388 results

1. pRep-Cap Scanning Saturation Mutagenesis (SSM) pooled library

   Pooled Library

   #199601

   Purpose

   pRep-Cap SSM library enables VP1, VP2, and VP3 expression under the control of the endogenous p40 promoter

   Depositor

   George Church

   Article

   Ogden et al Science. 2019 Nov 29;366(6469):1139-1143

   Expression

   Mammalian

   Species

   Aav2

   Use

   AAV

   Available Since

   June 13, 2023

   Availability

   Academic Institutions and Nonprofits only

2. hCRISPRi_dual_5_6

   Pooled Library

   #187248

   Purpose

   Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

   Depositor

   Marco Jost, Jonathan Weissman

   Article

   Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

   Species

   Synthetic

   Use

   Lentiviral

   Available Since

   Sept. 30, 2022

   Availability

   Academic Institutions and Nonprofits only

3. hCRISPRa-v2, Unassigned (h7), top 5 sgRNAs/gene

   Pooled Library

   #83986

   Purpose

   Human CRISPRa Pooled Library targeting unassigned genes

   Depositor

   Jonathan Weissman

   Article

   Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

   Available Since

   Jan. 12, 2017

   Availability

   Academic Institutions and Nonprofits only

4. Human Lentiviral sgRNA Library - Unknown Function

   Pooled Library

   #51043

   Purpose

   Sub-pool of Sabatini/Lander sgRNA library enriched for gene targets of unknown function.

   Depositor

   Eric Lander, David Sabatini

   Article

   Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available Since

   Feb. 7, 2014

   Availability

   Academic Institutions and Nonprofits only

5. SARS-CoV-2 RBD Wuhan-Hu-1 SSM Library

   Pooled Library

   #1000000182

   Depositor

   Jesse Bloom

   Available Since

   June 14, 2022

   Availability

   Academic Institutions and Nonprofits only

6. sgRNA pool for Streptococcus pneumoniae

   Pooled Library

   #170432

   Purpose

   Concise library targeting the whole genome of S. pneumoniae D39V with one sgRNA per operon or gene.

   Depositor

   Jan-Willem Veening

   Article

   Liu et al Cell Host Microbe. 2021 Jan 13;29(1):107

   Expression

   Bacterial

   Use

   CRISPR

   Available Since

   Aug. 31, 2021

   Availability

   Academic Institutions and Nonprofits only

7. mCRISPRa-v2, Mitochondria, Trafficking, and Motility (m4), top 5 sgRNAs/gene

   Pooled Library

   #84001

   Purpose

   Mouse CRISPRa Pooled Library targeting Mitochondria, Trafficking, and Motility genes

   Depositor

   Jonathan Weissman

   Article

   Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

   Available Since

   Jan. 12, 2017

   Availability

   Academic Institutions and Nonprofits only

8. Mouse Base Editing Sensor Library

   Pooled Library

   #179217

   Purpose

   sgRNAs that target frequently occurring cancer associated mutations identified in the MSK IMPACT dataset that can be modeled with cytosine base editing.

   Depositor

   Lukas Dow

   Article

   Sanchez-Rivera et al Nat Biotechnol. 2022 Feb 14. pii: 10.103

   Expression

   Mammalian

   Use

   Lentiviral

   Available Since

   June 16, 2022

   Availability

   Academic Institutions and Nonprofits only

9. mCRISPRa-v2, Unassigned (m7), top 5 sgRNAs/gene

   Pooled Library

   #84004

   Purpose

   Mouse CRISPRa Pooled Library targeting unassigned genes

   Depositor

   Jonathan Weissman

   Article

   Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

   Available Since

   Jan. 12, 2017

   Availability

   Academic Institutions and Nonprofits only

10. SARS-CoV-2_RBD_DMS_Library

    Pooled Library

    #1000000172

    Depositor

    Jesse Bloom

    Available Since

    March 29, 2021

    Availability

    Academic Institutions and Nonprofits only

11. TBG-mTSG

    Pooled Library

    #113585

    Purpose

    AAV-CRISPR library for pool mutagenesis of top tumor suppressor genes in mouse liver

    Depositor

    Sidi Chen

    Article

    Wang et al Sci Adv. 2018 Feb 28;4(2):eaao5508. doi:

    Expression

    Mammalian

    Use

    AAV, CRISPR, Lentiviral, and Luciferase

    Available Since

    July 23, 2019

    Availability

    Academic Institutions and Nonprofits only

12. CRISPRi non-coding library (CRiNCL) - Unique to HEK293T

    Pooled Library

    #86543

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available Since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

13. Pan-Druggable Cancer Library

    Pooled Library

    #182133

    Purpose

    Knockout library targeting cancer-related genes.

    Depositor

    Prashant Mali

    Article

    Hu et al Biomaterials. 2022 Jan;280:121276. doi:

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available Since

    Aug. 26, 2022

    Availability

    Academic Institutions and Nonprofits only

14. pUC57kan-T7-mt-gRNA library

    Pooled Library

    #82480

    Purpose

    This library is intended to be used as a technical tool for removal of mitochondrial DNA from mouse genomic DNA preparations.

    Depositor

    Wei Xie

    Article

    Wu et al Nature. 2016 Jun 30;534(7609):652-7.

    Available Since

    April 5, 2017

    Availability

    Academic Institutions and Nonprofits only

15. PYR1 Double Mutant Library

    Pooled Library

    #1000000181

    Depositor

    Timothy Whitehead

    Available Since

    June 21, 2022

    Availability

    Academic Institutions and Nonprofits only

16. p11-5’_10xN_PAM-site4 (RTW574)

    Pooled Library

    #160135

    Purpose

    Plasmid library harboring a randomized 10nt PAM 5’ of target site 4. Can be used to profile CRISPR-Cas PAM requirements of enzymes that recognize 5’ PAMs (e.g. Cas12a)

    Depositor

    Keith Joung, Benjamin Kleinstiver

    Article

    Walton et al Nat Protoc. 2021 Feb 5. pii: 10.1038/s41

    Species

    Synthetic

    Use

    CRISPR

    Available Since

    Feb. 8, 2021

    Availability

    Academic Institutions and Nonprofits only

17. pCMV-Rep78/68 Scanning Saturation Mutagenesis (SSM)

    Pooled Library

    #198050

    Purpose

    By supplying an AAV cap gene of interest in trans, researchers can use this library to investigate the effects of rep mutations on production of a wide range of AAV capsid serotypes

    Depositor

    George Church

    Article

    Jain et al Elife. 2024 Mar 27;12:RP87730. doi: 10.7

    Expression

    Mammalian

    Use

    AAV

    Available Since

    May 4, 2023

    Availability

    Academic Institutions and Nonprofits only

18. Toronto KnockOut Library (TKOv1)

    Pooled Library

    #1000000069

    Purpose

    CRISPR gRNA knockout pooled library for targeting the human genome

    Depositor

    Stephane Angers, Jason Moffat

    Available Since

    Jan. 28, 2016

    Availability

    Academic Institutions and Nonprofits only

19. CRISPRi non-coding library (CRiNCL) - iPSC & HFF

    Pooled Library

    #86550

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available Since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

20. Human Brunello kinome pooled library, guides 5-8 in lentiCRISPRv2 backbone

    Pooled Library

    #75315

    Purpose

    Human sgRNA library in backbone lentiCRISPRv2 targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available Since

    June 27, 2016

    Availability

    Academic Institutions and Nonprofits only