6,471 results

1. PZac2.1 hSyn1-Lck-13xLinker-BioID2-BioID2-HA

   Plasmid

   #176854

   Purpose

   Expresses membrane bound biotin ligase, BioID2, in neurons

   Depositor

   Baljit Khakh

   Article

   Soto et al Nature. 2023 Apr;616(7958):764-773. doi:

   Insert

   Lck-13xLinker-BioID2-BioID2-HA
   

   Use

   AAV

   Tags

   HA

   Expression

   Bacterial

   Promoter

   hSyn1

   Available Since

   April 11, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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2. pAAV_hDlx_DIO_ChR2_mCherry

   Plasmid

   #224459

   Purpose

   An AAV vector expressing ChR2-mCherry that is dependent on both Cre and the hDlx enhancer

   Depositor

   Gordon Fishell

   Article

   Wu et al bioRxiv 2024.07.20.604399

   Insert

   ChR2-mCherry
   

   Use

   AAV

   Expression

   Mammalian

   Available Since

   Sept. 3, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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3. psubCAG-WPRE-hVEGF-D-Strept

   Plasmid

   #119227

   Purpose

   Plasmid encodes Strep-tagged full-length (unprocessed) VEGF-D of human origin to be used for stimulation of lymphangiogenesis in mice in vivo.

   Depositor

   Kari Alitalo

   Insert

   VEGFD (VEGFD Human)
   

   Use

   AAV

   Tags

   Strept

   Promoter

   CAG

   Available Since

   Dec. 18, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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4. pAAV-hSyn-LMO7 (mNeonGreen-eKL9h-VChR1)

   Plasmid

   #205097

   Purpose

   fusion protein of mNeonGreen, eKL9h, and Volvox channelrhodopsin-1 (luminopsin LMO7) for bioluminescent optogenetics

   Depositor

   Ute Hochgeschwender

   Article

   Björefeldt et al Neurophotonics. 2024 Apr;11(2):021005. d

   Insert

   mNeonGreen, eKaz luciferase, Volvox Channelrhodopsin 1
   

   Use

   AAV

   Promoter

   hSyn

   Available Since

   Sept. 15, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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5. pAAV-hSyn-GRAB_OTmut

   Plasmid

   #185388

   Purpose

   Expresses the genetically-encoded fluorescent oxytocin(OT) control sensor GRAB_OTmut in neurons

   Depositor

   Yulong Li

   Article

   Qian et al Nat Biotechnol. 2023 Jan 2. doi: 10.1038

   Has Service

   AAV1 and AAV9

   Insert

   GPCR activation based oxytocin control sensor GRAB_OTmut
   

   Use

   AAV

   Promoter

   hSyn

   Available Since

   Sept. 20, 2022

   Availability

   Academic Institutions and Nonprofits only

   

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6. pAAV-TRE-DIO-mNeonGreen

   Plasmid

   #99132

   Purpose

   An AAV genome with tet-inducible, Cre-dependent expression of the fluorescent protein mNeonGreen

   Depositor

   Viviana Gradinaru

   Article

   Chan et al Nat Neurosci. 2017 Aug;20(8):1172-1179.

   Insert

   DIO-mNeonGreen
   

   Use

   AAV

   Expression

   Mammalian

   Promoter

   TRE

   Available Since

   March 15, 2019

   Availability

   Academic Institutions and Nonprofits only

   

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7. pAAV-CMV-CD4-sTC-M13-GFP-P2A-CaM-V5-sTN

   Plasmid

   #219781

   Purpose

   CaST-P2A for HEK cell expression

   Depositor

   Christina Kim

   Article

   Zhang et al Nat Methods. 2024 Sep;21(9):1725-1735. d

   Insert

   CD4-sTC-M13-GFP-P2A-CaM-V5-sTN
   

   Use

   AAV

   Tags

   HA and V5

   Expression

   Mammalian

   Promoter

   CMV

   Available Since

   July 12, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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8. EFS-Vector

   Plasmid

   #109395

   Purpose

   AAV-CRISPR knockout plasmid for direct in vivo genome editing

   Depositor

   Sidi Chen

   Article

   Wang et al Sci Adv. 2018 Feb 28;4(2):eaao5508. doi:

