pAdDeltaF6 Citations (143)
Originally described in: AAV packaging plasmidsUnpublished
Articles Citing pAdDeltaF6
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Programmable RNA-Guided RNA Effector Proteins Built from Human Parts.
Rauch S, He E, Srienc M, Zhou H, Zhang Z, Dickinson BC.
Cell. 2019 Jun 27;178(1):122-134.e12. doi: 10.1016/j.cell.2019.05.049. Epub 2019 Jun 20.
PubMed
Associated Plasmids |
| GPR108 Is a Highly Conserved AAV Entry Factor. Dudek AM, Zabaleta N, Zinn E, Pillay S, Zengel J, Porter C, Franceschini JS, Estelien R, Carette JE, Zhou GL, Vandenberghe LH. Mol Ther. 2020 Feb 5;28(2):367-381. doi: 10.1016/j.ymthe.2019.11.005. Epub 2019 Nov 13. PubMed |
| Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats. Frazier HN, Anderson KL, Ghoweri AO, Lin RL, Hawkinson TR, Popa GJ, Sompol P, Mendenhall MD, Norris CM, Thibault O. Aging Cell. 2020 Oct;19(10):e13220. doi: 10.1111/acel.13220. Epub 2020 Aug 27. PubMed |
| CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain. Mathiesen SN, Lock JL, Schoderboeck L, Abraham WC, Hughes SM. Mol Ther Methods Clin Dev. 2020 Oct 20;19:447-458. doi: 10.1016/j.omtm.2020.10.011. eCollection 2020 Dec 11. PubMed |
| AAV-mediated in vivo genome editing in vascular endothelial cells. Wu W, Yang Y, Yao F, Dong L, Xia X, Zhang S, Lei H. Methods. 2020 Dec 9. pii: S1046-2023(20)30263-2. doi: 10.1016/j.ymeth.2020.12.001. PubMed |
| Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3(Mashl/+), Mouse Model of Alternating Hemiplegia of Childhood. Hunanyan AS, Kantor B, Puranam RS, Elliott C, McCall A, Dhindsa J, Pagadala P, Wallace K, Poe J, Gunduz T, Asokan A, Koeberl DD, ElMallah MK, Mikati MA. Hum Gene Ther. 2021 Apr;32(7-8):405-419. doi: 10.1089/hum.2020.191. Epub 2021 Feb 12. PubMed |
| Hunger enhances food-odour attraction through a neuropeptide Y spotlight. Horio N, Liberles SD. Nature. 2021 Apr;592(7853):262-266. doi: 10.1038/s41586-021-03299-4. Epub 2021 Mar 3. PubMed |
| Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue. Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA. Acta Neuropathol Commun. 2021 Mar 12;9(1):41. doi: 10.1186/s40478-021-01141-6. PubMed |
| CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology. Xiao D, Zhang W, Wang Q, Li X, Zhang Y, Rasouli J, Casella G, Ciric B, Curtis M, Rostami A, Zhang GX. Mol Ther Methods Clin Dev. 2021 Feb 18;20:755-764. doi: 10.1016/j.omtm.2021.02.012. eCollection 2021 Mar 12. PubMed |
| CRISPR/Cas9 Mediated Deletion of the Angiotensinogen Gene Reduces Hypertension: A Potential for Cure? Sun H, Hodgkinson CP, Pratt RE, Dzau VJ. Hypertension. 2021 Jun;77(6):1990-2000. doi: 10.1161/HYPERTENSIONAHA.120.16870. Epub 2021 Apr 5. PubMed |
| Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models. Roy DS, Zhang Y, Aida T, Choi S, Chen Q, Hou Y, Lea NE, Skaggs KM, Quay JC, Liew M, Maisano H, Le V, Jones C, Xu J, Kong D, Sullivan HA, Saunders A, McCarroll SA, Wickersham IR, Feng G. Neuron. 2021 Aug 18;109(16):2590-2603.e13. doi: 10.1016/j.neuron.2021.06.005. Epub 2021 Jun 30. PubMed |
Compact RNA editors with small Cas13 proteins.
Kannan S, Altae-Tran H, Jin X, Madigan VJ, Oshiro R, Makarova KS, Koonin EV, Zhang F.
Nat Biotechnol. 2021 Aug 30. pii: 10.1038/s41587-021-01030-2. doi: 10.1038/s41587-021-01030-2.
PubMed
Associated Plasmids |
Revisiting astrocyte to neuron conversion with lineage tracing in vivo.
Wang LL, Serrano C, Zhong X, Ma S, Zou Y, Zhang CL.
Cell. 2021 Oct 14;184(21):5465-5481.e16. doi: 10.1016/j.cell.2021.09.005. Epub 2021 Sep 27.
PubMed
Associated Plasmids |
| NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis. Yu Y, Shen T, Zhong X, Wang LL, Tai W, Zou Y, Qin J, Zhang Z, Zhang CL. Glia. 2022 Feb;70(2):273-286. doi: 10.1002/glia.24104. Epub 2021 Oct 13. PubMed |
| Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells. Strasser L, Boi S, Guapo F, Donohue N, Barron N, Rainbow-Fletcher A, Bones J. Int J Mol Sci. 2021 Oct 25;22(21). pii: ijms222111499. doi: 10.3390/ijms222111499. PubMed |
| OGDHL ameliorates cognitive impairment and Alzheimer's disease-like pathology via activating Wnt/beta-catenin signaling in Alzheimer's disease mice. Yao L, Xu X, Xu Y, Li C, Xie F, Guo M, Liu Z, Liu X. Behav Brain Res. 2022 Feb 10;418:113673. doi: 10.1016/j.bbr.2021.113673. Epub 2021 Nov 16. PubMed |
| Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques. Arotcarena ML, Dovero S, Biendon N, Dutheil N, Planche V, Bezard E, Dehay B. Front Bioeng Biotechnol. 2021 Nov 15;9:762209. doi: 10.3389/fbioe.2021.762209. eCollection 2021. PubMed |
| Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors. Hamann MV, Beschorner N, Vu XK, Hauber I, Lange UC, Traenkle B, Kaiser PD, Foth D, Schneider C, Buning H, Rothbauer U, Hauber J. PLoS One. 2021 Dec 20;16(12):e0261269. doi: 10.1371/journal.pone.0261269. eCollection 2021. PubMed |
| A fast, aqueous, reversible three-day tissue clearing method for adult and embryonic mouse brain and whole body. Kosmidis S, Negrean A, Dranovsky A, Losonczy A, Kandel ER. Cell Rep Methods. 2021 Nov 22;1(7):100090. doi: 10.1016/j.crmeth.2021.100090. Epub 2021 Oct 11. PubMed |
| Optimized protocols for efficient gene editing in mouse hepatocytes in vivo using CRISPR-Cas9 technology. Chen Y, Ding Q. STAR Protoc. 2021 Dec 23;3(1):101062. doi: 10.1016/j.xpro.2021.101062. eCollection 2022 Mar 18. PubMed |
| Non-invasive administration of AAV to target lung parenchymal cells and develop SARS-CoV-2-susceptible mice. Yang MS, Park MJ, Lee J, Oh B, Kang KW, Kim Y, Lee SM, Lim JO, Jung TY, Park JH, Park SC, Lim YS, Hwang SB, Lyoo KS, Kim DI, Kim B. Mol Ther. 2022 May 4;30(5):1994-2004. doi: 10.1016/j.ymthe.2022.01.010. Epub 2022 Jan 7. PubMed |
| Brain-wide TVA compensation allows rabies virus to retrograde target cell-type-specific projection neurons. Han Z, Luo N, Kou J, Li L, Xu Z, Wei S, Wu Y, Wang J, Ye C, Lin K, Xu F. Mol Brain. 2022 Jan 29;15(1):13. doi: 10.1186/s13041-022-00898-8. PubMed |
| Only a small fraction of cells produce assembled capsids during transfection-based manufacturing of adeno-associated virus vectors. Dash S, Sharon DM, Mullick A, Kamen AA. Biotechnol Bioeng. 2022 Jun;119(6):1685-1690. doi: 10.1002/bit.28068. Epub 2022 Feb 28. PubMed |
Ratiometric Imaging of Mitochondrial Hydrogen Peroxide in Abeta42-Mediated Neurotoxicity.
