382 results

1. Human Lentiviral sgRNA Library - Unknown Function

   Pooled Library

   #51043

   Purpose

   Sub-pool of Sabatini/Lander sgRNA library enriched for gene targets of unknown function.

   Depositor

   Eric Lander, David Sabatini

   Article

   Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available Since

   Feb. 7, 2014

   Availability

   Academic Institutions and Nonprofits only

2. Human Lentiviral sgRNA Library - Ribosomal Proteins

   Pooled Library

   #51045

   Purpose

   Sub-pool of Sabatini/Lander sgRNA library enriched for ribosomal gene targets.

   Depositor

   Eric Lander, David Sabatini

   Article

   Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available Since

   Feb. 7, 2014

   Availability

   Academic Institutions and Nonprofits only

3. CRISPRi non-coding library (CRiNCL) - Unique to HEK293T

   Pooled Library

   #86543

   Depositor

   Jonathan Weissman

   Article

   Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

   Available Since

   March 8, 2017

   Availability

   Academic Institutions and Nonprofits only

4. Pan-Druggable Cancer Library

   Pooled Library

   #182133

   Purpose

   All-in-one CRISPR/Cas system with 74 individual elements. 63 elements target cancer-related genes with FDA-approved drug treatments, and 3 elements target key medulloblastoma driver genes.

   Depositor

   Prashant Mali

   Article

   Hu et al Biomaterials. 2022 Jan;280:121276. doi:

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available Since

   Aug. 26, 2022

   Availability

   Academic Institutions and Nonprofits only

5. PYR1 Double Mutant Library

   Pooled Library

   #1000000181

   Depositor

   Timothy Whitehead

   Available Since

   June 21, 2022

   Availability

   Academic Institutions and Nonprofits only

6. pUC57kan-T7-mt-gRNA library

   Pooled Library

   #82480

   Purpose

   Pool of sgRNAs to remove mouse mitochondrial DNA reads in the sequencing of genomic libraries

   Depositor

   Wei Xie

   Article

   Wu et al Nature. 2016 Jun 30;534(7609):652-7.

   Available Since

   April 5, 2017

   Availability

   Academic Institutions and Nonprofits only

7. pCMV-Rep78/68 Scanning Saturation Mutagenesis (SSM)

   Pooled Library

   #198050

   Purpose

   By supplying an AAV cap gene of interest in trans, researchers can use this library to investigate the effects of rep mutations on production of a wide range of AAV capsid serotypes

   Depositor

   George Church

   Article

   Jain et al Elife. 2024 Mar 27;12:RP87730. doi: 10.7

   Expression

   Mammalian

   Use

   AAV

   Available Since

   May 4, 2023

   Availability

   Academic Institutions and Nonprofits only

8. SARS-CoV-2_RBD_DMS_Library

   Pooled Library

   #1000000172

   Depositor

   Jesse Bloom

   Available Since

   March 29, 2021

   Availability

   Academic Institutions and Nonprofits only

9. Lourido Toxoplasma CRISPR Library V1

   Pooled Library

   #80636

   Purpose

   Plasmid sgRNA library containing ten guides against each of the 8,158 predicted Toxoplasma gondii protein coding genes.

   Depositor

   Sebastian Lourido

   Article

   Sidik et al Cell. 2016 Sep 8;166(6):1423-1435.e12. d

   Available Since

   Sept. 19, 2016

   Availability

   Academic Institutions and Nonprofits only

10. p11-5’_10xN_PAM-site4 (RTW574)

    Pooled Library

    #160135

    Purpose

    Plasmid library harboring a randomized 10nt PAM 5’ of target site 4. Can be used to profile CRISPR-Cas PAM requirements of enzymes that recognize 5’ PAMs (e.g. Cas12a)

    Depositor

    Benjamin Kleinstiver, Keith Joung

    Article

    Walton et al Nat Protoc. 2021 Feb 5. pii: 10.1038/s41

    Species

    Synthetic

    Use

    CRISPR

    Available Since

    Feb. 8, 2021

    Availability

    Academic Institutions and Nonprofits only

11. CRISPRi non-coding library (CRiNCL) - iPSC & HFF

    Pooled Library

    #86550

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available Since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

12. Human Brunello kinome pooled library, guides 5-8 in lentiCRISPRv2 backbone

    Pooled Library

    #75315

    Purpose

    Human sgRNA library in backbone lentiCRISPRv2 targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available Since

    June 27, 2016

    Availability

    Academic Institutions and Nonprofits only

13. Toronto KnockOut Library (TKOv1)

    Pooled Library

    #1000000069

    Purpose

    CRISPR gRNA knockout pooled library for targeting the human genome

    Depositor

    Stephane Angers, Jason Moffat

    Available Since

    Jan. 28, 2016

    Availability

    Academic Institutions and Nonprofits only

14. CRISPRi non-coding library (CRiNCL) - Unique to K562

    Pooled Library

    #86544

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available Since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

15. CRISPRi non-coding library (CRiNCL) - Common to all 5 cancer cell lines

    Pooled Library

    #86539

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available Since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

16. SARS-CoV-2 RBD Omicron BA.1 SSM Library

    Pooled Library

    #1000000187

    Depositor

    Jesse Bloom

    Available Since

    June 14, 2022

    Availability

    Academic Institutions and Nonprofits only

17. Human Whole Genome sgRNA iBAR Library

    Pooled Library

    #140633

    Purpose

    CRISPR pooled screen at high MOI by the embedded internal barcodes

    Depositor

    Wensheng Wei

    Article

    Zhu et al Genome Biol. 2019 Jan 24;20(1):20. doi:

    Use

    CRISPR and Lentiviral

    Available Since

    April 21, 2020

    Availability

    Academic Institutions and Nonprofits only

18. CRISPRi non-coding library (CRiNCL) - Unique to HFF

    Pooled Library

    #86541

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available Since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

19. Human Paralog Knockout Library (pgPEN)

    Pooled Library

    #171172

    Purpose

    CRISPR library targets human duplicate paralog gene pairs

    Depositor

    Alice Berger

    Article

    Parrish et al Cell Rep. 2021 Aug 31;36(9):109597. doi:

    Expression

    Mammalian

    Species

    Homo sapiens and Synthetic

    Use

    CRISPR and Lentiviral

    Available Since

    Sept. 28, 2021

    Availability

    Academic Institutions and Nonprofits only

20. hCRISPRi_dual_3_4

    Pooled Library

    #187247

    Purpose

    Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

    Depositor

    Marco Jost, Jonathan Weissman

    Article

    Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

    Species

    Synthetic

    Use

    Lentiviral

    Available Since

    Sept. 30, 2022

    Availability

    Academic Institutions and Nonprofits only