   Type

   Empty backbone

   Use

   AAV, CRISPR, Mouse Targeting, and Synthetic Biolo…

   Expression

   Mammalian

   Promoter

   EFs-NS

   Available Since

   Sept. 19, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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9. AiP14132 - pAAV-AiE0779m_3xC2-minBG-jGCaMP8m-WPRE3-BGHpA (Alias: CN4132)

   Plasmid

   #191735

   Purpose

   AI plasmid ALIAS: AiP14132. Expression of jGCaMP8m in striatal direct pathway medium spiny neurons (D1-MSNs)

   Depositor

   Allen Institute for Brain Science, Jonathan Ting

   Article

   Hunker et al Neuron. 2025 May 21;113(10):1507-1524.e1

   Insert

   jGCaMP8m
   

   Use

   AAV

   Mutation

   none

   Available Since

   Feb. 1, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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10. pAAV-EFS-TadA8e-Sauri-U6-sgRNA scaffold

    Plasmid

    #226921

    Purpose

    Encoding SauriABE8e and sgRNA cassette on a single AAV

    Depositor

    Yuxuan Guo

    Article

    Liu et al Circ Res. 2025 Jan 16. doi: 10.1161/CIRC

    Insert

    TadA8e, nSauriCas9
    

    Use

    AAV

    Promoter

    EFS

    Available Since

    Jan. 16, 2025

    Availability

    Academic Institutions and Nonprofits only

    

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11. pAAV-FLEX-SaCas9-U6-sgGabrg2

    Plasmid

    #124857

    Purpose

    Mutagenesis of Gabrg2

    Depositor

    Larry Zweifel

    Article

    Hunker et al Cell Rep. 2020 Mar 24;30(12):4303-4316.e

    Insert

    Gabrg2 (Gabrg2 Mouse)
    

    Use

    AAV, CRISPR, and Mouse Targeting

    Available Since

    May 3, 2019

    Availability

    Academic Institutions and Nonprofits only

    

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12. pAAV-EF1a-double floxed-EYFP-WPRE-HGHpA

    Plasmid

    #20296

    Purpose

    Cre-activated AAV expression of EYFP

    Depositor

    Karl Deisseroth

    Insert

    EYFP
    

    Use

    AAV

    Expression

    Mammalian

    Available Since

    May 14, 2009

    Availability

    Academic Institutions and Nonprofits only

    

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13. pEH_AAV_TERT_prom_-146C>T_C7C_1.8kb

    Plasmid

    #183081

    Purpose

    rAAV transfer plasmid with ITRs flanking: (1) TERT -146C>T promoter and exon 1 C7C (C21>T21), 1.8kb homologous recombination donor template with ~900 bp homology arms, and (2) PGK-Puro.

    Depositor

    Aviv Regev

    Article

    Hodis et al Science. 2022 Apr 29;376(6592):eabi8175.

    Insert

    TERT -146C>T promoter and exon 1 C7C (C21>T21), 1.8kb homologous recombination donor template with ~900 bp homology arms (TERT Human)
    

    Use

    AAV; Homologous recombination donor template

    Mutation

    -146C>T promoter, Exon 1 C7C (C21>T21) sile…

    Promoter

    None for primary insert (Though partial TERT prom…

    Available Since

    June 9, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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14. pAAV-hSyn-dLight1.1

    Plasmid

    #111066

    Purpose

    To generate Adeno-Associated viruses for expression of dLight1.1 under synapsin promoter

    Depositor

    Lin Tian

    Article

    Patriarchi et al Science. 2018 Jun 29;360(6396). pii: sci

    Has Service

    AAV1

    Insert

    dLight1.1
    

    Use

    AAV

    Tags

    Flag tag

    Available Since

    July 23, 2019

    Availability

    Academic Institutions and Nonprofits only

15. AiP978-pAAV-mscRE4-minBGpromoter-FlpO-WPRE-hGHpA

    Plasmid

    #163472

    Purpose

    Direct-expressing FlpO AAV Virus. Alias: AiP978 - pAAV-AiE2004m-minBG-FlpO-WPRE-HGHpA

    Depositor

    Allen Institute for Brain Science, Bosiljka Tasic

    Article

    Graybuck et al Neuron. 2021 Mar 23. pii: S0896-6273(21)

    Insert

    FlpO
    

    Use

    AAV

    Promoter

    Beta Globin minimal promoter

    Available Since

    Feb. 26, 2021

    Availability

    Academic Institutions and Nonprofits only

    