Li X, Zhang Y, Ai HW.
ACS Sens. 2022 Feb 28. doi: 10.1021/acssensors.1c01381.
PubMed
Associated Plasmids |
| Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKbeta. Wu F, Hill K, Fang Q, He Z, Zheng H, Wang X, Xiong H, Sha SH. Cell Mol Life Sci. 2022 Apr 19;79(5):249. doi: 10.1007/s00018-022-04268-4. PubMed |
| m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. Flamand MN, Meyer KD. Nucleic Acids Res. 2022 May 6;50(8):4464-4483. doi: 10.1093/nar/gkac251. PubMed |
| CMYA5 establishes cardiac dyad architecture and positioning. Lu F, Ma Q, Xie W, Liou CL, Zhang D, Sweat ME, Jardin BD, Naya FJ, Guo Y, Cheng H, Pu WT. Nat Commun. 2022 Apr 21;13(1):2185. doi: 10.1038/s41467-022-29902-4. PubMed |
| FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism. Zhao F, Zhang L, Zhang M, Huang J, Zhang J, Chang Y. Front Pharmacol. 2022 Apr 20;13:850128. doi: 10.3389/fphar.2022.850128. eCollection 2022. PubMed |
| Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice. Keasey MP, Lovins C, Jia C, Hagg T. Physiol Rep. 2022 May;10(9):e15301. doi: 10.14814/phy2.15301. PubMed |
Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex.
Kato K, Zhou W, Okazaki S, Isayama Y, Nishizawa T, Gootenberg JS, Abudayyeh OO, Nishimasu H.
Cell. 2022 May 25. pii: S0092-8674(22)00581-5. doi: 10.1016/j.cell.2022.05.003.
PubMed
Associated Plasmids |
| Dietary intervention preserves beta cell function in mice through CTCF-mediated transcriptional reprogramming. Wang RR, Qiu X, Pan R, Fu H, Zhang Z, Wang Q, Chen H, Wu QQ, Pan X, Zhou Y, Shan P, Wang S, Guo G, Zheng M, Zhu L, Meng ZX. J Exp Med. 2022 Jul 4;219(7). pii: 213256. doi: 10.1084/jem.20211779. Epub 2022 Jun 2. PubMed |
| Somatic genetics analysis of sleep in adult mice. Wang G, Li Q, Xu J, Zhao S, Zhou R, Chen Z, Jiang W, Gao X, Zhou S, Chen Z, Sun Q, Ma C, Chen L, Shi B, Guo Y, Wang H, Wang X, Li H, Cai T, Wang Y, Chen Z, Wang F, Liu Q. J Neurosci. 2022 Jun 3. pii: JNEUROSCI.0089-22.2022. doi: 10.1523/JNEUROSCI.0089-22.2022. PubMed |
Neural circuit pathology driven by Shank3 mutation disrupts social behaviors.
Kim S, Kim YE, Song I, Ujihara Y, Kim N, Jiang YH, Yin HH, Lee TH, Kim IH.
Cell Rep. 2022 Jun 7;39(10):110906. doi: 10.1016/j.celrep.2022.110906.
PubMed
Associated Plasmids |
| Formation of False Context Fear Memory Is Regulated by Hypothalamic Corticotropin-Releasing Factor in Mice. Kasama E, Moriya M, Kamimura R, Matsuki T, Seki K. Int J Mol Sci. 2022 Jun 3;23(11). pii: ijms23116286. doi: 10.3390/ijms23116286. PubMed |
| Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue. Ojima K, Kakegawa W, Yamasaki T, Miura Y, Itoh M, Michibata Y, Kubota R, Doura T, Miura E, Nonaka H, Mizuno S, Takahashi S, Yuzaki M, Hamachi I, Kiyonaka S. Nat Commun. 2022 Jun 16;13(1):3167. doi: 10.1038/s41467-022-30828-0. PubMed |
| Targeting miR-30d reverses pathological cardiac hypertrophy. Li J, Sha Z, Zhu X, Xu W, Yuan W, Yang T, Jin B, Yan Y, Chen R, Wang S, Yao J, Xu J, Wang Z, Li G, Das S, Yang L, Xiao J. EBioMedicine. 2022 Jul;81:104108. doi: 10.1016/j.ebiom.2022.104108. Epub 2022 Jun 22. PubMed |
| PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y. EMBO J. 2022 Aug 16;41(16):e110439. doi: 10.15252/embj.2021110439. Epub 2022 Jul 4. PubMed |
A luciferase prosubstrate and a red bioluminescent calcium indicator for imaging neuronal activity in mice.
Tian X, Zhang Y, Li X, Xiong Y, Wu T, Ai HW.
Nat Commun. 2022 Jul 8;13(1):3967. doi: 10.1038/s41467-022-31673-x.
