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M50 Super 8x TOPFlash Citations (205)

Plasmid Article: Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.
Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT Curr Biol. 2003 Apr 15. 13(8):680-5.
PubMed Journal

Articles Citing M50 Super 8x TOPFlash

Articles
Bacillus anthracis edema toxin activates nuclear glycogen synthase kinase 3beta. Larabee JL, DeGiusti K, Regens JL, Ballard JD. Infect Immun. 2008 Nov;76(11):4895-904. doi: 10.1128/IAI.00889-08. Epub 2008 Sep 2. PubMed
AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552. Zhao J, Yue W, Zhu MJ, Sreejayan N, Du M. Biochem Biophys Res Commun. 2010 Apr 23;395(1):146-51. doi: 10.1016/j.bbrc.2010.03.161. Epub 2010 Mar 31. PubMed
A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway. Trensz F, Haroun S, Cloutier A, Richter MV, Grenier G. Am J Physiol Cell Physiol. 2010 Nov;299(5):C939-47. doi: 10.1152/ajpcell.00253.2010. Epub 2010 Sep 1. PubMed
Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. Reddy VS, Valente AJ, Delafontaine P, Chandrasekar B. J Cell Physiol. 2011 Dec;226(12):3303-15. doi: 10.1002/jcp.22676. PubMed
Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Aisagbonhi O, Rai M, Ryzhov S, Atria N, Feoktistov I, Hatzopoulos AK. Dis Model Mech. 2011 Jul;4(4):469-83. doi: 10.1242/dmm.006510. Epub 2011 Feb 14. PubMed
Trenbolone enhances myogenic differentiation by enhancing beta-catenin signaling in muscle-derived stem cells of cattle. Zhao JX, Hu J, Zhu MJ, Du M. Domest Anim Endocrinol. 2011 May;40(4):222-9. doi: 10.1016/j.domaniend.2011.01.004. Epub 2011 Feb 26. PubMed
Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion. Ekstrom EJ, Sherwood V, Andersson T. PLoS One. 2011 Apr 8;6(4):e18674. doi: 10.1371/journal.pone.0018674. PubMed
Negative cross-talk between calcium-sensing receptor and beta-catenin signaling systems in colonic epithelium. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. J Biol Chem. 2012 Jan 6;287(2):1158-67. doi: 10.1074/jbc.M111.274589. Epub 2011 Nov 17. PubMed
Modulation of Wnt/beta-catenin signaling in human embryonic stem cells using a 3-D microwell array. Azarin SM, Lian X, Larson EA, Popelka HM, de Pablo JJ, Palecek SP. Biomaterials. 2012 Mar;33(7):2041-9. Epub 2011 Dec 15. PubMed

Associated Plasmids

RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. Lin FC, Liu YP, Lai CH, Shan YS, Cheng HC, Hsu PI, Lee CH, Lee YC, Wang HY, Wang CH, Cheng JQ, Hsiao M, Lu PJ. Oncogene. 2012 Sep 27;31(39):4302-16. doi: 10.1038/onc.2011.596. Epub 2012 Jan 9. PubMed
Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling. Miranda CJ, Braun L, Jiang Y, Hester ME, Zhang L, Riolo M, Wang H, Rao M, Altura RA, Kaspar BK. Aging Cell. 2012 Jun;11(3):542-52. doi: 10.1111/j.1474-9726.2012.00816.x. Epub 2012 Apr 4. PubMed
The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. Guo B, Chatterjee S, Li L, Kim JM, Lee J, Yechoor VK, Minze LJ, Hsueh W, Ma K. FASEB J. 2012 Aug;26(8):3453-63. doi: 10.1096/fj.12-205781. Epub 2012 May 18. PubMed
The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling. Borgal L, Habbig S, Hatzold J, Liebau MC, Dafinger C, Sacarea I, Hammerschmidt M, Benzing T, Schermer B. J Biol Chem. 2012 Jul 20;287(30):25370-80. doi: 10.1074/jbc.M112.385658. Epub 2012 May 31. PubMed
mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. Arun G, Akhade VS, Donakonda S, Rao MR. Mol Cell Biol. 2012 Aug;32(15):3140-52. doi: 10.1128/MCB.00006-12. Epub 2012 Jun 4. PubMed
Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells. Kirby LA, Schott JT, Noble BL, Mendez DC, Caseley PS, Peterson SC, Routledge TJ, Patel NV. PLoS One. 2012;7(6):e39329. doi: 10.1371/journal.pone.0039329. Epub 2012 Jun 26. PubMed
StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. Sinner DI, Kim GJ, Henderson GC, Igal RA. PLoS One. 2012;7(6):e39787. doi: 10.1371/journal.pone.0039787. Epub 2012 Jun 22. PubMed
Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of beta-catenin. Rines AK, Burke MA, Fernandez RP, Volpert OV, Ardehali H. FASEB J. 2012 Nov;26(11):4685-95. doi: 10.1096/fj.12-212282. Epub 2012 Aug 8. PubMed
The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling. Bernhard SM, Seidel K, Schmitz J, Klare S, Kirsch S, Schrezenmeier E, Zaade D, Meyborg H, Goldin-Lang P, Stawowy P, Zollmann FS, Unger T, Funke-Kaiser H. Biochem Pharmacol. 2012 Dec 15;84(12):1643-50. doi: 10.1016/j.bcp.2012.09.020. Epub 2012 Sep 26. PubMed
Lithium rescues synaptic plasticity and memory in Down syndrome mice. Contestabile A, Greco B, Ghezzi D, Tucci V, Benfenati F, Gasparini L. J Clin Invest. 2013 Jan;123(1):348-61. doi: 10.1172/JCI64650. Epub 2012 Dec 3. PubMed
Wnt/beta-catenin pathway is regulated by PITX2 homeodomain protein and thus contributes to the proliferation of human ovarian adenocarcinoma cell, SKOV-3. Basu M, Roy SS. J Biol Chem. 2013 Feb 8;288(6):4355-67. doi: 10.1074/jbc.M112.409102. Epub 2012 Dec 17. PubMed
Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1. Huard CC, Tremblay CS, Helsper K, Delisle MC, Schindler D, Levesque G, Carreau M. Blood. 2013 Mar 7;121(10):1729-39. doi: 10.1182/blood-2012-02-408997. Epub 2013 Jan 9. PubMed
SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/beta-catenin activation in breast cancer. Wang H, He L, Ma F, Regan MM, Balk SP, Richardson AL, Yuan X. J Biol Chem. 2013 Mar 1;288(9):6478-87. doi: 10.1074/jbc.M112.419184. Epub 2013 Jan 10. PubMed
Regeneration-associated WNT signaling is activated in long-term reconstituting AC133bright acute myeloid leukemia cells. Beghini A, Corlazzoli F, Del Giacco L, Re M, Lazzaroni F, Brioschi M, Valentini G, Ferrazzi F, Ghilardi A, Righi M, Turrini M, Mignardi M, Cesana C, Bronte V, Nilsson M, Morra E, Cairoli R. Neoplasia. 2012 Dec;14(12):1236-48. PubMed
SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/beta-catenin signaling. Thu KL, Radulovich N, Becker-Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL, Tsao MS. Oncogene. 2014 Jan 16;33(3):279-88. doi: 10.1038/onc.2012.595. Epub 2013 Jan 14. PubMed
Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target. Verjee LS, Verhoekx JS, Chan JK, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood KS, Nanchahal J. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E928-37. doi: 10.1073/pnas.1301100110. Epub 2013 Feb 19. PubMed
Androgen activates beta-catenin signaling in bladder cancer cells. Li Y, Zheng Y, Izumi K, Ishiguro H, Ye B, Li F, Miyamoto H. Endocr Relat Cancer. 2013 May 20;20(3):293-304. doi: 10.1530/ERC-12-0328. Print 2013 Jun. PubMed
Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A, Manetti F, Solinas A, Petricci E, Taddei M, Ruat M. Mol Pharmacol. 2013 May;83(5):1020-9. doi: 10.1124/mol.112.084590. Epub 2013 Feb 28. PubMed
Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: the involvement of the Wnt/beta-catenin signaling pathway. Wang S, Avery JE, Hannafon BN, Lind SE, Ding WQ. Biochem Pharmacol. 2013 Jun 1;85(11):1611-8. doi: 10.1016/j.bcp.2013.03.011. Epub 2013 Mar 21. PubMed
Agonism of Wnt-beta-catenin signalling promotes mesenchymal stem cell (MSC) expansion. Hoffman MD, Benoit DS. J Tissue Eng Regen Med. 2013 Apr 1. doi: 10.1002/term.1736. PubMed
Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis. Gozo MC, Aspuria PJ, Cheon DJ, Walts AE, Berel D, Miura N, Karlan BY, Orsulic S. Cell Death Differ. 2013 Aug;20(8):1031-42. doi: 10.1038/cdd.2013.34. Epub 2013 May 3. PubMed
Tumor necrosis factor alpha-induced hypoxia-inducible factor 1alpha-beta-catenin axis regulates major histocompatibility complex class I gene activation through chromatin remodeling. Ghosh S, Paul A, Sen E. Mol Cell Biol. 2013 Jul;33(14):2718-31. doi: 10.1128/MCB.01254-12. Epub 2013 May 13. PubMed
Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. Baril M, Es-Saad S, Chatel-Chaix L, Fink K, Pham T, Raymond VA, Audette K, Guenier AS, Duchaine J, Servant M, Bilodeau M, Cohen E, Grandvaux N, Lamarre D. PLoS Pathog. 2013;9(6):e1003416. doi: 10.1371/journal.ppat.1003416. Epub 2013 Jun 13. PubMed
KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. Lu H, Hu L, Yu L, Wang X, Urvalek AM, Li T, Shen C, Mukherjee D, Lahiri SK, Wason MS, Zhao J. Oncogene. 2014 May 29;33(22):2909-17. doi: 10.1038/onc.2013.247. Epub 2013 Jul 1. PubMed
MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Judson RL, Greve TS, Parchem RJ, Blelloch R. Nat Struct Mol Biol. 2013 Oct;20(10):1227-35. doi: 10.1038/nsmb.2665. Epub 2013 Sep 15. PubMed
WNT5A encodes two isoforms with distinct functions in cancers. Bauer M, Benard J, Gaasterland T, Willert K, Cappellen D. PLoS One. 2013 Nov 18;8(11):e80526. doi: 10.1371/journal.pone.0080526. eCollection 2013. PubMed
DKK1 promotes hepatocellular carcinoma cell migration and invasion through beta-catenin/MMP7 signaling pathway. Chen L, Li M, Li Q, Wang CJ, Xie SQ. Mol Cancer. 2013 Dec 10;12:157. doi: 10.1186/1476-4598-12-157. PubMed
Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling. Koval AV, Vlasov P, Shichkova P, Khunderyakova S, Markov Y, Panchenko J, Volodina A, Kondrashov FA, Katanaev VL. Biochem Pharmacol. 2014 Feb 15;87(4):571-8. doi: 10.1016/j.bcp.2013.12.007. Epub 2013 Dec 16. PubMed
The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression. Huard CC, Tremblay CS, Magron A, Levesque G, Carreau M. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2152-7. doi: 10.1073/pnas.1314226111. Epub 2014 Jan 27. PubMed
Preclinical activity of the oral proteasome inhibitor MLN9708 in Myeloma bone disease. Garcia-Gomez A, Quwaider D, Canavese M, Ocio EM, Tian Z, Blanco JF, Berger AJ, Ortiz-de-Solorzano C, Hernandez-Iglesias T, Martens AC, Groen RW, Mateo-Urdiales J, Fraile S, Galarraga M, Chauhan D, San Miguel JF, Raje N, Garayoa M. Clin Cancer Res. 2014 Mar 15;20(6):1542-54. doi: 10.1158/1078-0432.CCR-13-1657. Epub 2014 Jan 31. PubMed
Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. Osborn DP, Roccasecca RM, McMurray F, Hernandez-Hernandez V, Mukherjee S, Barroso I, Stemple D, Cox R, Beales PL, Christou-Savina S. PLoS One. 2014 Feb 4;9(2):e87662. doi: 10.1371/journal.pone.0087662. eCollection 2014. PubMed
Modulating and measuring Wingless signalling. Vincent JP. Methods. 2014 Jun 15;68(1):194-8. doi: 10.1016/j.ymeth.2014.03.015. Epub 2014 Mar 25. PubMed
High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma. Kuo PY, Leshchenko VV, Fazzari MJ, Perumal D, Gellen T, He T, Iqbal J, Baumgartner-Wennerholm S, Nygren L, Zhang F, Zhang W, Suh KS, Goy A, Yang DT, Chan WC, Kahl BS, Verma AK, Gascoyne RD, Kimby E, Sander B, Ye BH, Melnick AM, Parekh S. Oncogene. 2015 Mar 5;34(10):1231-40. doi: 10.1038/onc.2014.44. Epub 2014 Mar 31. PubMed
Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation. Zhuang L, Hulin JA, Gromova A, Tran Nguyen TD, Yu RT, Liddle C, Downes M, Evans RM, Makarenkova HP, Meech R. Stem Cells. 2014 Jun;32(6):1661-73. doi: 10.1002/stem.1674. PubMed
MiR-29b downregulates canonical Wnt signaling by suppressing coactivators of beta-catenin in human colorectal cancer cells. Subramanian M, Rao SR, Thacker P, Chatterjee S, Karunagaran D. J Cell Biochem. 2014 Nov;115(11):1974-84. doi: 10.1002/jcb.24869. PubMed
Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6(5a) isoform. Forsdahl S, Kiselev Y, Hogseth R, Mjelle JE, Mikkola I. PLoS One. 2014 Jul 16;9(7):e102559. doi: 10.1371/journal.pone.0102559. eCollection 2014. PubMed
Casein kinase 1 alpha phosphorylates the Wnt regulator Jade-1 and modulates its activity. Borgal L, Rinschen MM, Dafinger C, Hoff S, Reinert MJ, Lamkemeyer T, Lienkamp SS, Benzing T, Schermer B. J Biol Chem. 2014 Sep 19;289(38):26344-56. doi: 10.1074/jbc.M114.562165. Epub 2014 Aug 6. PubMed
Pin1 positively affects tumorigenesis of esophageal squamous cell carcinoma and correlates with poor survival of patients. Lin FC, Lee YC, Goan YG, Tsai CH, Yao YC, Cheng HC, Lai WW, Wang YC, Sheu BS, Lu PJ. J Biomed Sci. 2014 Aug 27;21:75. doi: 10.1186/s12929-014-0075-1. PubMed
Tenascin-C is required for normal Wnt/beta-catenin signaling in the whisker follicle stem cell niche. Hendaoui I, Tucker RP, Zingg D, Bichet S, Schittny J, Chiquet-Ehrismann R. Matrix Biol. 2014 Nov;40:46-53. doi: 10.1016/j.matbio.2014.08.017. Epub 2014 Sep 6. PubMed
Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. Pooja T, Karunagaran D. Eur J Pharmacol. 2014 Nov 5;742:55-64. doi: 10.1016/j.ejphar.2014.08.028. Epub 2014 Sep 6. PubMed
CD44 functions in Wnt signaling by regulating LRP6 localization and activation. Schmitt M, Metzger M, Gradl D, Davidson G, Orian-Rousseau V. Cell Death Differ. 2015 Apr;22(4):677-89. doi: 10.1038/cdd.2014.156. Epub 2014 Oct 10. PubMed
RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. Rodrigues P, Macaya I, Bazzocco S, Mazzolini R, Andretta E, Dopeso H, Mateo-Lozano S, Bilic J, Carton-Garcia F, Nieto R, Suarez-Lopez L, Afonso E, Landolfi S, Hernandez-Losa J, Kobayashi K, Ramon y Cajal S, Tabernero J, Tebbutt NC, Mariadason JM, Schwartz S Jr, Arango D. Nat Commun. 2014 Nov 21;5:5458. doi: 10.1038/ncomms6458. PubMed
MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway. Ahmed MI, Alam M, Emelianov VU, Poterlowicz K, Patel A, Sharov AA, Mardaryev AN, Botchkareva NV. J Cell Biol. 2014 Nov 24;207(4):549-67. doi: 10.1083/jcb.201404001. PubMed