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16. pAAV-MCU-EGFP

    Plasmid

    #181866

    Purpose

    Expresses GFP-tagged mitochondrial calcium uniporter (MCU) under control of the CaMKIIa promoter

    Depositor

    Hilmar Bading

    Article

    Qiu et al Nat Commun. 2013;4:2034. doi: 10.1038/nc

    Insert

    mitochondrial calcium uniporter (Mcu Mouse)
    

    Use

    AAV and Adenoviral

    Tags

    EGFP

    Expression

    Mammalian

    Promoter

    CaMKIIa

    Available Since

    March 17, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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17. pAAV-hSyn-ConVERGD-ConFonvConNon-eGFP-W3SL

    Plasmid

    #218753

    Purpose

    Provides AND intersectional (Cre+Flp+vCre+Vika) expression of eGFP

    Depositor

    Lindsay Schwarz

    Article

    Hughes et al bioRxiv. 2023 Feb 8:2023.02.07.527312. d

    Insert

    eGFP
    

    Use

    AAV

    Promoter

    hSyn

    Available Since

    May 1, 2024

    Availability

    Academic Institutions and Nonprofits only

    

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18. AAV-EF1a-DIO-oChIEF(E163A/T199C)-P2A-dTomato-WPRE-BGHpA

    Plasmid

    #51094

    Purpose

    Cre dependent expression of oChIEF kinetic variant E163A/T199C with physically uncoupled dTomato fluorophore

    Depositor

    Jonathan Ting

    Insert

    oChIEF(E163A/T199C)
    

    Use

    AAV

    Tags

    P2A-dTomato

    Expression

    Mammalian

    Mutation

    E163A/T199C

    Promoter

    EF1a

    Available Since

    May 13, 2014

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

19. AiP1277 - pAAV-AiE2051m-minBG-SYFP2-WPRE-BGHpA

    Plasmid

    #214479

    Purpose

    AiE2051m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

    Depositor

    Allen Institute for Brain Science, Bosiljka Tasic

    Article

    Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

    Insert

    SYFP2
    

    Use

    AAV

    Promoter

    minBG

    Available Since

    July 12, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

20. pAAV-EFS-DIO-GRAB_ATP1.0

    Plasmid

    #167581

    Purpose

    Express the ATP sensor GRAB_ATP1.0 in Cre positive cells

    Depositor

    Yulong Li

    Article

    Wu et al Neuron. 2021 Dec 17. pii: S0896-6273(21)

    Insert

    ATP sensor GRAB_ATP1.0 (P2RY1 Human)
    

    Use

    AAV

    Promoter

    EFS

    Available Since

    May 7, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

21. pAAV-CAG-EGFP barcode-3-SV40 polyA

    Plasmid

    #190867

    Purpose

    For barcoded retrograde labeling

    Depositor

    Yuejun Chen

    Article

    Xu et al Elife. 2024 Feb 23;13:e85419. doi: 10.75

    Insert

    EGFP-barcode3
    

    Use

    AAV

    Mutation

    WT

    Available Since

    Nov. 14, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

22. pAAV-CAG-EGFP barcode-4-SV40 polyA

    Plasmid

    #190868

    Purpose

    For barcoded retrograde labeling

    Depositor

    Yuejun Chen

    Article

    Xu et al Elife. 2024 Feb 23;13:e85419. doi: 10.75

    Insert

    EGFP-barcode4
    

    Use

    AAV

    Mutation

    WT

    Available Since

    Nov. 14, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

23. pAAV-hSyn1-EGFP-P2A-EGFPf-WPRE-HGHpA

    Plasmid

    #74513

    Purpose

    AAV vector that use human synapsin-1 promoter to drive the expression of EGFP and membrane-targeted EGFPf linked by self-cleaving P2A peptide.