PubMed
Associated Plasmids |
A truncated reverse transcriptase enhances prime editing by split AAV vectors.
Gao Z, Ravendran S, Mikkelsen NS, Haldrup J, Cai H, Ding X, Paludan SR, Thomsen MK, Mikkelsen JG, Bak RO.
Mol Ther. 2022 Jul 8. pii: S1525-0016(22)00422-1. doi: 10.1016/j.ymthe.2022.07.001.
PubMed
Associated Plasmids |
| Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity. Wu F, Luo S, Zhang Y, Hairui Wang Zhaofei Guo Chunting He Shuting Bai Penghui He Min Jiang Xiaoyan Chen, Guangsheng Du Xun Sun YO. Acta Pharm Sin B. 2022 Jul 12. doi: 10.1016/j.apsb.2022.07.004. PubMed |
| TOB is an effector of the hippocampus-mediated acute stress response. Youssef MMM, Hamada HT, Lai ESK, Kiyama Y, El-Tabbal M, Kiyonari H, Nakano K, Kuhn B, Yamamoto T. Transl Psychiatry. 2022 Jul 29;12(1):302. doi: 10.1038/s41398-022-02078-7. PubMed |
| The intrinsic and extrinsic effects of TET proteins during gastrulation. Cheng S, Mittnenzweig M, Mayshar Y, Lifshitz A, Dunjic M, Rais Y, Ben-Yair R, Gehrs S, Chomsky E, Mukamel Z, Rubinstein H, Schlereth K, Reines N, Orenbuch AH, Tanay A, Stelzer Y. Cell. 2022 Aug 18;185(17):3169-3185.e20. doi: 10.1016/j.cell.2022.06.049. Epub 2022 Jul 30. PubMed |
| Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. Guo T, Pan X, Jiang G, Zhang D, Qi J, Shao L, Wang Z, Xu H, Zhao Y. J Neurosci. 2022 Aug 9;42(38):7309-17. doi: 10.1523/JNEUROSCI.1060-22.2022. PubMed |
| LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway. Chen T, Shi Z, Zhao Y, Meng X, Zhao S, Zheng L, Han X, Hu Z, Yao Q, Lin H, Du X, Zhang K, Han T, Hong W. BMC Med. 2022 Sep 29;20(1):335. doi: 10.1186/s12916-022-02523-w. PubMed |
| Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits. Jiang Y, Han L, Meng J, Wang Z, Zhou Y, Yuan H, Xu H, Zhang X, Zhao Y, Lu J, Xu H, Zhang C, Zhang YW. Mol Ther Methods Clin Dev. 2022 Oct 7;27:246-258. doi: 10.1016/j.omtm.2022.10.002. eCollection 2022 Dec 8. PubMed |
| Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES. Nat Commun. 2022 Nov 2;13(1):6581. doi: 10.1038/s41467-022-34412-4. PubMed |
| Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4. D'Amato G, Phansalkar R, Naftaly JA, Fan X, Amir ZA, Rios Coronado PE, Cowley DO, Quinn KE, Sharma B, Caron KM, Vigilante A, Red-Horse K. Dev Cell. 2022 Nov 21;57(22):2517-2532.e6. doi: 10.1016/j.devcel.2022.10.007. Epub 2022 Nov 7. PubMed |
| Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins. Vos DY, Wijers M, Smit M, Huijkman N, Kloosterhuis NJ, Wolters JC, Tissink JJ, Pronk ACM, Kooijman S, Rensen PCN, Kuivenhoven JA, van de Sluis B. Arterioscler Thromb Vasc Biol. 2023 Jan;43(1):e29-e45. doi: 10.1161/ATVBAHA.122.318169. Epub 2022 Nov 10. PubMed |
| Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. Liu PP, Dai SK, Mi TW, Tang GB, Wang Z, Wang H, Du HZ, Tang Y, Teng ZQ, Liu CM. EMBO Mol Med. 2022 Dec 7;14(12):e15795. doi: 10.15252/emmm.202215795. Epub 2022 Nov 17. PubMed |
| Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury. Frohlich A, Olde Heuvel F, Rehman R, Krishnamurthy SS, Li S, Li Z, Bayer D, Conquest A, Hagenston AM, Ludolph A, Huber-Lang M, Boeckers T, Knoll B, Morganti-Kossmann MC, Bading H, Roselli F. J Neuroinflammation. 2022 Nov 19;19(1):279. doi: 10.1186/s12974-022-02634-4. PubMed |
| DOK7 Promotes NMJ Regeneration After Nerve Injury. Kosco ED, Jing H, Chen P, Xiong WC, Samuels IS, Mei L. Mol Neurobiol. 2023 Mar;60(3):1453-1464. doi: 10.1007/s12035-022-03143-4. Epub 2022 Dec 5. PubMed |
Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants.
Liebsch F, Eggersmann FR, Merkler Y, Kloppenburg P, Schwarz G.
eNeuro. 2023 Jan 4;10(1):ENEURO.0102-22.2022. doi: 10.1523/ENEURO.0102-22.2022. Print 2023 Jan.
PubMed
Associated Plasmids |
| Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors. Lim CKW, Miskalis AJ, Perez-Pinera P, Gaj T. Methods Mol Biol. 2023;2606:135-158. doi: 10.1007/978-1-0716-2879-9_11. PubMed |
| Protocol to map multi-transmitter neurons in the mouse brain using intersectional strategy. Xu J, Contractor A, Zhu Y. STAR Protoc. 2022 Dec 16;3(4):101907. doi: 10.1016/j.xpro.2022.101907. Epub 2022 Dec 6. PubMed |
| Lactate metabolism is essential in early-onset mitochondrial myopathy. Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P. Sci Adv. 2023 Jan 4;9(1):eadd3216. doi: 10.1126/sciadv.add3216. Epub 2023 Jan 4. PubMed |
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy.
Alves CRR, Ha LL, Yaworski R, Sutton ER, Lazzarotto CR, Christie KA, Reilly A, Beauvais A, Doll RM, de la Cruz D, Maguire CA, Swoboda KJ, Tsai SQ, Kothary R, Kleinstiver BP.
Nat Biomed Eng. 2023 Dec 6. doi: 10.1038/s41551-023-01132-z.
PubMed
Associated Plasmids |
An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice.
Grodem S, Nymoen I, Vatne GH, Rogge FS, Bjornsdottir V, Lensjo KK, Fyhn M.
Nat Commun. 2023 Feb 4;14(1):608. doi: 10.1038/s41467-023-36324-3.