Fezf2 promotes neuronal differentiation through localised activation of Wnt/beta-catenin signalling during forebrain development. Zhang S, Li J, Lea R, Vleminckx K, Amaya E. Development. 2014 Dec;141(24):4794-805. doi: 10.1242/dev.115691. PubMed
Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. Bisson JA, Mills B, Paul Helt JC, Zwaka TP, Cohen ED. Dev Biol. 2015 Feb 1;398(1):80-96. doi: 10.1016/j.ydbio.2014.11.015. Epub 2014 Dec 5. PubMed
Inhibition of mesothelioma cancer stem-like cells with adenovirus-mediated NK4 gene therapy. Deng XB, Xiao L, Wu Y, Jin F, Mossman B, Testa JR, Xiao GH. Int J Cancer. 2015 Jul 15;137(2):481-90. doi: 10.1002/ijc.29391. Epub 2014 Dec 27. PubMed
Disruption of cell-cell contact-mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential: winner of the Society for Biomaterials Student Award in the Undergraduate Category, Charlotte, NC, April 15 to 18, 2015. Chen AX, Hoffman MD, Chen CS, Shubin AD, Reynolds DS, Benoit DS. J Biomed Mater Res A. 2015 Apr;103(4):1291-302. doi: 10.1002/jbm.a.35383. Epub 2014 Dec 31. PubMed
Dose-dependent nuclear beta-catenin response segregates endomesoderm along the sea star primary axis. McCauley BS, Akyar E, Saad HR, Hinman VF. Development. 2015 Jan 1;142(1):207-17. doi: 10.1242/dev.113043. PubMed
Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Sugiyama M, Hasegawa H, Ito S, Sugiyama K, Maeda M, Aoki K, Wakabayashi T, Hamaguchi M, Natsume A, Senga T. Oncol Rep. 2015 Mar;33(3):1123-30. doi: 10.3892/or.2014.3681. Epub 2014 Dec 18. PubMed
Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric beta-catenin signaling. Wilkinson LJ, Neal CS, Singh RR, Sparrow DB, Kurniawan ND, Ju A, Grieve SM, Dunwoodie SL, Moritz KM, Little MH. Kidney Int. 2015 May;87(5):975-83. doi: 10.1038/ki.2014.394. Epub 2015 Jan 14. PubMed
Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts. Kulak O, Yamaguchi K, Lum L. Methods Mol Biol. 2015;1263:3-14. doi: 10.1007/978-1-4939-2269-7_1. PubMed
RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells. Ilmer M, Boiles AR, Regel I, Yokoi K, Michalski CW, Wistuba II, Rodriguez J, Alt E, Vykoukal J. Cancer Res. 2015 May 1;75(9):1883-96. doi: 10.1158/0008-5472.CAN-14-1327. Epub 2015 Mar 13. PubMed
Transformation of the intestinal epithelium by the MSI2 RNA-binding protein. Wang S, Li N, Yousefi M, Nakauka-Ddamba A, Li F, Parada K, Rao S, Minuesa G, Katz Y, Gregory BD, Kharas MG, Yu Z, Lengner CJ. Nat Commun. 2015 Mar 16;6:6517. doi: 10.1038/ncomms7517. PubMed
Curcumin and emodin down-regulate TGF-beta signaling pathway in human cervical cancer cells. Thacker PC, Karunagaran D. PLoS One. 2015 Mar 18;10(3):e0120045. doi: 10.1371/journal.pone.0120045. eCollection 2015. PubMed
Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells. Garnier A, Vykoukal J, Hubertus J, Alt E, von Schweinitz D, Kappler R, Berger M, Ilmer M. Int J Oncol. 2015 Jul;47(1):151-60. doi: 10.3892/ijo.2015.3016. Epub 2015 May 21. PubMed
An IkappaB Kinase-Regulated Feedforward Circuit Prolongs Inflammation. Perez JM, Chirieleison SM, Abbott DW. Cell Rep. 2015 Jul 28;12(4):537-44. doi: 10.1016/j.celrep.2015.06.050. Epub 2015 Jul 16. PubMed
beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Cai J, Maitra A, Anders RA, Taketo MM, Pan D. Genes Dev. 2015 Jul 15;29(14):1493-506. doi: 10.1101/gad.264515.115. Epub 2015 Jul 20. PubMed
Angiotensin II prevents calcification in vascular smooth muscle cells by enhancing magnesium influx. Herencia C, Rodriguez-Ortiz ME, Munoz-Castaneda JR, Martinez-Moreno JM, Canalejo R, Montes de Oca A, Diaz-Tocados JM, Peralbo-Santaella E, Marin C, Canalejo A, Rodriguez M, Almaden Y. Eur J Clin Invest. 2015 Nov;45(11):1129-44. doi: 10.1111/eci.12517. Epub 2015 Sep 13. PubMed
Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, Ricci L, Fan F, Tawfik O, Marks JR, Knapp JR, Yeh HW, Thomas P, Carrasco DR, Fields TA, Godwin AK, Behbod F. Breast Cancer Res. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z. PubMed
MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/beta-catenin pathway. Liu T, Hu K, Zhao Z, Chen G, Ou X, Zhang H, Zhang X, Wei X, Wang D, Cui M, Liu C. Oncotarget. 2015 Dec 8;6(39):41638-49. doi: 10.18632/oncotarget.5873. PubMed
Targeting the Neurokinin-1 Receptor Compromises Canonical Wnt Signaling in Hepatoblastoma. Ilmer M, Garnier A, Vykoukal J, Alt E, von Schweinitz D, Kappler R, Berger M. Mol Cancer Ther. 2015 Dec;14(12):2712-21. doi: 10.1158/1535-7163.MCT-15-0206. Epub 2015 Oct 29. PubMed
The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. Pai P, Rachagani S, Lakshmanan I, Macha MA, Sheinin Y, Smith LM, Ponnusamy MP, Batra SK. Mol Oncol. 2016 Feb;10(2):224-39. doi: 10.1016/j.molonc.2015.10.005. Epub 2015 Oct 19. PubMed
Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Maxfield KE, Taus PJ, Corcoran K, Wooten J, Macion J, Zhou Y, Borromeo M, Kollipara RK, Yan J, Xie Y, Xie XJ, Whitehurst AW. Nat Commun. 2015 Nov 16;6:8840. doi: 10.1038/ncomms9840. PubMed
Wnt/beta-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. Wickstrom M, Dyberg C, Milosevic J, Einvik C, Calero R, Sveinbjornsson B, Sanden E, Darabi A, Siesjo P, Kool M, Kogner P, Baryawno N, Johnsen JI. Nat Commun. 2015 Nov 25;6:8904. doi: 10.1038/ncomms9904. PubMed
beta-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1. Liu Y, Hancock M, Workman A, Doster A, Jones C. J Virol. 2016 Jan 6;90(6):3148-59. doi: 10.1128/JVI.02971-15. PubMed
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. Niwa Y, Suzuki T, Dohmae N, Simizu S. Mol Biol Cell. 2016 Jan 13. pii: mbc.E15-06-0373. PubMed
Prenatal beta-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A. Mol Psychiatry. 2016 Feb 2. doi: 10.1038/mp.2015.207. PubMed
Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells. Hoepfner J, Kleinsorge M, Papp O, Ackermann M, Alfken S, Rinas U, Solodenko W, Kirschning A, Sgodda M, Cantz T. Cell Biol Int. 2016 May;40(5):534-48. doi: 10.1002/cbin.10590. Epub 2016 Feb 25. PubMed
The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. Leow SC, Poschmann J, Too PG, Yin J, Joseph R, McFarlane C, Dogra S, Shabbir A, Ingham PW, Prabhakar S, Leow MK, Lee YS, Ng KL, Chong YS, Gluckman PD, Stunkel W. Development. 2016 Mar 15;143(6):950-61. doi: 10.1242/dev.131573. Epub 2016 Feb 18. PubMed
Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility. de Voer RM, Hahn MM, Weren RD, Mensenkamp AR, Gilissen C, van Zelst-Stams WA, Spruijt L, Kets CM, Zhang J, Venselaar H, Vreede L, Schubert N, Tychon M, Derks R, Schackert HK, Geurts van Kessel A, Hoogerbrugge N, Ligtenberg MJ, Kuiper RP. PLoS Genet. 2016 Feb 22;12(2):e1005880. doi: 10.1371/journal.pgen.1005880. eCollection 2016 Feb. PubMed
