We narrowed to 160,365 results for: des

#92383

CRISPRa

John Doench, David Root

Sanson et al Nat Commun. 2018 Dec 21;9(1):5416. doi:

July 13, 2018

Academic Institutions and Nonprofits only

#170432

Concise library targeting the whole genome of S. pneumoniae D39V with one sgRNA per operon or gene.

Jan-Willem Veening

Liu et al Cell Host Microbe. 2021 Jan 13;29(1):107

Aug. 31, 2021

Academic Institutions and Nonprofits only

#92384

CRISPRa

John Doench, David Root

Sanson et al Nat Commun. 2018 Dec 21;9(1):5416. doi:

July 13, 2018

Academic Institutions and Nonprofits only

#73178

Human sgRNA library in backbone lentiGuide-Puro targeting 19,114 genes and containing 76,441 unique sgRNAs along with 1000 non-targeting controls

John Doench, David Root

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Feb. 9, 2016

Academic Institutions and Nonprofits only

#73179

Human sgRNA library in backbone lentiCRISPRv2 targeting 19,114 genes and containing 76,441 unique sgRNAs along with 1000 non-targeting controls

John Doench, David Root

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Feb. 9, 2016

Academic Institutions and Nonprofits only

#73633

Mouse sgRNA library in backbone lentiGuide-Puro containing 78,637 unique sgRNAs targeting 19,674 genes along with 1000 non-targeting controls

John Doench, David Root

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Feb. 25, 2016

Academic Institutions and Nonprofits only

#73632

Mouse sgRNA library in backbone lentiCRISPRv2 containing 78,637 unique sgRNAs targeting 19,674 genes along with 1000 non-targeting controls

John Doench, David Root

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Feb. 25, 2016

Academic Institutions and Nonprofits only

#160129

Targets mouse metabolic genes and includes most metabolic enzymes and transporters.

Kivanc Birsoy

Zhu et al Cell Metab. 2020 Oct 28. pii: S1550-4131

Nov. 10, 2020

Academic Institutions and Nonprofits only

#191535

Targets 1,196 genes related to lipid droplet biology and cell metabolism.

James Olzmann

Roberts et al Dev Cell. 2023 Jul 18:S1534-5807(23)0033

March 1, 2023

Academic Institutions and Nonprofits only

#234855

A CRISPRi library for inducible, genome-wide gene repression in Pseudomonas aeruginosa PA14.

Xue Liu

Zhang et al Nat Commun. 2025 Jul 1;16(1):5870. doi:

June 5, 2025

Academic Institutions and Nonprofits only

#174514

Recoded E. coli strain without TCG, TCA, or TAG codons and deleted serT, serU and prfA genes. Full sequence - Genbank: CP071799.1

Jason W Chin

Robertson et al Science. 2021 Jun 4;372(6546):1057-1062.

Nov. 18, 2021

Academic Institutions and Nonprofits only

#138084

Targets 3' splice sites with paired gRNAs. Induces skipping of poison cassette exons and matching upstream constitutive exons. Compare loss of a constitutive coding exon with loss of a poison exon.

Robert Bradley

Thomas et al Nat Genet. 2020 Jan;52(1):84-94. doi: 10

March 6, 2020

Academic Institutions and Nonprofits only

#237425

This engineered E. coli S17-1 λpir strain, featuring a mutation in the gyrA gene (462Arg→Cys), was designed to confer resistance to the CcdB toxin, allowing it to survive with a ccdB-carrying plasmid.

Xue Liu

Zhang et al Nat Commun. 2025 Jul 1;16(1):5870. doi:

Aug. 7, 2025

Academic Institutions and Nonprofits only

#113569

Pooled lentiviral plasmid library containing ~8,000 single amino acid substitution and nonsense mutant variants of p53

William Hahn, David Root

Giacomelli et al Nat Genet. 2018 Oct;50(10):1381-1387. do

Jan. 4, 2019

Academic Institutions and Nonprofits only

#67988

Knockout library targeting 18,424 mouse genes. gRNAs were improved using a new design pipeline and improved gRNA scaffold.

Kosuke Yusa

Tzelepis et al Cell Rep. 2016 Oct 18;17(4):1193-1205. d

Oct. 14, 2016

Academic Institutions and Nonprofits only

#67989

Knockout library targeting 18,010 human genes. gRNAs were improved using a new design pipeline and improved gRNA scaffold.

