Addgene

We narrowed to 12,997 results for: SHI

Showing: 4001 - 4050 of 12997 results

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pNK882

Plasmid

#219729

Purpose

MoClo-compatible Level 0 - promoter vector carrying promoter MinSyn159x

Depositor

Alexander Mishin

Article

Shakhova et al Int J Mol Sci. 2022 Dec 6;23(23):15441.

Insert

promoter MinSyn159x

Use

Synthetic Biology

Tags

Expression

Plant

Mutation

Promoter

MinSyn159x

Available since

July 12, 2024

Availability

Academic Institutions and Nonprofits only

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pNK881

Plasmid

#219730

Purpose

MoClo-compatible Level 0 - promoter vector carrying promoter MinSyn1556x

Depositor

Alexander Mishin

Article

Shakhova et al Int J Mol Sci. 2022 Dec 6;23(23):15441.

Insert

promoter MinSyn1556x

Use

Synthetic Biology

Tags

Expression

Plant

Mutation

Promoter

MinSyn1556x

Available since

July 12, 2024

Availability

Academic Institutions and Nonprofits only

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pNK884

Plasmid

#219731

Purpose

MoClo-compatible Level 0 - promoter vector carrying promoter MinSyn1569x

Depositor

Alexander Mishin

Article

Shakhova et al Int J Mol Sci. 2022 Dec 6;23(23):15441.

Insert

promoter MinSyn1569x

Use

Synthetic Biology

Tags

Expression

Plant

Mutation

Promoter

MinSyn1569x

Available since

July 12, 2024

Availability

Academic Institutions and Nonprofits only

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pNK6030

Plasmid

#219732

Purpose

MoClo-compatible Level 0 - promoter vector carrying promoter MinSyn1637x

Depositor

Alexander Mishin

Article

Shakhova et al Int J Mol Sci. 2022 Dec 6;23(23):15441.

Insert

promoter MinSyn1637x

Use

Synthetic Biology

Tags

Expression

Plant

Mutation

Promoter

MinSyn1637x

Available since

July 12, 2024

Availability

Academic Institutions and Nonprofits only

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pNK885

Plasmid

#219733

Purpose

MoClo-compatible Level 0 - promoter vector carrying promoter MinSyn1824x

Depositor

Alexander Mishin

Article

Shakhova et al Int J Mol Sci. 2022 Dec 6;23(23):15441.

Insert

promoter MinSyn1824x

Use

Synthetic Biology

Tags

Expression

Plant

Mutation

Promoter

MinSyn1824x

Available since

July 12, 2024

Availability

Academic Institutions and Nonprofits only

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pNK878

Plasmid

#219734

Purpose

MoClo-compatible Level 0 - promoter vector carrying promoter MinSyn1904x

Depositor

Alexander Mishin

Article

Shakhova et al Int J Mol Sci. 2022 Dec 6;23(23):15441.

Insert

promoter MinSyn1904x

Use

Synthetic Biology

Tags

Expression

Plant

Mutation

Promoter

MinSyn1904x

Available since

July 12, 2024

Availability

Academic Institutions and Nonprofits only

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pMMK201

Plasmid

#207131

Purpose

Type 2 ptac promoter part

Depositor

Nicholas Shikuma

Article

Alker et al mBio. 2023 Aug 2:e0150223. doi: 10.1128/

Insert

ptac promoter

Use

Tags

Expression

Bacterial

Mutation

Promoter

Available since

April 2, 2024

Availability

Academic Institutions and Nonprofits only

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pGWT35S-TP-UnaG

Plasmid

#203484

Purpose

For particle bombardment. A plastid transit peptide fused UnaG under the control of the cauliflower mosaic virus (CaMV) 35S promoter.

Depositor

Yutaka Kodama

Article

Ishikawa et al Sci Adv. 2023 Jun 9;9(23):eadh4787. doi:

Insert

Plastid transit peptide fused UnaG

Use

Tags

Expression

Bacterial and Plant

Mutation

Promoter

Available since

Aug. 22, 2023

Availability

Academic Institutions and Nonprofits only

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pMpGWBhis03-Citrine-NLS

Plasmid

#188558

Purpose

Binary vector for the expression of Citrine-NLS with MpIGPDm selective marker in Marchantia polymorpha (igpd mutants) .