Synergistic role of beta-catenin1 and 2 in ovarian differentiation and maintenance of female pathway in Nile tilapia. Wu L, Wu F, Xie L, Wang D, Zhou L. Mol Cell Endocrinol. 2016 May 15;427:33-44. doi: 10.1016/j.mce.2016.03.002. Epub 2016 Mar 4. PubMed
An Epigenetic Reprogramming Strategy to Resensitize Radioresistant Prostate Cancer Cells. Peitzsch C, Cojoc M, Hein L, Kurth I, Mabert K, Trautmann F, Klink B, Schrock E, Wirth MP, Krause M, Stakhovsky EA, Telegeev GD, Novotny V, Toma M, Muders M, Baretton GB, Frame FM, Maitland NJ, Baumann M, Dubrovska A. Cancer Res. 2016 May 1;76(9):2637-51. doi: 10.1158/0008-5472.CAN-15-2116. Epub 2016 Mar 16. PubMed
The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy. Mohamed TM, Abou-Leisa R, Stafford N, Maqsood A, Zi M, Prehar S, Baudoin-Stanley F, Wang X, Neyses L, Cartwright EJ, Oceandy D. Nat Commun. 2016 Mar 29;7:11074. doi: 10.1038/ncomms11074. PubMed
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH 3rd, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH 3rd, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT. Nature. 2016 Apr 14;532(7598):250-4. doi: 10.1038/nature17392. Epub 2016 Apr 4. PubMed
Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Peuker K, Muff S, Wang J, Kunzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Rocken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S. Nat Med. 2016 May;22(5):506-15. doi: 10.1038/nm.4072. Epub 2016 Apr 4. PubMed
Cooperative Wnt-Nodal Signals Regulate the Patterning of Anterior Neuroectoderm. Yaguchi J, Takeda N, Inaba K, Yaguchi S. PLoS Genet. 2016 Apr 21;12(4):e1006001. doi: 10.1371/journal.pgen.1006001. eCollection 2016 Apr. PubMed
N-glycosylation of R-spondin1 at Asn137 negatively regulates its secretion and Wnt/beta-catenin signaling-enhancing activity. Tsuchiya M, Niwa Y, Simizu S. Oncol Lett. 2016 May;11(5):3279-3286. Epub 2016 Apr 7. PubMed
Barx2 and Pax7 regulate Axin2 expression in myoblasts by interaction with beta-catenin and chromatin remodelling. Hulin JA, Nguyen TD, Cui S, Marri S, Yu RT, Downes M, Evans RM, Makarenkova H, Meech R. Stem Cells. 2016 May 4. doi: 10.1002/stem.2396. PubMed
Growth hormone is permissive for neoplastic colon growth. Chesnokova V, Zonis S, Zhou C, Recouvreux MV, Ben-Shlomo A, Araki T, Barrett R, Workman M, Wawrowsky K, Ljubimov VA, Uhart M, Melmed S. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3250-9. doi: 10.1073/pnas.1600561113. Epub 2016 May 25. PubMed
JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression. Han F, Ren J, Zhang J, Sun Y, Ma F, Liu Z, Yu H, Jia J, Li W. Oncotarget. 2016 Jun 21;7(25):38626-38637. doi: 10.18632/oncotarget.9573. PubMed
MicroRNA-224 inhibits proliferation and migration of breast cancer cells by down-regulating Fizzled 5 expression. Liu F, Liu Y, Shen J, Zhang G, Han J. Oncotarget. 2016 Aug 2;7(31):49130-49142. doi: 10.18632/oncotarget.9734. PubMed
C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt/beta-catenin signaling in cells. Fujiwara M, Kato S, Niwa Y, Suzuki T, Tsuchiya M, Sasazawa Y, Dohmae N, Simizu S. FEBS Lett. 2016 Aug;590(16):2639-49. doi: 10.1002/1873-3468.12274. Epub 2016 Jul 13. PubMed
Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer. Bian Y, Chang X, Liao Y, Wang J, Li Y, Wang K, Wan X. Oncol Rep. 2016 Aug;36(2):803-10. doi: 10.3892/or.2016.4885. Epub 2016 Jun 17. PubMed
Axitinib blocks Wnt/beta-catenin signaling and directs asymmetric cell division in cancer. Qu Y, Gharbi N, Yuan X, Olsen JR, Blicher P, Dalhus B, Brokstad KA, Lin B, Oyan AM, Zhang W, Kalland KH, Ke X. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9339-44. doi: 10.1073/pnas.1604520113. Epub 2016 Aug 1. PubMed
RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells. Di Cecilia S, Zhang F, Sancho A, Li S, Aguilo F, Sun Y, Rengasamy M, Zhang W, Del Vecchio L, Salvatore F, Walsh MJ. Cancer Res. 2016 Oct 1;76(19):5615-5627. Epub 2016 Aug 12. PubMed
MUC4 is negatively regulated through the Wnt/beta-catenin pathway via the Notch effector Hath1 in colorectal cancer. Pai P, Rachagani S, Dhawan P, Sheinin YM, Macha MA, Qazi AK, Chugh S, Ponnusamy MP, Mallya K, Pothuraju R, Batra SK. Genes Cancer. 2016 May;7(5-6):154-68. doi: 10.18632/genesandcancer.108. PubMed
Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/beta-catenin signaling cascades and reversal of epithelial-mesenchymal transition. Shrivastava S, Jeengar MK, Thummuri D, Koval A, Katanaev VL, Marepally S, V G M N. Biofactors. 2016 Sep 1. doi: 10.1002/biof.1315. PubMed
Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells. Homet Moreno B, Zaretsky JM, Garcia-Diaz A, Tsoi J, Parisi G, Robert L, Meeth K, Ndoye A, Bosenberg M, Weeraratna AT, Graeber TG, Comin-Anduix B, Hu-Lieskovan S, Ribas A. Cancer Immunol Res. 2016 Oct;4(10):845-857. Epub 2016 Sep 2. PubMed
Selective targeting of CREB-binding protein/beta-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle. Koopmans T, Crutzen S, Menzen MH, Halayko AJ, Hackett TL, Knight DA, Gosens R. Br J Pharmacol. 2016 Sep 15. doi: 10.1111/bph.13620. PubMed
Real-Time Analysis of Endogenous Wnt Signalling in 3D Mesenchymal Stromal Cells. Saleh F, Carstairs A, Etheridge SL, Genever P. Stem Cells Int. 2016;2016:7132529. doi: 10.1155/2016/7132529. Epub 2016 Sep 7. PubMed
Low expression of galectin-3 is associated with poor survival in node-positive breast cancers and mesenchymal phenotype in breast cancer stem cells. Ilmer M, Mazurek N, Gilcrease MZ, Byrd JC, Woodward WA, Buchholz TA, Acklin K, Ramirez K, Hafley M, Alt E, Vykoukal J, Bresalier RS. Breast Cancer Res. 2016 Sep 29;18(1):97. PubMed
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways. Huang T, Alvarez AA, Pangeni RP, M Horbinski C, Lu S, Kim SH, James CD, J Raizer J, A Kessler J, Brenann CW, Sulman EP, Finocchiaro G, Tan M, Nishikawa R, Lu X, Nakano I, Hu B, Cheng SY. Nat Commun. 2016 Oct 4;7:12885. doi: 10.1038/ncomms12885. PubMed
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity. Kubota N, Kubota T, Kajiwara E, Iwamura T, Kumagai H, Watanabe T, Inoue M, Takamoto I, Sasako T, Kumagai K, Kohjima M, Nakamuta M, Moroi M, Sugi K, Noda T, Terauchi Y, Ueki K, Kadowaki T. Nat Commun. 2016 Oct 6;7:12977. doi: 10.1038/ncomms12977. PubMed
Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Sprowl-Tanio S, Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA, Grun F, Lyou Y, Waterman ML. Cancer Metab. 2016 Oct 3;4:20. eCollection 2016. PubMed