    Depositor

    Guoping Feng

    Article

    Zhang et al J Neurosci. 2016 Feb 17;36(7):2247-60. d

    Insert

    EGFP-p2A-EGFP-f
    

    Use

    AAV

    Available Since

    July 20, 2016

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

24. pAAV.CAG.SF-iGluSnFR.A184V

    Plasmid

    #106199

    Purpose

    Medium affinity glutamate sensor ** A newer version of this sensor is available. Please see iGluSnFR3 plasmids at https://www.addgene.org/browse/article/28220233/ **

    Depositor

    Loren Looger

    Article

    Marvin et al Nat Methods. 2018 Nov;15(11):936-939. do

    Insert

    SF-iGluSnFR.A184V
    

    Use

    AAV

    Mutation

    GltI: A184V

    Promoter

    CAG

    Available Since

    July 6, 2018

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

25. pAS133

    Plasmid

    #211504

    Purpose

    AAV genome to express mTagBF2 under control of EF1a. Use for tri-color experiments to define injection conditions for AAV-Perturb-seq

    Depositor

    Randall Platt

    Article

    Santinha et al Nature. 2023 Oct;622(7982):367-375. doi:

    Insert

    mTagBF2
    

    Use

    AAV, CRISPR, Cre/Lox, and Mouse Targeting

    Expression

    Mammalian

    Available Since

    Dec. 21, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

26. pAAV-U6-DR(RfxCas13d)-CAG-CasRx-pa

    Plasmid

    #233035

    Purpose

    To express a RfxCas13d-compatible gRNA and to express HA Tagged CasRx from a CAG promoter

    Depositor

    Jonathan Ploski

    Article

    Back et al Mol Ther Methods Clin Dev. 2025 Aug 20;3

    Insert

    RfxCas13d-compatible gRNA expression cassette and CasRx
    

    Use

    AAV

    Available Since

    April 1, 2025

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

27. AiP12311 - pAAV-AiE0226h-minBG-SYFP2-WPRE3-BGHpA (Alias: CN2311)

    Plasmid

    #230108

    Purpose

    AiE0226h is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

    Depositor

    Allen Institute for Brain Science, Boaz Levi

    Article

    Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

    Insert

    SYFP2
    

    Use

    AAV

    Promoter

    minBG

    Available Since

    Feb. 20, 2025

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

28. pAV-CAG-oScarlet-WPRE-BC5-pA

    Plasmid

    #220769

    Purpose

    Expression of oScarlet for cell isolation and Projection-TAG BC for multiplex projection tracing

    Depositor

    Vijay Samineni

    Article

    Yang et al Nat Commun. 2025 Jul 1;16(1):5557. doi:

    Insert

    oScarlert-WPRE-BC5
    

    Use

    AAV

    Promoter

    CAG

    Available Since

    Jan. 13, 2025

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

29. pAV-CAG-oScarlet-WPRE-BC4-pA

    Plasmid

    #220768

    Purpose

    Expression of oScarlet for cell isolation and Projection-TAG BC for multiplex projection tracing

    Depositor

    Vijay Samineni

    Article

    Yang et al Nat Commun. 2025 Jul 1;16(1):5557. doi:

    Insert

    oScarlert-WPRE-BC4
    

    Use

    AAV

    Promoter

    CAG

    Available Since

    Jan. 13, 2025

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

30. pAV-CAG-oScarlet-WPRE-BC3-pA

    Plasmid

    #220767

    Purpose

    Expression of oScarlet for cell isolation and Projection-TAG BC for multiplex projection tracing

    Depositor

    Vijay Samineni

    Article

    Yang et al Nat Commun. 2025 Jul 1;16(1):5557. doi:

    Insert

    oScarlert-WPRE-BC3
    

    Use

    AAV

    Promoter

    CAG

    Available Since

    June 13, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

31. pAAV-Ef1a-sCreDIO hChR2(H134R)-EYFP

    Plasmid

    #55642

    Purpose

    sCre-Dependent ChR2-EYFP

    Depositor

    Karl Deisseroth

    Article

    Fenno et al Nat Methods. 2014 Jul;11(7):763-72. doi:

    Insert

    hChR2(H134R)-EYFP
    

    Use

    AAV; Scre-dependent

    Tags

    EYFP

    Expression

    Mammalian

    Promoter

    Ef1a

    Available Since

    Aug. 8, 2014

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

32. pAAV-CaMKIIa-C1V1 (t/t)-TS-EYFP

    Plasmid

    #35499

    Purpose

    AAV expression of CaMKII-driven chimeric opsin variant C1V1 (E122T/E162T) for fast and potent optical excitation at red-shifted wavelengths.

