   Depositor

   Jesse Bloom

   Available Since

   June 14, 2022

   Availability

   Academic Institutions and Nonprofits only

5. Human Paralog Knockout Library (pgPEN)

   Pooled Library

   #171172

   Purpose

   Induces knockouts of paralogous gene pairs. Plasmids express a pair of guide RNAs targeting either individual genes or a pair of paralogs.

   Depositor

   Alice Berger

   Article

   Parrish et al Cell Rep. 2021 Aug 31;36(9):109597. doi:

   Expression

   Mammalian

   Species

   Homo sapiens and Synthetic

   Use

   CRISPR and Lentiviral

   Available Since

   Sept. 28, 2021

   Availability

   Academic Institutions and Nonprofits only

6. CRISPRi non-coding library (CRiNCL) - Unique to HFF

   Pooled Library

   #86541

   Depositor

   Jonathan Weissman

   Article

   Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

   Available Since

   March 8, 2017

   Availability

   Academic Institutions and Nonprofits only

7. hCRISPRi_dual_3_4

   Pooled Library

   #187247

   Purpose

   Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

   Depositor

   Marco Jost, Jonathan Weissman

   Article

   Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

   Species

   Synthetic

   Use

   Lentiviral

   Available Since

   Sept. 30, 2022

   Availability

   Academic Institutions and Nonprofits only

8. p11-3’_8xN_PAM-site2 (RTW555)

   Pooled Library

   #160133

   Purpose

   Plasmid library harboring a randomized 8nt PAM 3’ of target site 2. Can be used to profile CRISPR-Cas PAM requirements of enzymes that recognize 3’ PAMs (e.g. Cas9)

   Depositor

   Keith Joung, Benjamin Kleinstiver

   Article

   Walton et al Nat Protoc. 2021 Feb 5. pii: 10.1038/s41

   Species

   Synthetic

   Use

   CRISPR

   Available Since

   Feb. 8, 2021

   Availability

   Academic Institutions and Nonprofits only

9. Mouse Cardiac Transcriptional Regulators CRISPR Knockout Library

   Pooled Library

   #138015

   Purpose

   AAV library targeting transcriptional regulators expressed in cardiomyocytes.

   Depositor

   William Pu

   Article

   VanDusen et al bioRxiv 2019, 808402v1; doi: https://doi

   Species

   Mus musculus

   Use

   AAV, CRISPR, and Cre/Lox

   Available Since

   April 17, 2020

   Availability

   Academic Institutions and Nonprofits only

10. CRISPRi non-coding library (CRiNCL) - Unique to iPSC

    Pooled Library

    #86540

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available Since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

11. Sctrans-PP

    Pooled Library

    #153101

    Purpose

    CRISPR library targets all non-essential and conditionally essential transporter genes in S. cerevisiae

    Depositor

    Irina Borodina

    Article

    Wang et al Metab Eng. 2021 Jan 16. pii: S1096-7176(

    Expression

    Yeast

    Species

    Saccharomyces cerevisiae

    Use

    CRISPR

    Available Since

    Jan. 20, 2021

    Availability

    Academic Institutions and Nonprofits only

12. SARS-CoV-2 RBD XBB.1.5 SSM Library

    Pooled Library

    #1000000232

    Depositor

    Tyler Starr

    Available Since

    Oct. 25, 2023

    Availability

    Academic Institutions and Nonprofits only

13. Human Genome-wide Intron Tagging Library, Frame 1

    Pooled Library

    #216134

    Purpose

    Library of intron-targeting sgRNAs for pooled tagging of proteins with GFP or other protein tags at their endogenous genomic locus using an intron tagging approach.

    Depositor

    Stefan Kubicek

    Article

    Reicher et al Nat Cell Biol. 2024 May;26(5):745-756. d

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available Since

    April 19, 2024

    Availability

    Academic Institutions and Nonprofits only

14. Human Genome-wide Intron Tagging Library, Frame 0

    Pooled Library

    #216133

    Purpose

    Library of intron-targeting sgRNAs for pooled tagging of proteins with GFP or other protein tags at their endogenous genomic locus using an intron tagging approach.

    Depositor

    Stefan Kubicek

    Article

    Reicher et al Nat Cell Biol. 2024 May;26(5):745-756. d

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available Since

    April 19, 2024

    Availability

    Academic Institutions and Nonprofits only

15. Human CRISPR Poison Exon Knockout Library

    Pooled Library

    #138084

    Purpose

    Targets 3' splice sites with paired gRNAs. Induces skipping of poison cassette exons and matching upstream constitutive exons. Compare loss of a constitutive coding exon with loss of a poison exon.

    Depositor

    Robert Bradley

    Article

    Thomas et al Nat Genet. 2020 Jan;52(1):84-94. doi: 10

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available Since

    March 6, 2020

    Availability

    Academic Institutions and Nonprofits only

16. scQers promoter control series (p027, p028, p029, p041, p042)

    Pooled Library

    #1000000239

    Depositor

    Jay Shendure

    Available Since

    April 3, 2024

    Availability

    Academic Institutions and Nonprofits only

17. Human Transporter Knockout Library with UMIs

    Pooled Library

    #221409

    Purpose

    gRNA library to test the impact of transporters on biological processes

    Depositor

    RESOLUTE Consortium, Giulio Superti-Furga

    Article

    Wolf et al Cell Chem Biol. 2024 Dec 24:S2451-9456(2

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available Since

    Sept. 13, 2024

    Availability

    Academic Institutions and Nonprofits only

18. Sabatini/Lander Lab Ras synthetic lethal candidate focused human sgRNA library in lentiCRISPRv1

    Pooled Library

    #92352

    Purpose

    Focused gRNA library that targets synthetic lethal candidate and control genes with oncogenic Ras.

    Depositor

    Eric Lander, David Sabatini

    Article

    Wang et al Cell. 2017 Feb 1. pii: S0092-8674(17)300

    Species

    Homo sapiens

    Available Since

    June 7, 2017

    Availability

    Academic Institutions and Nonprofits only

19. CRISPRi non-coding library (CRiNCL) - Unique to U87

    Pooled Library

    #86542

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available Since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

20. KSHV Tiling Library

    Pooled Library

    #180272

    Purpose

    Tiles the entire ~154 kb of the BAC16 Kaposi’s Sarcoma-associated Herpes Virus genome. A guide every ~8 bp allows pooled screening of the viral genome.

    Depositor

    Britt Glaunsinger

    Article

    Morgens et al PLoS Pathog. 2022 Jan 18;18(1):e1010236.

    Expression

    Mammalian

    Species

    Kaposi’s sarcoma-associated herpes virus

    Use

    Lentiviral

    Available Since

    Feb. 11, 2022

    Availability

    Academic Institutions and Nonprofits only