Depositor

Yutaka Kodama

Article

Fukushima et al Plant Biotechnol (Tokyo). 2022 Dec 25;39

Insert

Citrine-NLS and MpIGPDm

Use

CRISPR; Entry vector

Tags

Expression

Mutation

Promoter

Available since

May 31, 2023

Availability

Academic Institutions and Nonprofits only

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pMpGWB302-er-mCherry

Plasmid

#186287

Purpose

Binary vector for the expression of er-mCherry (SP-mCherry-HDEL) in plants (for Agrobacterium-mediated genetic transformation and visualization of endoplasmic reticulum)

Depositor

Yutaka Kodama

Article

Ishikawa et al Plant J. 2022 Apr 27. doi: 10.1111/tpj.1

Insert

er-mCherry

Use

Tags

Expression

Bacterial

Mutation

Promoter

Available since

May 23, 2023

Availability

Academic Institutions and Nonprofits only

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pBZS-YP_009701874

Plasmid

#198378

Purpose

Express YP_009701874 in bacterial cells.

Depositor

Takashi Ito

Article

Miura et al BMC Biotechnol. 2022 Nov 4;22(1):33. doi

Insert

YP_009701874 (CVA-1_543R )

Use

Tags

Expression

Bacterial

Mutation

Promoter

Available since

April 14, 2023

Availability

Academic Institutions and Nonprofits only

Enlarge
pBZS-YP_001426001

Plasmid

#198361

Purpose

Express pBZS-YP_001426001 in bacterial cells.

Depositor

Takashi Ito

Article

Miura et al BMC Biotechnol. 2022 Nov 4;22(1):33. doi

Insert

YP_001426001 (N369L )

Use

Tags

Expression

Bacterial

Mutation

Promoter

Available since

April 14, 2023

Availability

Academic Institutions and Nonprofits only

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pBZS-YP_009665506

Plasmid

#198376

Purpose

Express YP_009665506 in bacterial cells.

Depositor

Takashi Ito

Article

Miura et al BMC Biotechnol. 2022 Nov 4;22(1):33. doi

Insert

YP_009665506 (NYs-1_727R )

Use

Tags

Expression

Bacterial

Mutation

Promoter

Available since

April 14, 2023

Availability

Academic Institutions and Nonprofits only

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pBZS-YP_009665369

Plasmid

#198375

Purpose

Express YP_009665369 in bacterial cells.

Depositor

Takashi Ito

Article

Miura et al BMC Biotechnol. 2022 Nov 4;22(1):33. doi

Insert

YP_009665369 (NYs-1_421L )

Use

Tags

Expression

Bacterial

Mutation

Promoter

Available since

April 14, 2023

Availability

Academic Institutions and Nonprofits only

Enlarge
pBZS-YP_009702000

Plasmid

#198379

Purpose

Express YP_009702000 in bacterial cells.

Depositor

Takashi Ito

Article

Miura et al BMC Biotechnol. 2022 Nov 4;22(1):33. doi

Insert

YP_009702000 (CVA-1_913R )

Use

Tags

Expression

Bacterial

Mutation

Promoter

Available since

April 7, 2023

Availability

Academic Institutions and Nonprofits only

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pAc5.1B-V5-SBP-FLuc_I

Plasmid

#146550

Purpose

Insect Expression of Fluc

Depositor

Elisa Izaurralde

Article

Kashima et al Genes Dev. 2010 Nov 1. 24(21):2440-50.

Insert

Fluc

Use

Tags

Expression

Insect

Mutation

Promoter

Available since

March 16, 2023

Availability

Academic Institutions and Nonprofits only

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C-SWAT IAA17

Plasmid

#193319

Purpose

C-SWAT compatible vector for C-terminal tagging with IAA17 (Auxin-Inducible Degron). ARF16(PB1)-P2A-osTIR1 has SIR4 homology arms for genome integration.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

IAA17

Use

Tags

IAA17

Expression

Yeast

Mutation

Promoter

Available since

Feb. 2, 2023

Availability

Academic Institutions and Nonprofits only

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pBAD/HisB (TIRSTD)-mEos3.2

Plasmid

#189719

Purpose

titratable expression of mEos3.2 in bacteria

Depositor

Daniel Daley

Article

Shilling et al Synth Biol (Oxf). 2022 Jul 5;7(1):ysac00

Insert

mEos3.2

Use

Tags

His-T7-EK

Expression

Bacterial

Mutation

Promoter

pBAD/HisB

Available since

Feb. 1, 2023

Availability

Academic Institutions and Nonprofits only

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C-SWAT Compatible pAIDA2(6FLAG)

Plasmid

#193321

Purpose

C-SWAT compatible vector for C-terminal tagging with TAP-AID*-6FLAG. osTIR1 is carried downstream of the C-terminal tag.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