PubMed
Associated Plasmids |
| A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing. Lin KZ, Li L, Ma WY, Yang X, Han ZP, Luo NS, Wang J, Xu FQ. Neural Regen Res. 2023 Aug;18(8):1827-1833. doi: 10.4103/1673-5374.358618. PubMed |
| Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice. Qiao S, Alasmi S, Wyatt A, Wartenberg P, Wang H, Candlish M, Das D, Aoki M, Grunewald R, Zhou Z, Tian Q, Yu Q, Gotz V, Belkacemi A, Raza A, Ectors F, Kattler K, Gasparoni G, Walter J, Lipp P, Mollard P, Bernard DJ, Karatayli E, Karatayli SC, Lammert F, Boehm U. Nat Commun. 2023 Feb 25;14(1):1098. doi: 10.1038/s41467-023-36681-z. PubMed |
| Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis. Yu Q, Gamayun I, Wartenberg P, Zhang Q, Qiao S, Kusumakshi S, Candlish S, Gotz V, Wen S, Das D, Wyatt A, Wahl V, Ectors F, Kattler K, Yildiz D, Prevot V, Schwaninger M, Ternier G, Giacobini P, Ciofi P, Muller TD, Boehm U. Nat Commun. 2023 Mar 22;14(1):1588. doi: 10.1038/s41467-023-37099-3. PubMed |
| A custom-made AAV1 variant (AAV1-T593K) enables efficient transduction of Japanese quail neurons in vitro and in vivo. Zoabi S, Andreyanov M, Heinrich R, Ron S, Carmi I, Gutfreund Y, Berlin S. Commun Biol. 2023 Mar 28;6(1):337. doi: 10.1038/s42003-023-04712-6. PubMed |
| Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease. Wang Z, Zhu S, Jia Y, Wang Y, Kubota N, Fujiwara N, Gordillo R, Lewis C, Zhu M, Sharma T, Li L, Zeng Q, Lin YH, Hsieh MH, Gopal P, Wang T, Hoare M, Campbell P, Hoshida Y, Zhu H. bioRxiv. 2023 Mar 21:2023.03.20.533505. doi: 10.1101/2023.03.20.533505. Preprint. PubMed |
| Genomic investigations of unexplained acute hepatitis in children. Morfopoulou S, Buddle S, Torres Montaguth OE, Atkinson L, Guerra-Assuncao JA, Moradi Marjaneh M, Zennezini Chiozzi R, Storey N, Campos L, Hutchinson JC, Counsell JR, Pollara G, Roy S, Venturini C, Antinao Diaz JF, Siam A, Tappouni LJ, Asgarian Z, Ng J, Hanlon KS, Lennon A, McArdle A, Czap A, Rosenheim J, Andrade C, Anderson G, Lee JCD, Williams R, Williams CA, Tutill H, Bayzid N, Martin Bernal LM, Macpherson H, Montgomery KA, Moore C, Templeton K, Neill C, Holden M, Gunson R, Shepherd SJ, Shah P, Cooray S, Voice M, Steele M, Fink C, Whittaker TE, Santilli G, Gissen P, Kaufer BB, Reich J, Andreani J, Simmonds P, Alrabiah DK, Castellano S, Chikowore P, Odam M, Rampling T, Houlihan C, Hoschler K, Talts T, Celma C, Gonzalez S, Gallagher E, Simmons R, Watson C, Mandal S, Zambon M, Chand M, Hatcher J, De S, Baillie K, Semple MG, Martin J, Ushiro-Lumb I, Noursadeghi M, Deheragoda M, Hadzic N, Grammatikopoulos T, Brown R, Kelgeri C, Thalassinos K, Waddington SN, Jacques TS, Thomson E, Levin M, Brown JR, Breuer J. Nature. 2023 May;617(7961):564-573. doi: 10.1038/s41586-023-06003-w. Epub 2023 Mar 30. PubMed |
| Role of TMEM100 in mechanically insensitive nociceptor un-silencing. Nees TA, Wang N, Adamek P, Zeitzschel N, Verkest C, La Porta C, Schaefer I, Virnich J, Balkaya S, Prato V, Morelli C, Begay V, Lee YJ, Tappe-Theodor A, Lewin GR, Heppenstall PA, Taberner FJ, Lechner SG. Nat Commun. 2023 Apr 5;14(1):1899. doi: 10.1038/s41467-023-37602-w. PubMed |
| In vivo screening identifies SPP2, a secreted factor that negatively regulates liver regeneration. Lin YH, Zeng Q, Jia Y, Wang Z, Li L, Hsieh MH, Cheng Q, Pagani CA, Livingston N, Lee J, Zhang Y, Sharma T, Siegwart DJ, Yimlamai D, Levi B, Zhu H. Hepatology. 2023 Oct 1;78(4):1133-1148. doi: 10.1097/HEP.0000000000000402. Epub 2023 Apr 12. PubMed |
| Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver. Wang Y, Hurley A, De Giorgi M, Tanner MR, Hu RC, Pennington MW, Lagor WR, Beeton C. PLoS One. 2023 Apr 11;18(4):e0283996. doi: 10.1371/journal.pone.0283996. eCollection 2023. PubMed |
| Computer-Aided Directed Evolution Generates Novel AAV Variants with High Transduction Efficiency. Han Z, Luo N, Wang F, Cai Y, Yang X, Feng W, Zhu Z, Wang J, Wu Y, Ye C, Lin K, Xu F. Viruses. 2023 Mar 26;15(4):848. doi: 10.3390/v15040848. PubMed |
| Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice. Bu W, Creighton CJ, Heavener KS, Gutierrez C, Dou Y, Ku AT, Zhang Y, Jiang W, Urrutia J, Jiang W, Yue F, Jia L, Ibrahim AA, Zhang B, Huang S, Li Y. Sci Adv. 2023 May 12;9(19):eade0059. doi: 10.1126/sciadv.ade0059. Epub 2023 May 12. PubMed |
| Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells. Jost P, Klein F, Brand B, Wahl V, Wyatt A, Yildiz D, Boehm U, Niemeyer BA, Vaeth M, Alansary D. Int J Mol Sci. 2023 Apr 24;24(9):7772. doi: 10.3390/ijms24097772. PubMed |
| USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer. Maier CR, Hartmann O, Prieto-Garcia C, Al-Shami KM, Schlicker L, Vogel FCE, Haid S, Klann K, Buck V, Munch C, Schmitz W, Einig E, Krenz B, Calzado MA, Eilers M, Popov N, Rosenfeldt MT, Diefenbacher ME, Schulze A. Cell Death Differ. 2023 Jul;30(7):1710-1725. doi: 10.1038/s41418-023-01173-6. Epub 2023 May 18. PubMed |
