We narrowed to 279 results for: Spr

1. Human Transporter Knockout Library with UMIs

   Pooled Library

   #221409

   Purpose

   gRNA library to test the impact of transporters on biological processes

   Depositor

   RESOLUTE Consortium, Giulio Superti-Furga

   Article

   Wolf et al Cell Chem Biol. 2024 Dec 24:S2451-9456(2

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Sept. 13, 2024

   Availability

   Academic Institutions and Nonprofits only

2. Human Genome-wide Intron Tagging Library, Frame 1

   Pooled Library

   #216134

   Purpose

   Library of intron-targeting sgRNAs for pooled tagging of proteins with GFP or other protein tags at their endogenous genomic locus using an intron tagging approach.

   Depositor

   Stefan Kubicek

   Article

   Reicher et al Nat Cell Biol. 2024 May;26(5):745-756. d

   Expression

   Mammalian

   Use

   CRISPR and Lentiviral

   Available since

   April 19, 2024

   Availability

   Academic Institutions and Nonprofits only

3. ACER

   Pooled Library

   #226117

   Purpose

   The Advanced Catalogue of Epigenetic Regulators (ACER) library allows scientists to study how different epigenetic proteins influence gene activity and contribute to diseases.

   Depositor

   Rui Lu

   Article

   Zhou et al Blood. 2024 Aug 16:blood.2023023644. doi

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Oct. 29, 2024

   Availability

   Academic Institutions and Nonprofits only

4. Human SLC SAM Library

   Pooled Library

   #132561

   Purpose

   Expresses gRNAs for activation of human Solute Carrier family genes

   Depositor

   Giulio Superti-Furga

   Article

   Rebsamen et al Life Sci Alliance. 2022 Sep 16;5(11):e20

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   May 18, 2020

   Availability

   Academic Institutions and Nonprofits only

5. Human Genome-wide Intron Tagging Library, Frame 0

   Pooled Library

   #216133

   Purpose

   Library of intron-targeting sgRNAs for pooled tagging of proteins with GFP or other protein tags at their endogenous genomic locus using an intron tagging approach.

   Depositor

   Stefan Kubicek

   Article

   Reicher et al Nat Cell Biol. 2024 May;26(5):745-756. d

   Expression

   Mammalian

   Use

   CRISPR and Lentiviral

   Available since

   April 19, 2024

   Availability

   Academic Institutions and Nonprofits only

6. SARS-CoV-2 Spike (S) Ectodomain Library C

   Pooled Library

   #157973

   Purpose

   Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

   Depositor

   Timothy Whitehead

   Article

   Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

   Expression

   Bacterial and Yeast

   Species

   Sars-cov-2

   Available since

   Sept. 13, 2021

   Availability

   Academic Institutions and Nonprofits only

7. SARS-CoV-2 Spike (S) Ectodomain Library B

   Pooled Library

   #157972

   Purpose

   Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

   Depositor

   Timothy Whitehead

   Article

   Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

   Expression

   Bacterial and Yeast

   Species

   Sars-cov-2

   Available since

   Sept. 13, 2021

   Availability

   Academic Institutions and Nonprofits only

8. SARS-CoV-2 Spike (S) Ectodomain Library A

   Pooled Library

   #157971

   Purpose

   Encodes Spike ectodomain mutations that stabilize 'up' prefusion conformation

   Depositor

   Timothy Whitehead

   Article

   Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

   Expression

   Bacterial and Yeast

   Species

   Sars-cov-2

   Available since

   Sept. 13, 2021

   Availability

   Academic Institutions and Nonprofits only

9. Human ABC Transporter Knockout Sub-library with UMIs

   Pooled Library

   #221410

   Purpose

   gRNA library to test the impact of transporters on biological processes (subset: ABC transporters and controls)

   Depositor

   RESOLUTE Consortium, Giulio Superti-Furga

   Article

   Wolf et al Cell Chem Biol. 2024 Dec 24:S2451-9456(2

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Sept. 13, 2024

   Availability

   Academic Institutions and Nonprofits only

10. CHyMErA Exon-deletion hgRNA Library

    Pooled Library

    #155200

    Purpose

    Hybrid guide RNA library targeting human alternative cassette exons for deletion and disruption

    Depositor

    Benjamin Blencowe, Jason Moffat

    Article

    Gonatopoulos-Pournatzis et al Nat Biotechnol. 2020 May;38(5):638-648.

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    Sept. 2, 2020

    Availability

    Academic Institutions and Nonprofits only

11. CHyMErA Paralog&Dual-targeting hgRNA Library

    Pooled Library

    #155199

    Purpose

    Hybrid guide RNA library targetings human paralog pairs and other protein-coding genes.

    Depositor

    Benjamin Blencowe, Jason Moffat

    Article

    Gonatopoulos-Pournatzis et al Nat Biotechnol. 2020 May;38(5):638-648.