Altering the Proteoglycan State of Transforming Growth Factor beta Type III Receptor (TbetaRIII)/Betaglycan Modulates Canonical Wnt/beta-Catenin Signaling. Jenkins LM, Singh P, Varadaraj A, Lee NY, Shah S, Flores HV, O'Connell K, Mythreye K. J Biol Chem. 2016 Dec 2;291(49):25716-25728. doi: 10.1074/jbc.M116.748624. Epub 2016 Oct 26. PubMed
The beta-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection. Zhu L, Thunuguntla P, Liu Y, Hancock M, Jones C. Virology. 2017 Jan;500:91-95. doi: 10.1016/j.virol.2016.10.014. Epub 2016 Oct 24. PubMed
Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS. EMBO J. 2017 Jan 4;36(1):5-24. doi: 10.15252/embj.201694660. Epub 2016 Oct 24. PubMed
The Aryl Hydrocarbon Receptor and Its Ligands Inhibit Myofibroblast Formation and Activation: Implications for Thyroid Eye Disease. Woeller CF, Roztocil E, Hammond CL, Feldon SE, Phipps RP. Am J Pathol. 2016 Dec;186(12):3189-3202. doi: 10.1016/j.ajpath.2016.08.017. Epub 2016 Nov 11. PubMed
A potential role for a beta-catenin coactivator (high mobility group AT-hook 1 protein) during the latency-reactivation cycle of bovine herpesvirus 1. Zhu L, Workman A, Jones C. J Virol. 2016 Dec 21. pii: JVI.02132-16. doi: 10.1128/JVI.02132-16. PubMed
MicroRNA-29 impairs the early phase of reprogramming process by targeting active DNA demethylation enzymes and Wnt signaling. Fraguas MS, Eggenschwiler R, Hoepfner J, Schiavinato JL, Haddad R, Oliveira LH, Araujo AG, Zago MA, Panepucci RA, Cantz T. Stem Cell Res. 2016 Dec 19;19:21-30. doi: 10.1016/j.scr.2016.12.020. PubMed
Pericyte and immune cells contribute to complement activation in tubulointerstitial fibrosis. Xavier S, Sahu RK, Landes SG, Yu J, Taylor RP, Ayyadevara S, Megyesi J, Stallcup WB, Duffield JS, Reis ES, Lambris JD, Portilla D. Am J Physiol Renal Physiol. 2017 Jan 4:ajprenal.00604.2016. doi: 10.1152/ajprenal.00604.2016. PubMed
Irx3 and Bmp2 Regulate Mouse Mesenchymal Cell Chondrogenic Differentiation in Both a Sox9-Dependent and -Independent Manner. Tamamura Y, Katsube K, Mera H, Itokazu M, Wakitani S. J Cell Physiol. 2017 Jan 6. doi: 10.1002/jcp.25776. PubMed
Wnt/beta-catenin signaling activates nephronectin expression in osteoblasts. Ikehata M, Yamada A, Morimura N, Itose M, Suzawa T, Shirota T, Chikazu D, Kamijo R. Biochem Biophys Res Commun. 2017 Mar 4;484(2):231-234. doi: 10.1016/j.bbrc.2017.01.053. Epub 2017 Jan 16. PubMed
A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection. Smith JL, Jeng S, McWeeney SK, Hirsch AJ. J Virol. 2017 Mar 29;91(8). pii: JVI.02388-16. doi: 10.1128/JVI.02388-16. Print 2017 Apr 15. PubMed
Wnt5a is a crucial regulator of neurogenesis during cerebellum development. Subashini C, Dhanesh SB, Chen CM, Riya PA, Meera V, Divya TS, Kuruvilla R, Buttler K, James J. Sci Rep. 2017 Feb 16;7:42523. doi: 10.1038/srep42523. PubMed
Klotho regulates CA1 hippocampal synaptic plasticity. Li Q, Vo HT, Wang J, Fox-Quick S, Dobrunz LE, King GD. Neuroscience. 2017 Apr 7;347:123-133. doi: 10.1016/j.neuroscience.2017.02.006. Epub 2017 Feb 12. PubMed
Combination of Interleukin-27 and MicroRNA for Enhancing Expression of Anti-Inflammatory and Proosteogenic Genes. Figueiredo Neto M, Figueiredo ML. Arthritis. 2017;2017:6365857. doi: 10.1155/2017/6365857. Epub 2017 Feb 7. PubMed
Wnt proteins synergize to activate beta-catenin signaling. Alok A, Lei Z, Jagannathan NS, Kaur S, Harmston N, Rozen SG, Tucker-Kellogg L, Virshup DM. J Cell Sci. 2017 May 1;130(9):1532-1544. doi: 10.1242/jcs.198093. Epub 2017 Mar 13. PubMed
Co-Activation of TGFbeta and Wnt Signalling Pathways Abrogates EMT in Ovarian Cancer Cells. Mitra T, Roy SS. Cell Physiol Biochem. 2017;41(4):1336-1345. doi: 10.1159/000464436. Epub 2017 Mar 9. PubMed
CRB3 downregulation confers breast cancer stem cell traits through TAZ/beta-catenin. Li P, Wang Y, Mao X, Jiang Y, Liu J, Li J, Wang J, Wang R, She J, Zhang J, Yang J, Liu Y, Liu P. Oncogenesis. 2017 Apr 24;6(4):e322. doi: 10.1038/oncsis.2017.24. PubMed
TCF7L1 promotes skin tumorigenesis independently of beta-catenin through induction of LCN2. Ku AT, Shaver TM, Rao AS, Howard JM, Rodriguez CN, Miao Q, Garcia G, Le D, Yang D, Borowiak M, Cohen DN, Chitsazzadeh V, Diwan AH, Tsai KY, Nguyen H. Elife. 2017 May 3;6. pii: e23242. doi: 10.7554/eLife.23242. PubMed
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz OH, Xue W, Katajisto P, Bhutkar A, Jacks T. Nature. 2017 May 18;545(7654):355-359. doi: 10.1038/nature22334. Epub 2017 May 10. PubMed
Beta-catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma. Savvidou I, Khong T, Cuddihy A, McLean C, Horrigan S, Spencer A. Mol Cancer Ther. 2017 May 12. pii: molcanther.0624.2016. doi: 10.1158/1535-7163.MCT-16-0624. PubMed
Targeting Wnt/beta-Catenin Activated Cells with Dominant-Negative N-cadherin to Reduce Neointima Formation. Hulin-Curtis S, Williams H, Wadey KS, Sala-Newby GB, George SJ. Mol Ther Methods Clin Dev. 2017 May 4;5:191-199. doi: 10.1016/j.omtm.2017.04.009. eCollection 2017 Jun 16. PubMed
Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. Balasubramaniam SL, Gopalakrishnapillai A, Petrelli NJ, Barwe SP. J Biol Chem. 2017 Jul 7;292(27):11388-11399. doi: 10.1074/jbc.M116.752352. Epub 2017 May 26. PubMed
Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction. De Pauw A, Andre E, Sekkali B, Bouzin C, Esfahani H, Barbier N, Loriot A, De Smet C, Vanhoutte L, Moniotte S, Gerber B, di Mauro V, Catalucci D, Feron O, Hilfiker-Kleiner D, Balligand JL. JCI Insight. 2017 Jun 15;2(12). pii: 91810. doi: 10.1172/jci.insight.91810. PubMed
DOT1L safeguards cartilage homeostasis and protects against osteoarthritis. Monteagudo S, Cornelis FMF, Aznar-Lopez C, Yibmantasiri P, Guns LA, Carmeliet P, Cailotto F, Lories RJ. Nat Commun. 2017 Jun 19;8:15889. doi: 10.1038/ncomms15889. PubMed
Constructing cellular niche properties by localized presentation of Wnt proteins on synthetic surfaces. Lowndes M, Junyent S, Habib SJ. Nat Protoc. 2017 Jul;12(7):1498-1512. doi: 10.1038/nprot.2017.061. Epub 2017 Jun 29. PubMed
Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Flack JE, Mieszczanek J, Novcic N, Bienz M. Mol Cell. 2017 Jul 20;67(2):181-193.e5. doi: 10.1016/j.molcel.2017.06.009. Epub 2017 Jul 6. PubMed
MicroRNA-139-5p inhibits bladder cancer proliferation and self-renewal by targeting the Bmi1 oncogene. Luo H, Yang R, Li C, Tong Y, Fan L, Liu X, Xu C. Tumour Biol. 2017 Jul;39(7):1010428317718414. doi: 10.1177/1010428317718414. PubMed
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K. Mol Cell. 2017 Aug 3;67(3):400-410.e7. doi: 10.1016/j.molcel.2017.06.025. Epub 2017 Jul 20. PubMed