| Histone H3 serotonylation dynamics in dorsal raphe nucleus contribute to stress- and antidepressant-mediated gene expression and behavior. Al-Kachak A, Fulton SL, Di Salvo G, Chan JC, Farrelly LA, Lepack AE, Bastle RM, Kong L, Cathomas F, Newman EL, Menard C, Ramakrishnan A, Safovich P, Lyu Y, Covington HE 3rd, Shen L, Gleason K, Tamminga CA, Russo SJ, Maze I. bioRxiv [Preprint]. 2023 Sep 16:2023.05.04.539464. doi: 10.1101/2023.05.04.539464. PubMed |
| FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation. Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI. Cell Rep. 2023 May 30;42(5):112530. doi: 10.1016/j.celrep.2023.112530. Epub 2023 May 18. PubMed |
| Ovulation is triggered by a cyclical modulation of gonadotropes into a hyperexcitable state. Gotz V, Qiao S, Das D, Wartenberg P, Wyatt A, Wahl V, Gamayun I, Alasmi S, Fecher-Trost C, Meyer MR, Rad R, Kaltenbacher T, Kattler K, Lipp P, Becherer U, Mollard P, Candlish M, Boehm U. Cell Rep. 2023 May 23;42(6):112543. doi: 10.1016/j.celrep.2023.112543. PubMed |
| Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome. Tabata H, Mori D, Matsuki T, Yoshizaki K, Asai M, Nakayama A, Ozaki N, Nagata KI. Biomolecules. 2023 Apr 27;13(5):763. doi: 10.3390/biom13050763. PubMed |
| Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function. Renauer P, Park JJ, Bai M, Acosta A, Lee WH, Lin GH, Zhang Y, Dai X, Wang G, Errami Y, Wu T, Clark P, Ye L, Yang Q, Chen S. Cancer Immunol Res. 2023 Aug 3;11(8):1068-1084. doi: 10.1158/2326-6066.CIR-22-0565. PubMed |
| AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction. Han Z, Luo N, Ma W, Liu X, Cai Y, Kou J, Wang J, Li L, Peng S, Xu Z, Zhang W, Qiu Y, Wu Y, Ye C, Lin K, Xu F. Nat Commun. 2023 Jun 26;14(1):3792. doi: 10.1038/s41467-023-39554-7. PubMed |
| Scalable, cell type-selective, AAV-based in vivo CRISPR screening in the mouse brain. Ramani B, Rose IVL, Pan A, Tian R, Ma K, Palop JJ, Kampmann M. bioRxiv [Preprint]. 2023 Jun 27:2023.06.13.544831. doi: 10.1101/2023.06.13.544831. PubMed |
| Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing. Fu Q, Lee YS, Green EA, Wang Y, Park SY, Polanco A, Lee KH, Betenbaugh M, McNally D, Yoon S. Biotechnol Bioeng. 2023 Jul 21. doi: 10.1002/bit.28508. PubMed |
| KMT2C knockout generates ASD-like behaviors in mice. Brauer B, Merino-Veliz N, Ahumada-Marchant C, Arriagada G, Bustos FJ. Front Cell Dev Biol. 2023 Jul 19;11:1227723. doi: 10.3389/fcell.2023.1227723. eCollection 2023. PubMed |
| Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia. Hu Y, Liu L, Chen Y, Zhang X, Zhou H, Hu S, Li X, Li M, Li J, Cheng S, Liu Y, Xu Y, Yan W. Nat Commun. 2023 Aug 24;14(1):5179. doi: 10.1038/s41467-023-40571-9. PubMed |
A split and inducible adenine base editor for precise in vivo base editing.
Zeng H, Yuan Q, Peng F, Ma D, Lingineni A, Chee K, Gilberd P, Osikpa EC, Sun Z, Gao X.
Nat Commun. 2023 Sep 11;14(1):5573. doi: 10.1038/s41467-023-41331-5.
PubMed
Associated Plasmids |
| Decreased CNNM2 expression in prefrontal cortex affects sensorimotor gating function, cognition, dendritic spine morphogenesis and risk of schizophrenia. Zhou DY, Su X, Wu Y, Yang Y, Zhang L, Cheng S, Shao M, Li W, Zhang Z, Wang L, Lv L, Li M, Song M. Neuropsychopharmacology. 2024 Jan;49(2):433-442. doi: 10.1038/s41386-023-01732-y. Epub 2023 Sep 15. PubMed |
| Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography. Shastry S, Chu W, Barbieri E, Greback-Clarke P, Smith WK, Cummings C, Minzoni A, Pancorbo J, Gilleskie G, Ritola K, Daniele MA, Johnson TF, Menegatti S. Biotechnol J. 2024 Jan;19(1):e2300230. doi: 10.1002/biot.202300230. Epub 2023 Sep 28. PubMed |
| Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease. Sela M, Poley M, Mora-Raimundo P, Kagan S, Avital A, Kaduri M, Chen G, Adir O, Rozencweig A, Weiss Y, Sade O, Leichtmann-Bardoogo Y, Simchi L, Aga-Mizrachi S, Bell B, Yeretz-Peretz Y, Or AZ, Choudhary A, Rosh I, Cordeiro D, Cohen-Adiv S, Berdichevsky Y, Odeh A, Shklover J, Shainsky-Roitman J, Schroeder JE, Hershkovitz D, Hasson P, Ashkenazi A, Stern S, Laviv T, Ben-Zvi A, Avital A, Ashery U, Maoz BM, Schroeder A. Adv Mater. 2023 Dec;35(51):e2304654. doi: 10.1002/adma.202304654. Epub 2023 Oct 27. PubMed |
| Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9. Thurkauf M, Lin S, Oliveri F, Grimm D, Platt RJ, Ruegg MA. Nat Commun. 2023 Sep 30;14(1):6116. doi: 10.1038/s41467-023-41769-7. PubMed |
| Double-Strand Break Repair Pathways Differentially Affect Processing and Transduction by Dual AAV Vectors. Maurer AC, Benyamini B, Fan VB, Whitney ON, Dailey GM, Darzacq X, Weitzman MD, Tjian R. bioRxiv [Preprint]. 2023 Sep 19:2023.09.19.558438. doi: 10.1101/2023.09.19.558438. PubMed |
| Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis. Ma L, Chang Q, Pei F, Liu M, Zhang W, Hong YK, Chai Y, Chen JF. Cell Stem Cell. 2023 Nov 2;30(11):1472-1485.e7. doi: 10.1016/j.stem.2023.09.012. Epub 2023 Oct 19. PubMed |