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    Sept. 2, 2020

    Availability

    Academic Institutions and Nonprofits only

12. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 1

    Pooled Library

    #168776

    Purpose

    Pooled library expressing barcoded SARS-CoV-2 RNA Binding Domain mutations

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Species

    Sars-cov-2

    Available since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

13. SARS-CoV-2 Spike (S) Receptor Binding Domain (RBD) library 2

    Pooled Library

    #168777

    Purpose

    Pooled library expressing barcoded SARS-CoV-2 RNA Binding Domain mutations

    Depositor

    Timothy Whitehead

    Article

    Francino-Urdaniz et al Cell Rep. 2021 Aug 31;36(9):109627. doi:

    Expression

    Yeast

    Species

    Sars-cov-2

    Available since

    Sept. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

14. CHyMErA LbCas12a Nuclease Optimization hgRNA Library

    Pooled Library

    #209734

    Purpose

    CHyMErA Cas12a Nuclease Optimization hgRNA Libraries allows assessment and comparison of the efficacy of different LbCas12a nucleases in the context of the Cas9-Cas12a CHyMErA system.

    Depositor

    Thomas Gonatopoulos-Pournatzis

    Article

    Xiao et al Mol Cell. 2024 Jul 11;84(13):2553-2572.e

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    June 20, 2024

    Availability

    Academic Institutions and Nonprofits only

15. CHyMErA AsCas12a Nuclease Optimization hgRNA Library

    Pooled Library

    #209735

    Purpose

    CHyMErA Cas12a Nuclease Optimization hgRNA Libraries allows assessment and comparison of the efficacy of different AsCas12a nucleases in the context of the Cas9-Cas12a CHyMErA system.

    Depositor

    Thomas Gonatopoulos-Pournatzis

    Article

    Xiao et al Mol Cell. 2024 Jul 11;84(13):2553-2572.e

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    June 20, 2024

    Availability

    Academic Institutions and Nonprofits only

16. CHyMErA Large-Scale Exon Deletion hgRNA Library

    Pooled Library

    #209736

    Purpose

    CHyMErA Exon Deletion hgRNA Library allows identification of frame-preserving exons that affect cell fitness in human cells using the CHyMErA screening platform.

    Depositor

    Thomas Gonatopoulos-Pournatzis

    Article

    Xiao et al Mol Cell. 2024 Jul 11;84(13):2553-2572.e

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    June 20, 2024

    Availability

    Academic Institutions and Nonprofits only

17. plIG-123_HA-GD2-28z_CAR_TF_Library

    Pooled Library

    #207478

    Purpose

    HA-GD2-28z CAR in combination with 100 transcription factors (and related proteins) and 2 controls (GFP/RFP). Library can be used to generate HDR templates for modular pooled knockin (ModPoKI) into th

    Depositor

    Alexander Marson

    Article

    Blaeschke et al Cell. 2023 Sep 14;186(19):4216-4234.e33.

    Species

    Homo sapiens

    Use

    CRISPR

    Available since

    Jan. 26, 2024

    Availability

    Academic Institutions and Nonprofits only

18. plIG-128_HA-GD2-28z_CAR_TFxTF_Library

    Pooled Library

    #207480

    Purpose

    HA-GD2-28z CAR in combination with ~10,000 transcription factor combinations (and related proteins) and controls (GFP/RFP combinations). Library can be used to generate HDR templates for modular poole

    Depositor

    Alexander Marson

    Article

    Blaeschke et al Cell. 2023 Sep 14;186(19):4216-4234.e33.

    Use

    CRISPR

    Available since

    Jan. 26, 2024

    Availability

    Academic Institutions and Nonprofits only

19. plIG-106_NY-ESO-1_TCR_SR_Library

    Pooled Library

    #207474

    Purpose

    NY-ESO-1 TCR in combination with 129 surface receptors and 2 controls (GFP/RFP). Library can be used to generate HDR templates for modular pooled knockin (ModPoKI) into the TRAC locus of human T cells

    Depositor

    Alexander Marson

    Article

    Blaeschke et al Cell. 2023 Sep 14;186(19):4216-4234.e33.

    Species

    Homo sapiens

    Use

    CRISPR

    Available since

    Jan. 26, 2024

    Availability

    Academic Institutions and Nonprofits only

20. plIG-107_NY-ESO-1_TCR_TF_Library

    Pooled Library

    #207475

    Purpose

    NY-ESO-1 TCR in combination with 100 transcription factors (and related proteins) and 2 controls (GFP/RFP). Library can be used to generate HDR templates for modular pooled knockin (ModPoKI) into the

    Depositor

    Alexander Marson

    Article

    Blaeschke et al Cell. 2023 Sep 14;186(19):4216-4234.e33.

    Species

    Homo sapiens

    Use

    CRISPR

    Available since

    Jan. 26, 2024

    Availability

    Academic Institutions and Nonprofits only