beta-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Long MJ, Lin HY, Parvez S, Zhao Y, Poganik JR, Huang P, Aye Y. Cell Chem Biol. 2017 Aug 17;24(8):944-957.e7. doi: 10.1016/j.chembiol.2017.06.009. Epub 2017 Jul 20. PubMed
The Dkk3 gene encodes a vital intracellular regulator of cell proliferation. Leonard JL, Leonard DM, Wolfe SA, Liu J, Rivera J, Yang M, Leonard RT, Johnson JPS, Kumar P, Liebmann KL, Tutto AA, Mou Z, Simin KJ. PLoS One. 2017 Jul 24;12(7):e0181724. doi: 10.1371/journal.pone.0181724. eCollection 2017. PubMed
Direct interaction of menin leads to ubiquitin-proteasomal degradation of beta-catenin. Kim B, Song TY, Jung KY, Kim SG, Cho EJ. Biochem Biophys Res Commun. 2017 Oct 7;492(1):128-134. doi: 10.1016/j.bbrc.2017.08.011. Epub 2017 Aug 4. PubMed
A Reciprocal Interaction between beta-Catenin and Osterix in Cementogenesis. Choi H, Kim TH, Yang S, Lee JC, You HK, Cho ES. Sci Rep. 2017 Aug 15;7(1):8160. doi: 10.1038/s41598-017-08607-5. PubMed
Unconventional MAPK-GSK-3beta Pathway Behind Atypical Epithelial-Mesenchymal Transition In Hepatocellular Carcinoma. Parveen S, Vedagiri D, Nair HG, Parthasarathy H, Harshan KH. Sci Rep. 2017 Aug 18;7(1):8842. doi: 10.1038/s41598-017-09179-0. PubMed
microRNA-145 downregulates SIP1-expression but differentially regulates proliferation, migration, invasion and Wnt signaling in SW480 and SW620 cells. Sathyanarayanan A, Chandrasekaran KS, Karunagaran D. J Cell Biochem. 2018 Feb;119(2):2022-2035. doi: 10.1002/jcb.26365. Epub 2017 Sep 18. PubMed
Fracture-Targeted Delivery of beta-Catenin Agonists via Peptide-Functionalized Nanoparticles Augments Fracture Healing. Wang Y, Newman MR, Ackun-Farmmer M, Baranello MP, Sheu TJ, Puzas JE, Benoit DSW. ACS Nano. 2017 Sep 26;11(9):9445-9458. doi: 10.1021/acsnano.7b05103. Epub 2017 Sep 13. PubMed
ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma. Ndoye A, Budina-Kolomets A, Kugel CH 3rd, Webster MR, Kaur A, Behera R, Rebecca VW, Li L, Brafford PA, Liu Q, Gopal YNV, Davies MA, Mills GB, Xu X, Wu H, Herlyn M, Nicastri MC, Winkler JD, Soengas MS, Amaravadi RK, Murphy ME, Weeraratna AT. Cancer Res. 2017 Nov 1;77(21):5873-5885. doi: 10.1158/0008-5472.CAN-17-0907. Epub 2017 Sep 8. PubMed
Combined activation of MAP kinase pathway and beta-catenin signaling cause deep penetrating nevi. Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardiere A. Nat Commun. 2017 Sep 21;8(1):644. doi: 10.1038/s41467-017-00758-3. PubMed
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability. Grey W, Ivey A, Milne TA, Haferlach T, Grimwade D, Uhlmann F, Voisset E, Yu V. Biochim Biophys Acta. 2018 Jan;1865(1):105-116. doi: 10.1016/j.bbamcr.2017.09.009. Epub 2017 Sep 20. PubMed
R-Spondin1/LGR5 Activates TGFbeta Signaling and Suppresses Colon Cancer Metastasis. Zhou X, Geng L, Wang D, Yi H, Talmon G, Wang J. Cancer Res. 2017 Dec 1;77(23):6589-6602. doi: 10.1158/0008-5472.CAN-17-0219. Epub 2017 Sep 22. PubMed
beta-Catenin Directs Nuclear Factor-kappaB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle. Koopmans T, Eilers R, Menzen M, Halayko A, Gosens R. Front Immunol. 2017 Sep 8;8:1086. doi: 10.3389/fimmu.2017.01086. eCollection 2017. PubMed
Lawsone derivatives target the Wnt/beta-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells. Hamdoun S, Fleischer E, Klinger A, Efferth T. Biochem Pharmacol. 2017 Dec 15;146:63-73. doi: 10.1016/j.bcp.2017.10.008. Epub 2017 Oct 20. PubMed
APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Cho SG. Oncol Lett. 2017 Oct;14(4):4845-4852. doi: 10.3892/ol.2017.6801. Epub 2017 Aug 23. PubMed
Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma. Hayashi M, Baker A, Goldstein SD, Albert CM, Jackson KW, McCarty G, Kahlert UD, Loeb DM. Oncotarget. 2017 Jul 21;8(45):78265-78276. doi: 10.18632/oncotarget.19432. eCollection 2017 Oct 3. PubMed
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Sassi Y, Avramopoulos P, Ramanujam D, Gruter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hubner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S. Nat Commun. 2017 Nov 20;8(1):1614. doi: 10.1038/s41467-017-01737-4. PubMed
MyD88 promotes myoblast fusion in a cell-autonomous manner. Hindi SM, Shin J, Gallot YS, Straughn AR, Simionescu-Bankston A, Hindi L, Xiong G, Friedland RP, Kumar A. Nat Commun. 2017 Nov 20;8(1):1624. doi: 10.1038/s41467-017-01866-w. PubMed
SAMMSON drives the self-renewal of liver tumor initiating cells through EZH2-dependent Wnt/beta-catenin activation. Li X, Li M, Chen J, Dai H, Wang L, Xiong Y, Zhong Y, Zhang L. Oncotarget. 2017 Oct 10;8(61):103785-103796. doi: 10.18632/oncotarget.21792. eCollection 2017 Nov 28. PubMed
RAPGEF5 Regulates Nuclear Translocation of beta-Catenin. Griffin JN, Del Viso F, Duncan AR, Robson A, Hwang W, Kulkarni S, Liu KJ, Khokha MK. Dev Cell. 2018 Jan 22;44(2):248-260.e4. doi: 10.1016/j.devcel.2017.12.001. Epub 2017 Dec 28. PubMed
Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-beta-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. Gowda P, Patrick S, Singh A, Sheikh T, Sen E. Mol Cell Biol. 2018 Apr 16;38(9). pii: MCB.00001-18. doi: 10.1128/MCB.00001-18. Print 2018 May 1. PubMed
Adenovirus Infection of Human Enteroids Reveals Interferon Sensitivity and Preferential Infection of Goblet Cells. Holly MK, Smith JG. J Virol. 2018 Apr 13;92(9). pii: JVI.00250-18. doi: 10.1128/JVI.00250-18. Print 2018 May 1. PubMed
PAWS1 controls Wnt signalling through association with casein kinase 1alpha. Bozatzi P, Dingwell KS, Wu KZ, Cooper F, Cummins TD, Hutchinson LD, Vogt J, Wood NT, Macartney TJ, Varghese J, Gourlay R, Campbell DG, Smith JC, Sapkota GP. EMBO Rep. 2018 Apr;19(4). pii: embr.201744807. doi: 10.15252/embr.201744807. Epub 2018 Mar 7. PubMed
Epstein-Barr virus stably confers an invasive phenotype to epithelial cells through reprogramming of the WNT pathway. Birdwell CE, Prasai K, Dykes S, Jia Y, Munroe TGC, Bienkowska-Haba M, Scott RS. Oncotarget. 2018 Jan 2;9(12):10417-10435. doi: 10.18632/oncotarget.23824. eCollection 2018 Feb 13. PubMed
Identification and characterization of a novel adenomatous polyposis coli mutation in adult pancreatoblastoma. Yamaguchi S, Fujii T, Izumi Y, Fukumura Y, Han M, Yamaguchi H, Akita T, Yamashita C, Kato S, Sekiya T. Oncotarget. 2018 Jan 6;9(12):10818-10827. doi: 10.18632/oncotarget.24017. eCollection 2018 Feb 13. PubMed
Linc00210 drives Wnt/beta-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner. Fu X, Zhu X, Qin F, Zhang Y, Lin J, Ding Y, Yang Z, Shang Y, Wang L, Zhang Q, Gao Q. Mol Cancer. 2018 Mar 14;17(1):73. doi: 10.1186/s12943-018-0783-3. PubMed