| RNA-based translation activators for targeted gene upregulation. Cao Y, Liu H, Lu SS, Jones KA, Govind AP, Jeyifous O, Simmons CQ, Tabatabaei N, Green WN, Holder JL Jr, Tahmasebi S, George AL Jr, Dickinson BC. Nat Commun. 2023 Oct 26;14(1):6827. doi: 10.1038/s41467-023-42252-z. PubMed |
| Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition. Verkade E, Shen W, Hovingh MV, Mulder NL, de Bruyn K, Koehorst M, de Vries HD, Bloks VW, Kuipers F, de Boer JF. Clin Sci (Lond). 2023 Nov 15;137(21):1637-1650. doi: 10.1042/CS20230812. PubMed |
| Human BST2 inhibits rabies virus release independently of cysteine-linked dimerization and asparagine-linked glycosylation. Tanwattana N, Wanasen N, Jantraphakorn Y, Srisutthisamphan K, Chailungkarn T, Boonrungsiman S, Lumlertdacha B, Lekchareonsuk P, Kaewborisuth C. PLoS One. 2023 Nov 3;18(11):e0292833. doi: 10.1371/journal.pone.0292833. eCollection 2023. PubMed |
| Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability. Pracucci E, Graham RT, Alberio L, Nardi G, Cozzolino O, Pillai V, Pasquini G, Saieva L, Walsh D, Landi S, Zhang J, Trevelyan AJ, Ratto GM. Nat Commun. 2023 Nov 4;14(1):7108. doi: 10.1038/s41467-023-42711-7. PubMed |
| Transgene Expression in Cultured Cells Using Unpurified Recombinant Adeno-Associated Viral Vectors. Benyamini B, Esbin MN, Whitney O, Walther N, Maurer AC. J Vis Exp. 2023 Oct 20;(200). doi: 10.3791/65572. PubMed |
Modular vector assembly enables rapid assessment of emerging CRISPR technologies.
McGee AV, Liu YV, Griffith AL, Szegletes ZM, Wen B, Kraus C, Miller NW, Steger RJ, Escude Velasco B, Bosch JA, Zirin JD, Viswanatha R, Sontheimer EJ, Goodale A, Greene MA, Green TM, Doench JG.
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| Delete_Simple and Highly Specific Targeting of Resident Microglia with Adeno-Associated Virus. Serrano C, Cananzi S, Shen T, Wang LL, Zhang CL. bioRxiv [Preprint]. 2023 Dec 13:2023.12.12.571321. doi: 10.1101/2023.12.12.571321. PubMed |
| Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells. Shao J, Li S, Qiu X, Jiang J, Zhang L, Wang P, Si Y, Wu Y, He M, Xiong Q, Zhao L, Li Y, Fan Y, Viviani M, Fu Y, Wu C, Gao T, Zhu L, Fussenegger M, Wang H, Xie M. Cell Res. 2024 Jan;34(1):31-46. doi: 10.1038/s41422-023-00896-y. Epub 2024 Jan 4. PubMed |
| SARS-CoV-2 Accessory Protein Orf7b Induces Lung Injury via c-Myc Mediated Apoptosis and Ferroptosis. Deshpande R, Li W, Li T, Fanning KV, Clemens Z, Nyunoya T, Zhang L, Deslouches B, Barchowsky A, Wenzel S, McDyer JF, Zou C. Int J Mol Sci. 2024 Jan 18;25(2):1157. doi: 10.3390/ijms25021157. PubMed |
| TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS. Yan J, Wang YM, Hellwig A, Bading H. Cell Rep Med. 2024 Feb 20;5(2):101413. doi: 10.1016/j.xcrm.2024.101413. Epub 2024 Feb 6. PubMed |
Streamlined Adeno-Associated Virus Production Using Suspension HEK293T Cells.
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| Long-term, high-resolution in vivo calcium imaging in pigeons. Nimpf S, Kaplan HS, Nordmann GC, Cushion T, Keays DA. Cell Rep Methods. 2024 Feb 26;4(2):100711. doi: 10.1016/j.crmeth.2024.100711. Epub 2024 Feb 20. PubMed |
| Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice. Chen Y, Chu JM, Wong GT, Chang RC. J Neuroimmune Pharmacol. 2024 Mar 1;19(1):8. doi: 10.1007/s11481-024-10107-z. PubMed |
| Enhancing prime editor activity by directed protein evolution in yeast. Weber Y, Bock D, Ivascu A, Mathis N, Rothgangl T, Ioannidi EI, Blaudt AC, Tidecks L, Vadovics M, Muramatsu H, Reichmuth A, Marquart KF, Kissling L, Pardi N, Jinek M, Schwank G. Nat Commun. 2024 Mar 7;15(1):2092. doi: 10.1038/s41467-024-46107-z. PubMed |
| Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury. Mohr ME, Li S, Trouten AM, Stairley RA, Roddy PL, Liu C, Zhang M, Sucov HM, Tao G. iScience. 2024 Feb 15;27(3):109219. doi: 10.1016/j.isci.2024.109219. eCollection 2024 Mar 15. PubMed |
| Type-I-interferon-responsive microglia shape cortical development and behavior. Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK, Kaminskaya E, Nakao-Inoue H, Schwer B, Arnold TD, Molofsky AB, Condello C, Andino R, Nowakowski TJ, Molofsky AV. Cell. 2024 Apr 11;187(8):1936-1954.e24. doi: 10.1016/j.cell.2024.02.020. Epub 2024 Mar 14. PubMed |
| Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection. Liu H, Zhang Y, Yip M, Ren L, Liang J, Chen X, Liu N, Du A, Wang J, Chang H, Oh H, Zhou C, Xing R, Xu M, Guo P, Gessler D, Xie J, Tai PWL, Gao G, Wang D. Mol Ther Methods Clin Dev. 2024 Mar 12;32(2):101230. doi: 10.1016/j.omtm.2024.101230. eCollection 2024 Jun 13. PubMed |
Astrocyte-secreted neurocan controls inhibitory synapse formation and function.
Irala D, Wang S, Sakers K, Nagendren L, Ulloa Severino FP, Bindu DS, Savage JT, Eroglu C.
Neuron. 2024 Mar 27:S0896-6273(24)00161-2. doi: 10.1016/j.neuron.2024.03.007.