TAP-AID*-6FLAG

Use

Tags

TAP-AID*-6FLAG

Expression

Yeast

Mutation

Promoter

Available since

Jan. 26, 2023

Availability

Academic Institutions and Nonprofits only

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C-SWAT AID*-6MYC osTIR1

Plasmid

#193320

Purpose

C-SWAT compatible vector for C-terminal tagging with AID*-6MYC for auxin induced gene knockdown. osTIR1 is flanked by SIR4 homology arms for integration into the genome.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

AID*

Use

Tags

6MYC

Expression

Yeast

Mutation

Promoter

Available since

Jan. 26, 2023

Availability

Academic Institutions and Nonprofits only

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C-SWAT AID*-6FLAG osTIR1

Plasmid

#182515

Purpose

C-SWAT compatible vector for C-terminal tagging with AID*-6FLAG for auxin induced gene knockdown. osTIR1 is flanked by SIR4 homology arms for integration into the genome.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

AID*

Use

Tags

6FLAG

Expression

Yeast

Mutation

Promoter

Available since

Jan. 24, 2023

Availability

Academic Institutions and Nonprofits only

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C-SWAT IAA17-6FLAG

Plasmid

#182516

Purpose

C-SWAT compatible vector for C-terminal tagging with IAA17 (Auxin-Inducible Degron) and 6FLAG. ARF16(PB1)-P2A-osTIR1 has SIR4 homology arms for genome integration.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

IAA17

Use

Tags

6FLAG

Expression

Yeast

Mutation

Promoter

Available since

Jan. 24, 2023

Availability

Academic Institutions and Nonprofits only

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C-SWAT IAA17-3HA

Plasmid

#182517

Purpose

C-SWAT compatible vector for C-terminal tagging with IAA17 (Auxin inducible degron) and 3HA. ARF16(PB1)-P2A-osTIR1 with SIR4 homology arms for genome integration.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

IAA17

Use

Tags

3HA

Expression

Yeast

Mutation

Promoter

Available since

Jan. 24, 2023

Availability

Academic Institutions and Nonprofits only

Enlarge
C-SWAT IAA17-3MYC

Plasmid

#182518

Purpose

C-SWAT compatible vector for C-terminal tagging with IAA17 (Auxin inducible degron) and 3MYC. ARF16(PB1)-P2A-osTIR1 with SIR4 homology arms for genome integration.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

IAA17

Use

Tags

3MYC

Expression

Yeast

Mutation

Promoter

Available since

Jan. 24, 2023

Availability

Academic Institutions and Nonprofits only

Enlarge
SIR4 gRNA HIS

Plasmid

#182520

Purpose

Expression vector for gRNA directed against SIR4 ORF.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

SIR4 gRNA (SIR4 Budding Yeast)

Use

Tags

Expression

Yeast

Mutation

Promoter

Available since

Jan. 24, 2023

Availability

Academic Institutions and Nonprofits only

Enlarge
CAN1 gRNA HIS

Plasmid

#182521

Purpose

Expression vector for gRNA directed against CAN1 ORF.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

CAN1 gRNA (CAN1 Budding Yeast)

Use

Tags

Expression

Yeast

Mutation

Promoter

Available since

Jan. 24, 2023

Availability

Academic Institutions and Nonprofits only

Enlarge
C-SWAT IAA17-6FLAG

Plasmid

#182522

Purpose

C-SWAT compatible vector for C-terminal tagging with IAA17 (Auxin Inducible Degron) and 6FLAG. ARF16(PB1)-P2A-osTIR1 with CAN1 homology arms for genome integration.

Depositor

Rob Mitra

Article

Shively et al ACS Synth Biol. 2023 Jan 17. doi: 10.102

Insert

IAA17

Use

Tags

6FLAG

Expression

Yeast

Mutation

Promoter

Available since

Jan. 24, 2023

Availability

Academic Institutions and Nonprofits only

Enlarge
pMpGE_En03-sgRNA-Target1 (MpRTN1)

Plasmid

#186291

Purpose

Gateway entry vector for sgRNA (target 1: MpRTN1). Transient expression of sgRNA (Target 1: MpRTN1) for MpRTN1 in plant cells

Depositor

Yutaka Kodama

Article

Ishikawa et al Plant J. 2022 Apr 27. doi: 10.1111/tpj.1

Insert

sgRNA-Target1

Use

CRISPR

Tags

Expression

Mutation

Promoter

Available since

Nov. 17, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pSLS.601

Plasmid

#184955

Purpose

Express -Eco1 ncRNA library variants

Depositor

Seth Shipman

Article

Lopez et al Nat Chem Biol. 2022 Feb;18(2):199-206. d

Insert

Eco1 ncRNA (variants)