Kosuke Yusa

Tzelepis et al Cell Rep. 2016 Oct 18;17(4):1193-1205. d

Oct. 14, 2016

Academic Institutions and Nonprofits only

#178284

Knockout library targeting the green monkey (Chlorocebus sabaeus) genome.

John Doench, David Root

Wei et al Cell. 2021 Jan 7;184(1):76-91.e13. doi:

Nov. 23, 2021

Academic Institutions and Nonprofits only

#159393

Mouse lentiviral genome-wide CRISPR library

Jason Moffat

Lawson et al Nature. 2020 Oct;586(7827):120-126. doi:

Nov. 9, 2020

Academic Institutions and Nonprofits only

#159392

Mouse lentiviral genome-wide CRISPR library

Jason Moffat

Lawson et al Nature. 2020 Oct;586(7827):120-126. doi:

Nov. 9, 2020

Academic Institutions and Nonprofits only

#197113

E. coli BL21(DE3) derivative for diterpenoid production with genome-integrated yeast MEV pathway, redox enzyme array, and Marionette cluster

Christopher Voigt

Lin et al Nature Catalysis. 6, 1016–1029 (2023). h

June 30, 2023

Academic Institutions and Nonprofits only

#197112

E. coli BL21(DE3) derivative for sesquiterpenoid production with genome-integrated yeast MEV pathway, redox enzyme array, and Marionette cluster

Christopher Voigt

Lin et al Nature Catalysis. 6, 1016–1029 (2023). h

June 30, 2023

Academic Institutions and Nonprofits only

#159391

Targets 182 immune evasion genes. Designed for loss-of-function screening against genes shown to increase sensistivity or resistance of cancer cells to cytotoxic T lymphocyte-mediated toxicity.

Jason Moffat

Lawson et al Nature. 2020 Oct;586(7827):120-126. doi:

Nov. 9, 2020

Academic Institutions and Nonprofits only

#61440

This E. coli chassis displays reduced endogenous reduction of aromatic and aliphatic aldehydes

Kristala Prather

Kunjapur et al J Am Chem Soc. 2014 Aug 20;136(33):11644

Feb. 1, 2015

Academic Institutions and Nonprofits only

#45473

Michele Swanson

Bryan et al Mol Microbiol. 2011 Apr;80(1):231-47. do

Feb. 24, 2016

Academic Institutions and Nonprofits only

#52701

KIlac with first 37 bases from Oplac1

Tanja Kortemme

Eames et al Science. 2012 May 18;336(6083):911-5. do

Aug. 19, 2014

Academic Institutions and Nonprofits only

#52702

KIlac with first 37 bases from Oplac2

Tanja Kortemme

Eames et al Science. 2012 May 18;336(6083):911-5. do

Aug. 19, 2014

Academic Institutions and Nonprofits only

#52703

Oplac1 with first 37 bases from KIlac

Tanja Kortemme

Eames et al Science. 2012 May 18;336(6083):911-5. do

Aug. 19, 2014

Academic Institutions and Nonprofits only

#45472

Michele Swanson

Bryan et al Mol Microbiol. 2011 Apr;80(1):231-47. do

Feb. 24, 2016

Academic Institutions and Nonprofits only

#52700

OpLac2 without the first 6 nucleotides of lacZ

Tanja Kortemme

Eames et al Science. 2012 May 18;336(6083):911-5. do

Aug. 19, 2014

Academic Institutions and Nonprofits only

#52704

Oplac2 with first 37 bases from KIlac

Tanja Kortemme

Eames et al Science. 2012 May 18;336(6083):911-5. do

Aug. 19, 2014

Academic Institutions and Nonprofits only

#52698

OpLac1 without the first 6 nucleotides of lacZ

Tanja Kortemme

Eames et al Science. 2012 May 18;336(6083):911-5. do

Aug. 19, 2014

Academic Institutions and Nonprofits only

#98568

Recoded strain C321.ΔA adaptively evolved for 1000+ generations in M9 minimal media + 1% glucose and biotin

George Church

Wannier et al Proc Natl Acad Sci U S A. 2018 Mar 20;11

Feb. 6, 2018

Academic Institutions and Nonprofits only

#71421

This E. coli MG1655 strain has a genome-integrated genetic module containing a rationally engineered 5-enzyme Entner-Doudoroff pathway (first version). The module also contains a Cm resistance marker.

Howard Salis

Ng et al Metab Eng. 2015 May;29:86-96. doi: 10.10

Feb. 18, 2016

Academic Institutions and Nonprofits only