Genetic analysis of Wnt/PCP genes in neural tube defects. Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH, Zhang T, Wang H. BMC Med Genomics. 2018 Apr 4;11(1):38. doi: 10.1186/s12920-018-0355-9. PubMed
MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma. Zhang X, Zhang X, Wang T, Wang L, Tan Z, Wei W, Yan B, Zhao J, Wu K, Yang A, Zhang R, Jia L. Cancer Lett. 2018 Jul 10;426:98-108. doi: 10.1016/j.canlet.2018.04.005. Epub 2018 Apr 11. PubMed
Promotion of malignant phenotype after disruption of the three-dimensional structure of cultured spheroids from colorectal cancer. Piulats JM, Kondo J, Endo H, Ono H, Hagihara T, Okuyama H, Nishizawa Y, Tomita Y, Ohue M, Okita K, Oyama H, Bono H, Masuko T, Inoue M. Oncotarget. 2018 Mar 23;9(22):15968-15983. doi: 10.18632/oncotarget.24641. eCollection 2018 Mar 23. PubMed
SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of beta-Catenin in Lung Cancer. Han F, Liu WB, Shi XY, Yang JT, Zhang X, Li ZM, Jiang X, Yin L, Li JJ, Huang CS, Cao J, Liu JY. EBioMedicine. 2018 May;31:253-266. doi: 10.1016/j.ebiom.2018.04.026. Epub 2018 May 5. PubMed
An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. Lu X, Pan X, Wu CJ, Zhao D, Feng S, Zang Y, Lee R, Khadka S, Amin SB, Jin EJ, Shang X, Deng P, Luo Y, Morgenlander WR, Weinrich J, Lu X, Jiang S, Chang Q, Navone NM, Troncoso P, DePinho RA, Wang YA. Cancer Res. 2018 Jul 15;78(14):3823-3833. doi: 10.1158/0008-5472.CAN-17-3564. Epub 2018 May 16. PubMed
Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. Lee Y, Kim NH, Cho ES, Yang JH, Cha YH, Kang HE, Yun JS, Cho SB, Lee SH, Paclikova P, Radaszkiewicz TW, Bryja V, Kang CG, Yuk YS, Cha SY, Kim SY, Kim HS, Yook JI. Nat Commun. 2018 Jun 12;9(1):2301. doi: 10.1038/s41467-018-04757-w. PubMed
A molecular mechanism for Wnt ligand-specific signaling. Eubelen M, Bostaille N, Cabochette P, Gauquier A, Tebabi P, Dumitru AC, Koehler M, Gut P, Alsteens D, Stainier DYR, Garcia-Pino A, Vanhollebeke B. Science. 2018 Aug 17;361(6403). pii: science.aat1178. doi: 10.1126/science.aat1178. Epub 2018 Jul 19. PubMed
The canonical Wnt/beta-catenin signaling pathway stimulates herpes simplex virus 1 productive infection. Zhu L, Jones C. Virus Res. 2018 Sep 2;256:29-37. doi: 10.1016/j.virusres.2018.07.020. Epub 2018 Aug 2. PubMed
JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling. Adhikari A, Davie J. Epigenetics Chromatin. 2018 Aug 17;11(1):46. doi: 10.1186/s13072-018-0217-x. PubMed
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia. Lee SH, Singh I, Tisdale S, Abdel-Wahab O, Leslie CS, Mayr C. Nature. 2018 Sep;561(7721):127-131. doi: 10.1038/s41586-018-0465-8. Epub 2018 Aug 27. PubMed
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R. Nat Commun. 2018 Sep 17;9(1):3787. doi: 10.1038/s41467-018-06162-9. PubMed
Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes beta-catenin. Kim J, Alavi Naini F, Sun Y, Ma L. Am J Cancer Res. 2018 Sep 1;8(9):1823-1836. eCollection 2018. PubMed
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/beta-Catenin Signaling. Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS. Cell Rep. 2018 Oct 16;25(3):571-584.e5. doi: 10.1016/j.celrep.2018.09.049. PubMed
Expression of the Hutchinson-Gilford Progeria Mutation Leads to Aberrant Dentin Formation. Choi H, Kim TH, Jeong JK, Strandgren C, Eriksson M, Cho ES. Sci Rep. 2018 Oct 18;8(1):15368. doi: 10.1038/s41598-018-33764-6. PubMed
Clotrimazole inhibits the Wnt/beta-catenin pathway by activating two eIF2alpha kinases: The heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase. Yonezawa H, Ogawa M, Katayama S, Shimizu Y, Omori N, Oku Y, Sakyo T, Uehara Y, Nishiya N. Biochem Biophys Res Commun. 2018 Nov 17;506(1):183-188. doi: 10.1016/j.bbrc.2018.10.053. Epub 2018 Oct 17. PubMed
Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic beta cells. Kalwat MA, Hwang IH, Macho J, Grzemska MG, Yang JZ, McGlynn K, MacMillan JB, Cobb MH. J Gen Physiol. 2018 Dec 3;150(12):1747-1757. doi: 10.1085/jgp.201812177. Epub 2018 Oct 23. PubMed
SLIT3 regulates endochondral ossification by beta-catenin suppression in chondrocytes. Kim H, Choi YJ, Lee YS, Park SY, Baek JE, Kim HK, Kim BJ, Lee SH, Koh JM. Biochem Biophys Res Commun. 2018 Dec 2;506(4):847-853. doi: 10.1016/j.bbrc.2018.10.167. Epub 2018 Oct 31. PubMed
Hypoxia Stimulates the Epithelial-to-Mesenchymal Transition in Lung Cancer Cells Through Accumulation of Nuclear beta-Catenin. Liu KH, Tsai YT, Chin SY, Lee WR, Chen YC, Shen SC. Anticancer Res. 2018 Nov;38(11):6299-6308. doi: 10.21873/anticanres.12986. PubMed
Oncogenic potential of N-terminal deletion and S45Y mutant beta-catenin in promoting hepatocellular carcinoma development in mice. Qiao Y, Xu M, Tao J, Che L, Cigliano A, Monga SP, Calvisi DF, Chen X. BMC Cancer. 2018 Nov 12;18(1):1093. doi: 10.1186/s12885-018-4870-z. PubMed
A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties. Liu SS, Maguire EM, Bai YS, Huang L, Liu Y, Xu L, Fauzi I, Zhang SQ, Xiao Q, Ma NF. Mol Cell Biol. 2019 Feb 4;39(4). pii: MCB.00357-18. doi: 10.1128/MCB.00357-18. Print 2019 Feb 15. PubMed
Identifying chondroprotective diet-derived bioactives and investigating their synergism. Davidson RK, Green J, Gardner S, Bao Y, Cassidy A, Clark IM. Sci Rep. 2018 Nov 21;8(1):17173. doi: 10.1038/s41598-018-35455-8. PubMed
Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling. Papadakos KS, Bartoschek M, Rodriguez C, Gialeli C, Jin SB, Lendahl U, Pietras K, Blom AM. Matrix Biol. 2018 Nov 28. pii: S0945-053X(18)30391-3. doi: 10.1016/j.matbio.2018.11.007. PubMed
SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients. Han F, Zhang MQ, Liu WB, Sun L, Hao XL, Yin L, Jiang X, Cao J, Liu JY. Respir Res. 2018 Dec 4;19(1):241. doi: 10.1186/s12931-018-0952-3. PubMed
Nutritional stress reprograms dedifferention in glioblastoma multiforme driven by PTEN/Wnt/Hedgehog axis: a stochastic model of cancer stem cells. Mondal S, Bhattacharya K, Mandal C. Cell Death Discov. 2018 Dec 5;4:110. doi: 10.1038/s41420-018-0126-6. eCollection 2018. PubMed
Cyclin G2 suppresses Wnt/beta-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1. Gao J, Zhao C, Liu Q, Hou X, Li S, Xing X, Yang C, Luo Y. J Exp Clin Cancer Res. 2018 Dec 14;37(1):317. doi: 10.1186/s13046-018-0973-2. PubMed
Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells. Brown BA, Connolly GM, Mill CEJ, Williams H, Angelini GD, Johnson JL, George SJ. Aging Cell. 2019 Feb;18(1):e12844. doi: 10.1111/acel.12844. Epub 2018 Dec 12. PubMed
Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. Ogorodnikov A, Levin M, Tattikota S, Tokalov S, Hoque M, Scherzinger D, Marini F, Poetsch A, Binder H, Macher-Goppinger S, Probst HC, Tian B, Schaefer M, Lackner KJ, Westermann F, Danckwardt S. Nat Commun. 2018 Dec 14;9(1):5331. doi: 10.1038/s41467-018-07580-5. PubMed
(Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations. Wang J, Shibayama Y, Zhang A, Ohsaki H, Asano E, Suzuki Y, Kushida Y, Kobara H, Masaki T, Wang Z, Nishiyama A. Br J Cancer. 2019 Jan;120(2):229-237. doi: 10.1038/s41416-018-0350-0. Epub 2018 Dec 17. PubMed
The Wnt modulator ICG001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR150/CD44 axis. Chan LS, Man OY, Kwok HH, Chen L, Chan KC, Lung HL, Ngan RK, Wong RN, Lo KW, Lee AW, Tsao GS, Kahn M, Lung ML, Mak NK. Int J Oncol. 2019 Mar;54(3):1010-1020. doi: 10.3892/ijo.2018.4664. Epub 2018 Dec 12. PubMed
Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Ferrari N, Ranftl R, Chicherova I, Slaven ND, Moeendarbary E, Farrugia AJ, Lam M, Semiannikova M, Westergaard MCW, Tchou J, Magnani L, Calvo F. Nat Commun. 2019 Jan 10;10(1):130. doi: 10.1038/s41467-018-07987-0. PubMed
beta-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and alpha-catenin. Cui S, Li L, Yu RT, Downes M, Evans RM, Hulin JA, Makarenkova HP, Meech R. Development. 2019 Mar 19;146(6). pii: dev.167080. doi: 10.1242/dev.167080. PubMed
Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact beta-Catenin but Not Notch Cascade in Mice. Qiao Y, Wang J, Karagoz E, Liang B, Song X, Shang R, Evert K, Xu M, Che L, Evert M, Calvisi DF, Tao J, Wang B, Monga SP, Chen X. Hepatology. 2019 Feb 8. doi: 10.1002/hep.30556. PubMed
Tryptophan-kynurenine pathway attenuates beta-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection. Majumdar T, Sharma S, Kumar M, Hussain MA, Chauhan N, Kalia I, Sahu AK, Rana VS, Bharti R, Haldar AK, Singh AP, Mazumder S. Cell Death Dis. 2019 Feb 15;10(3):161. doi: 10.1038/s41419-019-1420-9. PubMed
Hyaluronan-mediated motility receptor confers resistance to chemotherapy via TGFbeta/Smad2-induced epithelial-mesenchymal transition in gastric cancer. Zhang H, Ren L, Ding Y, Li F, Chen X, Ouyang Y, Zhang Y, Zhang D. FASEB J. 2019 May;33(5):6365-6377. doi: 10.1096/fj.201802186R. Epub 2019 Feb 25. PubMed
Innate extracellular vesicles from melanoma patients suppress beta-catenin in tumor cells by miRNA-34a. Lee JH, Dindorf J, Eberhardt M, Lai X, Ostalecki C, Koliha N, Gross S, Blume K, Bruns H, Wild S, Schuler G, Vera J, Baur AS. Life Sci Alliance. 2019 Mar 7;2(2). pii: 2/2/e201800205. doi: 10.26508/lsa.201800205. Print 2019 Apr. PubMed
Targeting FER Kinase Inhibits Melanoma Growth and Metastasis. Ivanova IA, Arulanantham S, Barr K, Cepeda M, Parkins KM, Hamilton AM, Johnston D, Penuela S, Hess DA, Ronald JA, Dagnino L. Cancers (Basel). 2019 Mar 24;11(3). pii: cancers11030419. doi: 10.3390/cancers11030419. PubMed
Proton pump inhibitor pantoprazole inhibits gastric cancer metastasis via suppression of telomerase reverse transcriptase gene expression. Zhang B, Ling T, Zhaxi P, Cao Y, Qian L, Zhao D, Kang W, Zhang W, Wang L, Xu G, Zou X. Cancer Lett. 2019 Jun 28;452:23-30. doi: 10.1016/j.canlet.2019.03.029. Epub 2019 Mar 23. PubMed
Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation. Wang CH, Hung PW, Chiang CW, Lombes M, Chen CH, Lee KH, Lo YC, Wu MH, Chang WC, Lin DY. Biochim Biophys Acta Mol Cell Res. 2019 Aug;1866(8):1282-1297. doi: 10.1016/j.bbamcr.2019.03.014. Epub 2019 Mar 29. PubMed
Cmannosylation of Rspondin2 activates Wnt/betacatenin signaling and migration activity in human tumor cells. Mizuta H, Kuga K, Suzuki T, Niwa Y, Dohmae N, Simizu S. Int J Oncol. 2019 Jun;54(6):2127-2138. doi: 10.3892/ijo.2019.4767. Epub 2019 Apr 1. PubMed
Molecular determinants of WNT9b responsiveness in nephron progenitor cells. Dickinson KK, Hammond LC, Karner CM, Hastie ND, Carroll TJ, Goodyer P. PLoS One. 2019 Apr 12;14(4):e0215139. doi: 10.1371/journal.pone.0215139. eCollection 2019. PubMed
Organoid culture media formulated with growth factors of defined cellular activity. Urbischek M, Rannikmae H, Foets T, Ravn K, Hyvonen M, de la Roche M. Sci Rep. 2019 Apr 17;9(1):6193. doi: 10.1038/s41598-019-42604-0. PubMed

Associated Plasmids

Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents. Coluccia A, La Regina G, Naccarato V, Nalli M, Orlando V, Biagioni S, De Angelis ML, Baiocchi M, Gautier C, Gianni S, Di Pastena F, Di Magno L, Canettieri G, Coluccia AML, Silvestri R. ACS Med Chem Lett. 2019 Jan 14;10(4):499-503. doi: 10.1021/acsmedchemlett.8b00532. eCollection 2019 Apr 11. PubMed
Antagonistic interactions between osterix and pyrophosphate during cementum formation. Choi H, Liu Y, Jeong JK, Kim TH, Cho ES. Bone. 2019 Aug;125:8-15. doi: 10.1016/j.bone.2019.05.001. Epub 2019 May 4. PubMed
Downregulated Wnt/beta-catenin signalling in the Down syndrome hippocampus. Granno S, Nixon-Abell J, Berwick DC, Tosh J, Heaton G, Almudimeegh S, Nagda Z, Rain JC, Zanda M, Plagnol V, Tybulewicz VLJ, Cleverley K, Wiseman FK, Fisher EMC, Harvey K. Sci Rep. 2019 May 13;9(1):7322. doi: 10.1038/s41598-019-43820-4. PubMed
Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D. Findlay AR, Bengoechea R, Pittman SK, Chou TF, True HL, Weihl CC. Neurol Genet. 2019 Apr 18;5(2):e318. doi: 10.1212/NXG.0000000000000318. eCollection 2019 Apr. PubMed
Silencing LGR6 Attenuates Stemness and Chemoresistance via Inhibiting Wnt/beta-Catenin Signaling in Ovarian Cancer. Ruan X, Liu A, Zhong M, Wei J, Zhang W, Rong Y, Liu W, Li M, Qing X, Chen G, Li R, Liao Y, Liu Q, Zhang X, Ren D, Wang Y. Mol Ther Oncolytics. 2019 Apr 19;14:94-106. doi: 10.1016/j.omto.2019.04.002. eCollection 2019 Sep 27. PubMed
Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/beta-catenin pathway inactivation through ICAT. Fan X, Song J, Zhao Z, Chen M, Tu J, Lu C, Wu F, Zhang D, Weng Q, Zheng L, Xu M, Ji J. Cancer Lett. 2019 Sep 28;460:119-127. doi: 10.1016/j.canlet.2019.06.008. Epub 2019 Jun 14. PubMed
Activation of Wnt signaling promotes olaparib resistant ovarian cancer. Yamamoto TM, McMellen A, Watson ZL, Aguilera J, Ferguson R, Nurmemmedov E, Thakar T, Moldovan GL, Kim H, Cittelly DM, Joglar AM, Brennecke EP, Wilson H, Behbakht K, Sikora MJ, Bitler BG. Mol Carcinog. 2019 Jun 10. doi: 10.1002/mc.23064. PubMed
WNT-3A-induced beta-catenin signaling does not require signaling through heterotrimeric G proteins. Bowin CF, Inoue A, Schulte G. J Biol Chem. 2019 Aug 2;294(31):11677-11684. doi: 10.1074/jbc.AC119.009412. Epub 2019 Jun 24. PubMed
Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells. Kishore C, Sundaram S, Karunagaran D. Chem Biol Interact. 2019 Aug 25;309:108725. doi: 10.1016/j.cbi.2019.108725. Epub 2019 Jun 22. PubMed

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