    Depositor

    Karl Deisseroth

    Article

    Yizhar et al Nature. 2011 Jul 27;477(7363):171-8. doi

    Has Service

    AAV9

    Insert

    ChR1-VChR1 Chimera
    

    Use

    AAV

    Tags

    EYFP

    Expression

    Mammalian

    Mutation

    E122T and E162T

    Promoter

    CaMKIIa

    Available Since

    April 18, 2012

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

33. pGP-AAV-CAG-FLEX-jGCaMP7c variant 1513-WPRE

    Plasmid

    #105323

    Purpose

    AAV-mediated expression of ultrasensitive protein calcium sensor under the CAG promoter, Cre-dependent expression

    Depositor

    GENIE Project, Douglas Kim

    Article

    Dana et al Nat Methods. 2019 Jul;16(7):649-657. doi

    Insert

    jGCaMP7c variant 1513
    

    Use

    AAV and Cre/Lox

    Tags

    T7 epitope, Xpress tag, 6xHis

    Expression

    Mammalian

    Promoter

    CAG

    Available Since

    Jan. 23, 2018

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

34. GEARBOCS

    Plasmid

    #218181

    Purpose

    CRISPR tool to target astrocytes

    Depositor

    Cagla Eroglu

    Article

    Bindu et al bioRxiv. 2023 Jan 19:2023.01.17.524433.

    Type

    Empty backbone

    Use

    AAV and CRISPR

    Available Since

    Aug. 23, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

35. pAAV-DIO-CAG-TVA-P2A-dTomato

    Plasmid

    #177016

    Purpose

    For expression of the avian TVA receptor in a cre-dependent manner

    Depositor

    Peter Jonas

    Insert

    TVA-P2A-dTomato (CD320 Coturnix japonica)
    

    Use

    AAV and Cre/Lox

    Tags

    dTomato

    Expression

    Mammalian

    Promoter

    CAGGS

    Available Since

    Feb. 4, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

36. CAG-FLEX-MCS-WPRE-SV40 - GCH2

    Plasmid

    #230815

    Purpose

    AAV cloning vector for CRE-dependent expression under the CAG promoter.

    Depositor

    Kimberly Ritola

    Type

    Empty backbone

    Use

    AAV and Cre/Lox; Cloning vector

    Available Since

    March 26, 2025

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

37. pAAV-Ef1a-FAS-TdTomato-WPRE-pA

    Plasmid

    #37092

    Purpose

    Expresses tdTomato in cells lacking Cre (Cre-Off, flanked by alternative lox FAS sites)

    Depositor

    Bernardo Sabatini

    Article

    Saunders et al Front Neural Circuits. 2012 Jul 27;6:47.

    Insert

    TdTomato
    

    Use

    AAV and Cre/Lox; Cre-off

    Promoter

    EF1a

    Available Since

    July 27, 2012

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

38. AiP13798 - pAAV-DLX2.0-minBG-SYFP2-P2A-mScarlet-10aa-H2B-WPRE3-BGHpA (Alias: CN3798)

    Plasmid

    #229935

    Purpose

    DLX2.0 is an enhancer sequence, designed to drive cytosolic SYFP2 and nuclear mScarlet expression in forebrain GABAergic neurons

    Depositor

    Allen Institute for Brain Science, Jonathan Ting

    Article

    Ben-Simon et al bioRxiv [Preprint]. 2024 Sep 26:2024.06.

    Insert

    SYFP2-P2A-mScarlet-10aa-H2B
    

    Use

    AAV

    Available Since

    Feb. 5, 2025

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

39. GEARBOCS-SPARCL1-N-mCherryTag

    Plasmid

    #218186

    Purpose

    To tag Hevin with mCherry at the N-terminal

    Depositor

    Cagla Eroglu

    Article

    Bindu et al bioRxiv. 2023 Jan 19:2023.01.17.524433.

    Insert

    sgRNA (Sparcl1 Mouse)
    

    Use

    AAV and CRISPR

    Available Since

    Aug. 23, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

40. pAAV-CAG-Archon1-KGC-EGFP-ER2

    Plasmid

    #108420

    Purpose

    AAV production plasmid encoding for Archon1 fluorescent voltage reporter

    Depositor

    Edward Boyden

    Article

    Piatkevich et al Nat Chem Biol. 2018 Feb 26. pii: 10.1038

    Insert

    Archon1-KGC-EGFP-ER2
    

    Use

    AAV

    Expression

    Mammalian

    Promoter

    CAG

    Available Since

    June 1, 2018

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge