M50 Super 8x TOPFlash Citations (340)
Originally described in: Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT Curr Biol. 2003 Apr 15. 13(8):680-5. PubMed Journal
Articles Citing M50 Super 8x TOPFlash
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| Bacillus anthracis edema toxin activates nuclear glycogen synthase kinase 3beta. Larabee JL, DeGiusti K, Regens JL, Ballard JD. Infect Immun. 2008 Nov;76(11):4895-904. doi: 10.1128/IAI.00889-08. Epub 2008 Sep 2. PubMed |
| AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552. Zhao J, Yue W, Zhu MJ, Sreejayan N, Du M. Biochem Biophys Res Commun. 2010 Apr 23;395(1):146-51. doi: 10.1016/j.bbrc.2010.03.161. Epub 2010 Mar 31. PubMed |
| A muscle resident cell population promotes fibrosis in hindlimb skeletal muscles of mdx mice through the Wnt canonical pathway. Trensz F, Haroun S, Cloutier A, Richter MV, Grenier G. Am J Physiol Cell Physiol. 2010 Nov;299(5):C939-47. doi: 10.1152/ajpcell.00253.2010. Epub 2010 Sep 1. PubMed |
| Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. Reddy VS, Valente AJ, Delafontaine P, Chandrasekar B. J Cell Physiol. 2011 Dec;226(12):3303-15. doi: 10.1002/jcp.22676. PubMed |
| Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Aisagbonhi O, Rai M, Ryzhov S, Atria N, Feoktistov I, Hatzopoulos AK. Dis Model Mech. 2011 Jul;4(4):469-83. doi: 10.1242/dmm.006510. Epub 2011 Feb 14. PubMed |
| Trenbolone enhances myogenic differentiation by enhancing beta-catenin signaling in muscle-derived stem cells of cattle. Zhao JX, Hu J, Zhu MJ, Du M. Domest Anim Endocrinol. 2011 May;40(4):222-9. doi: 10.1016/j.domaniend.2011.01.004. Epub 2011 Feb 26. PubMed |
| Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion. Ekstrom EJ, Sherwood V, Andersson T. PLoS One. 2011 Apr 8;6(4):e18674. doi: 10.1371/journal.pone.0018674. PubMed |
| Negative cross-talk between calcium-sensing receptor and beta-catenin signaling systems in colonic epithelium. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. J Biol Chem. 2012 Jan 6;287(2):1158-67. doi: 10.1074/jbc.M111.274589. Epub 2011 Nov 17. PubMed |
Modulation of Wnt/beta-catenin signaling in human embryonic stem cells using a 3-D microwell array.
Azarin SM, Lian X, Larson EA, Popelka HM, de Pablo JJ, Palecek SP.
Biomaterials. 2012 Mar;33(7):2041-9. Epub 2011 Dec 15.
PubMed
Associated Plasmids |
| RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. Lin FC, Liu YP, Lai CH, Shan YS, Cheng HC, Hsu PI, Lee CH, Lee YC, Wang HY, Wang CH, Cheng JQ, Hsiao M, Lu PJ. Oncogene. 2012 Sep 27;31(39):4302-16. doi: 10.1038/onc.2011.596. Epub 2012 Jan 9. PubMed |
| Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling. Miranda CJ, Braun L, Jiang Y, Hester ME, Zhang L, Riolo M, Wang H, Rao M, Altura RA, Kaspar BK. Aging Cell. 2012 Jun;11(3):542-52. doi: 10.1111/j.1474-9726.2012.00816.x. Epub 2012 Apr 4. PubMed |
| The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. Guo B, Chatterjee S, Li L, Kim JM, Lee J, Yechoor VK, Minze LJ, Hsueh W, Ma K. FASEB J. 2012 Aug;26(8):3453-63. doi: 10.1096/fj.12-205781. Epub 2012 May 18. PubMed |
| The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling. Borgal L, Habbig S, Hatzold J, Liebau MC, Dafinger C, Sacarea I, Hammerschmidt M, Benzing T, Schermer B. J Biol Chem. 2012 Jul 20;287(30):25370-80. doi: 10.1074/jbc.M112.385658. Epub 2012 May 31. PubMed |
| mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. Arun G, Akhade VS, Donakonda S, Rao MR. Mol Cell Biol. 2012 Aug;32(15):3140-52. doi: 10.1128/MCB.00006-12. Epub 2012 Jun 4. PubMed |
| Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells. Kirby LA, Schott JT, Noble BL, Mendez DC, Caseley PS, Peterson SC, Routledge TJ, Patel NV. PLoS One. 2012;7(6):e39329. doi: 10.1371/journal.pone.0039329. Epub 2012 Jun 26. PubMed |
| StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. Sinner DI, Kim GJ, Henderson GC, Igal RA. PLoS One. 2012;7(6):e39787. doi: 10.1371/journal.pone.0039787. Epub 2012 Jun 22. PubMed |
| Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of beta-catenin. Rines AK, Burke MA, Fernandez RP, Volpert OV, Ardehali H. FASEB J. 2012 Nov;26(11):4685-95. doi: 10.1096/fj.12-212282. Epub 2012 Aug 8. PubMed |
| The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling. Bernhard SM, Seidel K, Schmitz J, Klare S, Kirsch S, Schrezenmeier E, Zaade D, Meyborg H, Goldin-Lang P, Stawowy P, Zollmann FS, Unger T, Funke-Kaiser H. Biochem Pharmacol. 2012 Dec 15;84(12):1643-50. doi: 10.1016/j.bcp.2012.09.020. Epub 2012 Sep 26. PubMed |
| Lithium rescues synaptic plasticity and memory in Down syndrome mice. Contestabile A, Greco B, Ghezzi D, Tucci V, Benfenati F, Gasparini L. J Clin Invest. 2013 Jan;123(1):348-61. doi: 10.1172/JCI64650. Epub 2012 Dec 3. PubMed |
| Wnt/beta-catenin pathway is regulated by PITX2 homeodomain protein and thus contributes to the proliferation of human ovarian adenocarcinoma cell, SKOV-3. Basu M, Roy SS. J Biol Chem. 2013 Feb 8;288(6):4355-67. doi: 10.1074/jbc.M112.409102. Epub 2012 Dec 17. PubMed |
| Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1. Huard CC, Tremblay CS, Helsper K, Delisle MC, Schindler D, Levesque G, Carreau M. Blood. 2013 Mar 7;121(10):1729-39. doi: 10.1182/blood-2012-02-408997. Epub 2013 Jan 9. PubMed |
| SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/beta-catenin activation in breast cancer. Wang H, He L, Ma F, Regan MM, Balk SP, Richardson AL, Yuan X. J Biol Chem. 2013 Mar 1;288(9):6478-87. doi: 10.1074/jbc.M112.419184. Epub 2013 Jan 10. PubMed |
| Regeneration-associated WNT signaling is activated in long-term reconstituting AC133bright acute myeloid leukemia cells. Beghini A, Corlazzoli F, Del Giacco L, Re M, Lazzaroni F, Brioschi M, Valentini G, Ferrazzi F, Ghilardi A, Righi M, Turrini M, Mignardi M, Cesana C, Bronte V, Nilsson M, Morra E, Cairoli R. Neoplasia. 2012 Dec;14(12):1236-48. PubMed |
| SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/beta-catenin signaling. Thu KL, Radulovich N, Becker-Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL, Tsao MS. Oncogene. 2014 Jan 16;33(3):279-88. doi: 10.1038/onc.2012.595. Epub 2013 Jan 14. PubMed |
| Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target. Verjee LS, Verhoekx JS, Chan JK, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood KS, Nanchahal J. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E928-37. doi: 10.1073/pnas.1301100110. Epub 2013 Feb 19. PubMed |
| Androgen activates beta-catenin signaling in bladder cancer cells. Li Y, Zheng Y, Izumi K, Ishiguro H, Ye B, Li F, Miyamoto H. Endocr Relat Cancer. 2013 May 20;20(3):293-304. doi: 10.1530/ERC-12-0328. Print 2013 Jun. PubMed |
| Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A, Manetti F, Solinas A, Petricci E, Taddei M, Ruat M. Mol Pharmacol. 2013 May;83(5):1020-9. doi: 10.1124/mol.112.084590. Epub 2013 Feb 28. PubMed |
| Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: the involvement of the Wnt/beta-catenin signaling pathway. Wang S, Avery JE, Hannafon BN, Lind SE, Ding WQ. Biochem Pharmacol. 2013 Jun 1;85(11):1611-8. doi: 10.1016/j.bcp.2013.03.011. Epub 2013 Mar 21. PubMed |
| Agonism of Wnt-beta-catenin signalling promotes mesenchymal stem cell (MSC) expansion. Hoffman MD, Benoit DS. J Tissue Eng Regen Med. 2013 Apr 1. doi: 10.1002/term.1736. PubMed |
| Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis. Gozo MC, Aspuria PJ, Cheon DJ, Walts AE, Berel D, Miura N, Karlan BY, Orsulic S. Cell Death Differ. 2013 Aug;20(8):1031-42. doi: 10.1038/cdd.2013.34. Epub 2013 May 3. PubMed |
| Tumor necrosis factor alpha-induced hypoxia-inducible factor 1alpha-beta-catenin axis regulates major histocompatibility complex class I gene activation through chromatin remodeling. Ghosh S, Paul A, Sen E. Mol Cell Biol. 2013 Jul;33(14):2718-31. doi: 10.1128/MCB.01254-12. Epub 2013 May 13. PubMed |
| Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. Baril M, Es-Saad S, Chatel-Chaix L, Fink K, Pham T, Raymond VA, Audette K, Guenier AS, Duchaine J, Servant M, Bilodeau M, Cohen E, Grandvaux N, Lamarre D. PLoS Pathog. 2013;9(6):e1003416. doi: 10.1371/journal.ppat.1003416. Epub 2013 Jun 13. PubMed |
| KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. Lu H, Hu L, Yu L, Wang X, Urvalek AM, Li T, Shen C, Mukherjee D, Lahiri SK, Wason MS, Zhao J. Oncogene. 2014 May 29;33(22):2909-17. doi: 10.1038/onc.2013.247. Epub 2013 Jul 1. PubMed |
| MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Judson RL, Greve TS, Parchem RJ, Blelloch R. Nat Struct Mol Biol. 2013 Oct;20(10):1227-35. doi: 10.1038/nsmb.2665. Epub 2013 Sep 15. PubMed |
| WNT5A encodes two isoforms with distinct functions in cancers. Bauer M, Benard J, Gaasterland T, Willert K, Cappellen D. PLoS One. 2013 Nov 18;8(11):e80526. doi: 10.1371/journal.pone.0080526. eCollection 2013. PubMed |
| DKK1 promotes hepatocellular carcinoma cell migration and invasion through beta-catenin/MMP7 signaling pathway. Chen L, Li M, Li Q, Wang CJ, Xie SQ. Mol Cancer. 2013 Dec 10;12:157. doi: 10.1186/1476-4598-12-157. PubMed |
| Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling. Koval AV, Vlasov P, Shichkova P, Khunderyakova S, Markov Y, Panchenko J, Volodina A, Kondrashov FA, Katanaev VL. Biochem Pharmacol. 2014 Feb 15;87(4):571-8. doi: 10.1016/j.bcp.2013.12.007. Epub 2013 Dec 16. PubMed |
| The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression. Huard CC, Tremblay CS, Magron A, Levesque G, Carreau M. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2152-7. doi: 10.1073/pnas.1314226111. Epub 2014 Jan 27. PubMed |
| Preclinical activity of the oral proteasome inhibitor MLN9708 in Myeloma bone disease. Garcia-Gomez A, Quwaider D, Canavese M, Ocio EM, Tian Z, Blanco JF, Berger AJ, Ortiz-de-Solorzano C, Hernandez-Iglesias T, Martens AC, Groen RW, Mateo-Urdiales J, Fraile S, Galarraga M, Chauhan D, San Miguel JF, Raje N, Garayoa M. Clin Cancer Res. 2014 Mar 15;20(6):1542-54. doi: 10.1158/1078-0432.CCR-13-1657. Epub 2014 Jan 31. PubMed |
| Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. Osborn DP, Roccasecca RM, McMurray F, Hernandez-Hernandez V, Mukherjee S, Barroso I, Stemple D, Cox R, Beales PL, Christou-Savina S. PLoS One. 2014 Feb 4;9(2):e87662. doi: 10.1371/journal.pone.0087662. eCollection 2014. PubMed |