Use

Tags

Expression

Bacterial

Mutation

Library members with mutations described in manus…

Promoter

T7/lac

Available since

Nov. 4, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pBAD/HisB (TIREVOL)-mNG

Plasmid

#189722

Purpose

titratable expression of mNeonGreen in bacteria

Depositor

Daniel Daley

Article

Shilling et al Synth Biol (Oxf). 2022 Jul 5;7(1):ysac00

Insert

mNeonGreen

Use

Tags

His-T7-EK

Expression

Bacterial

Mutation

Promoter

pBAD

Available since

Oct. 4, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pBAD/HisB (TIR23)-sfGFP

Plasmid

#189676

Purpose

titratable expression of sfGFP in bacteria

Depositor

Daniel Daley

Article

Shilling et al Synth Biol (Oxf). 2022 Jul 5;7(1):ysac00

Insert

sfGFP

Use

Tags

His-T7-EK

Expression

Bacterial

Mutation

Promoter

pBAD

Available since

Oct. 4, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pMpGE010-sgRNA-Target1 (MpRTN1)

Plasmid

#186295

Purpose

Binary vector for CRISPR/Cas9 (target 1: MpRTN1) in plants (for Agrobacterium-mediated genetic transformation)

Depositor

Yutaka Kodama

Article

Ishikawa et al Plant J. 2022 Apr 27. doi: 10.1111/tpj.1

Insert

sgRNA-Target1

Use

CRISPR

Tags

Expression

Bacterial

Mutation

Promoter

Available since

Sept. 26, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pCIS.MTRIA-PAF

Plasmid

#184616

Purpose

For expression of a fluorescent sensor for platelet-activating factor in mammalian cells

Depositor

Hiroshi Hibino, Daisuke Ino

Article

Ino et al Nat Methods. 2022 Sep 22. pii: 10.1038/s

Insert

MTRIA-PAF

Use

Tags

Expression

Mammalian

Mutation

Promoter

CAG promoter

Available since

Sept. 22, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pCIS.MTRIA-UTS

Plasmid

#184620

Purpose

For expression of a fluorescent sensor for urotensin II in mammalian cells

Depositor

Hiroshi Hibino, Daisuke Ino

Article

Ino et al Nat Methods. 2022 Sep 22. pii: 10.1038/s

Insert

MTRIA-UTS

Use

Tags

Expression

Mammalian

Mutation

Promoter

CAG promoter

Available since

Sept. 22, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pCIS.MTRIA-LTB

Plasmid

#184605

Purpose

For expression of a fluorescent sensor for leukotriene B4 in mammalian cells

Depositor

Hiroshi Hibino, Daisuke Ino

Article

Ino et al Nat Methods. 2022 Sep 22. pii: 10.1038/s

Insert

MTRIA-LTB

Use

Tags

Expression

Mammalian

Mutation

Promoter

CAG promoter

Available since

June 22, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pCIS.MTRIA-NKB

Plasmid

#184609

Purpose

For expression of a fluorescent sensor for neurokinin B in mammalian cells

Depositor

Hiroshi Hibino, Daisuke Ino

Article

Ino et al Nat Methods. 2022 Sep 22. pii: 10.1038/s

Insert

MTRIA-NKB

Use

Tags

Expression

Mammalian

Mutation

Promoter

CAG promoter

Available since

June 21, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pCIS.MTRIA-C3a

Plasmid

#184601

Purpose

For expression of a fluorescent sensor for C3a complement in mammalian cells

Depositor

Hiroshi Hibino, Daisuke Ino

Article

Ino et al Nat Methods. 2022 Sep 22. pii: 10.1038/s

Insert

MTRIA-C3a

Use

Tags

Expression

Mammalian

Mutation

Promoter

CAG promoter

Available since

June 16, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pCIS.MTRIA-NTS

Plasmid

#184614

Purpose

For expression of a fluorescent sensor for neurotensin in mammalian cells

Depositor

Hiroshi Hibino, Daisuke Ino

Article

Ino et al Nat Methods. 2022 Sep 22. pii: 10.1038/s

Insert

MTRIA-NTS

Use

Tags

Expression

Mammalian

Mutation

Promoter

CAG promoter

Available since

June 16, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pCIS.MTRIA-NPFF

Plasmid

#184612

Purpose

For expression of a fluorescent sensor for neuropeptide FF in mammalian cells

Depositor

Hiroshi Hibino, Daisuke Ino

Article

Ino et al Nat Methods. 2022 Sep 22. pii: 10.1038/s

Insert

MTRIA-NPFF

Use

Tags

Expression

Mammalian

Mutation

Promoter

CAG promoter

Available since

June 15, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pCIS.MTRIA-NMB

Plasmid

#184610

Purpose

For expression of a fluorescent sensor for neuromedin B in mammalian cells

Depositor

Hiroshi Hibino, Daisuke Ino

Article

Ino et al Nat Methods. 2022 Sep 22. pii: 10.1038/s

Insert

MTRIA-NMB

Use

Tags

Expression

Mammalian

Mutation

Promoter

CAG promoter

Available since

June 14, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pGEM-Isce-Tol2-Tn5-neo