PubMed
Associated Plasmids |
| Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins. Stone ML, Lee J, Lee JW, Coho H, Tariveranmoshabad M, Wattenberg MM, Choi H, Herrera VM, Xue Y, Choi-Bose S, Zingone SK, Patel D, Markowitz K, Delman D, Balachandran VP, Beatty GL. Nat Immunol. 2024 May;25(5):755-763. doi: 10.1038/s41590-024-01820-1. Epub 2024 Apr 19. PubMed |
| Targeting low levels of MIF expression as a potential therapeutic strategy for ALS. Alfahel L, Gschwendtberger T, Kozareva V, Dumas L, Gibbs R, Kertser A, Baruch K, Zaccai S, Kahn J, Thau-Habermann N, Eggenschwiler R, Sterneckert J, Hermann A, Sundararaman N, Vaibhav V, Van Eyk JE, Rafuse VF, Fraenkel E, Cantz T, Petri S, Israelson A. Cell Rep Med. 2024 May 21;5(5):101546. doi: 10.1016/j.xcrm.2024.101546. Epub 2024 May 3. PubMed |
| Transient sensorimotor projections in the developmental song learning period. Louder MIM, Kuroda M, Taniguchi D, Komorowska-Muller JA, Morohashi Y, Takahashi M, Sanchez-Valpuesta M, Wada K, Okada Y, Hioki H, Yazaki-Sugiyama Y. Cell Rep. 2024 May 28;43(5):114196. doi: 10.1016/j.celrep.2024.114196. Epub 2024 May 7. PubMed |
| Delete_ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum. Martins-Costa C, Wiegers A, Pham VA, Sidhaye J, Doleschall B, Novatchkova M, Lendl T, Piber M, Peer A, Moseneder P, Stuempflen M, Chow SYA, Seidl R, Prayer D, Hoftberger R, Kasprian G, Ikeuchi Y, Corsini NS, Knoblich JA. Cell Stem Cell. 2024 Jun 6;31(6):866-885.e14. doi: 10.1016/j.stem.2024.04.014. Epub 2024 May 7. PubMed |
| Localized translation and sarcomere maintenance requires ribosomal protein SA in mice. Haddad R, Sadeh O, Ziv T, Erlich I, Haimovich-Caspi L, Shemesh A, van der Velden J, Kehat I. J Clin Invest. 2024 May 14;134(13):e174527. doi: 10.1172/JCI174527. PubMed |
| Exploring Ca(2+) Dynamics in Myelinating Oligodendrocytes through rAAV-Mediated jGCaMP8s Expression in Developing Spinal Cord Organ Cultures. Pachetti M, Palandri A, de Castro Reis F, Recupero L, Ballerini L. eNeuro. 2024 Jun 4;11(6):ENEURO.0540-23.2024. doi: 10.1523/ENEURO.0540-23.2024. Print 2024 Jun. PubMed |
| Clinical and Electrophysiological Outcomes of Left Bundle Area Pacing Compared to Biventricular Pacing: An Updated Meta-analysis. Lakshman H, Chowdhury M, Ahmed A, Woods E, Flemengos G, Abdou C, Patel H, Zughaib M, Bradley C. J Innov Card Rhythm Manag. 2024 May 15;15(5):5858-5865. doi: 10.19102/icrm.2024.15053. eCollection 2024 May. PubMed |
| Pharmaceutical targeting of the cannabinoid type 1 receptor impacts the crosstalk between immune cells and islets to reduce insulitis in humans. Wreven E, Ruiz de Adana MS, Hardiville S, Gmyr V, Kerr-Conte J, Chetboun M, Pasquetti G, Delalleau N, Thevenet J, Coddeville A, Vallejo Herrera MJ, Hinden L, Benavides Espinola IC, Gomez Duro M, Sanchez Salido L, Linares F, Bermudez-Silva FJ, Tam J, Bonner C, Egan JM, Olveira G, Colomo N, Pattou F, Gonzalez-Mariscal I. Diabetologia. 2024 Sep;67(9):1877-1896. doi: 10.1007/s00125-024-06193-6. Epub 2024 Jun 12. PubMed |
| Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice. Chung M, Imanaka K, Huang Z, Watarai A, Wang MY, Tao K, Ejima H, Aida T, Feng G, Okuyama T. Nat Commun. 2024 Jun 12;15(1):4531. doi: 10.1038/s41467-024-48430-x. PubMed |
| Histone serotonylation in dorsal raphe nucleus contributes to stress- and antidepressant-mediated gene expression and behavior. Al-Kachak A, Di Salvo G, Fulton SL, Chan JC, Farrelly LA, Lepack AE, Bastle RM, Kong L, Cathomas F, Newman EL, Menard C, Ramakrishnan A, Safovich P, Lyu Y, Covington HE 3rd, Shen L, Gleason K, Tamminga CA, Russo SJ, Maze I. Nat Commun. 2024 Jun 13;15(1):5042. doi: 10.1038/s41467-024-49336-4. PubMed |
| HSF5 Deficiency Causes Male Infertility Involving Spermatogenic Arrest at Meiotic Prophase I in Humans and Mice. Liu M, Wang L, Li Y, Zhi E, Shen G, Jiang X, Li D, Zhao X, Ruan T, Jiang C, Wang X, Zhang X, Zheng Y, Wu B, Ou N, Zhao G, Dai S, Zhou R, Yang L, Yang Y, Liu H, Shen Y. Adv Sci (Weinh). 2024 Sep;11(33):e2402412. doi: 10.1002/advs.202402412. Epub 2024 Jul 3. PubMed |
| Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum. Kakegawa W, Paternain AV, Matsuda K, Aller MI, Iida I, Miura E, Nozawa K, Yamasaki T, Sakimura K, Yuzaki M, Lerma J. Cell Rep. 2024 Jul 23;43(7):114427. doi: 10.1016/j.celrep.2024.114427. Epub 2024 Jul 9. PubMed |
Single-cell discovery of m(6)A RNA modifications in the hippocampus.
Feng S, Tellaetxe-Abete M, Zhang Y, Peng Y, Zhou H, Dong M, Larrea E, Xue L, Zhang L, Koziol MJ.
Genome Res. 2024 Jul 23;34(6):822-836. doi: 10.1101/gr.278424.123.