| Modulating and measuring Wingless signalling. Vincent JP. Methods. 2014 Jun 15;68(1):194-8. doi: 10.1016/j.ymeth.2014.03.015. Epub 2014 Mar 25. PubMed |
| High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma. Kuo PY, Leshchenko VV, Fazzari MJ, Perumal D, Gellen T, He T, Iqbal J, Baumgartner-Wennerholm S, Nygren L, Zhang F, Zhang W, Suh KS, Goy A, Yang DT, Chan WC, Kahl BS, Verma AK, Gascoyne RD, Kimby E, Sander B, Ye BH, Melnick AM, Parekh S. Oncogene. 2015 Mar 5;34(10):1231-40. doi: 10.1038/onc.2014.44. Epub 2014 Mar 31. PubMed |
| Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation. Zhuang L, Hulin JA, Gromova A, Tran Nguyen TD, Yu RT, Liddle C, Downes M, Evans RM, Makarenkova HP, Meech R. Stem Cells. 2014 Jun;32(6):1661-73. doi: 10.1002/stem.1674. PubMed |
| MiR-29b downregulates canonical Wnt signaling by suppressing coactivators of beta-catenin in human colorectal cancer cells. Subramanian M, Rao SR, Thacker P, Chatterjee S, Karunagaran D. J Cell Biochem. 2014 Nov;115(11):1974-84. doi: 10.1002/jcb.24869. PubMed |
| Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6(5a) isoform. Forsdahl S, Kiselev Y, Hogseth R, Mjelle JE, Mikkola I. PLoS One. 2014 Jul 16;9(7):e102559. doi: 10.1371/journal.pone.0102559. eCollection 2014. PubMed |
| Casein kinase 1 alpha phosphorylates the Wnt regulator Jade-1 and modulates its activity. Borgal L, Rinschen MM, Dafinger C, Hoff S, Reinert MJ, Lamkemeyer T, Lienkamp SS, Benzing T, Schermer B. J Biol Chem. 2014 Sep 19;289(38):26344-56. doi: 10.1074/jbc.M114.562165. Epub 2014 Aug 6. PubMed |
| Pin1 positively affects tumorigenesis of esophageal squamous cell carcinoma and correlates with poor survival of patients. Lin FC, Lee YC, Goan YG, Tsai CH, Yao YC, Cheng HC, Lai WW, Wang YC, Sheu BS, Lu PJ. J Biomed Sci. 2014 Aug 27;21:75. doi: 10.1186/s12929-014-0075-1. PubMed |
| Tenascin-C is required for normal Wnt/beta-catenin signaling in the whisker follicle stem cell niche. Hendaoui I, Tucker RP, Zingg D, Bichet S, Schittny J, Chiquet-Ehrismann R. Matrix Biol. 2014 Nov;40:46-53. doi: 10.1016/j.matbio.2014.08.017. Epub 2014 Sep 6. PubMed |
| Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. Pooja T, Karunagaran D. Eur J Pharmacol. 2014 Nov 5;742:55-64. doi: 10.1016/j.ejphar.2014.08.028. Epub 2014 Sep 6. PubMed |
| CD44 functions in Wnt signaling by regulating LRP6 localization and activation. Schmitt M, Metzger M, Gradl D, Davidson G, Orian-Rousseau V. Cell Death Differ. 2015 Apr;22(4):677-89. doi: 10.1038/cdd.2014.156. Epub 2014 Oct 10. PubMed |
| RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. Rodrigues P, Macaya I, Bazzocco S, Mazzolini R, Andretta E, Dopeso H, Mateo-Lozano S, Bilic J, Carton-Garcia F, Nieto R, Suarez-Lopez L, Afonso E, Landolfi S, Hernandez-Losa J, Kobayashi K, Ramon y Cajal S, Tabernero J, Tebbutt NC, Mariadason JM, Schwartz S Jr, Arango D. Nat Commun. 2014 Nov 21;5:5458. doi: 10.1038/ncomms6458. PubMed |
| MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway. Ahmed MI, Alam M, Emelianov VU, Poterlowicz K, Patel A, Sharov AA, Mardaryev AN, Botchkareva NV. J Cell Biol. 2014 Nov 24;207(4):549-67. doi: 10.1083/jcb.201404001. PubMed |
| Fezf2 promotes neuronal differentiation through localised activation of Wnt/beta-catenin signalling during forebrain development. Zhang S, Li J, Lea R, Vleminckx K, Amaya E. Development. 2014 Dec;141(24):4794-805. doi: 10.1242/dev.115691. PubMed |
| Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. Bisson JA, Mills B, Paul Helt JC, Zwaka TP, Cohen ED. Dev Biol. 2015 Feb 1;398(1):80-96. doi: 10.1016/j.ydbio.2014.11.015. Epub 2014 Dec 5. PubMed |
| Inhibition of mesothelioma cancer stem-like cells with adenovirus-mediated NK4 gene therapy. Deng XB, Xiao L, Wu Y, Jin F, Mossman B, Testa JR, Xiao GH. Int J Cancer. 2015 Jul 15;137(2):481-90. doi: 10.1002/ijc.29391. Epub 2014 Dec 27. PubMed |
| Disruption of cell-cell contact-mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential: winner of the Society for Biomaterials Student Award in the Undergraduate Category, Charlotte, NC, April 15 to 18, 2015. Chen AX, Hoffman MD, Chen CS, Shubin AD, Reynolds DS, Benoit DS. J Biomed Mater Res A. 2015 Apr;103(4):1291-302. doi: 10.1002/jbm.a.35383. Epub 2014 Dec 31. PubMed |
| Dose-dependent nuclear beta-catenin response segregates endomesoderm along the sea star primary axis. McCauley BS, Akyar E, Saad HR, Hinman VF. Development. 2015 Jan 1;142(1):207-17. doi: 10.1242/dev.113043. PubMed |
| Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Sugiyama M, Hasegawa H, Ito S, Sugiyama K, Maeda M, Aoki K, Wakabayashi T, Hamaguchi M, Natsume A, Senga T. Oncol Rep. 2015 Mar;33(3):1123-30. doi: 10.3892/or.2014.3681. Epub 2014 Dec 18. PubMed |
| Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric beta-catenin signaling. Wilkinson LJ, Neal CS, Singh RR, Sparrow DB, Kurniawan ND, Ju A, Grieve SM, Dunwoodie SL, Moritz KM, Little MH. Kidney Int. 2015 May;87(5):975-83. doi: 10.1038/ki.2014.394. Epub 2015 Jan 14. PubMed |
| Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts. Kulak O, Yamaguchi K, Lum L. Methods Mol Biol. 2015;1263:3-14. doi: 10.1007/978-1-4939-2269-7_1. PubMed |
| RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells. Ilmer M, Boiles AR, Regel I, Yokoi K, Michalski CW, Wistuba II, Rodriguez J, Alt E, Vykoukal J. Cancer Res. 2015 May 1;75(9):1883-96. doi: 10.1158/0008-5472.CAN-14-1327. Epub 2015 Mar 13. PubMed |
| Transformation of the intestinal epithelium by the MSI2 RNA-binding protein. Wang S, Li N, Yousefi M, Nakauka-Ddamba A, Li F, Parada K, Rao S, Minuesa G, Katz Y, Gregory BD, Kharas MG, Yu Z, Lengner CJ. Nat Commun. 2015 Mar 16;6:6517. doi: 10.1038/ncomms7517. PubMed |
| Curcumin and emodin down-regulate TGF-beta signaling pathway in human cervical cancer cells. Thacker PC, Karunagaran D. PLoS One. 2015 Mar 18;10(3):e0120045. doi: 10.1371/journal.pone.0120045. eCollection 2015. PubMed |
| Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells. Garnier A, Vykoukal J, Hubertus J, Alt E, von Schweinitz D, Kappler R, Berger M, Ilmer M. Int J Oncol. 2015 Jul;47(1):151-60. doi: 10.3892/ijo.2015.3016. Epub 2015 May 21. PubMed |
| An IkappaB Kinase-Regulated Feedforward Circuit Prolongs Inflammation. Perez JM, Chirieleison SM, Abbott DW. Cell Rep. 2015 Jul 28;12(4):537-44. doi: 10.1016/j.celrep.2015.06.050. Epub 2015 Jul 16. PubMed |
| beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Cai J, Maitra A, Anders RA, Taketo MM, Pan D. Genes Dev. 2015 Jul 15;29(14):1493-506. doi: 10.1101/gad.264515.115. Epub 2015 Jul 20. PubMed |
| Angiotensin II prevents calcification in vascular smooth muscle cells by enhancing magnesium influx. Herencia C, Rodriguez-Ortiz ME, Munoz-Castaneda JR, Martinez-Moreno JM, Canalejo R, Montes de Oca A, Diaz-Tocados JM, Peralbo-Santaella E, Marin C, Canalejo A, Rodriguez M, Almaden Y. Eur J Clin Invest. 2015 Nov;45(11):1129-44. doi: 10.1111/eci.12517. Epub 2015 Sep 13. PubMed |
| Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, Ricci L, Fan F, Tawfik O, Marks JR, Knapp JR, Yeh HW, Thomas P, Carrasco DR, Fields TA, Godwin AK, Behbod F. Breast Cancer Res. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z. PubMed |
| MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/beta-catenin pathway. Liu T, Hu K, Zhao Z, Chen G, Ou X, Zhang H, Zhang X, Wei X, Wang D, Cui M, Liu C. Oncotarget. 2015 Dec 8;6(39):41638-49. doi: 10.18632/oncotarget.5873. PubMed |
| Targeting the Neurokinin-1 Receptor Compromises Canonical Wnt Signaling in Hepatoblastoma. Ilmer M, Garnier A, Vykoukal J, Alt E, von Schweinitz D, Kappler R, Berger M. Mol Cancer Ther. 2015 Dec;14(12):2712-21. doi: 10.1158/1535-7163.MCT-15-0206. Epub 2015 Oct 29. PubMed |
| The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. Pai P, Rachagani S, Lakshmanan I, Macha MA, Sheinin Y, Smith LM, Ponnusamy MP, Batra SK. Mol Oncol. 2016 Feb;10(2):224-39. doi: 10.1016/j.molonc.2015.10.005. Epub 2015 Oct 19. PubMed |
| Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Maxfield KE, Taus PJ, Corcoran K, Wooten J, Macion J, Zhou Y, Borromeo M, Kollipara RK, Yan J, Xie Y, Xie XJ, Whitehurst AW. Nat Commun. 2015 Nov 16;6:8840. doi: 10.1038/ncomms9840. PubMed |
| Wnt/beta-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. Wickstrom M, Dyberg C, Milosevic J, Einvik C, Calero R, Sveinbjornsson B, Sanden E, Darabi A, Siesjo P, Kool M, Kogner P, Baryawno N, Johnsen JI. Nat Commun. 2015 Nov 25;6:8904. doi: 10.1038/ncomms9904. PubMed |
| beta-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1. Liu Y, Hancock M, Workman A, Doster A, Jones C. J Virol. 2016 Jan 6;90(6):3148-59. doi: 10.1128/JVI.02971-15. PubMed |
| Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. Niwa Y, Suzuki T, Dohmae N, Simizu S. Mol Biol Cell. 2016 Jan 13. pii: mbc.E15-06-0373. PubMed |
| Prenatal beta-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors. Belinson H, Nakatani J, Babineau BA, Birnbaum RY, Ellegood J, Bershteyn M, McEvilly RJ, Long JM, Willert K, Klein OD, Ahituv N, Lerch JP, Rosenfeld MG, Wynshaw-Boris A. Mol Psychiatry. 2016 Feb 2. doi: 10.1038/mp.2015.207. PubMed |
| Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells. Hoepfner J, Kleinsorge M, Papp O, Ackermann M, Alfken S, Rinas U, Solodenko W, Kirschning A, Sgodda M, Cantz T. Cell Biol Int. 2016 May;40(5):534-48. doi: 10.1002/cbin.10590. Epub 2016 Feb 25. PubMed |
| The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. Leow SC, Poschmann J, Too PG, Yin J, Joseph R, McFarlane C, Dogra S, Shabbir A, Ingham PW, Prabhakar S, Leow MK, Lee YS, Ng KL, Chong YS, Gluckman PD, Stunkel W. Development. 2016 Mar 15;143(6):950-61. doi: 10.1242/dev.131573. Epub 2016 Feb 18. PubMed |
| Identification of Novel Candidate Genes for Early-Onset Colorectal Cancer Susceptibility. de Voer RM, Hahn MM, Weren RD, Mensenkamp AR, Gilissen C, van Zelst-Stams WA, Spruijt L, Kets CM, Zhang J, Venselaar H, Vreede L, Schubert N, Tychon M, Derks R, Schackert HK, Geurts van Kessel A, Hoogerbrugge N, Ligtenberg MJ, Kuiper RP. PLoS Genet. 2016 Feb 22;12(2):e1005880. doi: 10.1371/journal.pgen.1005880. eCollection 2016 Feb. PubMed |
| Synergistic role of beta-catenin1 and 2 in ovarian differentiation and maintenance of female pathway in Nile tilapia. Wu L, Wu F, Xie L, Wang D, Zhou L. Mol Cell Endocrinol. 2016 May 15;427:33-44. doi: 10.1016/j.mce.2016.03.002. Epub 2016 Mar 4. PubMed |
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| beta-Catenin Directs Nuclear Factor-kappaB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle. Koopmans T, Eilers R, Menzen M, Halayko A, Gosens R. Front Immunol. 2017 Sep 8;8:1086. doi: 10.3389/fimmu.2017.01086. eCollection 2017. PubMed |
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| Inhibition of GSK3 Represses the Expression of Retinoic Acid Synthetic Enzyme ALDH1A2 via Wnt/beta-Catenin Signaling in WiT49 Cells. Li Y, Gong H, Ding J, Zhao F, Du J, Wan J, Zhang J, Liu S, Li J, Wang L, Zhou B. Front Cell Dev Biol. 2020 Mar 17;8:94. doi: 10.3389/fcell.2020.00094. eCollection 2020. PubMed |
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| LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/beta-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes. Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J. Mol Cancer. 2020 Jul 29;19(1):118. doi: 10.1186/s12943-020-01237-y. PubMed |
| SOX6 represses tumor growth of clear cell renal cell carcinoma by HMG domain-dependent regulation of Wnt/beta-catenin signaling. Chen L, Xie Y, Ma X, Zhang Y, Li X, Zhang F, Gao Y, Fan Y, Gu L, Wang L, Zhang X, Fu B. Mol Carcinog. 2020 Oct;59(10):1159-1173. doi: 10.1002/mc.23246. Epub 2020 Aug 14. PubMed |
| TBX3 acts as tissue-specific component of the Wnt/beta-catenin transcriptional complex. Zimmerli D, Borrelli C, Jauregi-Miguel A, Soderholm S, Brutsch S, Doumpas N, Reichmuth J, Murphy-Seiler F, Aguet M, Basler K, Moor AE, Cantu C. Elife. 2020 Aug 18;9. pii: 58123. doi: 10.7554/eLife.58123. PubMed |
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| Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/beta-catenin/STAT3 axis. Liu SC, Huang CS, Huang CM, Hsieh MS, Huang MS, Fong IH, Yeh CT, Lin CC. Toxicol Appl Pharmacol. 2021 Aug 1;424:115581. doi: 10.1016/j.taap.2021.115581. Epub 2021 May 18. PubMed |
| Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development. Krishnamurthy VV, Hwang H, Fu J, Yang J, Zhang K. J Mol Biol. 2021 Sep 3;433(18):167050. doi: 10.1016/j.jmb.2021.167050. Epub 2021 May 19. PubMed |
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| ICG-001, an Inhibitor of the beta-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of Osteosarcoma Cells. Danieau G, Morice S, Renault S, Brion R, Biteau K, Amiaud J, Cade M, Heymann D, Lezot F, Verrecchia F, Redini F, Brounais-Le Royer B. Pharmaceuticals (Basel). 2021 May 1;14(5). pii: ph14050421. doi: 10.3390/ph14050421. PubMed |
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Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments.
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| A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-beta-catenin signaling-mediated drug resistance and adverse effects. Lee HJ, Min HY, Yong YS, Ann J, Nguyen CT, La MT, Hyun SY, Le HT, Kim H, Kwon H, Nam G, Park HJ, Lee J, Lee HY. Theranostics. 2022 Jan 1;12(1):105-125. doi: 10.7150/thno.63788. eCollection 2022. PubMed |
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