Plasmid

#176619

Purpose

for generating PCR templates with Tol2 repeats and Isce sites for BAC recombination

Depositor

Nathan Lawson

Article

Shih et al Development. 2021 Nov 9. pii: 273393. do

Insert

I-SceI sites, Tol2 repeats and Tn5-neo cassette

Use

Unspecified

Tags

Expression

Mutation

Promoter

Available since

Nov. 29, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pMPRMA43

Plasmid

#172944

Purpose

pQE30 encoding Wzz mutant i191

Depositor

Renato Morona

Article

Papadopoulos et al J Bacteriol. 2010 Jul;192(13):3385-93. d

Insert

Shigella flexneri wzz i191 mutant gene

Use

Tags

6xHis

Expression

Bacterial

Mutation

Promoter

Available since

Sept. 23, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pMPRMA47

Plasmid

#172947

Purpose

pQE30 encoding Wzz mutant i255

Depositor

Renato Morona

Article

Papadopoulos et al J Bacteriol. 2010 Jul;192(13):3385-93. d

Insert

Shigella flexneri wzz i255 mutant gene

Use

Tags

6xHis

Expression

Bacterial

Mutation

Promoter

Available since

Aug. 26, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pMPRMA49

Plasmid

#172948

Purpose

pQE30 encoding Wzz mutant i81

Depositor

Renato Morona

Article

Papadopoulos et al J Bacteriol. 2010 Jul;192(13):3385-93. d

Insert

Shigella flexneri wzz i81 mutant gene

Use

Tags

6xHis

Expression

Bacterial

Mutation

Promoter

Available since

Aug. 23, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pMPRMA42

Plasmid

#172943

Purpose

pQE30 encoding Wzz mutant i290

Depositor

Renato Morona

Article

Papadopoulos et al J Bacteriol. 2010 Jul;192(13):3385-93. d

Insert

Shigella flexneri wzz i290 mutant gene

Use

Tags

6xHis

Expression

Bacterial

Mutation

Promoter

Available since

Aug. 23, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pMPRMA52

Plasmid

#172938

Purpose

pQE30 encoding Wzz mutant i138

Depositor

Renato Morona

Article

Papadopoulos et al J Bacteriol. 2010 Jul;192(13):3385-93. d

Insert

Shigella flexneri wzz i138 mutant gene

Use

Tags

6xHis

Expression

Bacterial

Mutation

Promoter

Available since

Aug. 23, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pMPRMA41

Plasmid

#172935

Purpose

pQE30 encoding Wzz mutant i231

Depositor

Renato Morona

Article

Papadopoulos et al J Bacteriol. 2010 Jul;192(13):3385-93. d

Insert

Shigella flexneri wzz i231 mutant gene

Use

Tags

6xHis

Expression

Bacterial

Mutation

Promoter

Available since

Aug. 23, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pMPRMA56

Plasmid

#172951

Purpose

pQE30 encoding Wzz mutant i66

Depositor

Renato Morona

Article

Papadopoulos et al J Bacteriol. 2010 Jul;192(13):3385-93. d

Insert

Shigella flexneri wzz i66 mutant gene

Use

Tags

6xHis

Expression

Bacterial

Mutation

Promoter

Available since

Aug. 18, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pMPRMA46

Plasmid

#172946

Purpose

pQE30 encoding Wzz mutant i279

Depositor

Renato Morona

Article

Papadopoulos et al J Bacteriol. 2010 Jul;192(13):3385-93. d

Insert

Shigella flexneri wzz i279 mutant gene

Use

Tags

6xHis

Expression

Bacterial

Mutation

Promoter

Available since

Aug. 18, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pMPRMA51

Plasmid

#172949

Purpose

pQE30 encoding Wzz mutant i247

Depositor

Renato Morona

Article

Papadopoulos et al J Bacteriol. 2010 Jul;192(13):3385-93. d

Insert

Shigella flexneri wzz i247 mutant gene

Use

Tags

6xHis

Expression

Bacterial

Mutation

Promoter

Available since

Aug. 12, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge

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