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| Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice. McCosh RB, Kreisman MJ, Tian K, Thomas SA, Breen KM. J Neurosci. 2024 Aug 21;44(34):e0084242024. doi: 10.1523/JNEUROSCI.0084-24.2024. PubMed |
| SHISA3 Reprograms Tumor-Associated Macrophages Toward an Antitumoral Phenotype and Enhances Cancer Immunotherapy. Zhang S, Yu B, Sheng C, Yao C, Liu Y, Wang J, Zeng Q, Mao Y, Bei J, Zhu B, Chen S. Adv Sci (Weinh). 2024 Sep;11(36):e2403019. doi: 10.1002/advs.202403019. Epub 2024 Jul 25. PubMed |
| Adenosine A(2B) receptors differently modulate oligodendrogliogenesis and myelination depending on their cellular localization. Cherchi F, Venturini M, Magni G, Frulloni L, Chieca M, Buonvicino D, Santalmasi C, Rossi F, De Logu F, Coppi E, Pugliese AM. Glia. 2024 Nov;72(11):1985-2000. doi: 10.1002/glia.24593. Epub 2024 Jul 30. PubMed |
| Disease-relevant upregulation of P2Y(1) receptor in astrocytes enhances neuronal excitability via IGFBP2. Shigetomi E, Suzuki H, Hirayama YJ, Sano F, Nagai Y, Yoshihara K, Koga K, Tateoka T, Yoshioka H, Shinozaki Y, Kinouchi H, Tanaka KF, Bito H, Tsuda M, Koizumi S. Nat Commun. 2024 Aug 8;15(1):6525. doi: 10.1038/s41467-024-50190-7. PubMed |
| Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes. Megagiannis P, Mei Y, Yan RE, Yuan L, Wilde JJ, Eckersberg H, Suresh R, Tan X, Chen H, Farmer WT, Cha K, Le PU, Catoire H, Rochefort D, Kwan T, Yee BA, Dion P, Krishnaswamy A, Cloutier JF, Stifani S, Petrecca K, Yeo GW, Murai KK, Feng G, Rouleau GA, Ideker T, Sanjana NE, Zhou Y. Cell Rep. 2024 Aug 27;43(8):114637. doi: 10.1016/j.celrep.2024.114637. Epub 2024 Aug 17. PubMed |
| Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication. Zhao X, Li Y, Zhang S, Sudwarts A, Zhang H, Kozlova A, Moulton MJ, Goodman LD, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, Duan J. medRxiv [Preprint]. 2024 Aug 15:2024.08.14.24312009. doi: 10.1101/2024.08.14.24312009. PubMed |
| Biolayer interferometry for adeno-associated virus capsid titer measurement and applications to upstream and downstream process development. Leibiger TM, Remmler LA, Green EA, Lee KH. Mol Ther Methods Clin Dev. 2024 Jul 25;32(3):101306. doi: 10.1016/j.omtm.2024.101306. eCollection 2024 Sep 12. PubMed |
| Impact of KDM6B mosaic brain knockout on synaptic function and behavior. Brauer B, Ancaten-Gonzalez C, Ahumada-Marchant C, Meza RC, Merino-Veliz N, Nardocci G, Varela-Nallar L, Arriagada G, Chavez AE, Bustos FJ. Sci Rep. 2024 Sep 2;14(1):20416. doi: 10.1038/s41598-024-70728-5. PubMed |
| Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells. Fu Q, Wang Y, Qin J, Xie D, McNally D, Yoon S. Appl Microbiol Biotechnol. 2024 Sep 4;108(1):459. doi: 10.1007/s00253-024-13281-5. PubMed |
| An autonucleolytic suspension HEK293F host cell line for high-titer serum-free AAV5 and AAV9 production with reduced levels of DNA impurity. Howe G, Bal M, Wasmuth M, Massaro G, Rahim AA, Ali S, Rivera M, Schofield DM, Omotosho A, Ward J, Keshavarz-Moore E, Mason C, Nesbeth DN. Mol Ther Methods Clin Dev. 2024 Aug 12;32(3):101317. doi: 10.1016/j.omtm.2024.101317. eCollection 2024 Sep 12. PubMed |
| CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA. Liu H, Zhao XF, Lu YN, Hayes LR, Wang J. J Clin Invest. 2024 Sep 17;134(21):e179016. doi: 10.1172/JCI179016. PubMed |
Simple and highly specific targeting of resident microglia with adeno-associated virus.
Serrano C, Cananzi S, Shen T, Wang LL, Zhang CL.
iScience. 2024 Aug 12;27(9):110706. doi: 10.1016/j.isci.2024.110706. eCollection 2024 Sep 20.
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| TXNIP regulates pulmonary inflammation induced by Asian sand dust. Pak SW, Kim WI, Lee SJ, Park SH, Cho YK, Kim JS, Kim JC, Kim SH, Shin IS. Redox Biol. 2024 Dec;78:103421. doi: 10.1016/j.redox.2024.103421. Epub 2024 Nov 6. PubMed |
| Free Cholesterol-Induced Liver Injury in Non-Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I. Shou JW, Ma J, Wang X, Li XX, Chen SC, Kang BH, Shaw PC. Adv Sci (Weinh). 2025 Jan;12(2):e2406191. doi: 10.1002/advs.202406191. Epub 2024 Nov 19. PubMed |
| Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells. Paul MA, Sigoillot SM, Marti L, Urra Quiroz FJ, Delagrange M, Cheung HW, Martinelli DC, Oriol E, Hakim V, Mailly P, Selimi F. Nat Neurosci. 2025 Feb;28(2):308-319. doi: 10.1038/s41593-024-01826-w. Epub 2024 Dec 10. PubMed |
| Quantitative proteomic analysis of residual host cell protein retention across adeno-associated virus affinity chromatography. Leibiger TM, Min L, Lee KH. Mol Ther Methods Clin Dev. 2024 Nov 18;32(4):101383. doi: 10.1016/j.omtm.2024.101383. eCollection 2024 Dec 12. PubMed |
| Rational engineering of minimally immunogenic nucleases for gene therapy. Raghavan R, Friedrich MJ, King I, Chau-Duy-Tam Vo S, Strebinger D, Lash B, Kilian M, Platten M, Macrae RK, Song Y, Nivon L, Zhang F. Nat Commun. 2025 Jan 2;16(1):105. doi: 10.1038/s41467-024-55522-1. PubMed |
| Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity. Tutas J, Tolve M, Ozer-Yildiz E, Ickert L, Klein I, Silverman Q, Liebsch F, Dethloff F, Giavalisco P, Endepols H, Georgomanolis T, Neumaier B, Drzezga A, Schwarz G, Thorens B, Gatto G, Frezza C, Kononenko NL. Nat Metab. 2025 Feb;7(2):297-320. doi: 10.1038/s42255-024-01196-4. Epub 2025 Jan 15. PubMed |
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